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Detect the Faintest Signals

The LSM 710

By Theodor Boveri

Translated and annotated by Sir Henry Harris

An English translation of Boveri’s famous monograph which was first published in Germanyin 1914.

Written almost a hundred years ago, Theodor Boveri’s Zur Frage der Entstehung malignerTumoren has had a momentous impact on cancer research. In it he argues that malignancy

arises as a consequence of chromosomal abnormalities and that multiplication is an inherent property of cells. Withastonishing prescience, Boveri predicts in this monograph the existence of tumor suppressor mechanisms and isperhaps the first to suggest that hereditary factors (genes) are linearly arranged along chromosomes. This newtranslation by Sir Henry Harris, Regius Professor of Medicine Emeritus at Oxford University and former Editor-in-Chief of Journal of Cell Science, includes extensive annotations in which he discusses the relevance of Boveri’sviews today. It is essential reading for all cancer researchers, as well as those interested in the history of cytogeneticsand cell biology.

2008, 82 pp. Paperback $24 ISBN 978-087969788-4

Co-published with The Company of Biologists

CONTENTS

I. Introduction

II. Some Observations from Experimental Cytology

III. Relevance to the Study of Tumours

IV. The Explanatory Value of the Hypothesis

V. Consideration of Some Objections

VI. Conclusion

References

To order or request additional information, please visit our Web site or:Call: 1-800-843-4388 (Continental US and Canada) 516-422-4100 (All other locations)

FAX: 516-422-4097 E-mail: cshpress@cshl.eduWrite: Cold Spring Harbor Laboratory Press, 500 Sunnyside Blvd., Woodbury, NY 11797-2924

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The Home for RNA Scientists

The RNA Society is an interdisciplinary, cohesive intellectual home for those interested in all aspects of

RNA Science.

We welcome new members from all areas of scientific research and we look forward to sharing the new per-

spectives they bring to the Society. There are many benefits to being a member of the RNA Society.

These include:

• Print copies and web access to the Society journal, RNA (Impact factor of 6.1 and an excellent immediacy index)

• Reduced costs for publishing your papers in RNA.

• The RNA Society Newsletter, a forum for disseminating information to members and discussing issues affecting the Society and RNA Science

• Reduced registration fees for the annual meeting of the Society

• Numerous opportunities for junior scientists to become involved in the Society

• The Directory of Members, available on the web and in print

• Free job postings on the Society Employment and Careers website

• Opportunities to request Travel Fellowship and Meeting Support for RNA-related meetings you are organizing.

Visit us at www.rnasociety.org and become a member of the RNA Society today!

The RNA Society, 9650 Rockville Pike, Bethesda, MD 20814-3998 USA

Phone: 301-634-7120 Fax: 301-634-7420

Email: rna@faseb.org

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To order or request additional information, please visit our Web site or:Call: 1-800-843-4388 (Continental US and Canada) 516-422-4100 (All other locations)FAX: 516-422-4097 E-mail: cshpress@cshl.eduWrite: Cold Spring Harbor Laboratory Press, 500 Sunnyside Blvd., Woodbury, NY 11797-2924

CONTENTS

PART 1: CHEMISTRY ANDGENETICS

1. The Mendelian View of the World2. Nucleic Acids Convey Genetic

Information3. The Importance of Weak Chemical

Interactions4. The Importance of High-Energy

Bonds5. Weak and Strong Bonds

Determine MacromolecularStructure

PART 2: MAINTENANCE OFTHE GENOME

6. The Structures of DNA and RNA

7. Genome Structure, Chromatin,and the Nucleosome

8. The Replication of DNA9. The Mutability and Repair of

DNA10. Homologous Recombination at the

Molecular Level11. Site-Specific Recombination and

Transposition of DNA

PART 3: EXPRESSION OF THEGENOME

12. Mechanisms of Transcription13. RNA Splicing14. Translation15. The Genetic Code

PART 4: REGULATION

16. Transcriptional Regulation inProkaryotes

17. Transcriptional Regulation inEukaryotes

18. Regulatory RNAs19. Gene Regulation in Development

and Evolution20. Genome Analysis and Systems

Biology

PART 5: METHODS

21. Techniques of Molecular Biology22. Model Organisms

INDEX

By James D. Watson, Cold Spring Harbor Laboratory, Tania A. Baker,Massachusetts Institute of Technology, Stephen P. Bell, Massachusetts Institute of

Technology, Alexander Gann, Cold Spring Harbor Laboratory, Michael Levine, University ofCalifornia, Berkeley, and Richard Losick, Harvard University

This sixth edition of James D. Watson’s classic textbook Molecular Biology of the Gene has beenthoroughly revised and updated. Accessible to anyone interested in molecular biology and genet-

ics, the book provides a historical basis for the field, concise descriptions of fundamental chemicalconcepts, a comprehensive survey of genome maintenance and expression, and a discussion of stan-dard techniques and model organisms commonly used in molecular biology studies. It includes allnew chapters on the regulatory RNAs and genomics and systems biology. The book has an accompa-nying Web site www.aw-bc.com, which contains interactive tutorials, animations, and critical-think-ing exercises designed to help students explore and visualize complex concepts.

2008, 841 pp., illus., indexHardcover $151 ISBN 978-080539592-1

This book is co-published with Benjamin Cummings. Requests for textbook examination copies, orders for course adoptions, and ALL individual orders outside of the U.S. should be sent to Benjamin Cummings at www.aw-bc.com.