disease systems biology

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Disease Systems Biology Lars Juhl Jensen

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Page 1: Disease Systems Biology

Disease Systems Biology

Lars Juhl Jensen

Page 2: Disease Systems Biology

signaling networks

Page 3: Disease Systems Biology

proteomics

Page 4: Disease Systems Biology
Page 5: Disease Systems Biology

NetPhorest & NetworKIN

Page 6: Disease Systems Biology

Miller, Jensen et al., Science Signaling, 2008

Page 7: Disease Systems Biology

Linding, Jensen, Ostheimer et al., Cell, 2007

Page 8: Disease Systems Biology

other modifications

Page 9: Disease Systems Biology

association networks

Page 10: Disease Systems Biology

STRING & STITCH

Page 11: Disease Systems Biology

Kuhn et al., Nucleic Acids Research, 2010

Page 12: Disease Systems Biology

data integration

Page 13: Disease Systems Biology

Korbel et al., Nature Biotechnology, 2004

Page 14: Disease Systems Biology

Jensen & Bork, Science, 2008

Page 15: Disease Systems Biology

Letunic & Bork, Trends in Biochemical Sciences, 2008

Page 16: Disease Systems Biology

more entity types

Page 17: Disease Systems Biology

text mining

Page 18: Disease Systems Biology

>10 km

Page 19: Disease Systems Biology

Reflect

Page 20: Disease Systems Biology

augmented browsing

Page 21: Disease Systems Biology

Pafilis, O’Donoghue, Jensen et al., Nature Biotechnology, 2009

Page 22: Disease Systems Biology

association mining

Page 23: Disease Systems Biology

web services

Page 24: Disease Systems Biology
Page 25: Disease Systems Biology

patient records

Page 26: Disease Systems Biology

text and registry data

Page 27: Disease Systems Biology

drugs

Page 28: Disease Systems Biology

side effects

Page 29: Disease Systems Biology

diseases

Page 30: Disease Systems Biology

patient trajectories

Page 31: Disease Systems Biology

patient stratification

Page 32: Disease Systems Biology
Page 33: Disease Systems Biology

genotype vs. phenotype

Page 34: Disease Systems Biology
Page 35: Disease Systems Biology

ReflectSune Frankild

Heiko Horn

Evangelos Pafilis

Michael Kuhn

Reinhardt Schneider

Sean O’Donoghue

Patient recordsFrancisco Roque

Peter Bjødstrup Jensen

Henriette Schmock

Marlene Dalgaard

Massimo Andreatta

Thomas Hansen

Karen Søeby

Søren Bredkjær

Anders Juul

Thomas Werge

Søren Brunak

STRING & STITCHDamian Szklarczyk

Andrea Franceschini

Michael Kuhn

Milan Simonovic

Alexander Roth

Pablo Minguez

Tobias Doerks

Jean Muller

Manuel Stark

Samuel Chaffron

Chris Creevey

Philippe Julien

Jan Korbel

Berend Snel

Martijn Huynen

Christian von Mering

Peer Bork

NetPhorest & NetworKINRune Linding

Heiko Horn

Martin Lee Miller

Gerard Ostheimer

Francesca Diella

Claus Jørgensen

Karen Colwill

Jing Jin

Pavel Metalnikov

Vivian Nguyen

Adrian Pasculescu

Marina Olhovsky

Michele Tinti

Lei Li

Marilyn Hsiung

Sirlester Parker

Jennifer Bordeaux

Thomas Sicheritz-

Pontén

Jes Alexander

Jin Gyoon Park

Stefan Knapp

Nikolaj Blom

Leona D. Samson

Rob Russell

Peer Bork

Shawn Li

Gianni Cesareni

Benjamin Turk

Søren Brunak

Michael Yaffe

Tony Pawson

”we” are many people