2..3.1. Do s tch t ca beta- amyloid peptid bi cc ion kim loi Fe2+, Cu2+, Zn 2+ hoc BACE1Beta- amyloid l mt sn phm phn tch ca mt protein ln hn c tn l amyloid beta precursor protein (APP), v c xc tc bi cc enzyme - v - secretasses, l mt qu trnh sinh l bnh thng trong c th. A pht sinh ny t kt t di s hin din ca kim loi ha tr II( Fe2+, Cu2+, Zn2+) v bm vo t bo thn kinh trong v no.[1]St to iu kin cho A protofibrils kt t, gy c tnh cng nh s kt t ca hyperphosphorylate ( PHF). cp sinh ha, A c nh ngha l mt redox-active metalloprotein c kt t bi s tng tc vi nhng ion kim loi nh ng , km v st, kt qu l chng t ng kt t li v hnh thnh oligomerization. V s tng tc vi st, c tm thy rng Fe3+ nh hng n s hnh thnh ca cc si amyloid ca A 1-42 v A 25-35. S tng tc oxy ha kh ca Fe3+ vi si A dn n tnh cht ha hc ca n b gim, ng thi sinh ra cc gc t do (reactive oxygen species (ROS)), gy ra s peoroxy ha mng lipid, ph v AND v oxi ha protein. Tng phn t bo A c kt t v oligomerized c lu lai gy c t bo v synaptotoxic trong nui cy t bo v trong c th. Ngoi ra, st cn c tm thy tch t trong t bo thn kinh vi NFT. Fe3+ c kh nng kt hp vi hyperphosphorylated o ra kt ta dn n s hnh thnh NFT trong bnh Alzheimer.Khng nhng th st c chng minh l thc y APP ni sinh v hnh thnh A tip theo.[1].