desyncra for tinnitus - patient trifold
TRANSCRIPT
Neurons in the auditory cortex become hyperactive and synchronized while neighboring regions display sympathetic behavior. This synchronized state is perceived by patients as tinnitus.
CR® Neuromodulation disrupts and desynchronizes hyperactivity in the brain
The Desyncra™ for Tinnitus therapy applies CR® Neuromodulation technology to disrupt and “desynchronize” this pathological behavior in the brain.
Research has revealed how the hyperactivity behind tinnitus can be observed in the auditory cortex.
The auditory cortex is physically organized according to the pitch of sounds that it perceives, from low to high pitch.
The Desyncra™ proprietary pitchmatching procedure makes use of this to target the therapy to the hyperactive region in the auditory cortex.
The Scientific SoluTion
Beyond TinnitusCR® Neuromodulation therapy offers solutions beyond tinnitus to other neurological pathologies, including Parkinson’s disease, epilepsy and migraine.
Desyncra™ for Tinnitus offers a unique, scientific solution to tinnitus.
The mode of delivery is quite different for each of these neurological conditions. Yet in each case, the CR® Neuromodulation is designed to disrupt the synchronized activity and reduce the patient’s symptoms.
Research WorldwideDesyncra™ research is global, including at Stanford University, Veterans Affairs Portland, and centers in England and Germany.
Published clinical research involving hundreds of patients
Discover more at desyncra.comDesyncra™ Inc. 1137 Pearl St #201 Boulder,CO 80302 United States
Office: 720-389-0669 Toll Free: 844-444-2266
DesyncraTM for Tinnitus has FDA clearance and carries the CE Mark.
Targeting the TinnitusRecent developments in neuroscience have led to a clearer understanding of the neural activity behind tinnitus. 1
Synchronized Partially Synchronized DesynchronizedSynchronized Partially Synchronized Desynchronized
Primary Auditory Cortex
Secondary Auditory Cortex
Coresponds to apex of cochlea
0.51 2 4 8 16
Coresponds to base of cochlea
1. Tass et al. Restor Neurol Neurosci. 2012 TI16-0106_Letter_E16-00
Neurotherapy on an iPodThe Desyncra™ therapy is delivered using a customized iPod device with custom designed earphones. The thera-peutic tones are tailored to your exact tinnitus profile.
Noninvasive targeted therapy tailored to you
Comfortable and ConvenientThe therapeutic tones are quiet and yet audible, so you can continue with your everyday activities.
36 Week TherapyDesyncra™ for Tinnitus offers therapy over 36 weeks.
The therapy starts with an initial fitting appointment, and is followed by further visits at 3, 8, 12, 24 and 36 weeks.
Your audiologist will ensure that the therapeutic tones are continually optimized to the profile of your tinnitus.
Followup sessions ensure continually optimized treatment
Changed Neural BehaviorDesyncra™ for Tinnitus is designed to change the patterns in neural tinnitus networks.
Reduced tinnitus brain wave activity
Improved symptoms are reflected in EEG imaging, showing reduced delta wave activity across tinnitus neural networks.
Reduced Tinnitus SymptomsDesyncra™ for Tinnitus is a targeted therapy designed to change the patterns in your tinnitus neuronal networks and reduce the distressing symptoms, including loudness and annoyance.
Reduced loudness and annoyance
36 Weeks
A B B B B B
A B Follow-UpInitial Fitting
Duration 90 Minutes 60 Minutes
Loudness & Pitch Discrimination
Pitch Match & Programming
Diagnostic Questionnaires
Before After
Long Term ReliefTypically patients experience benefits within a few weeks of starting therapy. However, the benefits last beyond the 36 week therapy period. CR® Neuromodulation technology is applied to disrupt and “desynchronize” this pathological behavior in the brain.
Over 3,000 tinnitus patients treated
Reduced Loudness and Annoyance (VAS Scores)
Before Therapy 24 Weeks
80
70
60
50
40
30
20
n=66
62
46 46
68
Loudness Annoyance
Figure 1: Williams et al. Front Neurol. 2015
Figure 2: Adapted from Adamchic et al. Human Brain Mapping 2014