discovery - fred hutch · yielded important insights into the evolutionary struggle between viruses...

STOCHASTIC MODELS REVEAL THE SPREAD OF DISEASE IN A PANDEMIC OUTBREAK.

2 0 0 8 A N N U A L R E P O R T

p a t h s o f

discovery

Table of Contents

Message from the President and Director 2

Message from the Chair of the Board of Trustees 3

Research 4

Donors 19

Financial Summary 24

Center Boards 26

Center Leadership 27

FRONT COVER: DRESSED IN BRIGHT RED, THE TWO X CHROMOSOMES OF A FEMALE CELL

IN A MALE PANCREAS (CENTER LEFT) REVEAL THE PHENOMENON OF MOTHER-CHILD CELL EXCHANGE.

Fred Hutchinson Cancer Research

Center’s scientists weave interdisciplinary

paths to nurture collaboration and

insight. Their scientific endeavors are

long and intense, with no shortcuts or

guarantees. Fueled by their passion for

treatments that offer healing and

for preventive steps

to circumvent the

devastation of cancer,

HIV/AIDS and related diseases, they

seek answers in the population and at

the molecular level. Our researchers

strive for breakthrough moments of

discovery—discovery for life.

for l i fediscovery p u r s u i n g

2

Message from the

President and Director

Dr. Lee Hartwell


P A T H S O F D I S C O V E R Y

The Hutchinson Center has become one of the world’s premier

research institutions thanks to our scientists who have grappled

with some of the most challenging questions in the biosciences, and our

staff who help bring ideas to fruition.

Over the years, the Center’s researchers have refined treatments for

leukemia, lymphoma and other blood diseases. As they have sought to

boost survival rates for once-fatal cancers, their research naturally has

led into new and unexpected directions.

Today, the Center remains a world leader in cancer research, but we

have also expanded our work into other areas, breaking new ground in

HIV/AIDS research and other life-threatening diseases.

Consider the research of some of our featured scientists in this annual report. Dr. Richard Nash, an

oncologist and specialist in leukemia, hopes that what we have learned from blood cancers and their

treatment may some day help people with autoimmune diseases such as systemic and multiple sclerosis.

Dr. Stan Riddell studies autoimmune responses to disease and the role our own T-cells play in fighting

cancer. Stan wants to boost the power of the immune system with better defenses by engineering a special

kind of T-cell so that it targets tumors more successfully.

Dr. Anne McTiernan’s work has focused international attention on the Center. As a cancer prevention

researcher, Anne’s detailed studies are showing us how exercise and diet could help reduce many cancers

that are caused by obesity and sedentary lifestyles.

These scientists are examples of the exceptional team of researchers here at the Hutchinson Center,

people whose passion for their work keeps us focused on the future. With your support, we can ensure

that their innovative work stays on the path of discovery.

If you have ever faced a life-threatening diagnosis, or watched a family

member, friend or colleague duel cancer, HIV/AIDS or a related

disease, you understand why the scientists at Fred Hutchinson Cancer

Research Center are working tirelessly to save lives.

Compassion for you and your loved ones is what drives Hutchinson

Center scientists and staff to seek a better future.

As you will learn in this annual report, this is an exciting time for

scientific research. Technology is playing an increasingly important role

in accelerating the pace of discovery —from Drs. Malik and Emerman

using computers to explore an ancient retrovirus to

Drs. Halloran and Longini using statistical models to study the spread of infectious diseases. The

scientists in this report represent the Center’s host of talented investigators, all of whom are seeking

answers to challenging questions in daring, new ways. In pursuing the paths of their discoveries, our

scientists follow the mission of the Center to eliminate cancer and related diseases.

Contributions like yours are essential to helping the Hutchinson Center sustain our world-class

research environment and fund these discoveries. Private donations play an instrumental role in the

Center’s ability to remain at the forefront of biomedical research by supporting innovative research that

often cannot be funded by government grants alone.

Thank you for sharing my commitment to improving and saving lives and furthering innovative

research at Fred Hutchinson Cancer Research Center.

Message from the Chair

of the Board of Trustees

Sally G. Narodick

Chair, Board of Trustees

S U P P O R T I N G D I S C O V E R Y

3

Michael Emerman, Ph.D.

Harmit Malik, Ph.D.

Biologists

4

U N D E R S T A N D I N G H I V B Y D E L V I N G D E E P L Y

I N T O O U R E V O L U T I O N A R Y P A S T

HIV BREAKS FREE FROM A CONQUERED T-CELL, PREPARED TO INVADE NEW TARGETS.

When we think about deadly viruses, evolutionary biologist

Dr. Harmit Malik explains, we need to understand that

their complexity and ferocity has been bred through tens of

millions of years of tugging and pulling against the human race.

“In this genetic conflict, either the host is winning or the

virus is winning,” Malik said, pointing to the roughly 8 percent

of the human genome that is made up of old retroviruses that

we carry inside of us like bits of shrapnel from ancient wars.

Today, we face HIV. It crossed

over from chimpanzees to humans

within the last 100 years, so far kill-

ing 25 million people and infecting

twice that many. Why does it kill us

and not chimpanzees, which are eas-

ily infected by HIV but not sickened

by it?

Malik and Dr. Michael Emerman,

a molecular biologist, have pondered

such questions for a long time. Most

recently, their collaboration has

yielded important insights into the

evolutionary struggle between viruses and humans. Ultimately,

they hope their research may lead to new drugs to fight HIV.

In one of their most startling collaborations, their labs used

the power of modern computers and DNA technology to

assemble a new version of an extinct retrovirus known as

Pan troglodytes endogenous retrovirus (PtERV), which infected

chimps and gorillas—but not humans—4 million years ago.

By reassembling the retrovirus in such a way that it could

reproduce only once, Malik and Emerman found that a

human protein known as TRIM5α easily defeated PtERV.

Every primate has a version of the TRIM5α protein. In the

rhesus monkey, for example, it kills HIV.

Malik and Emerman also modified the human TRIM5α

protein to resemble a version present in the ancestors of

humans, chimpanzees and gorillas, and found that it no longer

protected against the PtERV.

By modifying TRIM5α, they

also discovered that one version

protected against HIV but not

PtERV. In another modifica-

tion, it did the opposite.

Such polar opposites, they

agree, are the result of evolu-

tion. Because our TRIM5α

protein evolved to fight other

retroviruses, it likely left us

vulnerable to HIV, they say.

Is it possible to reproduce a

drug that behaves like a chimp’s TRIM5α does against HIV, or

change the human version ever so slightly so it kills HIV? These

are the kinds of challenges that Emerman and Malik ponder.

The two agree that studying, and in some cases reconstructing,

ancient viruses is not a trivial matter.

In this arms race that’s millions of years old, it pays to

understand the enemy, Malik said.

Richard Nash, M.D.

Immunotherapy Researcher/Oncologist

6

L E U K E M I A T R E A T M E N T S H O W S P R O M I S E

F O R S Y S T E M I C A N D M U L T I P L E S C L E R O S I S

A BRAIN SCAN SHOWS MULTIPLE SCLEROSIS LESIONS THAT COULD BE IMPROVED WITH T-CELL THERAPY.

As a hard-working member of the immune system, a T-cell

is an efficient killer, attacking anything it perceives as an

intruder, whether it’s a virus-infected cell, a cancer cell or a

bacterium.

But sometimes, a T-cell attacks a friend—and it goes on

attacking, unchecked, destroying healthy tissue and creating

serious autoimmune diseases such as multiple sclerosis and

lupus. Why the immune system goes so

very wrong has puzzled researchers

for decades.

As many as 80 autoimmune diseases

have been identified, and some of

them are capable of causing serious

complications, even death. One

example is systemic sclerosis (also

known as scleroderma), a disease with-

out effective treatment. “It’s one of the

most frustrating diseases to treat. There’s

high mortality and no therapies, and it

can hit you in so many ways,” said

Dr. Richard Nash.

By training, Nash is an oncologist,

a researcher in leukemia and other blood cancers. But thanks to

a unique and unexpected insight, he’s now applying his knowl-

edge in whole new ways. Along with colleagues, he is taking the

Hutchinson Center’s pioneering leukemia research and apply-

ing it to other diseases, such as systemic sclerosis and MS.

The standard treatment for leukemia and other blood

cancers is chemotherapy, radiation and transplantation of

bone marrow or blood stem cells. Nash is optimistic the same

approach may now help patients with autoimmune diseases.

It has taken some very unlucky patients—a rare few who

had both leukemia and systemic sclerosis—to uncover a

potential new use for transplantation.

With systemic sclerosis, a patient’s skin becomes very hard,

severely limiting movement. When one

of these patients received a stem cell

transplant for cancer, “we saw evidence

of skin improvement. The treatment

suggested that the fibrosis of the skin

was a reversible condition,” Nash said.

“And it appeared to stabilize

the organs.”

With transplantation, it may be

possible to remove the reactive cells that

are triggering the immune system to

attack the body. Currently, Nash’s lab

is conducting three clinical trials to

evaluate the safety and effectiveness

of high-dose chemotherapy and

stem-cell transplantation for systemic sclerosis and MS.

“For me, that’s part of the excitement of being in this

field … we’re doing something different and helping people,

and learning about potential new therapies. To be successful

in any project, collaboration and teamwork are very

important,” he said.

d e l v i n g i n t o

J. Lee Nelson, M.D.

Autoimmunity Researcher/Rheumatologist

D E L V I N G I N T O T H E A U T O I M M U N E I M P L I C A T I O N S O F

M O T H E R - C H I L D C E L L S H A R I N G

THE EXCHANGE OF MICROCHIMERIC CELLS BETWEEN MOTHER AND CHILD MAY HOLD CLUES FOR AUTOIMMUNE DISEASES.

It feels like a broken bone that never heals, a constant ache.

