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1997-2009
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1997-1999 - CRDF, GN1-432Clinical and Molecular Epidemiology of TB in the Republic of Georgia – Emory
University, Atlanta, GA,USA 2000-2001-CRDF, GB2-2012Clinical and Molecular Epidemiology of Drug-Resistant TB in Georgia- Emory
University, Atlanta, GA,USA 2001-2003- ISTC/BTEP#12, G-610p –SUCCESS STORYClinical and Molecular Epidemiology of Drug-Resistant TB in Georgia and the
Caucasus- Emory University, Atlanta, GA,USA 2004-2007 -BTEP/ISTC A-998Development of Multiple Drug resistant Tuberculosis (MDR TB) Surveillance and
National TB program (NTP) evaluations, Republics of Armenia and Georgia” 2004, August 30 – September 1, - GA-XO-1059-TB-04Multiple –Drug Resistant Tuberculosis: Epidemiologic, Diagnostic, and Therapeutic
Research Opportunities 2006-2008 – CRDF # GEX1-002711-TB06 Determination of Susceptibility to some second-line drugs of Mycobacterium
tuberculosis strains isolated in Georgia –VA Hospital, Syracuse, NY, USA 2006-2008-CRDF# GEX1-002712-TB06Characterization of Mycobacterium Tuberculosis Gene Expression Patterns DuringGrowth in the Human Lung –university of Louisville, KY, USA 2007-2009 –CRDF# GEB1-002725-TB-07Role of Hepatitis C Virus (HCV) as a Risk Factor for Anti-tuberculosis Drug-induced
Hepatic Toxicity- Emory University, Atlanta, GA,USA
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CRDF WorkshopMultiple –Drug Resistant Tuberculosis: Epidemiologic, Diagnostic, and Therapeutic Research Opportunities, 2004
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Steroids from some plants of Georgian flora as a potent antimycobacterial agents
Total Amount Requested from CRDF – $100 000 FSU PI- Merlani, Maia; Senior Research ScientistKutateladze Institute of Pharmacochemistry,
Georgian Academy of SciencesP. Sarajishvili st. 36, Tbilisi, 0159, Georgia US PI- Welch, John Thomas; Professor of Chemistry;
Dept of Chemistry, University at Albany, 1400 Washington Ave, Albany, NY 12222 USA
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Clinical and Molecular Epidemiology of Extrapulmonary and Combined TB Cases in Georgia.
Total Amount Requested from CRDF - $99 379 FSU PI – Nana Kiria, Head of Advisory Board
of National Center of Tuberculosis and Lung Disease
National Center of Tuberculosis and Lung Diseases
50 Maruashvili Street, Tbilisi 0101, Georgia US PI - Barry Kreiswirth, Director, PHRI TB
CenterPublic Health Research Institute225 Warren Street, Newark, NJ 07103
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Determination of susceptibility to some second-line drugs of Mycobacterium tuberculosis strains isolated in the Republic of Georgia.
Total Amount Requested from CRDF-$100 000 FSU PI -Vashakidze Lamara, Head of Phthisiology and
Pulmonology Chair of the Tbilisi State Medical University at the National Center of TB and Lung Diseases, MD,PH.D, Professor
National Center of Tuberculosis and Lung Diseases50 Maruashvili Street, Tbilisi 0101, Georgia US PI- Cynamon, Michael, Henry, Professor of Medicine, SUNY
Upstate Medical University, Chief, Infectious Diseases VAMC Syracuse, New York
Central New York Research Corporation800 Irving AvenueSyracuse, NY 13210
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TB Phage Total Amount Requested from CRDF -$99 700 FSU PI- Nonikashvili Marine, Assistant
Professor Phthisiology and Pulmonology Chair of the Tbilisi State Medical University at the
National Center of TB and Lung Diseases, MD,PH.D50 Maruashvili Street, Tbilisi 0101, Georgia US PI- NATALIA KUREPINA, Senior Scientist,
Public Health Research Institute TB Center, International Center for Public Health
225 Warren St, Room W210, Newark, NJ 07103, USA
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Characterization of M.tuberculosis gene expression patterns during growth in the human lung
Total Amount Requested from CRDF - $96539 FSU PI- Sergo Vashakidze, Surgeon Service
CoordinatorNational Center of Tuberculosis and Lung Diseases50 Maruashvili Street, Tbilisi 0101, Georgia US PI- Graham, James, E.; Assistant ProfessorUniversity of Louisville School of Medicine;
Department of Microbiology and ImmunologyHealth Sciences Ctr. Rm 316319 Abraham Flexner WayLouisville, KY 40292
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Role of Hepatitis C Virus (HCV) as a Risk Factor for Antituberculosis Drug-induced Hepatotoxicity
Total Amount Requested from CRDF - $100 000 FSU PI- Lali Kupreishvili, Clinical DirectorNational Center of Tuberculosis and Lung Diseases50 Maruashvili Street, Tbilisi 0101, Georgia US PI- Henry M.Blumberg; Professor of Medicine
and Program Director, Division of Infectious Diseases
Emory University—Division of Infectious Diseases
Atlanta, GA 30303 USA
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Use of Mycobacterial Bacteriophage for Treatment and Prevention of Drug-Resistant Tuberculosis 2008-2009
Electrochemical Lysis as a Novel Method of Treatment for Tuberculosis-2009
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Zalesky R, Abdullajev F, Khechinashvili G, Safarian M, Madaras T, Grzemska M, Englund E, Dittmann S, Raviglione M.
