Download - Organised by FEBS CONGRESS - CERTH · Organised by. 2 Final Programme 36th FEBS CONGRESS ... Presidenza Consiglio Nazionale delle Ricerche, CNR - Roma. 6 Final Programme 36th FEBS

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Torino, Italy - June 25-30, 2011

Biochemistry forTomorrow’s Medicine

Final programme

www.febs2011.it

Organised by

Final Programme2

36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”

36th FEBS Congress 3


CONTENTS

Organisers and Committees ................................................................................................................ 4

Welcome message ............................................................................................................................... 5

FEBS 2011 Patronages......................................................................................................................... 5

FEBS 2011 Sponsors ........................................................................................................................... 8

FEBS 2011 Exhibitors ........................................................................................................................... 9

Key Information ................................................................................................................................... 10

Poster Presentations ........................................................................................................................... 11

Plenary Lectures ................................................................................................................................. 13

Congress Symposia ........................................................................................................................... 14

Programme at a Glance ..................................................................................................................... 16

Pre-Congress Event ........................................................................................................................... 18

Programme day by day ....................................................................................................................... 19

Poster Sessions .................................................................................................................................. 46

Exhibition Area - Poster Areas ............................................................................................................ 47

Turin (Torino)........................................................................................................................................ 48

Final Programme4


Organised byFederation of European Biochemical Societies (FEBS)

Italian Society of Biochemistry and Molecular Biology (SIB)University of Torino (UNITO)

in collaboration withItalian Federation of Life Sciences (FISV)

Italian Society of Biophysics and Molecular Biology (SIBBM)Italian Society of Immunology, Clinical Immunology and Allergology (SIICA)

Italian Society of Pharmacology (SIF)Italian Proteome Association (ItPA)

Co-sponsored byDepartment of Life Sciences,

Italian Research Council Rome

Scientific Committee and International Advisory BoardChairman

Sergio Papa

Organising CommitteeChairman

Gianfranco Gilardi

Organising Secretariat

M.A.F. Servizi Srl - Congress DivisionCorso Svizzera 185 - Turin (Italy)

Phone +39 011 505900 - Fax +39 011 505976Via XX Settembre 23 - Genova (Italy)

www.mafservizi.it

Organisers and Committees



WELCOME TO THE 36th FEBS CONGRESS

Dear Colleagues,

On behalf of the Italian Society of Biochemistry and Molecular Biology, the co-organising Italian ScientificSocieties and the Scientific and Organising Committees of FEBS 2011-Torino, we are most pleased towelcome you all to the 36th FEBS Congress “Biochemistry for Tomorrow’s Medicine”. It is indeed significantthat our Congress takes places in Torino, the first capital city of Italy, coinciding this year with the celebra-tions of the 150th year of Italy’s unification.

The availability of the human genome with the exponential development of functional genomics and pro-teomics and other related fields have opened new paths in the elucidation of the molecular pathogenesisof major human diseases. The Congress brings together a forum of experts in the most advanced sectorsof Biochemistry and Molecular Biology, from fundamental aspects to applied ones aimed at human pa-thophysiology. The scientific achievements that will be presented in more than 1500 contributions willprovide a comprehensive view of the translational power of fundamental research and inspire the futureresearch activity of younger generations of biomedical investigators.

We hope that you will enjoy the Congress as well as the many touristic attractions and events in the city ofTorino and its surroundings.

Gianfranco GilardiChairman Organizing Committee

Sergio PapaChairman Scientific Committee

FEBS 2011 Patronages

Presidenza del Consiglio dei Ministri, Repubblica Italiana

Città di Torino

Presidenza Consiglio Nazionale delle Ricerche, CNR - Roma

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International Scientific Advisory BoardPhilip Cohen (UK)Pascale Cossart (F)Stephanie Dimmeler (D)Paul Freemont (UK)Joseph Houstek (CZ)Sirpa Jalkanen (FIN)

Chairman Sergio Papa

Chairman Gianfranco Gilardi Deputy Chairman Fiorella Altruda

MembersMarco Arese (SIB)Luciana Avigliano (SIB)Maria Cavaletto (SIB)Tiziana Crepaldi (SIB)Silvia Deaglio (SIB)Ada FunaroDario Ghigo (SIB)Giuliana Giribaldi (SIB)Carlo Giunta (SIB)Andrea Graziani (SIB)Emilio Hirsch (ABCD)Evelin Keiling Schwarzer (SIB)

Mauro Patrone (SIB)Enrica Pessione (SIB)Marco Piccinini (SIB)Menico Rizzi (SIB)Sheila Sadeghi (SIB)Guido Serini (SIB)Francesca Silvagno (SIB)Fabiola Sinigaglia (SIB)Guido Tarone (ABCD)Franco Turrini (SIB)Francesca Valetti (SIB)Bruno Venerando (SIB)

Honorary Chairman Paolo Arese

MembersLilia Alberghina (SIB)Andrea Bellelli (SIB)Irene Bozzoni (SIB)Maurizio Brunori (SIB)Federico Bussolino (SIB)Felice Cervone (FISV)Filiberto Cimino (SIB)Daniela Corda (SIB)Riccardo Cortese (SIB)Paolo Comoglio (FISV)Vincenzo Cuomo (SIF)Antonio De Flora (SIB)Giorgio Lenaz (SIB)Giovanna Lucchini (FISV)Lucio Luzzatto (FISV)

Giulio Magni (SIB)Fabio Malavasi (SIB)Jacopo Meldolesi (FISV)Paolo Mocarelli (ItPa)Salvatore Oliviero (FISV)Valerio Orlando (FISV, SIBBM)Pier Giuseppe Pelicci (FISV)Carola Ponzetto (SIB)Piero Pucci (SIB, ItPA)Menico Rizzi (SIB)Maria Grazia Roncarolo (FISV)Giuseppe Rotilio (SIB)Francesco Salvatore (SIB)Roberto Sitia (FISV)Tommaso Russo (SIB)

Karl Küchler (A)Nils-Goran Larsson (S)Iain Mattaj (D)Gerry Melino (UK)Pier Paolo Pandolfi (USA)Israel Pecht (IL)

Francesco Ramirez (USA)Francisco Sanchez-Madrid (E)Anthony Schapira (UK)Kai Simons (D)Vladimir Skulachev (RUS)

FEBS Executive CommitteeTomas Zima, ChairmanWinnie Eskild, Vice ChairIsrael Pecht, Secretary GeneralJohn Mowbray, TreasurerAdam Szewczyk,Congress CounsellorJaak Järv, Chairman of the Advanced Courses CommitteeVicente Rubio, Chairman of the Fellowships CommitteeFélix M. Goñi, Chairman of the Publication CommitteeJacques-Henry Weil, Chairman of the Science and Society CommitteeGul Güner-Akdogan, Chair of the Education CommitteeClaudina Rodrigues-Pousada,Chair of the Working Group on the Career of Young ScientistsLea Sistonen, Chair of the Working Group on Women in Science

Organising Committee

Scientific Committee

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FEBS 2011 Sponsors

FEBS

Department of Life Sciences, Italian Research Council, Rome

Regione Piemonte

Italian Association for Cancer Research, AIRC

Bracco

SMAT

GE Healthcare

Novartis Vaccines and Diagnostic

BioPmed

Aspect

Instruct



ABCAM

ACS PUBLICATION

BIOCHEMICAL SOCIETY

BIOLINE

CAYMAN CHEMICAL COMPANY

ELSEVIER

EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)

EMBO

EUROPEAN RESEARCH COUNCIL

FEBS

JACKSON IMMUNORESEARCH EUROPE

KOMABIOTECH

LEICA MICROSYSTEM

NEW ENGLAND BIOLABS/CELL SIGNALING TECHNOLOGY

NOVUS BIOLOGICALS

POLYPLUS TRANSFECTION

PROTEINTECH GROUP

SCIENCES/AAAS

SPRINGER

ST. JUDE CHILDREN’S RESEARCH HOSPITAL

TOCRIS BIOSCIENCE

WILEY-BLACKWELL

WISEPRESS BOOKSHOP

FEBS 2011 Exhibitors

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Key Information

VenueLingotto Conference CentreVia Nizza, 28010126 Torino

The Lingotto Con-gress Centre is 10minutes from thecentre of Turin andthe Porta Nuovatrain station.Connections canbe made by busand tram, and alsoby underground.The Lingotto train

station can be reached via the Olympic footbridge. Visitorsarriving from motorways or from city by-pass will be guideddirectly to the Lingotto’s underground car parks by road signs.

On Site RegistrationPlease register at the Registration Desk in front of theAuditorium. If you are pre-registered via on line system, pleasemake sure to take your registration confirmation with you toavoid any confusion.If you are not pre-registered via on line system, you canregister and pay directly at the registration desk.In case your payment was not recognised or did not reach usby June 20, 2011, copy of the bank transfer will not beconsidered as a proof of payment. Therefore, you will beasked to pay an onsite registration. All proven doublepayments will be refunded after the congress.

REGISTRATION FEES

ACADEMIC GRADUATE EUR 550

STUDENT EUR 200

NON-ACADEMIC EUR 700

ACCOMPANYING PERSON EUR 120

Participants applying for special fee must submit a proof oftheir age or their student status.The registration fee for participants includes: congressmaterial, abstract book, welcome reception.

Registration DeskThe registration desk is located on the ground floor of theLingotto Conference Centre.Opening Hours:June 25, 2011 08:00 – 19:00June 26, 2011 08:00 – 18:00June 27, 2011 08:00 – 18:00June 28, 2011 08:00 – 18:00June 29, 2011 08:00 – 18:00June 30, 2011 08:00 – 12:00

Emergency NumbersAmbulance: 118Police: 112 or 113Fire brigade: 115

The registration fee includes- Admission to all sessions, poster areas and exhibitions- Admission to Opening Ceremony and Welcome Reception- Congress documents in the Congress bag - Final Pro-

gramme Book, Abstract Book (Supplement of FEBSJournal), FEBS Letters Congress Special Issue, LateAbstract Book, Evaluation Form.

- Name badge

Accompanying persons fee includes:Admission to the Opening Ceremony and WelcomeReception.Please note that accompanying persons are not allowed to take partin the sessions.

Certificate of attendanceCertificate of attendance will be handed at the registrationdesk.

BadgesAlong with your registration, you will receive your badge. Thename badge must be worn when attending the sessions.Admittance to the sessions without the badge is not possible.Only full participants may attend the sessions.

Participants (Blue)

Accompanying Person (Magenta)

Speakers and Chairs (Red)

Executive Committee (Yellow)

Scientific and Organising Committees (Yellow)

Press (Grey)

Exhibitor (Violet)

Staff (Cyan)

YSF (Green)

One Day Badge (White)

Speakers preview roomIt is located in front of the Auditorium stairs. Please makesure to hand in your presentation at least 120 minutes priorto the start of your assigned session. Our staff in the speakerspreview room will be happy to assist you.

Presentation submissionOnly Power Point presentations (CD, USB stick) may be used.In the lecture rooms a video projector and laptop will be atyour disposal. Personal laptops are not permitted. Pleasetake your presentation to the Speakers preview room nolater than 120 minutes prior to your lecture and approach themedia technician. Presentation guidelines have beenprovided to all speakers prior to the congress.