Pain relievers and powerful steroids may not make a dent in

the excruciating pain. Nor do they relieve the swelling and

stiffness for many rheumatoid arthritis sufferers. But nature

sometimes offers relief: pregnancy. Like a fog lifting, most

pregnant rheumatoid arthritis patients experience life without

constant pain for the first time in years.

Seeing such transformations made Dr. Lee Nelson yearn for

answers. What could make an autoimmune disease like

rheumatoid arthritis turn off? The answer may lie in the

mother-child cell transfer that happens

during pregnancy.

Using the placenta as a corridor, some

cells travel between mom and baby, take

up guest residence in their hosts, and

stick around for decades. Nelson and her

interdisciplinary team study this mixing

of genetically distinct individuals, known

as microchimerism, to identify the good

and bad consequences of these foreign

cells in autoimmune diseases, transplanta-

tion, cancer and pregnancy complications.

Nelson, considered one of the world’s leading researchers

in this investigative frontier, has been studying the role that

microchimerism plays in the initiation and remission of auto-

immune diseases since 1986, the year she began her research

career at the Hutchinson Center.

The transferred cells can be found in many human tissues.

They are detected by looking for female cells in a male, or male

cells in a female, or through DNA analysis. The presence of

Y chromosomes in a woman, for example, signifies that

she has acquired cells from a male (most likely from a son

during pregnancy).

Scientists had assumed that a normal immune system would

destroy any maternal cells lingering in a child. That thinking

changed when Nelson and her team found maternal cells

survived decades later in healthy adults. That work

provided evidence for the idea that cells transferred from

mother to fetus are stem cells or related cells, capable of becom-

ing any type of cell, since stem cells can divide indefinitely.

She also found maternal cells in

the pancreas made insulin, suggesting

they may help regenerate the diseased

organ in diabetics. This finding sug-

gests that microchimerism might one

day be the crux of new therapies if

the non-native cells could be coaxed

to restore damaged tissues.

“We’re trying to hone in on treat-

ments,” Nelson said. “I would like to

help alleviate suffering in some way.”

Nelson also conducted the first study to look at microchi-

merism in an autoimmune disease. She found evidence for the

involvement of adopted fetal cells in scleroderma (also known

as systemic sclerosis), a life-threatening illness that makes the

skin hard and thick and often attacks internal organs.

Once a lone pioneer in this young field, she said, “This was

an interdisciplinary challenge that people had overlooked, and

it was ripe for important questions and big leaps forward.”

Thanks to Nelson, many of those questions are being answered.

9

Robert Gentleman, Ph.D.

Computational Biologist

10

M I N I N G G E N O M I C D A T A F O R C A N C E R ’ S

M O L E C U L A R S E C R E T S

UNRAVELING VAST DNA SEQUENCES, WRITTEN AS A-G-T-C CODES, REQUIRES POWERFUL TOOLS.

Common duplicate reads after filtering

> df1 <- df[df$type == "filtered", ]

> lapply(split(df1[, c("sequence", "count")], df1$lane), head)

$s_1_export.txtsequence count

101 TAGGACGTGGAATATGGCAAGAAAACTGAAAATCA 243102 GTAGGACGTGGAATATGGCAAGAAAACTGAAAATC 237103 GTGGAAAATTTAGAAATGTCCACTGTAGGACGTGG 177104 CCATATTCCACGTCCTACAGTGGACATTTCTAAAT 165105 AGGACGTGGAATATGGCAAGAAAACTGAAAATCAT 162106 CATGATTTTCAGTTTTCTTGCCATATTCCACGTCC 158


251 GTAGGACGTGGAATATGGCAAGAAAACTGAAAATC 357252 TAGGACGTGGAATATGGCAAGAAAACTGAAAATCA 324253 AGGACGTGGAATATGGCAAGAAAACTGAAAATCAT 194254 ACTGTAGGACGTGGAATATGGCAAGAAAACTGAAA 184255 CATGATTTTCAGTTTTCTTGCCATATTCCACGTCC 160256 GCCATATTCCACGTCCTACAGTGGACATTTCTAAA 151


401 GTAGGACGTGGAATATGGCAAGAAAACTGAAAATC 313402 TAGGACGTGGAATATGGCAAGAAAACTGAAAATCA 291403 ACTGTAGGACGTGGAATATGGCAAGAAAACTGAAA 235404 AGGACGTGGAATATGGCAAGAAAACTGAAAATCAT 205405 GTGGAAAATTTAGAAATGTCCACTGTAGGACGTGG 188406 CTGTAGGACGTGGAATATGGCAAGAAAACTGAAAA 177


551 TAGGACGTGGAATATGGCAAGAAAACTGAAAATCA 266552 GTAGGACGTGGAATATGGCAAGAAAACTGAAAATC 232553 AGGACGTGGAATATGGCAAGAAAACTGAAAATCAT 187554 ACTGTAGGACGTGGAATATGGCAAGAAAACTGAAA 164555 CTGTAGGACGTGGAATATGGCAAGAAAACTGAAAA 161556 TGTAGGACGTGGAATATGGCAAGAAAACTGAAAAT 139


701 TAGGACGTGGAATATGGCAAGAAAACTGAAAATCA 395702 GTAGGACGTGGAATATGGCAAGAAAACTGAAAATC 354703 AGGACGTGGAATATGGCAAGAAAACTGAAAATCAT 263704 ACTGTAGGACGTGGAATATGGCAAGAAAACTGAAA 232

5

Searching for the molecular roots of cancer is akin to

looking for the proverbial needle in a haystack. A smaller

haystack makes the job a lot easier, which is where Dr. Robert

Gentleman comes in. Technology and the need to sift through

a deluge of genomic information has transformed biology from

a purely lab-based science to an information science as well.

Gentleman, head of the Hutchinson Center’s Herbold

Computational Biology Program, creates computing tools to

analyze massive amounts of data from biological experiments

and uses mathematics and statistics to generate new insights

incorporating the exist-

ing data. The approach

helps researchers

understand cancer at

its most fundamental

level by illuminating

which cellular proteins

interact and how they

work together within a

cell. The process also saves both time and money over other

lab methods.

A former auto mechanic might seem like an unlikely

candidate to become a research scientist. But if you follow

Gentleman’s path from Hondas to Harvard to the Hutchinson

Center, his trajectory seems perfectly probable. The former

grease monkey has a penchant for challenges, so it makes sense

that he’d choose a research endeavor that’s moving at breakneck

speed. For brilliant young minds, biocomputing is the most

challenging field around.

Advances in knowledge and technology have transformed

biological research. Just a decade ago, scientists could only

analyze the expression of one gene at a time. Technological

advances now enable efficient analysis of half a million genes.

The new tools enable researchers to uncover novel potential

targets for therapies as well as to explore the underlying genetic

causes of many human diseases.

There has also been an explosion in the amount of informa-

tion available about the DNA sequence of the human genome.

Consequently, researchers have identified a large number of

novel genes within these previously unknown sequences. The

challenge currently facing

scientists is to find a way to

organize and catalog this vast

amount of information into a

usable form.

“Technology drove enor-

mous data sets, which drove

the need for clear, statistical

thinking,” Gentleman said.

“We have no true comprehension of cancer on a molecular level

yet. We need tools to understand how the genome works and

we need to know how things interact. If we’re going to go in

and poke something, we better know what the domino effect

will be.”

He and his colleagues around the globe collaborate to write

free software for the entire scientific community to use. “This is

a high-risk area, which is not where commercial software goes,”

he said. “We’re only interested in being as close to the edge of

scientific investigation as we can be. We share to learn. Real

change comes from people working well together.”

M. Elizabeth Halloran, M.D., D.Sc.

Ira Longini, Ph.D.

Biostatisticians

13

P R E D I C T I N G T H E S P R E A D O F I N F E C T I O U S D I S E A S E S

EVERY FEW DECADES, THE INFLUENZA VIRUS TRIGGERS MISERY THROUGHOUT THE WORLD.

When the World Health Organization declared smallpox

eradicated in 1980, there was a giddy overconfidence

that the deadly struggle against the microbial world was ending.

“There was this feeling that we had won the battle against

infectious diseases,” said Dr. Elizabeth Halloran, who studied

tropical diseases in the early 1980s, when there was waning

interest in the topic.

Halloran was not convinced microbes had been subdued,

much less conquered. Nor was Dr. Ira Longini, whose travels

through Latin America brought him face to face with tuber-

culosis, syphilis and other infectious

diseases that were presumably under

control.

With research funding and drug

development for such diseases in

full retreat at the time, Halloran and

Longini forged paths in the field of

biomathematics and biostatistics to

study the spread of infectious diseases.

Now, as collaborators, they’re among

the world’s leaders in the field, their

expertise sought widely in the struggle

against new and resurgent infectious diseases. During the last

year, they have consulted with federal and state officials and

have been consulted by world health organizations to help

develop intervention plans to control potential pandemics, such

as avian flu.

Today, the threat of a pandemic flu with the potential to

kill tens of millions is a top concern of public health officials

worldwide. HIV, malaria and tuberculosis kill as many as

6 million people each year. Tuberculosis alone is expected to

infect as many as 1 billion people in the next 20 years.

Small as they are, microbes make up 60 percent of the

planet’s biomass. With so many microbes out there, “We’re

further away than ever from closing the book on infectious

diseases,” the Infectious Diseases Society of America declared

last year.

It’s within this context that Halloran and Longini collabo-

rate to create mathematical models that predict the spread of

disease and simulate intervention strategies to save lives.

Using powerful computers to track the potential path of

infectious diseases, the duo believe their mathematical models

could help save the lives of hundreds of millions of people,

particularly against pandemic flu, which unchecked could

spread across the globe in a matter

of months.

