A versatile Digital Pathology platformwith a complete IHC solution

Digital IHC SolutionImmunohistochemistry

Aperio’sDigital

PathologyPlatform

For more information about our

Digital IHC Solution or our digital pathology

platform, please visit www.aperio.com/IHC

or call us at 866-478-4111.*Aperio products are FDA cleared for specific clinicalapplications, and are intended for research use for otherapplications. For clearance updates, visit www.aperio.com.

Copyright © 2008, Aperio. All rights reserved. ScanScope®,Spectrum™ and ImageScope™ are trademarks of Aperio.

IMC-1053-05012008

HE A D Q U A RT E R S

Aperio1360 Park Center DriveVista, CA 92081

Main: 866.478.4111Fax: 760.539.1116

info@aperio.comsupport@aperio.comwww.aperio.com

EU R O P E A N OP E R AT I O N

Aperio3 The SanctuaryEden Office ParkHam GreenBristol BS20 0DD, UK

Main: 011 44 1275 375 123Fax: 011 44 1275 373 501

europeinfo@aperio.comeuropesupport@aperio.comwww.aperio.com

Adopt Digital PathologyTake your first step with IHCAperio Provides a Complete Solution for IHC

• Efficient clinical workflow

• Reading of slides on a computer monitor

• Quantitative image analysis

• Professional reports

The Many Uses of Our Digital Pathology Platform

With our multi-use platform, the utility you

leverage goes far beyond IHC. You can use it for

many other Digital Pathology applications, including

secondary consultation, tumor boards, quality

assurance programs, proficiency training and

testing programs, and more.

We provide a new approach to IHC with an

all-digital solution, creating a highly efficient

clinical workflow.

Use the only FDA-cleared system that allows

you to run quantitative image analysis with

the click of a button while reading slides on

a computer monitor.

Read IHC Slides and Run IHC Image Analysison the Same System

Provide better patient care with faster turn-around times, better informed decisionsand more accurate and consistent test results.

Efficient Review of CasesLab Services

New CAP/ASCO HER2 GuidelinesAperio’s HER2 algorithm is the only algorithm that can be used to follow the new CAP/ASCO HER2 guidelines. Aperio provides automaticalgorithm tuning which allows you to correlate the algorithm results with a second test method such as FISH. Aperio’s HER2 algorithms notonly provide the coarse HER2 score, but also the underlying percentages of cells that you can easily use to apply any other scoring threshold.

Instant Access, Anytime, AnywhereImprove turnaround time and accessto specialists. Save travel time andenable pathologists to work anytimefrom anywhere, such as remotelyfrom another institution.

Case ManagementManage your work efficientlyusing case work lists.

View All Case, Specimen and Slide Information (incl. gross images and controls)Provide more informed decisions faster,with all information at your fingertips.

View H&E and IHC SlidesAutomatically SynchronizedSide-by-Side Identify tumor regions faster and more reliably.

Read IHC Slides on a Computer Monitor Aperio provides the only FDA-cleared system that allows you to read slides on a computer monitor.

All information at your fingertips

Run IHC Image Analysis with the Click of a ButtonCount thousands of cells inseconds and improve youraccuracy and consistency.

Data Flow Automate data flow fromquantitative analysis to reportswith automated score andinterpretation calculators.

Generate ReportsEliminate transcription stepsby entering data easily andaccurately using cannedcomments. Automaticallygenerate reports.

View multiple slides side by side Provide professional reports automatically

Use professional reports to communicate effectively with oncologistsand empower them to explain your pathology findings to patients.

Run IHC Image Analysis with the click of a buttonwhile reading the slide on a computer monitor

Optimize Your Clinical Workflowfrom Glass Slides to Reports

An all-digital solutionEasy to use and efficient

Scan slides easily with Aperio’s ScanScope® scanners, and then view theresulting digital slides over the Internet via Spectrum™ digital pathologyinformation management system.

Digital Pathology presents a greatopportunity for laboratories to offernew services, create new businesses,and attract new customers.

IHC Image AnalysisAccurate and consistent results.

HER2

Percentage: 52.3%

Intensity: 3+

3+ Percentage: 28.5%

2+ Percentage: 21.3%

1+ Percentage: 2.5%

0 Percentage: 47.7%

ER/PR

Slide ScanningHigh-quality and high-

throughput slide scanning

with walk-away automation.

Digital Slide Overlay Quantitative Results

Digital Slide Overlay Quantitative Results

Data EntryComplete automation using

barcodes and integration to

your LIS system.

Slide HandlingReduce costs, simplify your process,

and improve turn-around time by

handling all slides digitally.

Slide Preparation Service(optional)

Increase pathologists’ efficiency by

pre-identifying tumor regions and

pre-running image analysis (based on

pathologist’s annotation on H&E slide).

HER2 Score: 2+

3+ Percentage: 7.0%

2+ Percentage: 30.0%

1+ Percentage: 61.0%

0 Percentage: 2.0%