MessagesA message board will be located in the registration area. Youcan post your messages here.



LocationThe poster display area will be directly connected to theconference rooms and the exhibition area. Your posterboard will be marked with your Poster number. Thisnumber will be the same as in the FEBS JournalSupplement.

Poster mountingYou are asked to mount and discuss your poster on thedays as specified at page 46. Make sure to remove allposter-mounting materials from the board after the end

of your session. The Congress staff will remove postersnot taken down on time. However, the CongressOrganizers cannot ensure any further responsibility forthe material.

Poster materialThe size of your poster board is 120x90 cm (height xwidth) and will be marked with your poster number.Hanging material for the poster boards will be providedonsite.

AUDITORIUM

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Plenary Lectures

Pier Paolo PandolfiOpening Plenary Lecture PL-1

Co-sponsored by AIRCThe ceRNA hypothesis, the non-coding revolution and the future of cancer research and its therapy

Saturday June 25 - 18:00-19:00

Elena ContiSir Hans Krebs Lecture PL-2

Molecular mechanisms of RNA degradationSunday June 26 11:30-12:30

Pier Giuseppe PelicciTheodor Bücher Lecture PL-3

Regulation of self-renewal in Cancer Stem CellsSunday June 26 - 17:45-18:45

Luis SerranoEMBO Lecture PL-8

A quantitative systems biology study on a model bacteriumMonday June 27 -11:30-12:30

Sirpa JalkanenDatta Lecture PL-5

Homing-associated molecules as targets to prevent harmful inflammations and cancer spreadMonday June 27 - 17:45-18.45

John MattickIUBMB Lecture PL-6

Challenging the dogma: the central role of RNA in human development and cognitionTuesday June 28 - 11:30-12:30

Carol V. RobinsonWISE Plenary Lecture PL-7

Finding the right balance: from Rare Gases to Rotary motorsTuesday June 28 - 17:45-18:45

Hugo MaccioniPABMB Lecture PL-4

Organization of the synthesis of glycolipids in the Golgi complexWednesday June 29 - 11:30-12:30

Shiro SuetsuguFEBS Letters Award Lecture PL-9

Subcellular membrane curvature mediated by the BAR domain superfamily proteinsWednesday June 29 - 15:00-16:00

Karen van EunenFEBS Journal Prize Lecture PL-10

In vivo-like enzyme kinetics improve metabolic computer modelsWednesday June 29 - 15:00-16:00

Guido KroemerClosing Plenary Lecture PL-11

Autophagy, cytoprotection and longevityThursday June 30 - 11:15-12:15

Final Programme14


Congress Symposia

S1 The genome in the 3rd milleniumCoordinators: Valerio Orlando, Roma, Giovanna Lucchini, Milano

o S 1.1 Coding and noncoding information in genome functiono S 1.2 Mechanisms controlling genome integrityo S 1.3 Epigenetic control of cell fate

S2 Complexity in RNA biologyCoordinators: Irene Bozzoni, Roma, Riccardo Cortese, Pomezia

o S 2.1 Non coding RNA: evolution, functiono S 2.2 Small RNA in disease

S3 Following the life of a proteinCoordinators: Maurizio Brunori, Roma, Menico Rizzi, Novara, Daniela Corda, Napoli

o S 3.1 Protein synthesis, traffic and turnover

o S 3.2 Protein folding and bindingo S 3.3 NAD-dependent post-translational modifications

S4 Cell-cell communicationCoordinators: Antonio De Flora, Genova, Fiorella Altruda, Torino

o S 4.1. Intercellular trafficking of signal molecules

o S 4.2 Regulation of cell functions by intercellular contact systems

S5 Membrane dynamicsCoordinators: Jacopo Meldolesi, Milano, Daniela Corda, Napoli

o S 5.1 Membrane dynamicso S 5.2 Organelle dynamics

o S 5.3 Membrane dynamics and disease

S6 Molecular basis of developmentCoordinators: Roberto Sitia, Milano, Vania Broccoli, Milano

o S 6.1 Stress adaptation and developmento S 6.2 Cell shape determination

o S 6.3 Development of cognition and language

S7 Systems biologyCoordinator: Lilia Alberghina, Milano

o S 7.1 Omics and bioinformaticso S 7.2 Networks and circuits

S8 Molecular engineering for medicineCoordinator: Gianfranco Gilardi, Torino

o S 8.1 Synthetic biology for medicineo S 8.2 Biomedical application of nanotechnology

S9 Prokaryote biochemistry: friends and foes in the microbial worldCoordinators: Gianni Dehò, Milano, Enrica Pessione, Torino

o S 9.1 Probiotics as health-promoting agents

o S 9.2 Antimicrobial drug discovery: a new challenge for the future



S10 Metabolic control and disordersCoordinators: Luciana Avigliano, Roma, Giuseppe Rotilio, Roma, Giorgio Lenaz, Bologna

o S 10.1 Nuclear receptors and lipid metabolismo S 10.2 Molecular perspectives for diabeteso S 10.3 Redox balance and obesity

S11 Recent advances in cancer biologyCoordinators: Paolo Comoglio, Candiolo, Pier Giuseppe Pelicci, Milano, Carola Ponzetto, Torino

o S 11.1 Genes and pathways in cancero S 11.2 Cancer stem cells and metastasis

S12 Cellular senescence and agingCoordinators: Filiberto Cimino, Napoli, Antonio De Flora, Genova

o S 12.1 Plasticity of aging

o S 12.2 Cellular senescence

S13 Rare diseases reveal new biochemical mechanismsCoordinators: Sergio Papa, Bari, Francesco Salvatore, Napoli

o S 13.1 Rare metabolic diseaseso S 13.2 Mitochondrial diseases

S14 Biochemistry of the brain and neurodegenerative disordersCoordinators: Tommaso Russo, Napoli, Enzo Cuomo, Roma, Aldo Fasolo, Torino

o S 14.1 Recent advances in neurodegenerative disorderso S 14.2 Dopaminergic neurons and Parkinson’s disease

S15 Molecular basis of cardiovascular diseasesCoordinators: Federico Bussolino, Torino, Guido Tarone, Torino

o S 15.1 Development of vascular system

o S 15.2 Molecular basis of cardiovascular diseases

S16 Biochemistry of immunity and inflammationCoordinators: Gianpietro Semenzato, Padova, Fabio Malavasi, Torino, Alberto Mantovani, Milano

o S 16.1 Ectoenzyme network and diseaseso S 16.2 Structure and function of innate immunity receptors

o S 16.3 Receptors and signal transduction

S17 Biochemistry and molecular biology of malaria and tuberculosisCoordinators: Paolo Arese, Torino, Menico Rizzi, Novara

o S 17.1 Biochemistry and molecular biology of tuberculosiso S 17.2 Biochemistry and molecular biology of malaria

S18 Plant biochemistry for health and tomorrow’s medicineCoordinator: Felice Cervone, Roma

o S 18.1 Green factoryo S 18.2 Plant innate immunity

S19 Molecular and cellular therapeuticsCoordinators: Maria Grazia Roncarolo, Milano, Lucio Luzzatto, Firenze

o S 19.1 Vectors for therapeutic and experimental applications

o S 19.2 Gene and cell therapy for genetic diseases

Final Programme16

36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”Programme at a GlanceSaturday, June 25, 2011 Sunday, June 26, 2011 Monday, June 27, 2011

PARALLEL SYMPOSIA

8:30-11:00 Auditorium S3.1Protein synthesis, traffic and turnover

8:30-11:00 Hall 500 S1.1Coding and noncoding information in

genome function

8:30-11:00 Hall Gialla S5.1Membrane dynamics

8:30-11:00 Hall Istanbul S7.1Omics and boinformatics

8:30-11:00 Hall Londra S4.1Intercellular trafficking of signal

molecules

11:00-11:30 BREAK

11:30-12:30 AuditoriumSir Hans Krebs Plenary Lecture PL-2

Elena Conti, Munich - D

12:30-13:00 BREAK

13:00-15:00 POSTER SESSION

PARALLEL EVENTS

13:00-15:00 Hall Gialla TW-1Advances in molecular and

functional MRI

13:00-15:00 Hall Londra Biochemical education

13:30-15:00 Hall IstanbulWise workshop

14:00-15:00 Hall 500Chiara D’Onofrio Lecture

Luca Scorrano

PARALLEL SYMPOSIA

15:00-17:30 Auditorium S1.2Mechanisms controlling genome

integrity

15:00-17:30 Hall 500 S3.2Protein folding and binding

15:00-17:30 Hall Gialla S5.2Organelle dynamics

15:00-17:30 Hall Istanbul S7.2Networks and circuits

15:00-17:30 Hall Londra S4.2Regulation of cell functions byintercellular contact systems

17:45-18:45 AuditoriumTheodor Bücher Plenary Lecture

PL-3Pier Giuseppe Pelicci, Milan - I

19:00-20:00 Hall 500Britton Chance Memorial Session

Les Dutton, Philadelphia, USA

PARALLEL SYMPOSIA

8:30-11:00 Auditorium S1.3 Epigenetic control of cell fate

8:30-11:00 Hall 500 S3.3NAD-Dependent

Post-translation modifications

8:30-11:00 Hall Gialla S5.3Membrane dynamics and disease

8:30-11:00 Hall Istanbul S8.1Synthetic biology for medicine

8:30-11:00 Hall Londra S9.1 Probiotics as health-promoting

agents

11:00-11:30 BREAK

11:30-12:30 AuditoriumEMBO Lecture PL-8

Luis Serrano, Barcelona - E

12:30-13:00 BREAK


PARALLEL EVENTS

13:00-15:00 Hall Gialla TW-2Cellular events monitored by

in-cell NMR

13:00-15:00 Hall 500 Workshop PhD training in Europe:

where are we heading?