Mathematical models allow research-

ers to simulate the spread of disease

through different kinds of settings and

test different kinds of intervention. In

one such model, Longini and Halloran

tracked how quickly pandemic flu would

move across the United States if

nothing were done. In a simulated

60 days, the disease had spread to every

corner of the map. The number of dead:

tens of millions. They developed other models to help predict

which interventions—such as vaccination, keeping children out

of schools and asking people to work from home—would most

effectively control spread of the disease and save the most lives.

It’s a scary scenario, but Longini and Halloran believe the

tools are in place to save the world from disaster. And not just

from influenza.

“We hope that the tools we’re developing will be used for all

emerging diseases,” Longini said.

“You can’t control disease but you can intervene to save

lives,” Halloran said. “You can intervene and change the course

of events.’’

Stanley Riddell, M.D.

Immunotherapy Researcher/Oncologist

14

C A N C E R K I L L E R S W I T H S T A Y I N G P O W E R

T-CELLS SWARM A CANCER CELL.

very large tumors simply melt away,” Riddell said.

T-cells, however, have a fatal flaw. They die quickly. And

if an immune response isn’t sustained, cancer eventually

comes back.

Riddell and his colleagues knew immunity could last a

lifetime—that’s how vaccines work. So the researchers reasoned

that perhaps they were starting with the wrong T-cells.

They began advanced testing on dif-

ferent types of T-cells and found that one

type—central memory cells—had the

staying power the scientists were seeking.

They now had a sustainable starting point

for cancer immunotherapy: T-cells with the

capacity to survive.

Riddell’s next step involves drawing

blood samples from cancer patients, filter-

ing out their central memory cells and

engineering those cells with receptors to

target tumors.

The approach holds promise for fighting

different types of leukemia, including

chemotherapy-resistant acute lympho-

blastic leukemia in children, and breast,

ovarian and skin cancers. Riddell’s team’s insights may also

strengthen the work of University of Washington researchers

developing potential breast-cancer vaccines.

“We’re really trying to move immunotherapy with central

memory T-cells into the clinic quickly,” Riddell said. “We are

excited by the potential for success and believe that this therapy

can be applied to several types of cancer.”

In a perfect world, cancer doesn’t stand a chance of wreaking

havoc. Like a soldier guarding the home shores, the

immune system gives marching orders to a type of white blood

cell known as T-cells to remain vigilant for an invasion of

foreign cells, including cancerous ones. When a T-cell

recognizes an invader, it initiates a process that targets that cell

for destruction.

But cancer is a formidable foe, one that

Dr. Stanley Riddell is all too familiar with

after more than two decades of waging

war against it. “Tumors are very clever and

they utilize evasion strategies to limit the

effectiveness of the immune response,”

he said.

So he’s fortifying the immune system

with better weapons: long-lived T-cells

specially engineered to seek and destroy

cancer.

Through adoptive T-cell therapy,

Riddell and his fellow researchers

extract white blood cells from a cancer

patient and expose them to proteins made

in abundance by tumor cells. Scientists

then identify the few T-cells that recognize the tumor proteins

and stimulate those to divide, generating a billions-strong

population of cancer-fighting cells that can be infused back into

the patient. Ideally, this unique population of T-cells will find

its way to the tumor site and annihilate the cancer cells.

“When you see it work, it is so amazing—the bone marrow

just goes from being full of leukemia to being in remission and

16

EXERCISE AND HEALTHY EATING ARE POWERFUL ANTI-CARCINOGENS.

T A K I N G S T E P S T O W A R D C A N C E R P R E V E N T I O N

Anne McTiernan, M.D., Ph.D.

Cancer Prevention Researcher

We all know that exercise is good for us. But what kind

and how much?

As a cancer prevention researcher and pragmatist,

Dr. Anne McTiernan has no illusions about most folks’ com-

mitment to exercise. She understands that people want to know

exactly what they have to do—and how little they need to

do—to reap healthy rewards.

Thanks to McTiernan’s work, some specific answers now

exist about the role of exercise and weight loss in

reducing the risk of cancer. As director

of the Hutchinson Center’s Prevention

Center—a state-of-the-art facility for

conducting research on exercise and

diet—she designs studies with the aim

of reducing the 25 percent of cancers

caused by excess weight and sedentary

lifestyles.

Fewer than one-quarter of

Americans get minimum daily exercise,

even though regular physical activity

reduces body fat, lowers blood pressure,

cholesterol and the risk of diabetes and

cancer, and improves bone and joint

health, sex drive, sleep and memory.

“We have such an epidemic of

obesity and lack of exercise, which is one reason I’ve gravitated

to exercise and weight control,” McTiernan said. “It’s an area of

study that could have a significant impact.”

Exercise trials are uncommon because they’re expensive and

difficult to fund. McTiernan’s group is the first to specifically

look at the effects increased physical activity and weight loss

have on reducing the chance of getting cancer.

Such risk reduction has been difficult to quantify in the

past, but McTiernan has been able to definitely gauge impacts

by measuring so-called biomarkers in research participants.

Among her most important findings, overweight post-

menopausal women who exercised for 45 minutes five days

a week, whittled away unhealthy belly fat and lowered their

estrogen and testosterone levels, hormones that in excess can

contribute to cancer. In a different study, women who walked

leisurely just one to three hours a week

lowered their risk of dying from breast

cancer by one-quarter compared to

sedentary women; those who walked

three to eight hours weekly cut their

risk in half. Another study showed that

exercise six days a week brought both

sexes significant fat loss and a lowered

risk of colon cancer in men.

McTiernan’s groundbreaking work

has put the Hutchinson Center at the

forefront of the field, earning her an

invitation to join a federal scientific

advisory committee to develop the

nation’s first guidelines to focus on

physical activity—and the first to

recognize the impact of exercise on cancer-risk reduction.

“We’re trying to get specific answers for people: do I need to

lose 50 pounds or will 5 percent of my body weight do it? Will

exercising 20 minutes a day help?” McTiernan said. “Nothing

is guaranteed, but exercise and weight control are like wearing a

seat belt. It reduces your risk.”

“THE SEEDS OF GREAT DISCOVERIES ARE CONSTANTLY

FLOATING AROUND, BUT THEY ONLY TAKE ROOT IN

MINDS WELL PREPARED

TO RECEIVE THEM.”

A RETROVIRUS’ PATH BECOMES EVIDENT IN AN EVOLUTIONARY TREE.

“THE SEEDS OF

GREAT DISCOVERIES

ARE CONSTANTLY

FLOATING AROUND, BUT THEY ONLY

TAKE ROOT IN MINDS

WELL PREPARED

TO RECEIVE THEM.”

— JOSEPH HENRY

D o n o r s

21

PRIVATE CONTRIBUTORSFISCAL YEAR 2008

Private contributors fund many critical programs at Fred Hutchinson Cancer Research Center. During this fiscal year, individuals, corporations, foundations and other organizations donated $33.7 million through contributions, memorial and honor donations, and in-kind gifts. The following donors contributed $5,000 or more between July 1, 2007, and June 30, 2008. President’s Circle members — donors who have made contributions of $10,000 or more in flexible funding — are indicated by (PC). Charter members of the President’s Circle are indicated by (PC*). Corporate Affiliates members— corporations that have made contributions of $10,000 or more in flexible funding — are indicated by (CA).

Nobel Laureates CircleThe Nobel Laureates Circle recognizes contributors who have made cumulative gifts of $1 million or more. These key contributors are permanent members of the Circle which was established in 2001 to honor the Hutchinson Center’s Nobel Prize recipients, Drs. E. Donnall Thomas (1990), Lee Hartwell (2001) and Linda Buck (2004). By giving at this level, members of the Nobel Laureates Circle are at the forefront of philanthropic leadership and make a significant impact on the Hutchinson Center’s mission to eliminate cancer and related diseases as causes of human suffering and death.

Madeline and Howell E. Adams, Jr.Mr. Paul G. AllenAmerican Cancer Society Amgen FoundationAnonymous (3)Robert M. ArnoldAvon FoundationBill & Melinda Gates FoundationBurroughs Wellcome FundCanary FoundationCell Therapeutics, Inc.Charles E. Stuart Charitable FoundationMylo and Marion CharlstonDamon Runyon Cancer Research FoundationDavid Worthington Garner TrustDelta Tau Delta FraternityDorothy W. Day TrustJ. Orin and Charlene EdsonClairmont L. & Evelyn S. EgtvedtEntertainment Industry FoundationErna M. Jorgensen TrustThe Eucalyptus FoundationFannie E. Rippel FoundationFriends of José Carreras International Leukemia FoundationBill and Melinda GatesBob and Eileen Gilman Family

The GM FoundationCalvin A. Gorman EstateAlice Coulon HansonLee Hartwell and Theresa Naujack HartwellBob and Pat HerboldArthur P. Holm EstateHoward Hughes Medical InstituteYvonne Twining Humber EstateJ. Orin Edson FoundationJacob Green Charity Golf ClassicJames B. Pendleton Charitable TrustJames S. McDonnell FoundationNelda KleinschmidtLance Armstrong FoundationThe Leukemia & Lymphoma SocietyListwin Family FoundationLucille P. Markey Charitable TrustM. J. Murdock Charitable TrustMr. John A. McCone and Mrs. Theiline Pigott McConeMicrosoft CorporationMoneytree, Inc.The Moyer FoundationCraig and Marie MundieMuscular Dystrophy AssociationThe Norcliffe FoundationDorothy and Everett O’NeillThe Paul G. Allen Family FoundationProstate Cancer FoundationJames and Sherry RaisbeckRichard C. Goldstein Private FoundationJim Roberts and Pam BeckerSafeway Inc.James G. Scripps EstateThe Seattle FoundationSusan G. Komen for the CureHerman E. Tenzler EstateDr. and Mrs. E. Donnall ThomasMikal and Lynn ThomsenHazel Johnson Toly EstateBonnie and Jim TowneUnited Way of King CountyW. M. Keck FoundationRichard W. Weiland† The William Randolph Hearst Foundations