Tuberculosis control in the Caucasus: successes and constraints in DOTS implementation.
Int J Tuberc Lung Dis. 1999 May;3(5):394-401. Weinstock DM, Hahn O, Wittkamp M, Sepkowitz KA, Khechinashvili G,
Blumberg HM.Risk for tuberculosis infection among internally displaced persons
in the Republic of Georgia.Int J Tuberc Lung Dis. 2001 Feb;5(2):164-9. D. C. Richards, T. Mikiashvili, J. J. Parris, E. V. Kourbatova, J.CE Wilson, N.
Shubladze, T. Tertsvadze, G.Khechinashvili, C. del Rio, H. M Blumberg High Prevalence of Hepatitis C Virus Infection but not HIV co-
infection among Patients with Tuberculosis in the Republic of Georgia
Int. Journ. TB and Lung Disease, Vol.10, #4, April 2006, pp: 396-401(6) N.Mdivani, E.Zangaladze, N.Volkova, E. Kourbatova, T. Jibuti, N.Shubladze,
G.Khechinashvili, C.del Rio, A.Salakaia, and H.M. BlumbergHigh Prevalence of Multidrug-Resistant Tuberculosis in Georgia International Journal of Infectious Diseases (2008) 12, 635—644 Kuniholm Mark H; Mark Jennifer; Aladashvili Malvina; Shubladze N;
Khechinashvili G; Tsertsvadze Tengiz; del Rio Carlos; Nelson Kenrad ERisk factors and algorithms to identify hepatitis C, hepatitis B, and
HIV among Georgian tuberculosis patients.International journal of infectious diseases 2008;12(1):51-6.
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Gegia M, Mdivani N, Mendes RE, Li H, Akhalaia M, Han J, Khechinashvili G, Tang YW.
Prevalence of and molecular basis for tuberculosis drug resistance in the Republic of Georgia: validation of a QIAplex system for detection of drug resistance-related mutations.
Antimicrob Agents Chemother. 2008 Feb;52(2):725-9. Epub 2007 Dec L Vashakidze,* A. Salakaia,* N. Shubladze,* M. Cynamon,† K.
