LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08502 USA
Implants
A. Gastrointestinal B. Transdermal C. Implants
Dissolution Testing
By Dr. Luke Lee
A. In- Vitro Gastrointestinal
USP Apparatus 1,2,
USP Dissolution Method 1
USP Dissolution Method 2
12 position dissolution testers
Color touch screen display
Automated Sampling Manifold
Syringe holder
Auto dropping tray & vessel cover
UDT-804-2L Universal Dissolution
Tester
2L Dissolution Tester
UDT-804-4L Universal Dissolution
Tester
4L Dissolution Tester
UDT 816D-12/12T
12 position AIRBATH dissolution tester with 3 speed
zones
12 vessel Temp. reports
3 Speed zones
No water bath
SYSTEM 800S Automated Dissolution UV on-line System
SYSTEM 850BDL For HPLC off line analysis
Automated Dissolution Syringe Pump Sampling System
Media replacement lines
To collector
To collector
SYSTEM 850BDL - 4 bath sampling loop
Bath 2.
Bath 4.
Bath 3.
Bath 1.
DSC-800 System Controller
SYSTEM 850BDL-12 For HPLC off line analysis
Automated Dissolution Syringe Pump Sampling System
SYSTEM 850BDL-12 X 2 Automated Dissolution Syringe Pump Sampling System (Made in the USA)
SYSTEM 860D-12CDL Automated AIRBATH Dissolution Syringe Pump Sampling System
LOGAN SYSTEM 860CDL-12 Automated 3 Speed Zones Dissolution Sampling System with
Center-Point™ Camera
UDT-816 Universal Dissolution Tester
Syringe Pump / System Controller
Auto-sampler Camera System
LOGAN UDT-816
3 Speed Zones Universal Dissolution Tester With Center-Point™ Camera
For PADDLE TEST - Center-Point™ camera is located at the bottom of bath center to the vessel
LOGAN UDT-816
3 Speed Zones Universal Dissolution Tester
With IN-SHAFT camera for basket
For BASKET TEST - Camera is located inside the basket shaft
SYSTEM 860D-12CDL Automated AIRBATH Dissolution Syringe Pump Sampling System w/Cameras
Tablet in
Basket Test
Tablet in
Paddle Test
MDS 600PL
Media Delivery System
• The mobile unit brings pre-heated,
degassed media to dissolution testers.
• Fills 6 vessels to the same volume
simultaneously.
• Media de-aerated by heat, high speed
circulation, filtration and vacuum.
• Temperature accuracy controlled to +/-
0.2 C.
• Simultaneously delivers 6 vessels up
to 1000 ml within 2 minutes
• Detachable Oxygen meter to check
oxygen
• Printer report for Date, Time, Media
Type, Media Volume, Temperature,
Oxygen Dissolving Rate, pH, etc.
MDS 600PL
Media Delivery System Vacuum & Measurement Chambers
MDS 600PL
Media Delivery System
MDS-600 Delivery Manifold
UDT-804 Dissolution Tester
MDS 600T
Bench Top Media Delivery System
AVC-100 HTP Automated Vessel Cleaner
• For validation
• Color Touch Screen Display
• Mobile unit brings cleaner to bath
• Selectable methods for different products,
• High pressure turbo wash and vacuum
• Media neutralization in waste tank
• Automatic waste discharge
AVC-100 HTP Automated Vessel Cleaner
Wash Head
UDT-814 Dissolution Tester
USP Dissolution Apparatus 3
USP Dissolution Method 3
USP Dissolution Method 3
USP Dissolution Method 3
For USP Method 3 Tests
In line
sampling
Individual vessel
covers
USP Dissolution Method 3
LOGAN AUTOMATED DISSO III-7
SYSTEM
USP Dissolution Apparatus 4
USP Dissolution Method 4
Flow Cell
Piston Pump
To WasteFraction Collector
Splitter
Fresh Medium
Open Loop System
Close Loop System
USP Dissolution Method 4
• Peristaltic Pump
• Syringe Pump
• Piston Pump
USP Dissolution Method 4
Tablet cell12 mm
Cell forimplants
Cell forointments
and creams
Tablet cell22.6 mm
Cell forsuppositories
and softgelatin capsules
Cell forpowders
and granulates
USP Dissolution Method 4
USP Dissolution Method 4
USP Dissolution Method 4
Logan DRY HEAT USP 4 Sampling Systems
Transdermal Diffusion Cell
Testing
By Dr. Luke Lee
B. Transdermal
APPLICATION AREAS : • Hair • Eyes • Nose • Mouth • Nails • Skin--- Most popular area– 2 sq meters per human
What are the products that need transdermal testing?
Users of Transdermal Systems
How to perform Transdermal Testing?