Research Benefactors$1 million or moreAvon FoundationCanary FoundationEntertainment Industry FoundationThe Eucalyptus FoundationFriends of José Carreras International Leukemia FoundationAlice Coulon HansonHutch Holiday Gala (Grace Heffernan Arnold Guild and Gala Board of Trustees)The Leukemia & Lymphoma SocietyListwin Family FoundationSafeway Inc.Richard W. Weiland Estate

Research Patrons$500,000 - $999,999Anonymous (1)Peter Jerome Cervenak EstateCharles E. Stuart Charitable FoundationClimb to Fight Breast Cancer (CFBC Committee)J. Orin and Charlene EdsonPC

Bob and Eileen Gilman FamilyBob and Pat HerboldPC*Susie MorgantiPC

The Paul G. Allen Family FoundationSam and Betty Lebid Foundation

Research Partners$250,000 - $499,999American Cancer SocietyApoptos Inc. Bill & Melinda Gates FoundationDamon Runyon Cancer Research FoundationEdna Williams Curl TrustFate TherapeuticsGiles W. and Elise G. Mead FoundationHutch Award Luncheon (Hutch Award Luncheon Committee)J. Orin Edson FoundationJames B. Pendleton Charitable TrustLance Armstrong FoundationM. J. Murdock Charitable TrustMarsha Rivkin Center for Ovarian Cancer ResearchNational Marrow Donor ProgramPete Gross House Luncheon (Pete Gross House Council)Premier Chefs Dinner (Magnolia Guild and Chefs Advisory Board)Doris L. Sather EstateThe Seattle FoundationSusan G. Komen for the CureMae Sim Thomas EstateWashington State Department of HealthWayne D. Kuni and Joan E. Kuni Foundation

Research Associates$100,000 - $249,999American Society of Clinical OncologyAmerican Society of HematologyAmgen FoundationThe Anderson FoundationPC*Burroughs Wellcome FundCharles Epstein TrustThe Christopher Harper TrustDr. and Mrs. Edmund R. ClarkeRoger and Gloria CrouchPC*Mike and Karen DunlopPC*John and Christine EnsleinErna M. Jorgensen TrustFanconi Anemia Research Fund, Inc.Fisher Radio Seattle’s AM 570 KVIFriends of the HutchCalvin A. Gorman EstateThe Greater Kansas City Community FoundationHoward Hughes Medical Institute

Intel CorporationJacob Green Charity Golf ClassicThe John C. and Karyl Kay Hughes FoundationPC*Thomas “Red” Kelly EstateLymphoma Research FoundationPhoebe P. Marriott EstateMerck & Co., Inc.Microsoft CorporationThe Moyer FoundationMuscular Dystrophy AssociationProstate Cancer Research InstituteRichard C. Goldstein Private FoundationThe Rona Jaffe FoundationPC

Satellite HealthcareLoretta V. Schossow EstateJohn A. Tershin EstateMikal and Lynn ThomsenPC*Travel & Leisure Auction (Margaret E. Martindale Guild)United Way of King CountyThe V Foundation for Cancer ResearchW. M. Keck Foundation

Research Fellows$50,000 - $99,999American AirlinesAmerican Heart AssociationAnonymous (1)PC*Anonymous (1)PC

The Bayley Family FoundationDavid and Joanna BeitelPC*Todd, Mary and Geary Britton-SimmonsCostco Wholesale CorporationCuyamaca FoundationDavid Worthington Garner TrustDelta Tau Delta FraternityDorothy A. Jarosek TrustMark and Carolyn EdsonPC*Clairmont L. & Evelyn S. EgtvedtEmployees Community Fund of the Boeing CompanyFidelity Charitable Gift FundJane B. FolkrodEdward and Karen Fritzky FamilyPC*Florence Galbraith EstateGenentech, Inc.David and Patricia GiulianiPC*Rochelle GreenbergMr. David W. Hansen and Ms. Trish M. KingPC*Francis E. Hart EstateInserra Family FoundationJeffrey Rosenzweig Foundation for Pancreatic Cancer ResearchLisa Johnson of Johnson International IndustriesPC Grace M. Kaylor EstateMrs. Yvonne Gemmell KeeneKOMO 4 TelevisionLaird Norton Tyee Trust CompanyLinsco Private LedgerMartin-Fabert FoundationThe Michael Miyauchi FoundationNational Childhood Cancer Foundation Ocean Spray

19

20

D o n o r s

D o n o r s

Olympia GuildOra Lee A. Anderson TrustPancreatic Cancer Action NetworkPhi Beta Psi SororityPlatt ElectricCA

Satya and Rao Remala FoundationPC*The Stack FoundationSamuel† and Althea StroumSuskin FoundationJohn T. Toland EstateUniversity of WashingtonKenneth L. and Evelyn L. WaltersPC*Washington Research FoundationYvonne M. Betson Trust

Research Sponsors$25,000 - $49,999Alaska AirlinesAnonymous (2)PC*Anonymous (1)PC Bank of America CorporationBayley ConstructionCA

Carl and Renée BehnkePC*Sally Skinner BehnkePC*Anselmo Belmondo EstateLeslie BurrowsCancer Research InstituteCarlyle, Inc.Children’s Hospital & Regional Medical CenterClick Wine GroupCommunity Foundation for Southwest WashingtonDriving for a CureJack and Sheri EdsonPC*Edward JonesCarol and Karl EgePC*Eli Lilly and CompanyElmo Zumwalt III GuildMrs. Ruth E. FilePC

Cathryn Fortune and John ShimerFortune Family FoundationPC*The Foster FoundationAlan and Mary FrazierPC*Frazier Healthcare VenturesFred Hutchinson Team ShootoutGrand Chapter of Washington - Order of the Eastern StarErik and Susan HansenPC*Mr. and Mrs. John HarnishHarold & John Steinberg Memorial Nursing ScholarshipThe Helen Hay Whitney FoundationAlan and Wendy HigginsonPC

Fred and Dawn HinesPC* Mr. and Mrs. Charles HoganHuman Frontier Science ProgramMaxine Isham EstateEdith G. Iverson EstateHenry and Mary Ann JamesPC* Mr. and Mrs. J. Michael JohnstonPC*David Jones and Maryanne Tagney-JonesPC*King County Combined Federal CampaignKlingman OpenMike and Debbie KossPC*The Lambeth Family Designated FundLaura A. Landro and Richard E. SalomonRae and Mark LemberskyPC*Life Possibilities

Benito and Carmen LopezPC* David Mann and Ann Thomson MannPC*Maxim Group LLCMary Jane McElyea EstateMDRT FoundationMerrill Lynch, Pierce, Fenner & Smith, Inc.Mo-dazz for the ArtsNational Breast Cancer Foundation, Inc. News Talk 710 KIRONovartisCarol-Ann O’Mack and John DeiningerPC*Mr. and Mrs. Carroll O’MackPC*Milton and Ruth RubinPC*Russell InvestmentsRyan Hill Research Foundation at Virginia Mason Medical CenterSASCOSchwab Charitable FundGeorge H.J. ShawJack C. Shaw and Wenonah ShawSheldon Manufacturing, Inc.Frank and Harriet ShrontzPC*Lorene Spurling EstateHoward and Cynthia SteinbergGregory and Charlene SteinhauerPC*Jonathan G. Thomason and Megan L. ThomasonPC*Union Bank of CaliforniaDoug and Maggie WalkerPC* Washington State Employee Combined Fund DriveWyner/Stokes FoundationYvonne M. Betson Trust – Jeff and Ethel MaxwellPC*Mark and Donette ZbikowskiPC

Zillow.comJoseph and Janet ZinnPC*

Research Supporters$10,000 - $24,999Charles M. Ackerman and Barbara Clanton AckermanAcme Food Sales, Inc.Mr. and Mrs. Mike AdairAlexandria Real Estate Equities, Inc.American Research & Management CompanyMr. and Mrs. James K. Anderson, Jr.Ric and Kaylene AndersonPC*Anonymous (7)PC*Anonymous (4)PC

Dr. Frederick and Dita AppelbaumPC*Ms. Doree R. ArmstrongRobert M. ArnoldPC

Stephen D. ArnoldPC*Athena PartnersThe Ayco Charitable FoundationPeggie F. Nishimura Bain† PC*Joe and Karyn BarerPC

Mrs. and Mr. Angela K. BarrieRon and Joan BayleyPC

Bell Lumber & PoleMr. and Mrs. Jerry J. BelurBen Bridge JewelerYahn Bernier and Beth McCawEvva M. Betts EstateBK Invitational Golf Tournament

Bill and Jeanne BlissPC

bmiThe Boeing CompanyBonneville SeattleMr. and Mrs. Louis L. BorickPC

Cathy Boshaw and Doug EdlundPC*Edgar and Elisabeth BottlerPC*Mr. and Mrs. Erik P. BreivikPC*Sally V. BrotmanPC*Glen A. BuettgenbachPC*Shari and Frederick BurnsPC*Mr. Gary L. BylundPC*CAC Real Estate Management Co., Inc.Cancer Center for Detection and PreventionCangen BiotechnologiesMr. Joseph A. CarbonePC

Carlson Family FoundationPC*Mrs. Cecelia C. CarrPC*Mr. and Mrs. John H. CaseCelgeneSpencer W. Chaffey EstateVibhas and Arundhati ChandorkarPC*Charles B. See FoundationPC*Brad and Judy ChasePC*Dr. and Mrs. Martin A. “Mac” CheeverDale ChihulyChihuly, Inc.Mr. Ryan A. ChristensenThe Church of Jesus Christ of Latter-Day Saints FoundationCiti Global Impact Funding Trust, Inc.Continental AirlinesCornerstone Advisors, Inc.Thomas G. Corrigan EstateCRAVEMr. and Mrs. Thomas J. Cusick IIIDick and Jill DavisMr. Steve Davis and Mr. Bob EvansPC

