1996 other bioactive products

other bioactive productsU 1300

01 - 283Total Synthesis of dl-Ascofuranone and Related Compounds. —The antitumor protective agent ascofuranone (VI) is accomplished by couplingreaction of the terpenoid side chain derivative (II) having a furanone moietywith the protected phenol derivative (III). This strategy is also applied to thesynthesis of oxidized and cyclized analogues of ascofuranone. The dehydroanalogues (VIII) and (IX) exhibit IC 50 1.3-4.0·10-3 (µmol cm-3), in comparisonto the cytotoxicity of prostaglandin A2 (2.8·10-3). — (SAIMOTO, H.; OHRAI,S.; SASHIWA, H.; SHIGEMASA, Y.; HIYAMA, T.; Bull. Chem. Soc. Jpn. 68(1995) 9, 2727-2734; Dep. Mater. Sci., Fac. Eng., Univ., Koyama, Tottori 680,Japan; EN)

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