PARALLEL SYMPOSIA

15:00-17:30 Auditorium S14.1Recent advances in

neurodegenerative disorders

15:00-17:30 Hall 500 S10.1 Nuclear receptors and lipid

metabolism

15:00-17:30 Hall Gialla S6.1Stress adaptation and development

15:00-17:30 Hall Istanbul S8.2Biomedical application of

nanotechnology

15:00-17:30 Hall Londra S9.2Antimicrobial drug discovery: a new

challenge for the future

17:45-18:45 AuditoriumPrakash Datta Plenary Lecture PL-5

Sirpa Jalkanen, Turku - FIN

Pre-Congress Event

10:00-16:00 Hall Londra

Bio-NMR Satellite MeetingNMR in Biology

AUDITORIUM

16:30-17:30

Opening Ceremony

17:30-18:00

Musical interlude

18:00-19:00Opening Plenary Lecture PL-1

Co-sponsored by the ItalianAssociation for Cancer Research

(AIRC) Pier Paolo Pandolfi, Boston - USA

19:00-21:00Welcome Reception

Lingotto Hall



Tuesday, June 28, 2011 Wednesday, June 29, 2011 Thursday, June 30, 2011

PARALLEL SYMPOSIA

8:30-11:00 Auditorium S14.2 Dopaminergic neurons and

Parkinson’s disease

8:30-11:00 Hall 500 S10.2Molecular perspectives

for diabetes

8:30-11:00 Hall Gialla S6.2Cell shape determination

8:30-11:00 Hall Istanbul S18.1 Green factory

8:30-11:00 Hall Londra S12.1 Plasticity of aging

11:00-11:30 BREAK

11:30-12:30 AuditoriumIUBMB Lecture PL-6

John Mattick, Brisbane - AUS

12:30-13:00 BREAK


PARALLEL EVENTS

13:00-15:00 Hall 500Science and society

Session on genetic diseases

PARALLEL SYMPOSIA

15:00-17:30 Auditorium S2.1 Non coding RNA: evolution,

function

15:00-17:30 Hall 500 S10.3Redox balance and obesity

15:00-17:30 Hall Gialla S6.3Development of cognition and

language

15:00-17:30 Hall Istanbul S18.2Plant innate immunity

15:00-17:30 Hall Londra S12.2Cellular senescence

17:45-18:45 Auditorium WISE Plenary Lecture PL-7

Carol V. Robinson, Oxford - UK

20:30-22:00Centro di Biotecnologie MolecolariPublic Science and Society Forum on

Biochemistry for tomorrow’sMedicine

PARALLEL SYMPOSIA

8:30-11:00 Auditorium S2.2 Small RNA in disease

8:30-11:00 Hall 500 S11.1 Genes and pathways in cancer

8:30-11:00 Hall Gialla S16.1Ectoenzyme network and diseases

8:30-11:00 Hall Istanbul S13.1Rare metabolic diseases

8:30-11:00 Hall Londra S15.1Development of vascular system

11:00-11:30 BREAK

11:30-12:30 AuditoriumPABMB Plenary Lecture PL-4 Hugo Maccioni, Córdoba - RA

12:30-13:00 BREAK


PARALLEL EVENTS

13:00-15:00 Hall 500Workshop:

Integrating molecular bioscienceeducation with medical training

13:00-15:00 Hall LondraWorkshop:

Fluorescence Spectroscopy: a toolfor protein chemistry

15:00-16:00 AuditoriumFEBS Publication Award Lectures

15:00-16:00 AuditoriumFEBS Letters Award Lecture PL-9

Shiro Suetsugu, Tokyo - J

15:00-16:00 AuditoriumFEBS Journal Prize Lecture PL-10Karen van Eunen, Groningen - NL

PARALLEL SYMPOSIA

16:15-18:45 Auditorium S19.1Vectors for therapeutic andexperimental applications

16:15-18:45 Hall 500 S11.2 Cancer stem cells and metastasis

16:15-18:45 Hall Gialla S16.2 Structure and function of innate

immunity receptors

16:15-18:45 Hall Istanbul S13.2Mitochondrial diseases

16:15-18:45 Hall Londra S17.1Biochemistry and molecular biology

of tubercolosis

20:30-23:00 Social Dinner

PARALLEL SYMPOSIA

8:30-11:00 Auditorium S19.2 Gene and cell therapy for genetic

diseases

8:30-11:00 Hall Gialla S16.3Receptors and signal transduction

8:30-11:00 Hall Istanbul S15.2 Molecular basis of cardiovascular

diseases

8:30-11:00 Hall Londra S17.2Biochemistry and molecular biology

of malaria

11:15-12:15Closing Plenary Lecture PL-11

Guido Kroemer, Villejuif - F

12:15 - 12:45CLOSING CEREMONY

FEBS COUNCIL MEETINGHotel Majestic, Torino

June 30th- July 1st

AUDITORIUM

Final Programme18


Saturday June 25, 2011

Pre-Congress Event10:00 - 16:00

Bio-NMR Satellite MeetingNMR in Biology

This satellite meeting is intended to presentthe opportunities provided by NMR todayto the broad biological community. Theopportunity that biologists can exploit theEuropean programme for access to Bio-NMR (www.bio-nmr.net) researchinfrastructures is presented.

10:00Welcome by Israel PechtFEBS - Secretary GeneralWeizmann Institute of Science, Rehovot,Israel

10:10Ivano BertiniBio-NMR Project Coordinator CERM,Italy

Opening and Introduction

10:30Harald SchwalbeCenter for Biomolecular Magnetic Resonance,J. W. Goethe-University, Frankfurt am Main,Germany

NMR spectroscopic investigationsof RNA folding in vitro and in cells

11:10Rolf BoelensBijvoet Center for Biomolecular Research,Utrecht University, Netherlands

Structure and dynamics in generegulation and DNA repair

11:50Jacob AnglisterWeizmann Institute of Science, Israel

Observation of intermolecularinteractions in large proteincomplexes by 2D-double differenceNOESY: application to the 44 kDainterferon-receptor complex

12:30Lunch (kindly offered by Bruker)

13:50Roberta PierattelliCERM & Department of Chemistry, University ofFlorence, Italy

13C direct detection biomolecularNMR.

14:30Markus ZweckstetterMax Plank Institute for Biophysical Chemistry,Germany

Frontiers of structural biology:The dynamic structure of disorderedproteins and proteins in themembrane

15:10Mikael OlivebergDepartment of Biochemistry and Biophysics,Stockholm University, Sweden

In-cell NMR of the ALS-associatedprotein Cu/Zn SOD1

15:50Closing remarks

Organising CommitteeWiktor KozminskiWarsaw University, Poland

Miquel PonsIRB Barcelona, Spain

Isabella Caterina FelliCERM, University of Firenze, Italy

Scientific SecretariatChiara VenturiCERM, University of Firenze, Italy

HALL LONDRA



Opening Ceremony16:30 - 17:30

AUDITORIUM

Opening PlenaryLecture PL-1Co-sponsored by the Italian Association forCancer Research

Chairpersons:Israel PechtRehovotSergio PapaBari

Pier Paolo PandolfiHarvard Medical School - Boston - USA

The ceRNA hypothesis, thenon-coding revolution and the futureof cancer research andits therapy

Plenary Lecture18:00 - 19:00

Welcome Reception19:30 - 21:30

AUDITORIUM

Gianfranco GilardiChairman Organizing Committee

Sergio PapaChairman Scientific Committee

Tomas ZimaFEBS Chairman

Filiberto CiminoPresident SIB

Israel PechtFEBS Secretary General“Presentation of FEBS Diplôme d’Honneurrecipients”

Welcome address by theAuthorities

LINGOTTO HALL

Musical interlude

Saturday June 25, 2011

Final Programme20


Sunday June 26, 2011

Parallel Symposia 8:30 - 11:00

AUDITORIUM

SymposiaS1.1 Coding and noncodinginformation in genome functionChairpersons:Thomas GingerasNew York

Valerio OrlandoRoma

8:30 - 9:00 S1.1.1Thomas JenuweinFreiburg

Epigenetic control by histonemethylation.

9:00 - 9:30 S1.1.2Job DekkerWorcester

Three-dimensional architecture ofthe human genome.

9:30 - 10:00 S1.1.3Thomas R. GingerasNew York

Important lessons from a complexgenome.

10:00 - 10:30 S1.1.4Geoff FaulknerEdinburgh

Retrotransposition and the geneticidentity of human neurons.

10:30 - 10:45 S1.1.5Beatrice BodegaRoma

Repetitive elements transcription andmobilization contribute to humanskeletal muscle differentiation andduchenne muscular dystrophyprogression.

10:45 - 11:00 S1.1.6Giorgio DieciParma

Non-canonical termination signalrecognition by RNA polymerase III inthe human genome.

HALL 500 HALL GIALLA

Symposia

S3.1 Protein synthesis, trafficand turnoverChairpersons:Aaron CiechanoverHaifa

Menico RizziNovara

8:30 - 9:00 S3.1.1Aaron CiechanoverNobel Laureate, Haifa

The Ubiquitin Proteolytic System -From Basic Mechanisms throughHuman Diseases and onto DrugDevelopment.

9:00 - 9:30 S3.1.2Mark SafroRehovot

Structural diversity amongcytoplasmic and organellar aaRSsmay lead to incorporation of free-radical damaged amino acids intoproteins.

9:30 - 10:00 S3.1.3Hidde PloeghCambridge MA

Quality control in the endoplasmicreticulum: removal of unwantedproteins.

10:00 - 10:30 S3.1.4Peter-Michael KloetzelBerlin

The proteasome and the ubiquitinsystem: The two faces of one enzyme.

17:00 - 17:15 S3.2.5Gert BangeHeidelberg

New insights into the coordination ofprotein export by the flagellar type 3secretion system.

17:15 - 17:30 S3.2.6Katerina ChatziHeraclion, CreteThe signal peptides and the earlymature domain cooperate for efficientsecretion.

SymposiaS 5.1 Membrane dynamicsChairpersons:Vivek MalhotraBarcelona

Jacopo MeldolesiMilano

8:30 - 9:00 S5.1.1Alberto LuiniNapoli

Control systems of the secretorypathway.

9:00 - 9:30 S5.1.2Vivek MalhotraBarcelona

Protein sorting and packing alongthe secretory pathway.

9:30 - 10:00 S5.1.3Marino ZerialDresden

Systems analysis of endocytosis andsignalling.

10:00 - 10:30 S5.1.4Enrique Rodriguez-BoulanNew York

Clathrin adaptors and polarizedtrafficking in epithelia.

10:30 - 10:45 S5.1.5Sarah CarpentierBruxelles

A reappraisal of the role ofphosphoinositide 3-kinase in apicalreceptor-mediated endocytosis bykidney proximal tubular cells.

10:45 - 11:00 S5.1.6Gregory D FairnToronto

Phosphatidylserine polarization isrequired for proper Cdc42localization and for development ofcell polarity.



SymposiaS4.1. Intercellular trafficking ofsignal moleculesChairpersons:Shin-ichiro ImaiSt. Louis

Antonio De FloraGenova

8:30 - 9:00 S4.1.1Elena ZocchiGenova

Abscisic acid and cyclic ADP-riboseare first and second messenger ininflammatory cells, hemopoieticprogenitors and pancreatic beta-cells.

9:00 - 9:30 S4.1.2Friedrich Koch-NolteHamburg

New tools for activating and blockingthe P2X7 ion channel - a key sensorof NAD and ATP released from cells. 9:30 - 10:00 S4.1.3Alberto DarszonCuernavaca

How sperm find the egg.

10:00 - 10:30 S4.1.4Shin-ichiro ImaiSt. Louis

The pathophysiological importanceof NAMPT-mediated NAD+biosynthesis in the regulation ofmetabolism and aging in mammals.

10:30 - 11:00 S4.1.5Egor PlotnikovMoscow

Cell-to-cell crosstalk betweenmesenchymal multipotent stromalcells and renal tubular cellsin co-culture.

HALL ISTANBUL HALL LONDRA

AUDITORIUM

Symposia

S 7.1 Omics and bioinformaticsChairpersons:Sampsa HautaniemiHelsinki

Cecilia SacconeBari

8:30 - 9:00 S7.1.1Sampsa HautaniemiHelsinki

Efficient bioinformatics approachesfor large-scale data analysis.

9:00 - 9:30 S7.1.2Alfonso ValenciaMadrid

Challenging Our Understanding ofProtein Interaction Networks.

9:30 - 10:00 S7.1.3Peer BorkHeidelberg

Extracting phylogenetic andfunctional signals frommetagenomics data.

10:00 - 10:30 S7.1.4Søren BrunakKongens Lyngby

Integrating phenotypic data fromelectronic patient records withmolecular level systems biology.

