diagnosis and management of adrenal disorderscauses of addison’s disease autoimmune •tb, fungal,...
TRANSCRIPT
![Page 1: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/1.jpg)
Diagnosis and Management of Adrenal Disorders
Keith Cryar, MDA. Keith Cryar, MD
![Page 2: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/2.jpg)
Adrenal Disorders
• Addison’s disease
• Hypoaldosteronism
Adrenocortical Hypofunction
• Cushing’s syndrome
• Hyperaldosteronism
Adrenocortical Hyperfunction
• Pheochromocytoma
Adrenal medulla hyperfunction
• Unsuspected adrenal mass found on imaging
Adrenal Incidentaloma
![Page 3: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/3.jpg)
Adrenocortical Hypofunction
•Addison’s disease
•Aldosterone deficiencyPrimary
hypofunction
•Secondary adrenal insufficiency
•Hyporeninemic hypoaldosteronism
Secondary hypofunction
![Page 4: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/4.jpg)
![Page 5: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/5.jpg)
Causes of Addison’s Disease
Autoimmune
• TB, fungal, HIV, others
Infectious
Metastatic cancer
Adrenal hemorrhage or infarction
• Ketoconazole, rifampin, phenytoin, flucanazole, others
Drugs
Hereditary disorders
![Page 6: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/6.jpg)
Addison’s Disease from
Autoimmunity
May be associated with other autoimmune processes
Polyglandular autoimmune sydromesSchmidt Syndrome- primary adrenal
and primary thyroid deficiencies
Spares the medulla
Most common
![Page 7: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/7.jpg)
Signs and Symptoms
Abdominal pain
Anorexia and weight loss
Dehydration and hypotension
Nausea & vomiting
Hyponatremia and hyperkalemia
Hypoglycemia
Hyperpigmentation, vitiligo, or both
![Page 8: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/8.jpg)
![Page 9: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/9.jpg)
![Page 10: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/10.jpg)
![Page 11: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/11.jpg)
Addison’s Disease
Often presents as a medical emergency
Treatment should not be delayed awaiting diagnosis
Labs can be obtained even as therapy is started (with caveats)
![Page 12: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/12.jpg)
Diagnosis of
Addison’s Disease
Low cortisol and high ACTH confirms primary adrenal insufficiency
Cortisol results available quickly
ACTH results not be available for days
![Page 13: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/13.jpg)
Emergency Treatment
Patient is treated with 4mg of dexamethasone and IV fluids while a rapid ACTH (cortrosyn) test is performed
Adrenal suppression from glucocorticoids takes several days to develop
Dexamethasone does not react with the cortisol assay, so it does not confuse the results
![Page 14: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/14.jpg)
Rapid ACTH stimulation test
Baseline cortisol (and ACTH)
Administer cosyntropin 250 µg (synthetic
ACTH)
Cortisol drawn 30 min. and 1 hour later
Any reading > 18.5 μg/ml is a normal
response
Abnormal responses occur with both
primary and secondary adrenal insufficiency
![Page 15: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/15.jpg)
Etiologies of Secondary
Adrenal Insufficiency
Hypothalamic or pituitary tumors
Isolated ACTH deficiency
• Produce long-term suppression of the hypothalamic/pituitary/adrenal axis
• If not tapered appropriately, adrenal insufficiency occurs
• The most common cause of adrenal insufficiency
Exogenous glucocorticoids
![Page 16: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/16.jpg)
Differences from primary
adrenal insufficiency
Mineralocorticoid deficiency uncommon
No hyperpigmentation
![Page 17: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/17.jpg)
Treatment of Adrenal Insufficiency
Status Hydrocortisone
Normal Daily 15 to 30 mg PO in 2-3 doses
Minor stress 30-50 mg PO in 2-3 doses
Moderate stress
45-75 mg PO or IV in 3-4 doses
Severe stress 150-200 IV in 4 doses
![Page 18: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/18.jpg)
Hypoaldosteronism
Characterized by hyperkalemia
(elevated potassium)
Should be considered in any
patient with persistent
hyperkalemia in whom there is no
obvious cause
![Page 19: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/19.jpg)
Non-aldosterone
Causes of Hyperkalemia
• Easily diagnosed with BUN and creatinine
Advanced renal
failure
• Diminished sodium and water delivery to the distal site of potassium secretion
• Most often occurs in patients with severe heart failure
Marked volume
depletion (actual or effective)
![Page 20: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/20.jpg)
Causes of Hypoaldosteronism
Aldosterone deficiency
Hyporeninemic hypoaldosteronism
Aldosterone resistance
![Page 21: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/21.jpg)
Aldosterone deficiency
Addison’s diseaseCongenital
adrenal hyperplasia (CAH)
Heparin and low molecular weight
heparin
Adrenal hemorrhage and
direct suppression
![Page 22: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/22.jpg)
Hyporeninemic hypoaldosteronism
• Characteristically diabetes
Renal disease
• Acute glomerulonephritis
Volume expansion
• ACE inhibitors, NSAIDS, cyclosporine, HIV
Misc.