Dr. H. Joachim Deeg and Mrs. Francoise Deeg-Le GalDick and Chris DiCerchioPC*Eric and Holly DillonPC*The Dolsen FoundationPC*Mac and Patti DouglasPC

Jan DuletPC*Mr. and Mrs. Kevin P. EaganPC*Barbara Feasey and Bill BryantPC*Fidelity Brokerage Services LLCPhelps and Christel FisherMyrtle I. Forrest EstateFoss Maritime CompanyMr. Robert FreyMrs. E. Peter GarrettThe Geiger Family FoundationPC*Bruce and Alice GeismarPC*Gene Juarez Salons & SpaMr. and Mrs. Robert L. GerthPC*Mr. Miles Gilburne and Ms. Nina ZoltPC

Aaron and Betty Gilman FamilyMr. and Mrs. Wayne C. GottPC*Ken and Betsy GreenbaumPC*Mark Groudine and Cynthia PutnamThomas and Jennifer HanlyPC

John and Suzanne HansenPC

Mr. and Mrs. Mark C. HansenLee Hartwell and Theresa Naujack HartwellPC*Jeff and Candace HavensPC

Hal and Jerry HaynesElizabeth Hebert and Donald GuthriePC*

Conrad HewittThe HG FoundationMr. and Mrs. Mike HickeyPC*Pete and Leslie Magid HigginsPC*Mr. and Mrs. Neal HoobermanPeter and Margaret HorvitzPC*Mr. Bradley J. HorwitzThe Horwitz Family Memorial FoundationPC

Mr. Norman E. Hubbard and Ms. Lynne ThompsonPC

The Hutchinson FamilyPC*The Ildhuso FamilyPC*Infinity PharmaceuticalsMr. and Mrs. Chris R. IshiiPC*Jeremy and Jacquelyn JaechPC*Mrs. Kristen JarvisJean E. Thomson FoundationPC*Jewish Community Foundation of Greater HartfordMike and Diane JohanssonPC*John L. Scott Real EstateJohn M. Gilbertson FoundationJohn R. and Paula Blood Family TrustArnold KasPC*Donna KellyKenneth and Dorothy L. Anderson Family FoundationKeyes FoundationPC*King County Employee Charitable CampaignThe Kinsman FoundationNelda KleinschmidtKMS Financial ServiceJames and Lorna KneelandReg and Ann KoehlerPC*Judy KornellJackie and Skip KotkinsPC*Mrs. Frederick KullmanMr. and Mrs. Roger W. KuulaPC*Sandra L. La HayePC*Lane Powell PCCA

Lehman BrothersThe Lester and Bernice Smith FoundationPC*Jim and Maureen LicoPC

The Louis L. Borick FoundationPC*Dan Madsen and Amanda KingMark and Nikki MahanPC*Mandarin Oriental, New YorkDavid and Nathan Mandelbaum FamilyPC*Mariners CareMattaini Family FoundationPC*Matthews CellarsBev and Jim MauserTrish and Peter MayJohn and Liz McAdamPC*Rob and Teddy McGregorPC

Mikimoto Co. Ltd.Rick and Joyce MinerPC

Mr. and Mrs. Michael J. MitrovichMonterey Fund, Inc.Mr. and Mrs. Thomas G. MorminoJoan Morse and Dean HachamovitchPC

Karen and Jamie MoyerPC*Muckleshoot Indian TribePC

Shan and Lee MullinPC*Kit and Sally NarodickPC*Paul and Carol Neiman

“THERE’S A HUGE LEVEL OF COMMITMENT IN SCIENCE.

YOU DON’T GO HOME JUST BECAUSE IT’S A CERTAIN TIME;

21

YOU GO HOME WHEN YOUR RESEARCH IS THE BEST IT CAN BE.”

—DR. STANLEY RIDDELL

Robert Nelsen and Ellyn HenneckePC*Martin and Vicki NelsonPC*Nintendo of America Inc.Northern TrustNorthern Trust Bank, FSBNSB PostechLee and Deborah OateyMr. Bruce A. ObergMr. and Mrs. James OdomOsiris Therapeutics, Inc.PDL Biopharma, Inc.Harry Jonathan PearcePC*Ms. Pamela S. Pearson and Mr. Michael VoegtlinMark and Nancy PellegrinoPC*Pete and Wilma Olsen FoundationPC*Donald and Diane PetersonPC*Pfizer Inc.John B. Piacentini FamilyPC*Paul and Beth PicardoPC*Dean and Gwenn Polik and Valerie PolackPC*Arlen and Debra PrenticePC*The Pride FoundationProteolix, Inc.Puget Sound EnergyBruce and Celia PymPC*P. S. RadhakrishnanAlexandra RectorResidence Inn by Marriott - Seattle Downtown/Lake UnionJim Roberts and Pam BeckerPC*Ronald D. and Joan A. RobertsPC

Mrs. R. Elaine RobinsonPC

Mr. Tom Robinson and Ms. Carla MurrayPC

Roke FoundationMichael B. Rubin and Sharon K. BirzerJon and Judy RunstadPC*Sajasa Construction, Inc.CA

Don E. Sandberg EstateSandberg Northwest VolvoSavings & Finance Commercial Bank LimitedScandinavian AirlinesSchnitzer Investment Corp.Keith and Jennifer SchorschPC*Jim and Bet SchulerSchwartz Brothers RestaurantsCA

Seattle Cancer Care AllianceBill and Marlene SemplePC*The Sign of the OrzJim and Jan SinegalPC*Singapore AirlinesSiRAS.comNate and Luanne SkowPC

Mr. and Mrs. Philip M. Smart, Jr. Mr. and Mrs. Steven SmithPC*Sound Community Bank/Laurie StewartDoug and Marilyn SouthernPC*Sports Radio 950 KJRTom and Diane St. JohnPC*Michael and Debbie SteinPC*Allyn Stellmacher and Terry SamilsonPC

John and Sherry StilinPC

Cynthia StroumPC*The Stroum Family FoundationSymetra FinancialDr. and Mrs. E. Donnall ThomasPC*Thrasher Koffey FoundationBonnie and Jim TownePC*

Turner Construction CompanyCA

United Jewish Foundation of Metropolitan DetroitUniversity Mechanical Contractors, Inc.Tom and Margo Van HalmPC*Van Sloun FoundationNeil and Sylvia Van SlounPC*Lawrence Votta and Maria MartinezW Real Estate ServicesHans and Anne Marie WachtmeisterPC*Shannon and Lucy Wall EstateMr. Joseph N. Walter and Ms. Kathy L. MaresPC

Washington HoldingsJim and Diane WatsonJohn W. and Elizabeth WeaverPC Nancy WeintraubNancy L. WellsPC*Ms. Mary H. WieseDoug and Ann WilliamsPC*Mr. Donald WilliamsonPC

The Woldenberg FoundationPatricia C. YoungmanMelinda YountPC Janet and Richard YulmanPC*Zimmer Gunsul Frasca Architects LLP CA

ZymoGenetics, Inc.CA

Research Friends$5,000 - $9,999Aero Controls, Inc.Affiliated Engineers IncAkiko Mikami Shimatsu FoundationAnonymous (2)AnthropologieMr. and Mrs. Ron R. BaileyBallard Technology, Inc.Betty BanghartCharles and Linda BarboBarclayDeanThe Barton Family FoundationBD BiosciencesBear Stearns & Co. Inc.Benaroya FoundationMs. Jayme L. BensonMr. and Mrs. Bradley J. BergMr. Arnie BerghBeta Sigma Phi, Xi Gamma ZetaThe Bishop Family Legacy FoundationDr. and Mrs. Joel M. BlumbergMr. and Mrs. Peter C. BoalThe Bob Tonkin Memorial ClassicSandra A. BoeskovBonhams & ButterfieldsMabel L. Bonnichsen EstatePaul and Lynn BordelonMr. and Mrs. Philip BordenRobert James Bracken EstateMr. and Mrs. Mark S. BrittonMr. James BrownriggBuilders Financial Services LLCFred and Joan BurnsteadCAC GroupMr. and Mrs. Bob CarrDr. Bruce L. A. Carter and Ms. Jean EnersenCathay PacificMadam Ho ChingRobert ChristiansenClovis FoundationRoger and Kimberly Collins

Combined Federal Campaign Kitsap-Mason CountiesEva Corets and Josh BeloffLarry and Vickie CulverMr. and Mrs. Michael L. DarlandMr. and Mrs. Matthew J. DeinesDelta Dental Washington Dental ServiceMr. and Mrs. Eugene W. DevlinMr. and Mrs. Donald A. DickLarry and Gayle DickensonThe Diffenbaugh FoundationMr. and Mrs. John D. DiffenbaughDirect Resources Group, Inc.Mr. and Mrs. Matthew J. DoronJulie Edsforth and Jabe BlumenthalEl GauchoMr. and Mrs. Thomas A. EllisonMr. and Mrs. Steven J. ElsoeJoan EnticknapMr. and Mrs. Joseph FaltermeierMr. Justin B. FieldFingerprint Communications, LLCFischer FamilyMr. Jim FordMr. Lloyd D. Frink and Ms. Janet AngellJune B. Gasparovich EstateMr. John Gebert, Jr.Genzyme CorporationFrederick M. Goldberg and Carolyn LakewoldGoldman, Sachs & Co.Roger and Jennifer GrambihlerGrand FoundationDr. and Mrs. John W. GreenMr. Leonard W. GreenNancy Greenwood Vehrs and Jeff VehrsGuy Carpenter & Company, LLCGW Cadbury Charitable TrustMr. Felix R. HarkeHarris myCFO FoundationHarry and Faye Rosenberg TrustMr. and Mrs. O. Peder HaslestadMs. Jean S. HeidtThe Hemp Family LLCRichard and Marilyn HerzbergMr. and Mrs. Harold W. HillMr. and Mrs. Richard HollandHotel 1000Mr. and Mrs. Hong B. HueyIntegra ChemicalInterstate Distributor Co.Mr. and Mrs. Claude A. IsingThe Joby Foundation Inc.Mr. and Mrs. Jon JonesKate Shea FoundationMr. and Mrs. Mel KattenKeith L. Betts and Marian L. Betts TrustOlive Kerry EstateKIRO TelevisionKitsap BankMr. and Mrs. Tim KittilsbyMr. Justin KnightCarolyn and Kevin KoesterNora KorgKosan BiosciencesKPFF Consulting EngineersYvonne P. and Jack LameyMr. and Mrs. Brad LangeLease Crutcher LewisMr. James C. LogsdonMr. John C. Logsdon