10:30 - 10:45 S7.1.5Andrei DrabovichToronto

Targeted Mass Spectrometry forQuantitative Proteomic Analysis ofEnergy Metabolic Pathways in BreastCancer Cells

10:45 - 11:00 S7.1.6Enzo ScifoHelsinki

Systems biology approachestowards Neuronal ceroidlipofuscinoses interactome.

Sir Hans KrebsPlenary Lecture PL-2Chairpersons:Adam SzewczykWarsawMenico RizziNovara

Elena ContiMax Planck Institute of Biochemistry - Munich - D

Molecular mechanisms of RNAdegradation


Parallel Symposia08:30 - 11:00

➜

Break 11:00 - 11:30

Final Programme22


Technical Workshop TW-1

13:00 - 15:00Advances in Molecular andFunctional MRISponsored by Aspect Imaging Ltd

13:00 - 13:30Klaas NicolayBiomedical NMR,Technical University Eindhoven,The Netherlands

Quantitative MRI techniques formolecular and cellular imaging

13:30 - 14:00Ayelet Akselrod-BallinDepartment of Biological Regulation, WeizmannInstitute, Israel

MRI-Optical multimodal imaging

14:00 - 14:30Simonetta Geninatti CrichCenter of Molecular Imaging, University ofTorino, Italy

Design and testing of Targeting andResponsive probes for MRIpreclinical applications

14:30 - 15:00Pernille Rose JensenAlbeda Research Ltd., Denmark

Imaging of metabolic reactions byhyperpolarized 13C DNP-MR

13:00 - 15:00Biochemical Education

High School Scientific Education: aBridge towards Medicine, Biologyand Biotechnology UniversityCoursesEducazione Scientifica nella Scuola Mediasuperiore: un Ponte verso i Corsi Universitari diMedicina, Biologia e Biotecnologie

Organised by Italian Society of Biochemistryand Molecular Biology

CULTURA SCIENTIFICA DI BASEED ACCESSO ALLA FORMAZIONEUNIVERSITARIA IN AREABIOMEDICACoordinatori:Paola IzzoUniversità di NapoliAmalia BosiaUniversità di Torino

13:00Giovanni BonioloUniversità di Milano

Ruolo di una formazione scientificadi base nella Società della Scienza

13:15Alberto CalatroniUniversità di Messina

Il ruolo della Chimica Medicanell’attuale processo di formazionedel Medico

13:30Roberto CirioUniversità di Torino-INFN Torino

Il ruolo della Fisica nell’attualeprocesso di formazione del Medico

13:45Carla MigliavaccaLiceo Scientifico Statale Antonelli - Novara

Didattica delle ScienzeBiomolecolari nella Scuola MediaItaliana: stato dell’arte e prospettive

13:50Discussion

NUOVI APPROCCIALL’INSEGNAMENTO DELLEDISCIPLINE BIOMOLECOLARINELLA SCUOLA MEDIACoordinatori:Fiorella AltrudaUniversità di TorinoFabiola SinigagliaUniversità del Piemonte Orientale “A.Avogadro”

14:00 - 14:10Lanfranco MasottiLife Learning Center - Bologna

Il Life Learning Center: un centro diformazione e aggiornamentoculturale per studenti e docenti delleScuole medie”

14:10 - 14:20Elena SpoldiEnrica FavaroLife Learning Center - Torino

L’esperienza maturata al LifeLearning Center di Torino

14:20 - 14:30Giovanni PaolellaUniversità di Napoli Federico II - CEINGE Napoli

E-learning: un metodo innovativo perla didattica delle ScienzeBiomolecolari

14:30 - 14:40Rita TrisoglioLiceo Scientifico Statale Antonelli - Novara

Apprendere le Scienze della Vita conapproccio di tipo sperimentale

14:40 - 14:55Elisabetta GaitaMaria Chiara RossiI.S.A. Sobrero - Casale Monferrato

Nuove proposte di formazione inambito degli Istituti di FormazioneTecnica superiore (IFTS)

15:00End Session

HALL LONDRA


Break 12:30-13:00

POSTER AREA

13:00 - 15:00Poster Sessions

P01, P03, P04, P05, P06, P07, P08,P09, P18, P20, P21, P22, P23-P27,P24, P25, P26, P28, P32.

HALL GIALLA

The sessionsbetween

13:00 and 15.00are held in parallel



CHIARA D’ONOFRIOLECTUREChairperson:Valerio OrlandoRoma

Luca ScorranoDulbecco-Telethon Institute at the VenetianInstitute of Molecular Medicine - Genève

Keeping mitochondria in shape: amatter of life, differentiation and death

WISE Workshop

13:30 - 15:00“Future in science and Science inFuture: Ideas and Expectations ofWomen Scientists”Presentation byMaria Laura Scarinofollowed by a panel discussion

HALL 500

Special Lecture14:00 - 15:00

HALL ISTANBUL

Final Programme24




SymposiaS1.2 Mechanisms controllinggenome integrityChairpersons:

John F.X. DiffleyHerts

Maria Pia LongheseMilano

15:00 - 15:30 S1.2.1John F.X. DiffleyHerts

Early Events in Eukaryotic DNAReplication.

15:30 - 16:00 S1.2.2Yosef ShilohTel Aviv

The ATM-Mediated DNA DamageResponse: The System and thePathways.

16:00 - 16:30 S1.2.3Julia Promisel CooperLondon

Telomeres and the challenges tochromosomal integrity.

16:30 - 17:00 S1.2.4Andrea MusacchioMilano

The structural basis of chromosomesegregation.

SymposiaS 3.2 Protein folding andbindingChairpersons:William A. EatonBethesda

Maurizio BrunoriRoma

15:00 - 15:30 S3.2.1William A. EatonBethesda

Single-Molecule FRET and TransitionPaths in Protein Folding.

15:30 - 16:00 S3.2.2Alan R. FershtCambridge UK

Folding approaching the speed limit.

16:00 - 16:30 S3.2.3Joel L. SussmanRehovot

Intrinsically Disordered Proteins: ARole in Nervous SystemDevelopment.

16:30 - 17:00 S3.2.4Peter TompaBudapest

Unusual binding modes ofintrinsically disordered proteins.

10:30 - 10:45 S3.1.5Michael GriffinParkville

Methionine oxidation inducesamyloid fibril formation byapolipoprotein A-I.

10:45 - 11:00 S3.1.6Stefano GianniRoma

The folding problem simplified:protein families, circular permutantsand heteromorphic pairs.

Symposia

S 5.2 Organelle dynamicsChairpersons:Luca ScorranoGenève

Sharon ToozeLondon

15:00 - 15:30 S5.2.1Ligia C. GomesPadova

Autophagy and mitochondrialelongation: sustaining cell viabilityunder difficult conditions.

15:30 - 16:00 S5.2.2Graça RaposoParis

Endosome dynamics in thebiogenesis of Lysosome RelatedOrganelles.

16:00 - 16:30 S5.2.3Sharon ToozeLondon

Molecular insights into autophagy.

16:30 - 17:00 S5.2.4Graham WarrenVienna

Golgi Biogenesis.

17:00 - 17:15 S5.2.5Alexey M. BelkinBaltimore

Unconventional secretion of tissuetransglutaminase involvesphospholipid- dependent deliveryinto recycling endosomes.

17:15 - 17:30 S5.2.6Nurit Pereg-AzouzTel Aviv

Rab GTPases and Mast CellExocytosis.

AUDITORIUM HALL 500 HALL GIALLA



AUDITORIUM

SymposiaS 4.2 Regulation of cellfunctions by intercellularcontact systemsChairpersons:Charles StreuliManchester

Fiorella AltrudaTorino

15:00 - 15:30 S4.2.1Charles StreuliManchester

How integrins control breastdevelopment and function.

15:30 - 16:00 S4.2.2Ugo CavallaroMilano

Neural adhesion molecules as novelplayers in cancer progression.

16:00 - 16:30 S4.2.3Walter BirchmeierBerlin

Wnt/beta-catenin signaling in stemand cancer stem cells.

16:30 - 17:00 S4.2.4Tomitake TsukiharaHyogo

Structural studies of connexin-26 gapjunction channel.

Symposia

S 7.2 Networks and circuitsChairpersons:Thomas HöferHeidelberg

Lilia AlberghinaMilano

15:00 - 15:30 S7.2.1Barbara BakkerGroningen

System organization of mammalianfatty-acid metabolism.

15:30 - 16:00 S7.2.2Carstern CarlbergLuxembourg

Systems biology approaches tonuclear receptor signaling.

16:00 - 16:30 S7.2.3Thomas HöferHeidelberg

A recruitment-reaction model forchromatin-associated regulatoryprocesses.

16:30 - 17:00 S7.2.4Thomas KirkwoodNewcastle upon Tyne

All Our Tomorrows: The Science ofHuman Ageing.

17:00 - 17:15 S7.2.5Michele CaselleTorino

The role of incoherent microRNA-mediated feedforward loops in noisebuffering.

17:15 - 17:30 S7.2.6Lucia NapioneTorino

Unraveling the influence ofendothelial cell density on VEGF-Asignalling.

THEODOR BÜCHERLECTURE PL-3Chairpersons:Tomas ZimaPrague

Paolo AreseTorino

Pier Giuseppe PelicciEuropean Institute of Oncology - Milano - I

Regulation of self-renewal in CancerStem Cells



➜

"Britton ChanceMemorial Session"

19:00 - 20:00Chair introduction:Angelo AzziBoston

Israel PechtRehovot

Sergio PapaBari

Memorial LectureLes DuttonPhiladelphia

Reflections inBiochemistry


ROOM 500

Final Programme26


Monday June 27, 2011


SymposiaS1.3 Epigenetic controlof cell fateChairpersons:Geneviève AlmouzniParis

Salvatore OlivieroSiena

8:30 - 9:00 S1.3.1Geneviève AlmouzniParis

Epigenetic challenges in centromereinheritance during the cell cycle.

9:00 - 9:30 S1.3.2Dirk SchübelerBaselGenetic determinants of generepression.

9:30 - 10:00 S1.3.3Renato ParoBasel

Epigenetic reprogramming duringtissue regeneration.

10:00 - 10:30 S1.3.4Amanda FisherLondon

Pluripotent stem cells and epigeneticreprogramming.

10:30 - 10:45 S1.3.5Maryam ShahhoseiniTehran

Evidence for a dynamic role of thehistone variant H2A.Z in epigeneticregulation of normal/carcinomaswitch.

10:45 - 11:00 S1.3.6Chiara LanzuoloRoma

PcG complexes set the stage forinheritance of epigenetic genesilencing in early S phase beforereplication.

SymposiaS 3.3 NAD-dependentpost-translational modificationsChairpersons:Fritz NolteHamburg

Daniela CordaNapoli

8:30 - 9:00 S3.3.1Andreas LadurnerHeidelberg

Macrodomains mediate NADmetabolite-dependent nucleardynamics.

9:00 - 9:30 S3.3.2Daniela CordaNapoli

Novel developments in proteinmono-ADP-ribosylation.

9:30 - 10:00 S3.3.3Mathias ZieglerBergen

NAD+ - a key molecule in cellularsignalling.