![Page 23: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/23.jpg)
Aldosterone resistance
Amiloride Triamterene Spironolactone
![Page 24: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/24.jpg)
Cushing’s Syndrome
glucocorticoid excess
![Page 25: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/25.jpg)
Cushing’sSyndrome
Clinical Features
Progressive obesity (classically truncal)
Skin atrophy, easy bruisability, striae, fungal infections, hyper-pigmentation, hirsutism, acne
Menstrual irregularities
Glucose intolerance or diabetes
Hypertension, hypokalemia
Thromboembolisms
Psychological changes
![Page 26: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/26.jpg)
Glucocorticoid Excess
• The clinical manifestations of glucocorticoid excess
• Includes glucocorticoid excess from any source
Cushing's Syndrome
• Glucocorticoid excess specifically due to ACTH secretion from a pituitary adenoma
• Does cause Cushing’s Syndrome
Cushing's disease
![Page 27: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/27.jpg)
Does the Patient have a
Disease?
Serum cortisol may be secondarily elevated from many causes besides
excess ACTH production or autonomous adrenal gland secretion
Evaluation can be difficult
Before invasive or imaging studies, it is important to perform screening
studies
![Page 28: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/28.jpg)
Screening for
Cushing's Syndrome
Low dose dexamethasone suppression
Outpatient screening only
Test has a low false negative rate
High false positive result if done in the hospital!!
![Page 29: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/29.jpg)
Low dose dexamethasone
suppression
• Checking AM dexamethasone level confirms absorption and adherence
1.0 mg dexamethasone 10-11 pm
• serum cortisol should be < 5 μg/dL
• salivary cortisol should be <2 n/mL
8 am cortisol
![Page 30: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/30.jpg)
Diagnosis of
Cushing’s syndrome
Urine free cortisol (24 hour urine collection)
Positive if more than 3 times upper normal
Indeterminate if 1-3 times upper normal
If indeterminate, check late evening serum or salivary cortisol (lack of diurnal variation)
![Page 31: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/31.jpg)
Etiologies of
Cushing's Syndrome
•Pituitary (Cushing's Disease)
•Ectopic ACTH
ACTH dependent
•Adrenal adenoma
•Adrenal carcinoma
•Exogenous glucocorticoids
ACTH independent
![Page 32: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/32.jpg)
Hypothalamic-pituitary
(Cushing's Disease)
• A “normal” patient would have a low ACTH if their cortisol was high
ACTH is usually elevated, but can be
“normal”
• Low and high dose protocols
ACTH can be suppressed with higher levels of glucocorticoids
• May need inferior petrosal vein sampling to confirm the source is pituitary
A pituitary tumor may not be visible in
½ the cases
• Only an issue for failure to localize pituitary adenoma and unsuspected,occult carcinoid
Ectopic ACTH secretion by some
carcinoid tumors can also exhibit ACTH
suppressibility
![Page 33: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/33.jpg)
Ectopic ACTH
ACTH secretion by a tumor (usually several times the upper limit of normal)
Values can overlap with Cushing’s disease early in the course of the cancer
Ectopic ACTH does not respond to dexamethasone suppression (unless carcinoid)
![Page 34: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/34.jpg)
ACTH Independent
Cushing’s Syndrome
ACTH is suppressed by the elevated cortisol
Adrenal adenoma or carcinoma
Exogenous glucocorticoids (most common)
![Page 35: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/35.jpg)
Exogenous glucocorticoids
Don’t forget joint and back injections
Patient may forget or not realize steroids were injected
ACTH suppression may last for days to weeks depending on the dose and
duration
May present with adrenal insufficiency if taken off
glucocorticoids too quickly
![Page 36: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/36.jpg)
Levels of ACTH in
Cushing’s Syndrome
Cushing's Disease -Normal to high
ACTH
Ectopic ACTH –typically a very
high ACTH
Exogenous steroids or adrenal etiology-
suppressed ACTH
![Page 37: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/37.jpg)
![Page 38: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/38.jpg)
![Page 39: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/39.jpg)
![Page 40: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/40.jpg)
![Page 41: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/41.jpg)
![Page 42: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/42.jpg)
Hyperaldosteronism
•Autonomous production by adrenals
Primary
•Stimulation of adrenal production from other causes
Secondary
![Page 43: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/43.jpg)
Primary Hyperaldosteronism
• Adenoma - 75-85% of cases
• Bilateral hyperplasia -15-25% of cases
• Carcinoma - <1% of cases
Autonomous adrenal
production
• Hypertension - one of the potentially curable forms of hypertension
• Hypokalemia
Clinical manifestations
![Page 44: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/44.jpg)
Diagnosis of Primary Hyperaldosteronism
• Normal subjects and patients with essential hypertension is 4 to 10
• More than 20 in most patients with primary aldosteronism
Plasma aldosterone
concentration (ng/dl) to
plasma renin activity (ng/ml per hour) ratio
