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FARDAH AKIL
CLINICAL PICTURES & PREDISPOSITION FACTORS
IN PATIENTS WITH EROSIVE AND NON EROSIVE
GASTROESOPHAGEAL REFLUX DISEASE
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INT O UCTION
Gastroesophageal reflux (GERD) is a disease with
heterogenicity feature, already known but usually is
annoyed
GERD appear if refluxate come into oesophagus with
enough amount and time so that could stimulate mucosa
symptoms wout mucosal damages (esophagitis)
GERD ha!e !arious of clinical symptoms, where
heartburnwout regurgitationreflux as spesific symptoms,
beside dyspepsia and extraesophageal symptoms
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"ased on upper endoscopy patients with heartburn or
GERD can subdi!ided into # catagories $ those with orwithout erosi!e esophagitis
%re!alence of GERD #&' on adult, male is e*ual with
female (gender analysis)
EGERD + with mild stage, male female - #'.$&
%atophysiology and pathogenesis of GERD were
multifactorial, initially in esophagus, gastroesophageal
/unction, gastroduodenal 0 genetic
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%rogression of GERD is influenced by an interplay betweenendogen and exogen factors
1n 2sia symptom of GERD not se!ere, /ust in 3ERD setting
4ohort analysis in 5apan $ mild EGERD to se!ere EGERD &678,
"arrett oesophagus 9 with predisposition factors $ older age,
female, initial symptoms when diagnosed with endoscopy
examination, hiatal hernia 9, atropic gastritis 0 :7pylori infection
;imited data in 1ndonesia < =yafruddin (&>>?) $ esofagitis ##7?in dyspeptic patients
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4apability of endoscopy to diagnose EGERD $ high
sensiti!ity 0 specificity, to e!aluate population pre!alence
not common
GERD incidence is difficult to assess
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PURPOSE
To determine the distribution of
endoscopic result, factor associated andclinical variation of symptoms among
GERD patients undergoing upper
gastrointestinal endoscopy
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SUBJECT AND METHODS
@bser!ational study with cross sectional approach in!ol!ing dyspeptic patients in #
teaching hospital in Aakassar
=tudy was conducted between #666 3o!ember to
#66 @ctober
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2ll sub/ects were *uestioned in regard to clinical symptoms
before endoscopic examination
Diagnosis 0 classification of reflux esophagitis was based
on the ;2 4lassification
2bsence of reflux esophagitis with typical symptoms of
GERD was diagnosis as ha!ing 3ERD
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Erosi!e and 3on'erosi!e GERD were analysed
in relation to age, gender, and some of
predisposition factors $ hiatus hernia, coffe
drinking, smoking and the used of 3=21D
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RESULT
Of 1290 dyspeptic patients, 540 (41.9%)
were diagnosed as having G!" #ased ontypica$ syptos of G!"
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Bable &74haracteristics of GERD patients
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Babel #7 Distribution of endoscopic results in GERD patients
C GERD - Gastroesophageal reflux disease, EGERD - Erosi!e GERD, 3ERD - 3on erosi!ereflux disease
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C GERD - Gastroesophageal reflux disease, EGERD - Erosi!e GERD, 3ERD - 3on erosi!e
reflux disease p 67686 significant
Bable .7 Distribution of GERD patients by gender
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Bable 7 Distribution of GERD patients by age
C GERD - Gastroesophageal reflux disease, EGERD - Erosi!e GERD, 3ERD - 3on erosi!e
reflux disease p+ 6768
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!
"
#
$
%
&
'one (ile reflu) Erosif Ulcer Gastriccancer
'ERD
EGERD
Graphic &7 Findings of gastric lesions in GERD patients
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Babel 87 %redisposisition factors of GERD patients
EGERD - Erosi!e GERD, 3ERD - 3on erosi!e reflux disease, 3=21D - 3on steroid anti inflammation drugs
p+ 67686
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Graphic #7 =ymptoms pattern of GERD patients with reflux as a common
symptom
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Graphic .7 Distribution of symptoms pattern of GERD patients
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CONCLUSION
3ERD constituted larger proportion and mostlyseen in female while EGERD was commonly inmale
=ymptoms pattern between EGERD dan3ERD are identical
Bhe findings of gastric lesions was found toha!e relationship with GERD symptom
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EGERD in patients with GERD in
Aakassar was found higher and ma/ority
case was grade 2 0 "
=ome of predisposition factors in this
study are not associated in the se!erity of
GERD
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