10:00 - 10:30 S3.3.4Michael HottigerZurich

ARTD1/PARP1 ADP-ribosylateslysine residues of the core histonetails.

10:30 - 10:45 S3.3.5Silvia GaravagliaNovara

High-resolution crystal structure ofperiplasmic Haemophilus influenzaeNAD nucleotidase, lead to reveal anovel enzymatic function of humanCD73.

10:45 - 11:00 S3.3.6Valentina AudritoTorino

Nicotinamide blocks proliferation andinduces apoptosis of chroniclymphocytic leukemia cells throughactivation of the p53/miR-34a/SIRT1tumor suppressor network.

SymposiaS 5.3 Membrane dynamics anddiseaseChairpersons:Sergio GrinsteinToronto

Giorgio LenazBologna

8:30 - 9:00 S5.3.1William BalchLa Jolla

Proteostasis, Folding and MembraneTraffic- Protecting the Proteome inHuman Disease.

9:00 - 9:30 S5.3.2Ari HeleniusZürich

Role of endosomes in virus entry.

9:30 - 10:00 S5.3.3Sergio GrinsteinToronto

Membrane dynamics duringphagocytosis.

10:00 - 10:30 S5.3.4Ira MilosevicNew Haven

Endocytic mechanisms at neuronalsynapses.

10:30 - 10:45 S5.3.5Joao FreireLisboa

Assigning a role to the Dengue VirusCapsid Protein during cellularinfection.

10:45 - 11:00 S5.3.6Paulina Podszywalow-bartnickaWarsaw

Quantitative proteomics analysis ofsecretome and secretedmicrovesicles of chronic myeloidleukemia cells using SILAC method.




AUDITORIUM

SymposiaS 8.1 Synthetic biology formedicineChairpersons:Anthony CassLondon

Gianfranco GilardiTorino

8:30 - 9:00 S8.1.1Anthony CassLondon

Exploiting Conformational Change inBiosensor Design.

9:00 - 9:30 S8.1.2Rita BernhardtSaarbrücken

Bacterial hydroxylases and theirpotential to synthesize pharmaceutical products.

9:30 - 10:00 S8.1.3Debashis GhoshNew York

Ligand-Binding Interactions andQuaternary Association In HumanAromatase.

10:00 - 10:30 S8.1.4Mark HowarthOxford

From flesh-eating bacteria to proteinsuperglue.

10:30 - 10:45 S8.1.5Rocío de MiguelViscasillas Zaragoza

Ferritin: nanotechnology at theservice of the new biomedicine.

10:45 - 11:00 S8.1.6Sergii GrebinykKyiv

Modulation of ROS production andcytosolic Ca2+ homeostasis byfullerenes C60 in oncotrasformed T-cells.

SymposiaS 9.1 Probiotics as health-promoting agentsChairpersons:Katharina RiedelBraunschweig

Enrica PessioneTorino

8:30 - 9:00 S9.1.1Katharina RiedelBraunschweig

Moonlighting proteins as biomarkersfor probiotic safety.

9:00 - 9:30 S9.1.2Brian HendersonLondon

Bacteria-Host Dual CommunicationUses Molecular Chaperones.

9:30 - 10:00 S9.1.3Effie TsakalidouAthens

Milk protein fragments inducebacteriocin biosynthesis inStreptococcus macedonicus:perspectives in food preservation andinfection control.

10:00 - 10:30 S9.1.4Yves Le LoirFrance

Interactions between Lactic acidbacteria and Staphylococcus aureus:an old story with new healthperspectives.

10:30 - 10:45 S9.2.5Halil DundarAnkara

Purification, characterization andpartial amino acid sequence ofmesentericin W3, a new anti-ListeriaBacteriocin.

10:45 - 11:00 S9.2.6Renato GennaroTrieste

Reduced phosphorylation of LPSdecreases E.coli susceptibility to thehuman antimicrobial peptide LL-37.

Plenary Lecture11:30-12:30


Break 11:00 - 11:30

➜HALL ISTANBUL HALL LONDRA

EMBO LECTURE PL-8Chairperson:Maurizio BrunoriRoma

Luis SerranoCentre for GenomicRegulation - Barcelona - E

A quantitative systems biology studyon a model bacterium

Final Programme28




P01, P03, P04, P05, P06, P07, P08,P09, P18, P20, P21, P22, P23-P27,P24, P25, P26, P28, P32

POSTER AREA

HALL 500

HALL GIALLA

13:00 - 15:00WORKSHOPPhD Training in Europe:Where Are We Heading?

Chairpersons:Gül Akdogan GünerTurkeyJason PerretBelgium

Organised by the FEBS EducationCommittee

Gül Akdogan GünerTurkey

Jason PerretBelgium

Introduction to the Workshop

Michael J MulvanyDenmarkGraduate School of Health Sciences, AarhusUniversity, and Vice-President, ORPHEUS

European Vision in PhD Education

Detlef RiesnerGermanyDüsseldorf University Co-Founder, Chairman ofthe Supervisory Board Qiagen NV

What industry, in particular BiotecIndustry expects?

Panel Discussion

Break 12:30 - 13:00

The sessionsbetween


13:00 - 15:00Technical Workshop TW-2

Cellular events monitoredby in-cell NMR

13:00 - 13:30 Ivano BertiniMagnetic Resonance Center (CERM),University of Firenze, Italy

13:30 - 14:00 Volker DötschCenter for Biomolecular Magnetic Resonance(BMRZ), Goethe University, Germany

14:00 - 14:30 Philip SelenkoLeibniz Institute of MolecularPharmacology (FMP), Germany

14:30 - 15:00 Open discussion

Final Programme30


SymposiaS 6.1 Stress adaptation anddevelopmentChairpersons:David RonCambridge UK

Roberto SitiaMilano

15:00 - 15:30 S6.1.1David RonCambridge, UK

Protein folding homeostasis in theendoplasmic reticulum.

15:30 - 16:00 S6.1.2Roberto SitiaMilano

ERp44 acts as a pH-dependentchaperone to retrieve client proteinsfrom the Golgi complex.

16:00 - 16:30 S6.1.3Naihe JingShanghai

BMP signaling and neurogenesis ofdeveloping spinal cord.

16:30 - 17:00 S6.1.4Richard I MorimotoEvanston

The Stress of Misfolded Proteins inAging and Disease.

17:00 - 17:15 S6.1.5Ester ZitoCambrigde

Oxidative protein folding by anendoplasmic reticulum localizedperoxiredoxin.

17:15 - 17:30 S6.1.6Fulvio SaccocciaRoma

Crystal structure of Schistosomamansoni Peroxiredoxin I: insights intoa general mechanism of assembly ofstress-regulated chaperones.



SymposiaS 10.1 Nuclear receptors andlipid metabolismChairpersons:Nagy LaszloDebrecen

Luciana AviglianoRoma

15:00 - 15:30 S10.1.1Nagy LaszloDebrecen

Decision-making by macrophagesand dendritic cells using RXRheterodimeric receptors to sense theirlipid environment.

15:30 - 16:00 S10.1.2Peter TontonozLos Angeles

Nuclear Receptor Regulation ofCholesterol Metabolism.

16:00 - 16:30 S10.1.3Bart StaelsLille

Role of PPAR signalling in diabeticdyslipidemia.

16:30 - 17:00 S10.1.4Susanne MandrupOdense

The transcriptional network of PPARgamma in adipocyte developmentand function.

17:00 - 17:15 S10.1.5Nico MitroMilano

Liver x receptor activation protectsfrom diabetic neuropathy by restoringfatty acid biosynthesis.

17:15 - 17:30 S10.1.6Santina BruzzoneGenova

Glucose-induced increase of abscisicacid (aba) levels in human plasmaand aba- stimulated glucose uptakeby adipocytes.

SymposiaS 14.1 Recent advances inneurodegenerative disordersChairpersons:Maria Grazia SpillantiniCambridge, UK

Tommaso RussoNapoli

15:00 - 15:30 S14.1.1Luca SteardoRoma

Astrocytes in neurodegeneration:potential target for Alzheimer’sdisease treatment.

15:30 - 16:00 S14.1.2Maria Grazia SpillantiniCambridge, UK

Parkinson’s disease, a dying backpathology associated with synapticalpha-synuclein aggregation.

16:00 - 16:30 S14.1.3Dominic WalshDublin

Aβ dimers, non-infectious prion andtherapeutic antibodies.

16:30 - 17:00 S14.1.4Inna SlutskyTel Aviv

Amyloid-beta: from release tosynaptic function.

17:00 - 17:15 S14.1.5Ilaria CanobbioPavia

The Alzheimer’s disease associatedamyloid beta-peptide supportsplatelet adhesion and activation.

17:15 - 17:30 S14.1.6Christian Lefebvre d’hellencourtSaint Denis

Anti-inflammatory effects of autotaxinon microglial cells.




SymposiaS 8.2 Biomedical application ofnanotechnologyChairperson:Nicola RosatoRoma

15:00 - 15:30 S8.2.1Silke KrolMilanoFunctionalized Nanoparticles - At theborder between drug and deliverysystem.

15:30 - 16:00 S8.2.2Ruth DuncanCardiff

Clinical status of lysosomotropic/endosomotropic polymer conjugatesdesigned as nanomedicines.

16:00 - 16:30 S8.2.3Fernando PalacioSaragozza

Multifunctional coating platform forthe biomedical applications ofmagnetic nanoparticles.

16:30 - 17:00 S8.2.4Cornelia PalivanBasel

Artificial Organelles Based onPolymer Nanoreactors.

17:00 - 17:15 S8.2.5Ekaterina SouslovaMoscow

Near infrared fluorescent proteins.

17:15 - 17:30 S8.2.6Alessandra BalduiniPavia

Silk fibroin engineered 3D System forthe Study of Megakaryocytes andFunctional Platelet Production.

SymposiaS 9.2 Antimicrobial drugdiscovery: a new challenge forthe futureChairpersons:Jean Marie PagèsMarseille

Gianni DehòMilano

15:00 - 15:30 S9.2.1Claudio O. GualerziCamerino

The quest for antibiotics andcharacterization of new inhibitorstargeting the translational apparatus.

15:30 - 16:00 S9.2.2Lloyd CzaplewskiOxfordshire

Inhibitors of bacterial cell division.

16:00 - 16:30 S9.2.3Jean Marie PagèsMarseille

Bypass the membrane barrierstrategy in multidrug resistant Gram-negative bacteria.

16:30 - 17:00 S9.2.4Vanessa SperandioDallas

Inter-kingdom chemical signaling inhost-bacterial associations.

17:00 - 17:15 S9.1.5Flaminia AlaleonaRoma

The bacterial high affinity Zn-uptakesystem: a possible target for novelantibiotics.

17:15 - 17:30 S9.1.6Valentina StelitanoRoma

Characterization of proteins fromPseudomonas aeruginosa involvedin c-di-GMP turnover.

AUDITORIUM


PRAKASH DATTALECTURE PL-5Chairpersons:Ian MowbrayLondon

Carola PonzettoTorino

Sirpa JalkanenUniversity of Turku - Turku - FIN

Homing-associated molecules astargets to prevent harmfulinflammations and cancer spread.