•Transdermal Diffusion Cells •Skin / Membranes •Drive Consoles
Topical: Temperature 32 C The drug stays on the surface of the skin or is absorbed by skin
Transdermal: Temperature 37 C The drug penetrates the skin and gets into blood stream
Transdermal Diffusion Cells :
Vertical cell / Franz Cell
LOGAN vertical Cell
Logan nail cells
Nail holder
LOGAN Horizontal Cells / Side By
Side Cells
Logan cornea cells
Horizontal Cells / Side By Side Cells
Artificial Skin – Strat-M membrane
Strat-M Membrane
2. Place the Strat-M Membrane on the Diffusion cell
Strat-M Membrane
3. Load samples on Strat-M Membrane
All cells must be clean
63
Media Degassing Station
Degassing Media
LOGAN FDC-6
Transdermal diffusion cell drive console
Temperature Controller
Water
Tank
FDC-6 Drive Console
Franz cells
LOGAN SDC-6
Transdermal Diffusion Cell Drive Console ( 6 Side By Side Cells)
LOGAN SFDC-6
Transdermal Diffusion Cell Drive Console ( 3 Verital Cells & 3 Side By Side Cells)
LOGAN DHC-6T
Dry Heat Transdermal System
LOGAN DHC-6T
Dry Heat Transdermal System
For sampling, the cell support plate lays flat
LOGAN DHC-6T
Dry Heat Transdermal System
For media replacement, the cell support plate tilts to purge the bubbles
LOGAN FDC-6T
Semi- Automated System
LOGAN FDC-6T
Semi-Automated Systems
LOGAN SYSTEM 913-12 Automated Transdermal
Diffusion Cell System
SYRINGE
PUMP
SCT- DL SAMPLE
COLLECTOR
SYSTEM CONTROLLER
FDC-6T DIFFUSION CELL DRIVE CONSOLE
LOGAN SYSTEM 914-12 Automated Transdermal
DRYHEAT Diffusion Cell System
SYRINGE
PUMP
SCT- DL SAMPLE
COLLECTOR
SYSTEM CONTROLLER
DHC-6T DIFFUSION CELL DRIVE CONSOLE
DEAR-1200 ONLINE DIGASSING SYSTEM (Optioanl)
DEAR-100 w/ Vacuum bottle
Heat Plate (Not included)
LOGAN SYSTEM 912
Automated Transdermal Diffusion Cell
Sampling System
USP Apparatus 5,6,
USP Dissolution Apparatus 5
USP Dissolution Apparatus 5
USP Dissolution Method 5
USP Dissolution Apparatus 5
USP Dissolution Method 6
USP Dissolution Apparatus 6
For USP Dissolution Apparatus 4 & 7
Tests
C. Implants / Suspensions
USP Dissolution Method 4
Logan Suspension Test Sampling Systems
USP Dissolution Method 4
Logan Suspension Cells
USP Dissolution Method 4
USP Dissolution Method 4
Logan Suspension Test Sampling Systems
USP Dissolution Method 4
USP Dissolution Method 7
LOGAN DISSO III-7 Rate Tester
USP 7 Balloon Holders
LOGAN DISSO III-7 Rate Tester
USP 7 Balloon Holders
LOGAN DISSO III-7 Rate Tester
USP 7 Balloon Holders
LOGAN DISSO III-7 Rate Tester
USP 7 Sample Holders
USP 7 Sample Holders & vessels
USP Dissolution Method 7
Glass Tubes
250 ml Glass Tube 50 ml Glass Tube
LOGAN DISSO III-7 USP 7 Tube Carrier—7
50 ml tubes for small volume media
150-250 ml media in the 300 ml
Tubes
USP Dissolution Method 7
USP Dissolution Method 7
DISK for smaller patched
USP Dissolution Method 7
USP Dissolution Method 7
LOGAN SYSTEM 7000-24
Automated USP 7
Heart Stents Test System
LOGAN Fully Automated USP 7 System
LOGAN SYSTEM 7000-24
Automated USP 7
Hip Stem Test System
LOGAN SYSTEM 7000-24 Automated Hip Stem Test System
USP Physical Testers
DST-3/6 Disintegration Tester
•Easy-To-Use input keypad
•Audible end of run signal
•Modular design for 1 to 6
simultaneous tests
• 2 Single in-line layout for easy
viewing of all basket assembles
•Meets and exceeds all USP
requirements and
specifications
FAB-2S Friability Tester
•As per USP specification
•Adjustable speed at 20-70 rpm
•Test with one or two drums
•Select counter or timer
•Easy input key pad
•Microprocessor control & LCD
display
FAB-2SP Friability Tester
•As per USP specification
•Adjustable speed at 20-70 rpm
•Test with one or two drums
•Select of counter or timer
•Easy input key pad
•Microprocessor control & LCD
display
•Printer / report center
LOGAN HDT-400L
Automated Hardness Tester For: Hardness / Thickness / Diameter / Weight measurements
LOGAN TAP-2S Automated Tap Density Tester
Meets all current USP, BP, JP
guidelines.
LED Display for TIME or
COUNTER.
Microprocessor Technology
Control System.
Easy To Use Input Keypad.
Modular Design for One or Two
Platforms.
Simultaneous tapping and rotary
motion
LOGAN TAP-2SP Automated Tap Density Tester w/ Printer
Meets all current USP, BP, JP
guidelines.
LED Display for TIME or COUNTER.
Microprocessor Technology
Control System.
Easy To Use Input Keypad.
Modular Design for One or Two
Platforms.
Simultaneous tapping and rotary
motion
Report printer
Thank you! Prepare by Dr. Luke Lee
www.loganinstruments.com www.loganinstruments.cn