dr. farida oesman sppk dr. elly santosa sppk dr. ninik...
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dr. Farida Oesman SpPKdr. Elly Santosa SpPK
dr. Ninik Sukartini SpPKDepartment of Clinical Pathology
Medical Faculty, University of Indonesia
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SKIN DISEASES
• INFECTION• INFLAMMATION• AUTOIMMUNE
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DIAGNOSIS
• ANAMNESIS•CLINICAL FEATURES• LABORATORY ASSAY
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MICROORGANISM DISEASES
• FUNGAL
• VIRAL
• BACTERIAL
• CANDIDIASIS• TINEA• HERPES SIMPLEX• VARICELLA ZOSTER• IMPETIGO• FOLLICULITIS
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METHODE
BACTERIAL/FUNGALDETECTION• DIRECT (MICROSCOPIC)• ISOLATION• NUCLEIC ACIDSEROLOGY• ANTIBODY DETECTION• ANTIGEN DETECTIONOTHER• HEMATOLOGY
• ACUTE PHASE PROTEIN
• KOH : Candida, Trichophyton sp GRAM : S. aureus, S.epidermidis• CULTURE: blood agar, Sabouraud• PCR
• IgM, IgG
• LEUCOCYTE, DIFF, PLATELET COUNT• CRP
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ASSAY SPECIMEN
• MICROSCOPIC• ISOLATION• NUCLEIC ACID• SEROLOGY• HEMATOLOGY• ACUTE PHASE PROTEIN
• SKIN SCRAPING, HAIR, NAIL• SKIN SCRAPING, HAIR, NAIL• BLOOD• BLOOD• BLOOD• BLOOD
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• CULTURE• PCR
• ANTIGEN
POSITIVE
CONFIRMDIAGNOSIS
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ANTIBODYDETECTION
PRIMARYINFECTION
SECONDARYINFECTION
• IgM (+), IgG (-)• IgM (+), IgG (+)
• IgM (-) , IgG (+)• IgM (+), IgG (+)
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ASSAY BACTERIALINFECTION
VIRALINFECTION
• LEUCOCYTE COUNT• DIFFERENTIAL COUNT• PLATELET COUNT
INCREASED
NEUTROPHILIASHIFT LEFTINCREASED
DECREASED
LYMPHOCYTOSIS
DECREASED
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HYPERSENSITIVITY DISEASES
• TYPE I
• TYPE IV
• ATOPIC ECZEMA• ACUTE URTICARIA
• ALLERGIC CONTACT DERMATITIS
INFLAMMATION
HYPERSENSITIVITY REACTION
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ASSAY RESULT
TYPE I• IgE LEVEL• IgE SPECIFIC• EOSINOPHIL COUNTINFLAMATION REACTION• INFLAMMATORY CYTOKINE• ACUTE PHASE PROTEIN
• INCREASED• POSITIVE • INCREASED
• IL-4, IL-5, IL-10 ↑
• CRP ↑
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AUTOIMMUNESKIN DISEASE
SKIN DAMAGETRIGGERED BY
• AUTOANTIBODIES TO SKIN ANTIGEN
BULLOUS SKIN DISEASES• DEPOSITION OF
IMMUNE COMPLEXES VASCULITIS, SLE
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AUTOANTIBODIES DISEASES
SKIN ANTIGEN• EPIDERMAL INTER CELLULAR CEMENT• BASEMENT MEMBRANE
SYSTEMIC ANTIGEN• NUCLEAR
• PEMPHIGUS VULGARIS
• BULLOUS PEMPHIGOID
• SUBACUTE CUTANEOUS LE• DISCOID LE
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ASSAY RESULT
• AUTOANTIBODIES• COMPLEMENT LEVEL
• POSITIVE• DECREASED
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DISEASES ASSAY
• LE• STAPHYLCOCCAL SCALDED SKIN SYNDROME (SSSS) • TOXIC SHOCK SYNDROME (TSS)
• RENAL FUNCTION: CREATININE ↑• LIVER FUNCTION : SGOT ↑ SGPT ↑
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