Break 17:30 - 17:45


Final Programme32


Tuesday June 28, 2011


SymposiaS 6.2 Cell shape determinationChairpersons:Frank CostantiniNew York

Vania BroccoliMilano

8:30 - 9:00 S6.2.1Frank CostantiniNew York

Cellular behaviours during renalbranching morphogenesis.

9:00 - 9:30 S6.2.2Carl-Philipp HeisenbergKlosterneuburg

Cell and tissue mechanics inzebrafish gastrulation.

9:30 - 10:00 S6.2.3Sandrine Etienne-MannevilleParis

Adherens junctions and astrocytepolarity.

10:00 - 10:30 S6.2.4Ian G. MacaraVirginia

Polarity Proteins in Morphogenesisand Metastasis.

10:30 - 10:45 S6.2.5Tania IncittiTrento

Turning stem cells into retina:possible strategies for the cure ofretinal degenerations.

10:45 - 11:00 S6.2.6Benedetta CerrutiTorino

Polarity and coordinated cell divisionin epithelial morphogenesis.

SymposiaS 10.2 Molecular perspectivesfor diabetesChairpersons:Johan AuwerxLausanne

Massimo FedericiRoma

8:30 - 9:00 S10.2.1Johan AuwerxLausanne

Transcriptional cofactors and NAD+ inthe control of metabolism.

9:00 - 9:30 S10.2.2Massimo FedericiRoma

Ectodomain shedding proteasesacting at the interface of metabolicand vascular disorders.

9:30 - 10:00 S10.2.3Agnieszka DobrzynWarsaw

Regulation of cardiac energymetabolism - the role of long-chainfatty acids.

10:00 - 10:30 S10.2.4Jiarui WuShanghai

Systems Biology for diabeticbiomarker discovery.

10:30 - 10:45 S10.2.5Maurizio CrestaniMilano

Class I histone deacetylases andenergy metabolism: new players in“diabesity?

10:45 - 11:00 S10.2.6Lorena Ivona StefanCraiova

Evaluation of metabolic status in type2 diabetes mellitus patients by protonnuclear magnetic resonancespectroscopy method (1H-NMR).

SymposiaS 14.2 Dopaminergic neuronsand Parkinson’s diseaseChairpersons:Alain ProchiantzParis

Aldo FasoloTorino

8:30 - 9:00 S14.2.1Antonio SimeoneNapoli

Otx2 in adult meso-diencephalicdopaminergic neurons.

9:00 - 9:30 S14.2.2Anders BjörklundLund

Use of stem cells for cell replacementin Parkinson´s disease.

9:30 - 10:00 S14.2.3Alain ProchiantzParis

Engrailed Homeoproteins protectmesencephalic dopaminergicneurons in animal models ofParkinson disease.

10:00 - 10:30 S14.2.4Marten SmidtUtrecht

A Pitx3 regulatory network indevelopment and maintenance ofmesodiencephalic dopamineneurons.

10:30 - 10:45 S14.2.5Beatriz Alvarez-CastelaoMadrid

Synphilin-1 inhibits alpha-synucleindegradation by the proteasome.

10:45 - 11:00 S14.2.6Anna Maria SardanelliBari

Mitochondrial respiratory dysfunctionin PARK6 and PARK2 familialParkinsonism.




AUDITORIUM

SymposiaS 12.1 Plasticity of agingChairpersons:Luigi FontanaSt. Louis

Ariela BenigniBergamo

8:30 - 9:00 S12.1.1Rafael de CaboBaltimore

Sirtuin activating compounds,resveratrol and SRT1720, extendhealthspan and lifespan of C57BL6male mice.

9:00 - 9:30 S12.1.2David Gems-Linda PartridgeLondon

Nutrient-sensing pathways and aging.

9:30 - 10:00 S12.1.3Michael HallBasel

TOR signaling, from yeast to human.

10:00 - 10:30 S12.1.4Fontana LuigiSt. Louis

Caloric restriction and aging.

10:30 - 11:00 S12.1.5Sarah HempenstallAberdeen

Effects of dietary restriction andageing on mitochondrial function inmale C57BL/6 mice.

SymposiaS 18.1 Green factoryChairpersons:Cathie MartinNorwich

Alessandro VitaleMilano

8:30 - 9:00 S18.1.1Cathie MartinNorwich

Engineering phenylpropanoidproduction in crops for healthy foods.

9:00 - 9:30 S18.1.2Eva StögerVienna

Plant-made pharmaceuticalantibodies.

9:30 - 10:00 S18.1.3Roberto BassiVerona

Domestication of wild unicellularalgae for growth in photobioreactors.

10:00 - 10:30 S18.1.4Jules BeekwilderWageningen

Metabolic engineering of terpenoidsfor green pharmaceuticals.

10:30 - 10:45 S18.1.5Monika SztajnertWroclaw

Flax produces biologically activecannabinoids.

10:45 - 11:00 S18.1.6Kwok Wai LaiHong Kong SAR

The occurrence of ACC- dependentethylene biosynthesis might haveplayed important role in thespeciation of β-cyanoalaninesynthase (CAS) from the O-acetylserine sulfhydrylase (OASS)family proteins during land plantevolution.


IUBMBLECTURE PL-6

Chairpersons:Angelo AzziPresident IUBMP, Boston

Antonio De FloraGenova

John MattickUniversity of Queensland - Brisbane - AUS

Challenging the dogma: the centralrole of RNA in human developmentand cognition


Break 11:00 - 11:30


Final Programme34


«Science & Society»Session on genetic Diseases

13:00 - 15:00Chairpersons:Jacques-Henry WeilStrasbourg

Patrizia GallettiNapoli

Marina Cavazzana CalvoDepartment of Biotherapy, Hopital NeckerEnfants Malades, Université Paris Descartes,France

Gene therapy: Acquired results,expected advances and obstacles

Gert-Jan B. van OmmenDept of Human Genetics, Leiden UniversityMedical Centre, The Nethederlands

Progress in exon skipping therapy forDuchenne muscular dystrophy andthe future of RNA-based genetictherapy

Bart LoeysAntwerp University Hospital, Belgium

Connective tissue diseases andcytokines: A pathway to treatment

Milan MacekInstitute of Biology and Medical Genetics,University Hospital Motol and 2nd School ofMedicine, Charles University, Czech Republic

Organization of care for geneticdiseases in a diverse Europe

HALL 500



P02, P10, P11, P12, P13, P14, P15,P16, P17, P19, P29, P30, P31 P33

POSTER AREA

Break 12:30 - 13:00

The sessionsbetween


Final Programme36




SymposiaS 6.3 Development of cognitionand languageChairpersons:Pico CaroniBasel

Wieland B. HuttnerDresden

15:00 - 15:30 S6.3.1Wieland B. HuttnerDresden

Neural stem cells and the evolution ofthe cerebral cortex.

15:30 - 16:00 S6.3.2Alexander DityatevNovgorod/Genova

From recognition molecules tocognition.

16:00 - 16:30 S6.3.3Edvard I. MoserTrondheim

Neural mechanisms for mapping ofspace.

16:30 - 17:00 S6.3.4Pico CaroniBasel

Structural traces of learning andmemory in the hippocampus.

17:00 - 17:30 S6.3.5Cecile PaganParis

Alterations of the melatonin Pathwayas a susceptibility factor to Autism.

SymposiaS 10.3 Redox balance andobesityChairpersons:Vladimir SkulachevMoscowGiuseppe RotilioRoma

15:00 - 15:30 S10.3.1Louis CasteillaToulouse

Redox balance and adipogenesis.

15:30 - 16:00 S10.3.2Paul HolvoetLeuven

Interaction between oxidative stressand inflammation in obesity.

16:00 - 16:30 S10.3.3Vladimir SkulachevMoscow

Mitochondria-targeted penetratingions as inhibitors of the agingprogramme and obesity.

16:30 - 17:00 S10.3.4Gerry MelinoRomap53 family, involvement of p73 inmetabolism and senescence: why weneed it?

17:00 - 17:15 S10.3.5Jun-Yuan HuangTaipei

Haematopoietic haeme oxygenase-1impacts obesity-induced adiposemacrophage infiltration and insulinresistance.

17:15 - 17:30 S10.3.6Jin-Kyung ChoGyeonggi-do

Effects of exercise intensity on globalhepatic mRNA expression in high fat-induced obese mice.

SymposiaS 2.1 Non coding RNA:evolution, functionChairpersons:Pier Paolo PandolfiBoston

Irene BozzoniRoma

15:00 - 15:30 S2.1.1Witold FilipowiczBasel

Regulation of microRNA Repressionand microRNA Turnover inMammalian Cells.

15:30 - 16:00 S2.1.2Caroline DeanNorwich

Non-coding RNAs in the control offlowering time.

16:00 - 16:30 S2.1.3Lucas KaaijUtrecht

Functional analysis of Tdrd1 andTdrd6 in the zebrafish Piwi pathway.

16:30 - 17:00 S2.1.4Olga DontsovaMoscow

Functional role of ribosomal RNAmethylation.

17:00 - 17:15 S2.1.5Marcella CesanaRoma

Role of microRNAs in DuchenneMuscular Dystrophy and in muscledifferentiation.

17:15 - 17:30 S2.1.6Ranjan PereraOrlando

The melanoma-upregulated longnoncoding RNA SPRY4-IN1modulates apoptosis and invasion.




Symposia12.2 Cellular senescenceChairpersons:Lenhard K. RudolphUlm

Filiberto CiminoNapoli

15:00 - 15:30 S12.2.1Daniel PeeperAmsterdam

Senescence and tumor suppression.

15:30 - 16:00 S12.2.2Lenhard K. Rudolph Ulm

Checkpoint responses to telomeredysfunction in stem cells.

16:00 - 16:30 S12.2.3Fabrizio d’Adda di FagagnaMilano

Molecular mechanisms of cellularsenescence.

16:30 - 17:00 S12.2.4Judith Campisi - Marco DemariaBerkeley

Cellular senescence linksinflammation and aging.

17:00 - 17:15 S12.2.5Zbigniew KorwekWarsaw

Does activation of DNA damageresponse in human T cells lead tocellular senescence?

17:15 - 17:30 S12.2.6Raffaella FaraonioNapoli

Adoptive expression of a set ofmiRNAs induces cellular senescencein human fibroblasts.

SymposiaS 18.2 Plant innate immunityChairpersons:Ulla BonasHalle

Felice CervoneRoma

15:00 - 15:30 S18.2.1Ulla BonasHalle

How bacterial pathogen effectorproteins manipulate the plant cell.

15:30 - 16:00 S18.2.2Brian StaskawiczBerkeley

Role of pathogen effectors in plantinnate immunity.

16:00 - 16:30 S18.2.3Jonathan JonesNorwich

Discovering and validating plantpathogen effectoromes.

16:30 - 17:00 S18.2.4Giulia De LorenzoRoma

Healthy food for a healthy life:engineering resistance byconstructing chimeric receptors forpathogen recognition.

17:00 - 17:15 S18.2.5Marcel ZamockyVienna

Bifunctional catalase-peroxidase issecreted by the rice blast fungusMagnaporthe grisea during oxidativeburst.

17:15 - 17:30 S18.2.6Eugene RogozhinMoscow

Novel antifungal defensins fromseeds of wild plants.