Mr. Michael A. LogsdonLopez, Hodes, Restaino, Millman and SkikosLouise H. & Edward R. Meyer Memorial TrustMagicHour FilmsJon and Nancy MagnussonHelen and David MandleyJoyce E. Marshall EstateMr. and Mrs. Mario MazzolaBruce and Jolene McCawMark A. and Marna L. McNaughtonMDS Analytical TechnologiesJessica MeiselsMellon Bank N.A.Merchant & GouldNecia G. Miles EstateMr. and Mrs. John F. Miller, Jr.Richard and Kathryn MiyauchiMr. and Mrs. R. David MushenKarin and Scott NagelNational Brain Tumor FoundationNC Machinery CompanyMyrtle M. Nelsen EstateMr. and Mrs. Eugene K. NeubergerMr. and Mrs. Wayne E. NiemuthNorth American Management Corp.North Mason Cancer CrusadersPamela B. Katten Memorial Leukemia Research FoundationChristopher P. Parios and Susan WyantMr. Paul S. PariserMrs. Terry PeroMr. and Mrs. Wayne M. PerryElsbeth PfeifferMr. and Mrs. John M. PinkertonMr. and Mrs. Matt PoolMr. and Mrs. Stephen S. PoorePrecor, Inc.Q13 FOX/MYQ2James and Sherry RaisbeckJames V. Ramsdell, Jr.Raymond James & Associates, Inc.REB Enterprises, Inc.Mrs. Sally ReiquamChad and Carol RichardsonMs. Lynn Ristig and Mr. Craig ShrontzThurston and Catherine RoachMr. and Mrs. Henry M. RobinettRobinett Investment Co., LLCJohn McVickar Robinson and Elizabeth W. RobinsonNea Lynn RobinsonMr. and Mrs. Gene E. RoeglinRose-Marie and Jack R. Anderson FoundationRowan UniversityKimberly Y. Ruhana and George W. RuhanaS*BioMrs. Colleen E. SchaferMr. and Ms. Alan D. SclaterRuth Martens ScottSeattle Genetics, Inc.Seattle SeahawksSeredigmMs. Amy E. ShigoAndrew ShortMr. and Mrs. Raymond SichSiemens Building Technologies, Inc.Mr. and Mrs. John Skovron

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D o n o r s

“WHEN RESEARCH DOESN’T TURN OUT THE WAY YOU EXPECT IT TO,

FIGURE OUT WHY.

Mr. Laurence H. SmeadNed and Carolyn SnowRonald and Angela SouzaMr. and Mrs. Frank L. and Esther A. SpringerStafford Frey CooperLaurie StewartMs. Edith S. SullivanThe Swanson FamilyMs. Myra H. TanitaTeam PhotogenicMr. and Mrs. Bruce G. ThayerMr. and Mrs. Thomas M. TodaroMr. and Mrs. Frank J. Tonkin, Jr.Trident Seafoods CorporationGary and Amanda TucciUeland FoundationUnited Way of Tri-StateThe UPS FoundationUW MedicineMr. Neil R. WachterWashington Mutual FoundationDavid and Marsha WeilMichael and Paula WeintraubWindstar CruisesMr. Chuck WolfeChristine and William WoodcockWoods & AssociatesMr. and Mrs. Scott Allan WroblewskiMark A. Young and Kelly JohnsonZaaz, Inc.

Legacy Partners in ResearchLegacy Partners in Research are individuals who support the Hutchinson Center through a bequest in their will, life income gift, life insurance, retirement assets or other planned gifts. As Legacy Partners in Research, they create a legacy for them-selves and their families and play a pivotal role in benefiting future generations.

Charles M. Ackerman and Barbara Clanton AckermanMr. Donald D. AckleyDorothy J. AlbroArleta Rae AllenJune M. AllenMs. Chelea AlwineJan A. AmenAlex and Helen AndersenMs. Glenda W. AndersonGlenn and Lois AndersonMrs. Grace AndersonStuart L. and Karen C. AndersonMs. Victoria AndrewsAnonymous (122)Frederick J. and Jane C. ArtzRobert and Clodagh AshDr. Elizabeth AtwoodN. Faye BachmeierPatricia M. BartlettMr. Alfred A. BastonThomas P. and I. Georgina BayleyMs. Diana BeckersBarbara M. BedayanRod BelcherMr. Will H. BennettMrs. Constance M. BenstonMarc A. BergerMrs. Sidonia Berglund

Yahn Bernier and Beth McCawMr. and Mrs. Harry C. BerrymanHenry A. and Marjorie M. BickelSandra Kailes BillerEllen O. BlackstoneSandra A. BoeskovBarbara A. BonamyChristine BorgenRobert and Sheila BosankoArthur R. and Bernice J. BowersSandra BrentlingerElmore G. and Dorcas BrolinGlen A. BuettgenbachMr. and Mrs. Angelo BulgarelliMrs. Jennie K. BurwellMr. and Mrs. Jack and Patty BushStephen D. CameronClint and Ruth CannonPhillip and Violette CarlsonMrs. Lucy CarneyDouglas A. CaseHazel E. CaseMary E. CederlundCora ChadsMylo and Marion CharlstonMs. Barbara ChesterMr. Lawrence N. ChristianSusan L. ChristiansenDr. and Mrs. Edmund R. ClarkeEmanuel and Susan CohenMr. Milton M. CohenGladys M. CollinsBob and Sylvia CookFred CorradoMr. Martin J. CostelloMary Pat CottyMr. and Mrs. Fenwick J. CraneRoger and Gloria CrouchLamont Crumley and D. Dianne Wilson-CrumleyMargaret CullorMrs. Leah CurrieDaryl Drew Charitable FoundationMr. Roy V. De BritzJoan A. De BruinTillie I. De LeonMr. and Mrs. Henry W. and Frances C. DeckerLou DenneyLeslie and Deborah DischChris and Viki Parrott DragichWayne D. and Susan E. DuPontMr. James P. DyePeter S. and Sandra W. DyerMr. and Mrs. Robert L. EckerDemerise EddyCecil David Enman and Norma J. EnmanThomas G. and Kay Nozaki EwingJune FarallaMr. Richard FaulstichJohn and Rosemary FedorochkoMary Jane FeeClifford H. FiscusMrs. Lorraine M. FlanaganAnton M. and Barbara C. FleischmanJane B. FolkrodBob and Lanie FranzaRichard and Linda FraschBill and Deryn FultonLarry GahlhoffKen and Lisa Geisen

Jane GerhardtJames D. and Paula J. GillmoreEileen GoebelRichard GoldsteinMs. Rosemary GoranssonMr. and Mrs. Wayne C. GottMr. Mark J. GraliaRon and Cathy GrantMrs. Norman GroudineJohn and Ann GuerinDonald and Pauline HaganMs. Helen HamiltonSharla and Don HamiltonMartha W. HanscomArthur H. HansenAlice Coulon HansonMary Alberta HargroveAndy and Carol HarrisMr. and Mrs. Robert Harrower, Jr.Mrs. Mary E. HarvillPeder and Theodora HaslestadJohn and Roberta HayesHal and Jerry HaynesDr. Frederick and Margaret HazeltinePatricia and Robert D. Heffernan, Jr.Mr. and Mrs. Severt S. Hegland, Jr.Ms. Jean S. HeidtMr. and Mrs. David C. HendersonRalph and Gail HendricksonGregory and Anne-Marie HenryConrad W. HewittLarry and Marcia HilbergMrs. K. L. HillardVivian and Les HouleMr. and Mrs. James W. HowardBarbara HowellMr. and Mrs. George C. HudspethMr. and Mrs. Paul S. HunterFloyd and Barbara HuttonMr. and Mrs. James G. HuttonDr. and Mrs. Gordon L. ImlayDavid and Gigi JackDouglas L. JacobsDorothy Doyle JohnsonMr. Douglas B. JohnsonJames A. and Holly F. JohnsonRichard P. and Caroline I. JonesThomas M. Jones and Judith A. EdwardsElaine N. KaaldEllen KamMiyoko KanetaMs. Heidi KassMs. Deborah KaufmanBrant A. KeeneyJames M. and Lavina S. KempMr. and Mrs. Donald N. KinkeadMr. Robert G. KinneyMrs. Nelda S. KleinschmidtFrederick and Julianne KlippertNora KorgMr. and Mrs. Gary A. KrapeMr. and Mrs. David KremersDonna L. KyleLarry and Linda LaBolleMr. William M. and Dr. Geraldine K. LandisMr. and Mrs. Gus LangeLolita LanningGloria L. LarkinE. Margaret LawrenceRoy and Vel Leonard

