Demography and deleterious alleles in maize

Jeffrey Ross-Ibarra @jrossibarra • www.rilab.org

Dept. Plant Sciences • Center for Population Biology • Genome Center University of California Davis

photo by lady_lbrty

Burkhard Schulz

Arif Mümtaz

IAMDGC 2015

population genetics of deleterious alleles

Ne effective population size s selection coefficient

selection effective when 2Nes > 1

Lawrie and Petrov 2014

2Nes=0

2Nes=52Nes=100

population genetics of deleterious alleles

Ne effective population size s selection coefficient

selection effective when 2Nes > 1

genetic load: difference between fitness of optimal and averaged genotype

Lawrie and Petrov 2014

2Nes=0

2Nes=52Nes=100

population genetics of deleterious alleles

Ne effective population size s selection coefficient

selection effective when 2Nes > 1

increased load due to out-of-Africa bottleneckhe

tero

zygo

us p

er in

divi

dual

hom

ozyg

ous

deriv

ed p

er

indi

vidu

al

Lohmueller et al 2008

rela

tive

dive

rsity

(B)

distance (cM)

mutation distribution of

selective effects

distance from sitesum over all selected sites

⇡e

⇡0⇡ e

�P

x

R 10

u

x

f

x

(t)dt

t(1+(1�t)rx

/t)2

Nordborg 1996

Genome-wide diversity reduced by linked selection

purifying selection reduces diversity at linked sites

rela

tive

dive

rsity

(B)

distance (cM)

mutation distribution of

selective effects

distance from sitesum over all selected sites

⇡e

⇡0⇡ e

�P

x

R 10

u

x

f

x

(t)dt

t(1+(1�t)rx

/t)2

Nordborg 1996

How does demography affect the impact of selection on linked sites?

Genome-wide diversity reduced by linked selection

purifying selection reduces diversity at linked sites

Suketoshi Taba

high nucleotide diversity in maize

VS = 1.5-2%

high nucleotide diversity in maize

VS

Photo: Peter Yang

VS=

considerable segregating genetic load

Jones 1924 Darwin 1876

maizeteosinte

Photos: Matt Hufford, Brandon Gaut, John Doebley

how has the demography of domestication changed the impacts of selection against deleterious alleles?

13 teosinte

23 landrace maizeChia et al. 2012

Maize HapMap2

teosintelandrace

Tim Beissinger USDA-ARS (U. Missouri) beissingerlab.org ANGSD: Korneliussen et al 2014

•3-5X sequencing depth •allele frequencies, diversity from genotype-likelihoods

genic nongenic genic nongenicpairw

ise n

ucle

otid

e di

vers

itymaize teosinte

diversity suggests selection and demography

Tim Beissinger USDA-ARS (U. Missouri) beissingerlab.org ANGSD: Korneliussen et al 2014

•3-5X sequencing depth •allele frequencies, diversity from genotype-likelihoods

genic nongenic genic nongenicpairw

ise n

ucle

otid

e di

vers

ity

Tajima’s D Tajima’s D

dens

itymaize teosinte

diversity suggests selection and demography

nucl

eotid

e di

vers

ity

distance to nearest substitution (cM)

classic hard sweeps rare in maize

classic hard sweeps rare in maize

Sattah et al. 2011

maize

classic hard sweeps rare in maize

maize

classic hard sweeps rare in maize

teosinte

purifying selection removing diversity in genes

purifying selection removing diversity in genes

teos

inte

maize

DATA

teos

inte

maize

MODEL

domestication: bottleneck and expansion

dadi: Gutenkunst 2009

teos

inte

maize

DATA

teos

inte

maize

MODEL

domestication: bottleneck and expansion

dadi: Gutenkunst 2009

0.05Na

Na

Na 3Na

teosinte maize

pairwise diversity reflects long-term Ne

pairwise diversity reflects long-term Ne

⇡ =X

ij

xixj⇡ij

⇡1 > ⇡2

Ne ~ 150,000 Ne ~ 50,000

pairwise diversity reflects long-term Ne

teosinte maize

0.05Na

Na

Na 3Nadadi diffusion:Ne ~ 450,000

model underestimates expansion

0.05Na

Na

Na 3Nadadi diffusion:Ne ~ 450,000

SeeDs singletons:Ne ~ 1,000,000

model underestimates expansion

0.05Na

Na

Na 3Nadadi diffusion:Ne ~ 450,000

SeeDs singletons:Ne ~ 1,000,000

1e+05

1e+07

1e+09

1e+03 1e+042e+04 1e+05years(u=3e−8, generation=1)

