![Page 1: Flow Diagram of the Main HOPE Trial and the HOPE-TOO Trial Extension](https://reader036.vdocuments.site/reader036/viewer/2022070403/568139db550346895da1909a/html5/thumbnails/1.jpg)
Flow Diagram of the Main HOPE Trial and the HOPE-TOO Trial Extension
The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347
![Page 2: Flow Diagram of the Main HOPE Trial and the HOPE-TOO Trial Extension](https://reader036.vdocuments.site/reader036/viewer/2022070403/568139db550346895da1909a/html5/thumbnails/2.jpg)
Baseline Characteristics
of All HOPE Study Patients
and of the Patients at
Centers Continuing in
the Trial Extension
(HOPE-TOO)
The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347
![Page 3: Flow Diagram of the Main HOPE Trial and the HOPE-TOO Trial Extension](https://reader036.vdocuments.site/reader036/viewer/2022070403/568139db550346895da1909a/html5/thumbnails/3.jpg)
Incidence and Relative Risks of Cancers and Deaths Due to Cancer
The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347
![Page 4: Flow Diagram of the Main HOPE Trial and the HOPE-TOO Trial Extension](https://reader036.vdocuments.site/reader036/viewer/2022070403/568139db550346895da1909a/html5/thumbnails/4.jpg)
Kaplan-Meier Analysis of the Effects of Vitamin E on Incident Cancer and
Major Cardiovascular Events for All 9541 Study Patients
The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347
![Page 5: Flow Diagram of the Main HOPE Trial and the HOPE-TOO Trial Extension](https://reader036.vdocuments.site/reader036/viewer/2022070403/568139db550346895da1909a/html5/thumbnails/5.jpg)
Incidence and Relative Risks of Site-Specific Cancers
The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347
![Page 6: Flow Diagram of the Main HOPE Trial and the HOPE-TOO Trial Extension](https://reader036.vdocuments.site/reader036/viewer/2022070403/568139db550346895da1909a/html5/thumbnails/6.jpg)
Incidence and Relative Risks of Major Vascular Events, Deaths, and Secondary
Cardiovascular Outcomes
The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347
![Page 7: Flow Diagram of the Main HOPE Trial and the HOPE-TOO Trial Extension](https://reader036.vdocuments.site/reader036/viewer/2022070403/568139db550346895da1909a/html5/thumbnails/7.jpg)
Kaplan-Meier Analysis of the Effects of Vitamin E
on All Heart Failure Events and Hospital Admissions
for Heart Failure in HOPE and HOPE-TOO Patients
The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347
![Page 8: Flow Diagram of the Main HOPE Trial and the HOPE-TOO Trial Extension](https://reader036.vdocuments.site/reader036/viewer/2022070403/568139db550346895da1909a/html5/thumbnails/8.jpg)
Lung Cancer in Large Randomized Trials of Vitamin E
The HOPE and HOPE-TOO Trial Investigators JAMA. 2005;293:1338-1347