Martha LePrellJoe and Lyn LightfootMr. and Mrs. Stephen H. LindquistRalph and Lynda LipePaul S. MacMichaelMr. Edward E. MaloofWilbur C. MannStephanie D. MapelliMr. and Mrs. Robert J. MargulisDr. and Mrs. Herbert A. MarraHank, Fuchsia and Marcia MartinJeff and Ethel Maxwell Mr. and Mrs. Robert McDanielMrs. Alma L. McDonaldMary Jane McElyeaMarcia McGreevy-Lewis and Robert D. Lewis, M.D.Douglas G. and Ruth J. McKnightBarbara F. MeehanElinor K. MenterRobert Miller and Marlys Owen-JonesMrs. Anne A. MoldremJohnny and Susie MorgantiMrs. Gladys M. MorrisonMr. and Mrs. James A. MorrisonJudy MukaiMr. and Mrs. Al NeelleyNick and Carol Westlund Supporting OrganizationMiss Elsa NordinMrs. Ella NuckollsEverett and Dorothy O’NeillMrs. Jean B. O’NeillMr. Charles L. O’SheaAlice OehlerCarole A. OlsonMiss Elvi M. OlssonMr. Stanford E. OpdykeRobert B. OverhusMrs. James OwenStanley OzboltMr. and Mrs. Geoffrey and Netta PageKenneth and Lorrayne PalmerMr. and Mrs. Jack G. ParksT. Keith and Janet PatrickHarry and Katherine PearceKristian PearsonFrederick and Elizabeth PedersenMary R. PelanDaniel J. PetersGeorge and Cynthia PierceJulia B. PoduchBradford and Sandra PorterDeirdre and Dickson PrestonMarietta E. PriebeMr. Ross PurintunMr. and Mrs. Robert and Teresa QuigleyGustav and Claire T. RaaumSherry Y. RaeMrs. Della L. RamsdenWeldin and Jo Ann ReadMrs. Sally ReiquamBruce and Karen RichardsDouglass and Lea RichterMr. and Mrs. Joe A. Riedel, Jr.Mrs. Margaret RobargeMarilyn H. RogersClaudia RollinsMr. and Mrs. Thomas E. RothMilton and Ruth RubinMr. and Mrs. Allan N. Rumpf

23

Mr. Robert H. RutledgeCynthia and Gerry SalkowskiSam and Betty Lebid FoundationMary L. Sanderson-SchinmanPatricia L. SchaumbergBrent and Susan SchlossteinLoretta SchossowMs. Rosalyn H. SchuknechtRobert E. SchultzMr. Casey SepanskiDorothy L. ShattuckBarbara Jean ShenkPam and Geoff SheridanPearl L. ShernoffMr. C. Larry ShullMs. Annette SiversenMr. Eugene G. SivertsonBernice and George SmithMrs. Phyllis H. SmithDr. and Mrs. Richard SmithRuth B. SmithSamuel E. and J. Michelle SmithJoseph T. SmudinMr. Frank W. SoderlingGregory P. SokolowskiHerba Irene SolstadMary and Steve SolumMrs. Kathleen P. SpadingJosephine and Stephen SpearJames SpeckbrockMr. and Mrs. Frank L. and Esther A. SpringerMrs. Caren A. StaleyEvelyn Casey SteenMrs. Idalene StrangJanet SwansonConnie TaylorKen and Judy ThomasDick and Ruth ThomassenMr. and Mrs. Charles M. and Marjorie J. ThorneCapt. Donald A. ThorntonOlive TiceMr. and Mrs. Michael J. ToennessenClaribel TrigveMr. and Mrs. David T. TroxelKarl R. and Marcile H. TurnerMrs. Walter A. TurnerMr. and Mrs. Robert E. VallatMary C. VanderzichtJean Baur ViereckMr. Jerry WarfieldWilliam H. WarnerJim and Diane WatsonMrs. Robert E. WeaverSteve and Dana WeinerLewis G. WeissSandra E. WeissCatherine and Steven WellsAnne T. WhiteMrs. Edward WhitleyWilliam and Susanna WiegantChristopher L. and Ruby D. WildeCarl H. WittenbergMs. Dawn M. WoodPenny M. WoodsSarah WoodsJames and Herma WynPatricia C. YoungmanMrs. Veva J. ZardMrs. Arline Zidell

Inner CircleThe Inner Circle is comprised of current and former faculty, staff and their spouses; past and present members of the Board of Trustees, Board of Ambassadors and Senior Council and their spouses; as well as past members of the former Foundation Board of Directors and their spouses. It recognizes those who support the Hutchinson Center through a bequest in their will, life income gift, life insurance, retirement assets or other planned gifts.

Steven J. and Lisa M. AndersonAnonymous (6)Robert M. ArnoldRich and Leslie BegertCarl and Renée BehnkeSally Skinner BehnkeBrian R. and Shelley J. BuckWilliam W. and Kathy Lynn ChristoffersenMr. and Mrs. John D. EasthamKarl and Carol EgeRobert N. and Ingrid Lahti EisenmanNoemi A. EpsteinMs. Linda L. GainerJanice A. and Robert L. GerthKenneth and Beryl GoodchildDr. William Grady and Dr. Karen TsuchiyaSheri Ray GreavesMarcia and Glenn HarringtonDebra and Chuck HollandDeborah E. KirsnerLynette A. KleinReginald S. Koehler IIIJudy KornellShelley M. KuniMs. Karen E. LaneJerrold D. Liebermann and Linda J. HarrisJeffrey and Ethel MaxwellRachelle A. McCallumPatricia McCowanNeil and Nancy McReynoldsKaren and Jamie MoyerShan and Lee MullinHan and Shawn NachtriebPaul and Carol NeimanMartin and Vicki NelsonDr. Gilbert S. Omenn and Martha A. DarlingJohn and Deanna OppenheimerGuy and Arlene OttJohn and Jean RolfeMichael T. and Nancy A. RyanMarilla SatterwhiteDr. and Mrs. E. Donnall ThomasMrs. Barbara Thrasher

Seattle Cancer Care AllianceThe Seattle Cancer Care Alliance (SCCA) unites the adult and pediatric cancer-care services of Fred Hutchinson Cancer Research Center, UW Medicine and Children’s Hospital and Regional Medical Center. In fiscal year 2008, 1,182 donors contributed more than $2.1 million to the SCCA to support efforts to provide premier, patient-focused care and access to groundbreaking clinical research to patients from around the world.

Research Benefactors$1 million or moreSafeway Inc.

Research Fellows$50,000 - $99,999Entertainment Industry FoundationThe Madhouse ProjectSeattle SymphonyThomas C. Wright Foundation

Research Sponsors$25,000 - $49,999Fred Hutchinson Cancer Research CenterLisa Lund Fund

Research Supporters$10,000 - $24,999Auburn Regional Medical CenterBroadway Across America/Live NationCentral Washington HospitalChildren’s Hospital & Regional Medical CenterFairfax HospitalMs. Catherine L. FallenHarrison Medical CenterHighline Medical CenterLegacy Salmon CreekPerkins Coie LLPSacred Heart Medical CenterSeattle Center MarketingSt. Joseph HospitalSt. Joseph Hospital & Medical CenterVirginia Mason Clinic/Medical CenterYakima Valley Memorial Hospital Center for Child Health Services

Research Friends$5,000 - $9,999Mr. and Mrs. Rajeev BajajCharles B. See FoundationMr. Ray HickeyHoly Family HospitalMeghan’s Mountain Charitable Foundation, Inc.Pacific NW 4 Wheel Drive AssociationPeaceHealth Saint John Medical CenterProvidence Everett Medical CenterProvidence Saint Peter HospitalSaint Francis HospitalThe Schneider Family FoundationMrs. Barbara StiefUnited Way of King County

Marsha Rivkin Center for Ovarian Cancer ResearchIn partnership with the Hutchinson Center and Swedish Medical Center, the Marsha Rivkin Center for Ovarian Cancer Research is a nonprofit organization dedicated to saving lives and reducing suffering through improved treatment, early detection and prevention of ovarian cancer. The Rivkin Center funds pilot studies, issues scientific scholar awards, conducts ovarian symposiums and provides ovarian-cancer screening in conjunction with cutting-edge research projects.

Marsha Rivkin Center ContributorsThe following donors contributed $5,000 or more between January 1 and December 31, 2007.

$100,000 - $249,999Bensussen Deutsch & Associates Inc.Fisher Foundation for Family Health

$50,000 - $99,99998.9 KWJZJanet L. Brown Estate

$25,000 - $49,999Chuck and Karen Lytle

$10,000 - $24,999Anonymous (1)Donna R. BenaroyaEric and Gloria BensussenBob Bridge ToyotaMs. Lynda M. GilmanKING 5 TelevisionLadies Auxiliary VFWThe Lester & Bernice Smith FoundationMartin-Fabert FoundationDavid and Mette NanessSwedish Medical Center First Hill Auxiliary

$5,000 - $9,999Mr. and Mrs. Wayne AndersonApple American GroupAthena PartnersBank of AmericaCell Therapeutics, Drs. James and Sue BiancoMr. Mark J. CraemerGrandmasters, LLCMr. Luther HauganHealth Care Property Investors, IncMr. David A. HoffmanJim and Lorna KneelandMaryAnne and Richard KobylkaMrs. Lisa Kreissler and Mr. Allen DerheimAllan B. LearnedMr. C. Eric MorseMr. and Mrs. Paul RussoThe Schuler Family Foundation, Mr. and Mrs. James K. SchulerMr. and Mrs. Frank SixtStuart and Karen Sloan

† DeceasedCA Corporate AffilitatesPC President’s CirclePC* President’s Circle charter member

THAT ANSWER IS USUALLY MUCH MORE INTERESTING THAN IF IT HAD TURNED OUT.”