effe

ctive

pop

ulat

ion

size

popBKN_4HapBKN_6HapTIL_4Hap_JaliscoTIL_6Hap

MSMC coalescent:Ne ~ 1,000,000,000

model underestimates expansion

0.05Na

Na

Na 3Nadadi diffusion:Ne ~ 450,000

SeeDs singletons:Ne ~ 1,000,000

1e+05

1e+07

1e+09

1e+03 1e+042e+04 1e+05years(u=3e−8, generation=1)

effe

ctive

pop

ulat

ion

size

popBKN_4HapBKN_6HapTIL_4Hap_JaliscoTIL_6Hap

MSMC coalescent:Ne ~ 1,000,000,000

49M hectares:Ne ~ 5,000,000,000

model underestimates expansion

rapid growth changes linked selection

nucl

eotid

e di

vers

ity

distance to gene (cM)

rapid growth changes linked selection

sing

leto

n di

vers

ity

distance to gene (cM)

simulations find effect for s (1/2Nteo)

singletonspairwise diversity

simulations find effect for s (1/2Nteo)

bottleneck reduced neutral diversity

singletonspairwise diversity

simulations find effect for s (1/2Nteo)no change 2Ns 1

singletonspairwise diversity

simulations find effect for s (1/2Nteo)

singletons show reduced diversity

2Ns 10

singletonspairwise diversity

simulations find effect for s (1/2Nteo)

2Ns >>1 in both

singletonspairwise diversity

simulations find effect for s (1/2Nteo)

2Ns >>1 in both

singletonspairwise diversity

patterns of linked selection affected by both long-term and recent demographic change

Mexico lowland

9,000 BP

Matsuoka et al. 2002; Piperno 2006 Perry et al. 2006; Piperno et al. 2009

geographic spread post-domestication

Mexico highland6,000 BP

Mexico lowland

9,000 BP

Matsuoka et al. 2002; Piperno 2006 Perry et al. 2006; Piperno et al. 2009

geographic spread post-domestication

Mexico highland6,000 BP

S. America lowland

6,000 BP

Mexico lowland

9,000 BP

Matsuoka et al. 2002; Piperno 2006 Perry et al. 2006; Piperno et al. 2009

geographic spread post-domestication

Mexico highland6,000 BP

S. America lowland

6,000 BP

S. America Highland

4,000 BP

Mexico lowland

9,000 BP

Matsuoka et al. 2002; Piperno 2006 Perry et al. 2006; Piperno et al. 2009

geographic spread post-domestication

Mexico highland6,000 BP

S. America lowland

6,000 BP

S. America Highland

4,000 BP

Mexico lowland

9,000 BP

SeeD 1M SNPs

4K samples

●

●

y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 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⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 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x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 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x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23y = 0.039 − 8.8e−07 ⋅ x, R = 0.23

0.00

0.02

0.04

0.06

0 2000 4000 6000 8000geographical distance to Balsas Valley (km)

perc

enta

ge o

f pol

ymor

phic

site

s

elevation100020003000

region●

●

●

Central AmericaMexicoSouth America

Sarah Hearne, CIMMYT

repeated colonization decreases Ne

distance from origin

hete

rozy

gosit

y

Mexico highland6,000 BP

S. America lowland

6,000 BP

S. America Highland

4,000 BP

Mexico lowland

9,000 BP

SeeD 1M SNPs

4K samples

repeated colonization decreases Ne

Takuno et al. 2015

Mexico Lowland

Mexico Highland

NA

NB

NC

N1 N2

N2P

tD tE

tF

NA

NB

NC

N1 N2

N2P

tD tE

tF

tmex

Nmex

NA

NB

NC

N1 N2

tD tE

tF

N3 N4

NC �ĮNA

N1 �ȕNC

N2 ����ȕ�NC

N2P� �ȖN2

NC �ĮNA

N1 �ȕNC

N2 ����ȕ�NC

N2P� �ȖN2

NC �ĮNA

N1 �ȕ1NC

N2 ����ȕ1�NC

N3 �ȕ2N2

N4 ����ȕ2�N2

N4P �ȖN4

tG

N4P Lowland Highland mexicana Mexico

Lowland SA

Lowland SA

Highland

Model IA Model IB Model II

Figure 2 Demographic models of maize low- and high-land populations. Parameters in bold were estimated inthis study. See text for details.