(PAC/PRA ratio)
• Usually with oral salt loading
• Can be with IV
Failure of serum or
urine aldosterone to suppress with
a high salt load
![Page 45: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/45.jpg)
Secondary Hyperaldosteronism
• Inadequate volume or low perfusion
Physiologic response to
various conditions of
reduced effective arterial
blood volume
• Hypovolemia
• Edematous statesExtrarenal
• Impaired renal tubular absorption of Na and Cl
• Accelerated hypertension
• Renovascular lesions
• Renin-secreting neoplasms (rare)
Renal
![Page 46: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/46.jpg)
Pheochromocytoma
A rare disease, probably occurring in less than 0.2 percent of patients with
hypertension
About half have paroxysmal hypertension and the other half appear
to have essential hypertension
Worth diagnosing because it can be life-
threating and is a treatable form of
hypertension
![Page 47: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/47.jpg)
Clinical features of pheochromocytoma
Classic triad of symptoms
• Episodic headache
• Sweating
• Tachycardia
Not all patients have the three classic symptoms,
but most have two of the three
Symptoms are common in the
general population
![Page 48: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/48.jpg)
Other clinical
features
Pallor
Orthostatic hypotension (may
reflect a low plasma volume)
Visual blurring, papilledema
Weight loss
HyperglycemiaPsychiatric disorders
Dilated cardiomyopathy
![Page 49: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/49.jpg)
Diagnosis
• Hypertension and symptoms
• Associated with MEN IIA and MEN IIB
Clinical suspicion
• Always precedes imaging
Biochemical confirmation
• Solitary adrenal lesion in 90% of cases
Localization
![Page 50: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/50.jpg)
Biochemical confirmation
• High false positive results
• Low false negative
• Use for lower suspicion
Plasma values
• Free catecholamines (epinephrine and norepinephrine)
• Metanephrines
• VMA (vanillylmandelic acid)
• Use for higher suspicion or MEN syndromes
24 hour urine
![Page 51: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/51.jpg)
Results of urine
studies
Values should be at least twice the upper limits of normal
There are multiple drugs and foods that interfere with the metabolite assays
Special diet
Discontinue interfering
medications (look up before starting urine collection)
Labetalol is the only hypertensive
interfering with fractionated
catecholamines
![Page 52: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/52.jpg)
Localization
• 10% are extra-adrenal
• 95% are within the abdomen
• On MRI, T2-weighted images appear hyperintense
Can use CT or MRI
• See adrenal incidentaloma below
• Localization should not precede making a biochemical diagnosis
Non-functional
adrenal tumors
are common
![Page 53: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/53.jpg)
Other imaging
techniques
• MIBG scanNorepinephrine analogue
• Fluorodeoxyglucose PET or FDG-PET
Increased uptake of glucose
• Octreotide
• Dotatate PET scan –most sensitive
Somatostatin receptor
![Page 54: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/54.jpg)
For reference: not on test
![Page 55: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/55.jpg)
Adrenal Incidentaloma
• Unsuspected
Found on imaging studies done for other
reasons
• 2-3% of >50 year olds
• Up to 7% of those over 70 years
Asymptomatic adrenal masses
• Functional without clinical symptoms or signs
Up to 10% are subclinical
• Primary -benign or malignant
• Metastatic or infectiousDifferential Dx
![Page 56: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/56.jpg)
Assessment of
incidental adrenal
mass
H&P to look for evidence of malignancy or adrenal hormone excess
Most patients with cancer metastatic to adrenals have evidence of cancer elsewhere
Imaging characteristics may provide clues
![Page 57: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/57.jpg)
Biochemical Evaluation
Functional tumors are can be subclinical, so biochemical evaluation is needed
Check for cortisol, aldosterone, DHEAS, and catecholamine excess
![Page 58: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/58.jpg)
Size of non-
functional adenomas
<3.5-4 cm are usually followed with imaging in 6-12 months
>6 cm are usually resected
Tumors 4-6 cm may go either way depending on presence or absence of suspicious features on imaging
![Page 59: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/59.jpg)
Endocrinology Basics
• Individual lab values outside the “normal” range may be entirely appropriate depending on the clinical status
Endocrine systems are
dynamic.
• If a hormone is low, its regulating hormone should be elevated
• If a hormone is elevated, its regulating hormone should be low
Normal is a relative value
• Imaging can be performed quicker than biochemical testing
• Non-functioning, benign tumors are common in endocrine organs
• You may develop tunnel vision and misdiagnose
Avoid the temptation to
jump to imaging until you know the patient has
a disease.
![Page 60: Diagnosis and Management of Adrenal DisordersCauses of Addison’s Disease Autoimmune •TB, fungal, HIV, others Infectious Metastatic cancer Adrenal hemorrhage or infarction •Ketoconazole,](https://reader033.vdocuments.site/reader033/viewer/2022042203/5ea3fcedd7c5b375853dbf03/html5/thumbnails/60.jpg)