—DR. LEE NELSON

2008(Unaudited)

2007(Audited)

OPERATING REVENUES FISCAL YEAR 2008

n Research Grants and Contracts 78%

n NetContributions 7%

n Investment Income 4%

n Other Income 11%

OPERATING EXPENSES FISCAL YEAR 2008

n Program Services– Research 77%

n Facilities and Administration 21%

n Fundraising 2%

F i n a n c i a l S u m m a r y

Revenues and Other Support(in thousands of dollars)

Research Grants and Contracts $294,244 $273,621

Net Contributions 27,634 27,669

Investment Income 15,936 20,930

Other Income 43,299 33,990

Total Revenues $381,113 $356,210

Expenses(in thousands of dollars)

Program Services – Research $286,905 $262,755

Facilities and Administration 77,538 73,061

Fundraising 6,861 5,616

Total Expenses $371,304 $341,432

Change in Net Assets from Operations $ 9,809 $ 14,778

Change in Net Assets from Financing Activities – 19,243 8,592

Total Increase/(Decrease) in Net Assets – 9,434 23,370

Net Assets Balance at Beginning of Year 209,676 186,306

Net Assets Balance at End of Year $200,242 $209,676

Fred Hutchinson Cancer Research Center

Fiscal Years 2008 and 2007

24

Thank you for joining us in our mission to eliminate cancer and related

diseases as causes of suffering and death. Private donations like yours

are essential for allowing Fred Hutchinson Cancer Research Center to

rapidly respond to novel research opportunities that can lead to important

medical breakthroughs.

Financial support from our donors enables us to attract and retain

the world’s top scientists, provide our researchers with state-of-the-art

technology needed to advance their work and launch innovative pilot

projects to explore new ways to eliminate cancer and related diseases.

Private gifts also leverage significant additional investment by allowing

investigators to successfully compete for prestigious foundation grants that

do not cover the full cost of research.

The many accomplishments that keep the Hutchinson Center at

the forefront of biomedical research could not be achieved without your

generous gifts.

USES OF CONTRIBUTIONS FISCAL YEAR 2008

n Direct Research Investments 80% and Patient Care n Fundraising Expenses 20%

SOURCES OF CONTRIBUTIONS FISCAL YEAR 2008

n Planned Giving 29%

n Principal/Major Gifts 23%

n Foundation Relations 17%

n Annual Giving 12%

n Special Events 10%

n President’s Circle 8%

n Corporate Relations 1%

25

C e n t e r B o a r d s FISCAL YEAR 2008

Board of Trustees

Sally G. Narodick, Chair

Douglas W. Walker, Vice Chair

Jeffrey P. Maxwell, Treasurer

Steve Davis, Secretary

Ronald E. Bayley

Richard P. Begert

Edward D. Davila, M.D.

Karl J. Ege

Alan D. Frazier

Robert J. Herbold

Peter A. Horvitz

Henry James

Richard E. Jones

Henry L. Kotkins, Jr.

Don J. Listwin

Gary Locke

Patricia B. May

Joan Ellen Morse

Karen Moyer

Robert T. Nelsen

Martin O. Nelson, Jr.

Charlotte H. Reed

John Thurston Roach

Keith M. Schorsch

Stephen V. Sundborg, S.J.

Douglas E. Williams, Ph.D.

26

Senior Council

Constance M. Anderson

Robert M. Arnold

Robert E. Bayley

Sally S. Behnke

Deborah L. Bevier

Eric S. Bremner

William W. Christoffersen

Vincent F. Coviello, Jr.

David R. Davis, M.D.

Barbara R. Ells

Phelps K. Fisher

David B. Frohnmayer

Ben J. Gantt, Jr.

Jack M. Geoffroy

Denver C. Ginsey

Slade Gorton

Irving M. Haug

Frank H. Hopkins

John L. Hutchinson

Kay D. Jones

Reginald S. Koehler III

Stanley M. Little, Jr.

David C. Lycette

Patricia A. McDonald

Neil L. McReynolds

J. Shan Mullin

Amb. Della Newman

Gilbert S. Omenn, M.D., Ph.D.

George B. Rathmann, Ph.D.

Charles E. Riley

Jean B. Rolfe

James F. Ryan

Harriet Shrontz

The Honorable

Charles Z. Smith

Cynthia Stroum

Rev. William J. Sullivan, S.J.

Gerald R. Swanson

James G. Talbot

Bonnie A. Towne

George A. Walker

Cindy Zehnder

† Deceased

Board of Ambassadors

Richard W. Anderson, Co-chair

Carl G. Behnke, Co-chair

Jean B. Rolfe, Co-chair

Constance M. Anderson

Robert M. Arnold

Robert E. Bayley

Sally S. Behnke

Ronald J. Berenson, M.D.

Deborah L. Bevier

Eric S. Bremner

Fred Brown

Philip K. Bussey

Hugh Chang

William W. Christoffersen

Rudolph F. Crew. Ed.D.

David R. Davis, M.D.

Barbara R. Ells

Phelps K. Fisher

Edward V. Fritzky

Ben J. Gantt, Jr.

Jack M. Geoffroy†

Robert L. Gerth

Denver C. Ginsey

Kenneth J. Goodchild

S. John Goodwin

Slade Gorton

Stephen M. Graham

Kenneth S. Greenbaum

Irving M. Haug

Charles L. Hirsch

Ronald S. Howell

John L. Hutchinson

Jeremy A. Jaech

Julius P. Johnston III

Kay D. Jones

Perrin Kaplan

Reginald S. Koehler III

David C. Lycette

David A. Mann

Patricia A. McDonald

Neil L. McReynolds

J. Shan Mullin

Craig J. Mundie

Amb. Della Newman

Gilbert S. Omenn, M.D., Ph.D.

Admiral William A. Owens

Nancy D. Pellegrino

Bruce M. Pym

Charles E. Riley

H. Jon Runstad

Katherine J. Savitt

Harriet Shrontz

The Honorable

Charles Z. Smith

Alessandra Spencer

Michael A. Stein

Cynthia Stroum

Gerald R. Swanson

Rev. Robert V. Taylor

Bonnie A. Towne

George A. Walker

Mary H. Wiese

Scott F. Wilson

John C. Woodin

Cindy Zehnder

C e n t e r L e a d e r s h i p

At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of world-

renowned scientists and humanitarians work together to prevent, diagnose and treat

cancer, HIV/AIDS and related diseases. Our researchers, including three Nobel laureates,

bring a relentless pursuit and passion for health, knowledge and hope to their work and

the world.

With research excellence that spans the full spectrum of cancer research, we are

uniquely qualified not only to discover, but to implement lifesaving breakthroughs.

To achieve our goal of improving human health around the world, our scientists lead studies

in the following areas: Early Detection and Intervention, Immunotherapy, Tumor Research,

Fundamental Research, Leukemia and Lymphoma Research, International Research,

Prevention Research, and Childhood Cancers.

In addition to our groundbreaking research, we also provide a range of support services

for the patients and families who come to the Hutchinson Center for lifesaving treatment.

Programs include the Pete Gross House and Hutch School, Cancer Information Service,

the Long-Term Follow-Up Program as well as the Fred Hutchinson Cancer Research Center

Survivorship Program, part of the LIVESTRONGTM Survivorship Center of Excellence

Network, and the Cancer Prevention Clinic located at the Seattle Cancer Care Alliance.

Annual Report

published by the External Affairs

and Communications Department

Fred Hutchinson Cancer Research Center

PO Box 19024

Seattle, WA 98109-1024

206.667.5000

www.fhcrc.org

© 2008 Fred Hutchinson

Cancer Research Center

Gordon Todd

Editor

Barbara Hoberecht

Art Director

Susie Fitzhugh

Portrait Photographer

Ignacio Lobos

Colleen Steelquist

Writers

Photo credits:Meghan Mullarky, cover; Ignacio Lobos, page 17;Dr. Florian Hladik, page 28

Printed on recycled paper

F r e d H u t c h i n s o n C a n c e r R e s e a r c h C e n t e r

27

Lee Hartwell, Ph.D.


Myra Tanita

Executive Vice President and

Chief Operating Officer

Mark Groudine, M.D., Ph.D.

Executive Vice President and

Deputy Director

Frederick Appelbaum, M.D.

Senior Vice President and Director

Clinical Research Division

Barbara Trask, Ph.D.


Human Biology Division

James Roberts, M.D., Ph.D.


Basic Sciences Division

Ross Prentice, Ph.D.


Public Health Sciences Division

Larry Corey, M.D.

Senior Vice President and Co-Director

Vaccine and Infectious

Disease Institute

Scott Rusch

Vice President

Facilities and Operations

Bob Robbins, Ph.D.

Vice President

Information Technology

Janell Baldwin

Vice President

Shared Resources

Han Nachtrieb

Vice President

Human Resources

Doug Shaeffer

Vice President

General Counsel

Ulrich Mueller, Ph.D.

Vice President

Industry Relations and

Technology Transfer

Randy Main

Vice President of Finance

and Chief Financial Officer

Nancy Wells

Vice President

Development

Linda Gainer

Vice President

External Affairs and

Communications

of discovery

“DISCOVERY IS SEEING WHAT EVERYBODY HAS SEEN,

AND THINKING WHAT NOBODY HAS THOUGHT.”

—ALBERT SZENT-GYÖRGYI

THE EXPLORATORY NATURE OF SCIENTIFIC INVESTIGATION IS DISPLAYED IN DR. MICHAEL EMERMAN’S NOTES.

BACK COVER: STOCHASTIC MODELS REVEAL THE SPREAD OF DISEASE IN A PANDEMIC OUTBREAK.

d e d i c a t e d t o

HIV HIDES IN A DENDRITIC CELL OF THE GENITAL LINING.

a future

Seattle’s reputation as a leader in high technology and biotechnology and the allure of the region’s natural beauty attract the world’s best minds to Fred Hutchinson Cancer Research Center.

We draw inspiration from our diverse landscape—from rivers and ocean to mountains and forest. At the Hutchinson Center, we live and breathe a life of science.

Mail Stop J5-200, PO Box 19024, Seattle, WA 98109-1024 206.667.4399 1.800.279.1618 www.fhcrc.org

discovery - fred hutch · yielded important insights into the evolutionary struggle between viruses...

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