Barbakadze,*M. Kikvidze,* L. Papitashvili,* M. Nonikashvili,* N. Solomonia,* N. Bejanishvili,* I. Khurtsilava*
Prevalence and risk factors for drug resistance among hospitalized tuberculosis patients in Georgia
INT J TUBERC LUNG DIS 2009;13(9):1–6 Lomtadze N, Aspindzelashvili R, Janjgava M, Mirtskhulava V, Wright
A, Blumberg HM, Salakaia A.Prevalence and risk factors for multidrug-resistant
tuberculosis in Georgia: a population based study. Int J Tuberc Lung Dis 2009; 13: 68–73. Mdivani N, Li H, Akhalaia M, Gegia M, Goginashvili L, Kernodle DS,
Khechinashvili G, Tang YW.Monitoring Therapeutic Efficacy by Real-Time Detection of
Mycobacterium tuberculosis mRNA in Sputum.Clin Chem. 2009 Jul 2. [Epub ahead of print]
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CRDF , Emory Global Health Institute:
Risk factors for extensively drug resistant tuberculosis and evaluation of the GenoType MTBDRplus assay for rifampin and isoniazid susceptibility rapid testing in country of Georgia PI-M.Leonard, E.Zangaladze, Co-PI-N.Tukvadze, N.Lomtadze
“Prevalence and risk factors for extensively drug resistant tuberculosis (XDR TB) and evaluation of the GenoType MTBDRplus assay for rifampin and isoniazid susceptibility rapid testing in a population based study in Tbilisi, country of Georgia”, Year awarded: 2008. PIs Nino Lomtadze, Michael Leonard
Emory International Training & Research Programs
In country training grant funded by National Institutes of Health/Fogarty International Center (D43 TW007124 and D43 TW01042):
Evaluation of performance and feasibility of implementation of the GenoType MTBDRplus assay for rapid multidrug resistant tuberculosis detection in country of Georgia PI-N.Tukvadze
“Prevalence and Risk Factors for Extensively Drug Resistant TB (XDR-TB): A Population Based Study”, Year awarded: 2007. PI. Nino Lomtadze
“Prevalence and Risk factors for latent Tuberculosis infections among health care workers in Georgia”. Year awarded: 2007. PI. Veriko Mirtskhulava
Emory Global Health institute:
“Impact of Vitamin D Supplementation on Host Immunity to Mycobacteriumtuberculosis and Response to Treatment: Building Translational Research Capacity in Nutrition and Infectious Diseases in the Republic of Georgia”, Year awarded: 2008. PI. Thomas Ziegler, Archil Salakaia; Georgian Co-Is: Nestan Tukvadze, Veriko Mirtskhulava, Nino Lomtadze
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Henry M. Blumberg, Professor Department: Medicine, Division of Infectious Diseases, Emory University
TB epidemiology research
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Carlos del Rio, Professor and Chair of the Hubert Department of Global Health at the Rollins School of Public Health and Professor of Medicine in the Division of Infectious Diseases at the Emory University School of Medicine. He is also Vice Chair in the Department of Medicine and Chief of the Emory Medical Service at Grady Memorial Hospital and Co-director for the Clinical Science and International Research Core of the Emory Center for AIDS Research.
HIV and TB epidemiology
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Kenrad Nelson-Dept. of Medicine, Div. of Infectious DiseasesJohns Hopkins School of Medicine
TB epidemiology research
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Gary Magnant –CEO Sage Science, Inc. CEO at Sage Science
Founder of Sage Science, Inc. a biotechnology tools company. Co-inventor.
President at ActivBiotics (formerly Merlin)
Co-founder. Co-inventor. CEO at ThermoCeramiX, Inc. Co-founder. Co-inventor. VP at MJ Research, Inc. Business development. Sales
management. CEO of Genesys division.
CEO at Owl Scientific Co-founder. Inventor. Co-inventor.
Partner search
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Michael Cynamon -University Hospital Upstate Medical University
New compounds, animal studies, TB epidemiology
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James Graham – Associate Professor , University of Louisville
Identifying factors produced by Mycobacterium tuberculosis bacteria when growing in human blood cells and lung tissues
Characterizing how pathogenic bacteria change to allow growth in different specific environments during infection
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Natalia Kurepina-Assistant Professor, Public Health Research Institute TB Center, International Center for Public Health
TB phage research, DNA fingerprinting
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Evgenia Rainina –senior research scientist, the US DOE Pacific Northwest National Laboratory
TB phage-lysogenic properties
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William Bishai- Professor, Co-Director, Center for Tuberculosis ResearchDept. of Medicine, Div. of Infectious DiseasesJohns Hopkins School of Medicine
Surgery resectates research
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Alexander Pasechnikov, MSF-South Caucasus and Mid-Asia –TB epidemiology
Kamal Aliev, Azerbaijan-Regional TB epidemiology proposal
Olga Lovacheva-Научный секретарь редколлегии журнала «Проблемы туберкулеза» и редактор журнала «Новые лекарственные препараты»
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Eka Zangaladze, NCDC of Georgia, Molecular Epidemiology laboratory-TB molecular research(RFLP, spolygotyping, MIRU-VNTR, sequencing, PFGE)
Zemfira Alavidze, Amiran Meipariani, Tamar Berishvili-Eliava Bacteriophage Institute- phage detection, propagation, description
Tengiz Tsertsvadze-AIDS Center Maia Merlani-Kutateladze Pharmacochemistry
Institute-new compounds for TB drugs.
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New approach to rapid MDR-XDR case detection.
Depression TB phage Electrochemical lysis in TB treatment
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