AUDITORIUM



20:30 - 22:00

Public Science &Society Forum on“Biochemistry forTomorrow’sMedicine”MBC - Centro di Biotecnologie Molecolari,Via Nizza 52 - Torino

The contribution of biochemicalresearch for major humandiseases.

Il contributo della ricercabiochimica per le maggiori malattieumane.

WISE/EMBOWoman in ScienceAward 2011Laudation by the Nominator for theAwardee

17:45 - 18:45Wolfgang BaumeisterMax-Planck-insitute of Biochemistry,Martinsried, Germany


WISE LECTURE PL-7Chairperson:Lea SistonenTurkuLuciana AviglianoNapoli

Carol V. RobinsonDepartment of Chemistry Universityof Oxford - UK

Finding the right balance: From RareGases to Rotary motors.

Final Programme38


Wednesday June 29, 2011


SymposiaS 2.2 Small RNA in diseaseChairpersons:John RossiDuarte

Riccardo CortesePomezia

8:30 - 9:00 S2.2.1Reuven AgamiAmsterdam

Selective inhibition of miRNAaccessibility is required for p53tumour suppressive activity.

9:00 - 9:30 S2.2.2John RossiDuarte

Aptamer and dendrimer mediateddelivery of therapeutics small RNAs.

9:30 - 10:00 S2.2.3Adrian KrainerNew York

Oligonucleotide Therapeutics forCorrecting Defective RNA Splicing.

10:00 - 10:30 S2.2.4Maria Carmo-FonsecaLisboa

Co-transcriptional RNA checkpoints.

10:30 - 10:45 S2.2.5Constance CiaudoZurich

Characterisation of new small RNApopulations in mouse EmbryonicStem cells.

10:45 - 11:00 S2.2.6Mary-jessica LaguetteCape Town

Sequence Variants within the 3’-UTRof the COL5A1 gene alters mRNAstability: Implications for musculoskeletal soft tissue injuries.

SymposiaS 11.1 Genes and pathways incancerChairpersons:René BernardsAmsterdam

Carola PonzettoTorino

8:30 - 9:00 S11.1.1René BernardsAmsterdam

Dissecting mechanisms of cancerdrug resistance through functionalgenetics.

9:00 - 9:30 S11.1.2Chris J. MarshallLondon

Rho GTPase signalling in invasionand metastasis.

9:30 - 10:00 S11.1.3Michael StrattonCambridge

Evolution of the Cancer Genome.

10:00 - 10:30 S11.1.4Grahame HardieDundee

AMP-activated protein kinase, atumour suppressor that opposesthe metabolic changes in cancercells.

10:30 - 10:45 S11.1.5Hanna KryhGothenburg

Characterisation of amplicon junctionsequences in genomic regionssurrounding the MYCN gene inneuroblastoma tumors; Implicationsfor clinical follow-up of high-riskpatients.

10:45 - 11:00 S11.1.6Emanuela PupoTorino

Hydrogen sulphide promotes calciumsignals and migration in tumour-derived endothelial cells.

SymposiaS16.1 Ectoenzyme network anddiseasesChairpersons:Simon RobsonBoston

Fabio MalavasiTorino

8:30 - 9:00 S16.1.1Simon RobsonBoston

Ectonucleotidases, regulatory T cellsand the conditioning of vascular andimmune responses in inflammatorybowel disease.

9:00 - 9:30 S16.1.2Laura AirasTurku

CD73 as a regulator of CNSinflammation.

9:30 - 10:00 S16.1.3Silvia DeaglioTorino

Nucleotide-metabolising enzymes intumour-host interactions: the chroniclymphocytic leukemia model.

10:00 - 10:30 S16.1.4Richard EbsteinJerusalem

CD38 mediates social behaviour inclinical and non-clinical subjects.

10:30 - 10:45 S16.1.5Irini EvnouchidouAgia Paraskevi Attikis

Specific ER aminopeptidase 1 SNPsaffect antigen processing in vitro anddemonstrate substrate inhibitionkinetics.

10:45 - 11:00 S16.1.6Alejandra Ochoa-ZarzosaMorelia

Prolactin and Staphylococcus aureusinhibit nuclear factor kappa Bactivation in bovine mammaryepithelial cells.




AUDITORIUM

SymposiaS 13.1 Rare metabolic diseasesChairpersons:Stylianos E. AntonarakisGenève

Francesco SalvatoreNapoli

8:30 - 9:00 S13.1.1Stylianos E. AntonarakisGeneva

The Connectivity of GenomicElements.

9:00 - 9:30 S13.1.2Miguel C. SeabraLondon

Pathogenesis of diseases involvingdefects in Rab GTPase function andmembrane traffic.

9:30 - 10:00 S13.1.3Francesco SalvatoreNapoli

Nature and nurture in geneticdiseases: the cases of hereditaryfructose intolerance andhyperphenylalaninemias.

10:00 - 10:30 S13.1.4Santiago Rodríguez de CórdobaMadrid

Pathogenic mechanisms in Lafora’sdisease.

10:30 - 10:45 S13.1.5Giulia NacciTorino

Isolation and cloning of stimulatoryanti-PDGF receptor auto-antibodiesfrom the immunological repertoire ofpatients with systemic sclerosis.

10:45 - 11:00 S13.1.6Mirko PinottiFerrara

Aberrant splicing reverts a potentiallylethal coagulation deficiency causedby A+1G/T splicing mutation.

SymposiaS 15.1 Development of vascularsystemChairpersons:Ralf AdamsMünster

Massimo SantoroTorino

8:30 - 9:00 S15.1.1Lena Claesson WelshUppsala

VEGF in control of vascular function

9:00 - 9:30 S15.1.2Ralf AdamsMuenster

Angiogenesis - growth of new bloodvessels and beyond.

9:30 - 10:00 S15.1.3Deepak SrivastavaSan Francisco

Regulatory networks controllingcardiac cell fate.

10:00 - 10:30 S.15.1.4Guido SeriniTorino

Regulation of integrin function inendothelial cells: a matter ofconformation and traffic.

10:30 - 10:45 S15.1.5María Soledad AlvarezValencia

Effect of Cycloxygenase 2 in cardiacischemia-reperfusion injury.

10:45 - 11:00 S15.1.6Olena SemenykhinaKyiv

Exogenous hydrogen sulphide as amodulator of the mitochondrialpermeability transition pore openingin rat heart.



Break 11:00 - 11:30


PABMBLECTURE PL-4Chairpersons:Jorge BabulPresident PABMB, Santiago

Rubio VicenteValencia

Hugo J.F. MaccioniNational University of Córdoba - Córdoba- RA

Organization of the synthesis ofglycolipids in the Golgi complex

Final Programme40


HALL 500

13:00 - 15:00Poster SessionsP02, P10, P11, P12, P13, P14, P15,P16, P17, P19, P29, P30, P31 P33

13:00 - 15:00Workshop:Integrating MolecularBioscience Educationwith Medical Training

Organised byFEBS Education Committee

Chairpersons:Karmela BarisicCroatiaKeith ElliottUK

Introduction to the Workshop

13:00 - 13:30Karmela BarisicCroatia

Keith ElliottUK

Why integrate? The evidence tosupport integration of scientific andclinical learning within undergraduatemedical curricula”

13:30 - 14:00Karen MattichPeninsula College of Medicine and Dentistry,Universities of Exeter and Plymouth, UK

”Integrating Molecular Bioscienceswithin the Medical Curriculum: theMaastricht Approach”

14:00 - 14:30Jan F. C. GlatzDirector of Education, BiomedicalSciences Maastricht University, The Netherlands”How to Integrate MolecularBioscience in Medical Training”

14:30 - 15:00Tomáš ZimaDean of the 1st Medical Faculty, CharlesUniversity Prague, Czech Republic

Panel Discussion


FEBS PublicationsAward LectureChairpersons:Felix WielandManaging Editor FEBS LettersRichard PerhamEditor in Chief of FEBS Journal

FEBS Letters AwardLecture PL-9Shiro SuetsuguUniversity of Tokyo, Japan

Subcellular membrane curvaturemediated by the BAR domainsuperfamily proteins.

FEBSJournal PrizeLecture PL-10Karen van EunenUniversity Medical Centre Groningen,The Netherlands

In vivo-like enzyme kinetics improvemetabolic computer models


AUDITORIUM

POSTER AREA

The sessionsbetween

13:00 and 15:00are held in parallel

HALL LONDRA

13:00 - 15:00Workshop:FluorescenceSpectroscopy: a toolfor protein chemistrySponsored by Perkin Elmer Ltd

13:00 - 15:00Steve UpstonePerkin Elmer Ltd, UK

Theory and applications offluorescence spectroscopy in proteinstructure-function

Final Programme42




SymposiaS 11.2 Cancer stem cells andmetastasisChairpersons:Peter FriedlNijmegen

Paolo ComoglioTorino

16:15 - 16:45 S11.2.1Juliane HannemannHamburg

Circulating tumour cells and cancermicrometastasis.

16:45 - 17:15 S11.2.2Peter FriedlNijmegen

Intravital imaging of cancer invasionand experimental therapy response:role of integrins.

17:15 - 17:45 S11.2.3Paolo ComoglioTorino

MET and invasive growth: a geneticprogramme for stem and cancer stemcells.

17:45 - 18:15 S11.2.4Stefano PiccoloPadova

Mechanisms of metastasissuppression.

18:15 - 18:30 S11.2.5Giulio Di MininTriesteA genome-scale protein interactionprofile of Drosophila p53 uncoversadditional nodes of the human p53network.

8:30 - 18:45 S11.2.6Arkaitz CarracedoDerio

Regulation of metabolism in healthand disease by cancer genes: a newfunction for the promyelocyticleukaemia protein.

SymposiaS 16.2 Structure and function ofinnate immunity receptorsChairpersons:Luke O'NeillDublin

Lorenzo MorettaGenova

16:15 - 16:45 S16.2.1Luke O’NeillDublin

Toll-like receptor and NOD-likereceptor signaling in inflammationand infection.

16:45 - 17:15 S16.2.2Veit HornungBonn

Intracellular sensing of DNA by theinnate immune system.

17:15 - 17:45 S16.2.3Lorenzo MorettaGenova

Human NK receptors: functionalcharacteristics and clinicalapplications.

17:45 - 18:15 S16.2.4Olaf GrossEpalinges

Inflammasomes: IL-1beta cleavageand beyond.

18:15 - 18:30 S16.2.5Sara SerraTorino

Ectoenzyme-generated extracellularadenosine creates local conditionsfavouring growth and survival ofchronic lymphocytic leukaemia cells.

8:30 - 18:45 S16.2.6Serdar DoganAntalya

Polymorphism in the TNF-alpha genepromoter at position -1031 isassociated with increased circulatinglevels of TNF-alpha, myeloperoxidaseand nitrotyrosine in primary Sjogren’sSyndrome.

SymposiaS 19.1 Vectors for therapeuticand experimental applicationsChairpersons:Maria Grazia RoncaroloMilano

Lucio LuzzattoFirenze

16:15 - 16:45 S19.1.1Lucio LuzzattoFirenze

Prospects and problems of genetherapy of haemoglobinopathies.

16:45 - 17:15 S19.1.2Thierry VandenDriesscheLeuven

Haemophilia as trailblazer for genetherapy.

17:15 - 17:45 S19.1.3Tony CathomenHannover

Development and application ofdesigner nucleases.

