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1996 other bioactive products other bioactive products U 1300 01 - 283 Total Synthesis of dl-Ascofuranone and Related Compounds. — The antitumor protective agent ascofuranone (VI) is accomplished by coupling reaction of the terpenoid side chain derivative (II) having a furanone moiety with the protected phenol derivative (III). This strategy is also applied to the synthesis of oxidized and cyclized analogues of ascofuranone. The dehydro analogues (VIII) and (IX) exhibit IC 50 1.3-4.0·10-3 (μmol cm-3), in comparison to the cytotoxicity of prostaglandin A2 (2.8·10-3). — (SAIMOTO, H.; OHRAI, S.; SASHIWA, H.; SHIGEMASA, Y.; HIYAMA, T.; Bull. Chem. Soc. Jpn. 68 (1995) 9, 2727-2734; Dep. Mater. Sci., Fac. Eng., Univ., Koyama, Tottori 680, Japan; EN) 1

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Page 1: ChemInform Abstract: Total Synthesis of dl-Ascofuranone and Related Compounds

1996 other bioactive products

other bioactive productsU 1300

01 - 283Total Synthesis of dl-Ascofuranone and Related Compounds. —The antitumor protective agent ascofuranone (VI) is accomplished by couplingreaction of the terpenoid side chain derivative (II) having a furanone moietywith the protected phenol derivative (III). This strategy is also applied to thesynthesis of oxidized and cyclized analogues of ascofuranone. The dehydroanalogues (VIII) and (IX) exhibit IC 50 1.3-4.0·10-3 (µmol cm-3), in comparisonto the cytotoxicity of prostaglandin A2 (2.8·10-3). — (SAIMOTO, H.; OHRAI,S.; SASHIWA, H.; SHIGEMASA, Y.; HIYAMA, T.; Bull. Chem. Soc. Jpn. 68(1995) 9, 2727-2734; Dep. Mater. Sci., Fac. Eng., Univ., Koyama, Tottori 680,Japan; EN)

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Exp 05: Compounds - Chemchem.ws/dl-1009/exp_05.pdf · Exp 05: Compounds Part B: Ionic Compounds ‣ A binary compound of a metal and a non-metal forms ions — not a molecule. ‣

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THERMOPLASTIC DISTRIBUTION - Industrial … KONDUIT * Compounds LNP* LUBRICOMP * Compounds LNP* LUBRILOY * Compounds LNP* STAT-KON* Compounds LNP* STAT-LOY* Compounds LNP* THERMOCOMP

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82G - alc.gov.bc.ca · ALC Website: This map represents Agricultural ... DL 937 DL 126 DL 0676 DL 106 DL 426 DL 7206 DL 26029 DL 1021 DL 128 DL 2313A DL 10144

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