17:45 - 18:15 S19.1.4Luigi NaldiniMilano

Targeting gene transfer to improvethe efficiency and safety of genetherapy.




SymposiaS 13.2 Mitochondrial diseasesChairpersons:Douglas WallaceIrvine

Sergio PapaBari

16:15 - 16:45 S13.2.1Massimo ZevianiMilano

OXPHOS-related mechanisms andpathways unraveled by newmitochondrial disorders.

16:45 - 17:15 S13.2.2Arnold MunnichParis

Human diseases with impairedmitochondrial translation.

17:15 - 17:45 S13.2.3Douglas WallacePhiladelphia

Energyomics-energenomics: amitochondrial etiology of commondiseases.

17:45 - 18:15 S13.2.4Michael RyanMelbourne

Understanding mitochondrialcomplex I assembly and misassemblyin disease.

18:15 - 18:30 S13.2.5Vittoria PetruzzellaBari

Survey of genes involved inmitochondrial biogenesis in earlydevelopment of zebrafish ascandidates for mitochondrialpathologies.

8:30 - 18:45 S13.2.6Cláudio M. GomesOeiras

Pathogenesis mechanisms inmitochondrial beta oxidationdiseases: protein misfolding, functionand small molecules.

SymposiaS 17.1 Biochemistry andmolecular biology oftuberculosisChairpersons:Roland BroschParis

Giovanna RiccardiPavia

16:15 - 16:45 S17.1.1Clifton E. BarryBethesda

The biochemistry of activation ofnitroimidazole antibiotics inMycobacterium tuberculosis.

16:45 - 17:15 S17.1.2Stewart ColeLausanne

New medicines for tuberculosis:benzothiazinones.

17:15 - 17:45 S17.1.3Roland BroschParis

ESX/Type VII secretion in tuberclebacilli - a key factor in virulence andprotection.

17:45 - 18:15 S17.1.4Katarina MikusovaBratislava

Playing biochemistrywith mycobacterial cell wall - an oldgood drug target.

18:15 - 18:30 S17.1.5Vadim NikitushkinMoscow

Muropeptides of mycobacterialpeptidoglycan are the factors ofdormant mycobacteria resuscitation.

8:30 - 18:45 S17.1.6Franca RossiNovara

Structural investigations on M.tuberculosis proteins involved in DNArepair.


20:30 - 23:00

Social Dinner


➜

Final Programme44


Thursday June 30, 2011


SymposiaS 15.2 Molecular basis ofcardiovascular diseasesChairpersons:Federico BussolinoTorino

Guido TaroneTorino

8:30 - 9:00 S15.2.1Stefan EngelhardtMuenchen

Cardiac muscle microRNAs.

9:00 - 9:30 S15.2.2Emilio HirschTorino

Genetic modeling of PI3K inhibition.

9:30 - 10:00 S15.2.3Alain TedguiParis

Role of innate and adaptive immunityin atherosclerosis.

10:00 - 10:30 S15.2.4Eli KeshetJerusalem

Adaptive responses in the ischemicmyocardium.

10:30 - 11:00 S15.2.5Muhammad AslamGiessen

Adrenomedullin 2 enhancesmacrovascular endothelial barrierfunction while it disrupts coronarymicrovascular barrier via differentialregulation of Rac1.

SymposiaS 16.3 Receptors and signaltransductionChairpersons:Hua Eleanor YuDuarte

Alberto MantovaniMilano

8:30 - 9:00 S16.3.1Oreste AcutoOxford

T cell antigen receptor signalling.

9:00 - 9:30 S16.3.2Ada FunaroTorino

Clinical and biological significance ofCD157 in ovarian carcinoma.

9:30 - 10:00 S16.3.3Manolis PasparakisCologne

Intracellular signalling pathwaysregulating epithelial homeostasis andinflammation.

10:00 - 10:30 S16.3.4Hua Eleanor YuDuarte

STAT3 in cancer inflammation andimmunity.

10:30 - 10:45 S16.3.5Christina ThomasEpalinges

NLR expression and inflammasomeactivation in neutrophils.

10:45 - 11:00 S16.3.6Antonio InforzatoRozzano

Modular organisation andglycosylation of the long petraxinPTX3 dictate its biological functions.

SymposiaS 19.2 Gene and cell therapy forgenetic diseasesChairpersons:Natalie CartierParis

Alessandro AiutiMilano

8:30 - 9:00 S19.2.1Natalie CartierParis

Gene therapy strategies for geneticleukodystrophies.

9:00 - 9:30 S19.2.2Alessandro AiutiMilano

Gene Therapy for PrimaryImmunodeficiencies.

9:30 - 10:00 S19.2.3Juan BuerenMadrid

New Approaches for the GeneTherapy of Inherited Bone MarrowFailure Syndromes: The FanconiAnaemia Model.

10:00 - 10:30 S19.2.4Shin-ichi MuramatsuTochigi

Gene therapy for Parkinson’s disease:Strategies for the local production ofdopamine.

10:30 - 10:45 S19.2.5Mikhail A. RubtsovMoscow

Treatment of lymphoid cells with thetopoisomerase II poison etoposideleads to an increased juxtaposition ofAML1 and ETO genes on the surfaceof nucleoli.

10:45 - 11:00 S19.2.6Giuseppina CovelloTrento

Antisense RNA-induced exon-skipping for the gene therapy offrontotemporal dementia andparkinsonism associated withchromosome 17 (FTDP-17).

AUDITORIUM HALL GIALLA HALL ISTANBUL



AUDITORIUM

SymposiaS 17.2 Biochemistry andmolecular biology of malariaChairpersons:Maria MotaLisboa

Paolo AreseTorino

8:30 - 9:00 S17.2.1Maria MotaLisboa

Plasmodium-Host-Plasmodiuminteractions: how is malariasuperinfection controlled?

9:00 - 9:30 S17.2.2Dominique Soldati-FavreGenève

Molecular events governing the lyticcycle in apicomplexa.

9:30 - 10:00 S17.2.3Michael LanzerHeidelberg

Transporters as mediators of drugresistance in the human malariaparasite Plasmodium falciparum.

10:00 - 10:30 S17.2.4Artur ScherfParis

The study of antigenic variation inPlasmodium falciparum: Mind gamesor a novel therapeutic approach.

10:30 - 10:45 S17.2.5Rachel CerdanMontpellier

Membrane biosynthesis enzyme ofPlasmodium falciparum erythrocyticstages as a putative antimalarialtarget.

10:45 - 11:00 S17.2.6Oleksii SkorokhodTorino

Role of malaria pigment hemozoinand hemozoin-generated4-hydroxynonenal on inhibition oferythropoiesis in malaria anaemia.

Closing PlenaryLecture PL-11Chairpersons:Jaak JärvTallinLucio LuzzattoFirenze

Guido KroemerGustave Roussy Institut - Villejuif - FR

Autophagy, cytoprotection andlongevity



➜

Closing Ceremony

Closing remarks by

Sergio PapaChairman Scientific Committee of the36th FEBS Congress

Israel PechtFEBS Secretary General

Presentation of the37th FEBS/22nd IUBMBCongress 2012 SevillaMiguel Angel de la Rosa

HALL LONDRA

12:15 - 12:45

Final Programme46


Poster Sessions

Group 18:30 am June 26 - 6:00 pm June 27

P01 Genomes: structure, information and epigenetic controlP03 Protein structure, functional mechanisms, turnoverP04 Cell-cell communicationP05 Membrane dynamicsP06 Molecular basis of developmentP07 Systems biologyP08 Molecular engineering for medicineP09 Prokaryote biochemistryP18 Plant biochemistryP20 ApoptosisP21 Signal transductionP22 BioinformaticsP23-P27 BioenergeticsP24 Membrane phospholipidsP25 Protein kinases and phosphatasesP26 Free radical balance and oxidative stressP28 ProteomicsP32 Metals in biology

Group 28:30 am June 28 - 6:00 pm June 29

P02 RNA biologyP10 Metabolic control and disordersP11 Cancer biologyP12 Cellular senescence and agingP13 Rare diseasesP14 Biochemistry of the brain and neurodegenerative disordersP15 Molecular basis of cardiovascular diseasesP16 Biochemistry of immunity and inflammationP17 Biochemistry and molecular biology of malaria and tuberculosisP19 Molecular and cellular therapeuticsP29 Cell organelle dynamicsP30 GlycobiologyP31 Developmental biologyP33 Varia



01-02 SPRINGER03 ST. JUDE CHILDREN’S RESEARCH HOSPITAL04 ELSEVIER05 CAYMAN CHEMICAL COMPANY06-10 WILEY-BLACKWELL07 WISEPRESS BOOKSHOP08 TOCRIS BIOSCIENCE09 SCIENCES/AAAS11 NEW ENGLAND BIOLABS/CELL SIGNALING

TECHNOLOGY12 NOVUS BIOLOGICALS13 EMBO

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Turin (Torino)

Turin is a major city as well as a business and cul-tural centre in northern Italy, capital of the Piedmontregion, located mainly on the left bank of the Po Riversurrounded by the Alpine arch. The population of thecity proper is 909,193 (November 2008) while the popu-lation of the urban area is estimated by Eurostat to be1.7 million inhabitants; the Turin metropolitan area isestimated by OECD to have a population of 2.2 million.

Turin is a flourishing, industrious and cosmopolitanEuropean city, which enjoys state-of-the-art technologyand architectural developments. The city boasts a richculture and history, and is known for its numerous artgalleries, restaurants, churches, palaces, operahouses, piazzas, parks, gardens, theatres, libraries,museums and other venues. Turin is well-known for itsbaroque, rococo, neo-classical, and Art Nouveau ar-chitecture. Much of the city's public squares, cas-tles, gardens and elegant palazzi (such as PalazzoMadama), were built by Sicilian architect FilippoJuvarra, who modelled these buildings on the Baroqueand classical style of Versailles. Examples of theseFrench-themed edifices include the Royal Palace ofTurin, the Palazzina di caccia of Stupinigi and theBasilica di Superga. Turin is sometimes called the "cra-dle of Italian liberty", due to its having been the birth-place and home of notable politicians and people whocontributed to the Risorgimento, such as Cavour. Pres-tigious and important museums, such as the MuseoEgizio and the Mole Antonelliana are also found in thecity. Turin's several monuments and sights make it oneof the world's top 250 tourist destinations, and the tenthmost visited city in Italy in 2008.

Turin used to be a major European political centre, be-ing Italy's first capital city in 1861 and being home to theHouse of Savoy, Italy's royal family. Even though muchof its political significance and importance had been lostby World War II, it became a major European crossroadfor industry, commerce and trade, and currently is one ofItaly's main industrial centres, being part of the famous"industrial triangle", along with Milan and Genoa.

Turin is well known as the home of the Shroud of Tu-rin, the football teams Juventus F.C. and Torino F.C.,the headquarters of automobile manufacturers Fiat,Lancia and Alfa Romeo, and as host of the 2006 WinterOlympics. Several International Space Station mod-ules, such as Harmony and Columbus, were also manu-factured in Turin. It was the capital of the Duchy of Sa-voy from 1563, then of the Kingdom of Sardinia ruledby the Royal House of Savoy and finally the first capitalof a unified Italy.



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