A HWE cut-off of P < 0.005 was used for each subpopu-lation due to our under-calling of heterozygotes. In total, weincluded 18,745 silent SNPs for the Mexican populations inModels IA and IB, 14,508 for the S. American populations inModel I and 11,305 for the Mexican lowland population andthe S. American populations in Model II. We obtained similarresults under more or less stringent thresholds for significance(P < 0.05 ⇠ 0.0005; data not shown), though the number ofSNPs was very small at P < 0.005. Demographic parameterswere inferred with the software �a�i (Gutenkunst et al. 2009),which uses a diffusion method to calculate an expected JFDand evaluates the likelihood of the data using a multinomialassumption.Model IA: This model is applied to the Mexican and S. Amer-ican populations. We assume the ancestral diploid popula-tion representing parviglumis follows a standard Wright-Fishermodel with constant size. The size of the ancestral popula-tion is denoted by NA. At tD generations ago, the bottleneckevent begins at domestication, and at tE generations ago, thebottleneck ends. The population size and duration of the bot-tleneck are denoted by NB and tB = tD � tE , respectively.The population size recovers to NC = ↵NA in the lowlands.Then, the highland population is differentiated from the low-land population at tF generations ago. The size of the low- andhighland populations at time tF is determined by a parameter� such that the population is divided by �NC and (1� �)NC .We assume that the population size in the lowlands is constantbut that the highland population experiences exponential ex-pansion after divergence: its current population size is � timeslarger than that at tF .isn’t this really a shrinking population in the lowlands, since �NC < NC ? wouldn’t

we want instead for lowlands to stay at NC and a new population branching off? how

much do we worry about this? actually, our conclusion holds when Iassumed the pop size of lowlands stays at NC . However, the

likelihood is a bit better in my original model.Model IB: We expand Model IA for the Mexican populationsby incorporating admixture from the teosinte mexicana to thehighland Mexican maize population. do we say ”Mexico population” or

”Mexican” (and thus ”South American”) ”population” throughout? as long as we’re

consistent probably OK either way. vote to Mexican population second

The time of differentiation between parviglumis and mexicanaoccurs at tmex generations ago. The mexicana population sizeis assumed to be constant at Nmex. At tF generations ago,the Mexican highland population is derived from admixturebetween the Mexican lowland population and a portion Pmex

from the teosinte mexicana .

Model II: The final model is for the Mexican lowland, S.American lowland and highland populations. This modelwas used for simulating SNPs with ascertainment bias (seebelow). At time tF , the Mexican and S. American lowlandpopulations are differentiated, and the sizes of populationsafter splitting are determined by �1. At time tG, S. Amer-ican lowland and highland populations are differentiated,and the sizes of populations at this time are determined by�2. As in Model IA, the S. American highland population isassumed to experience population growth with the parameter �.

Estimates of a number of our model parameters were avail-able from previous work. NA was set to 150,000 using esti-mates of the composite parameter 4NAµ ⇠ 0.018 from parvig-lumis (Eyre-Walker et al. 1998; Tenaillon et al. 2001, 2004;Wright et al. 2005; Ross-Ibarra et al. 2009) and an estimateof the mutation rate µ ⇠ 3 ⇥ 10

�8 (Clark et al. 2005) persite per generation. The severity of the domestication bottle-neck is represented by k = NB/tB (Eyre-Walker et al. 1998;Wright et al. 2005), and following Wright et al. (2005) we as-sumed k = 2.45 and tB = 1, 000 generations. Taking intoaccount archaeological evidence (Piperno et al. 2009), we as-sume tD = 9, 000 and tE = 8, 000. We further assumedtF = 6, 000 for Mexican populations in Models IA and IB(Piperno 2006), tF = 4, 000 for S. American populationsin Model lA (Perry et al. 2006; Grobman et al. 2012), andtmex = 60, 000, Nmex = 160, 000 (Ross-Ibarra et al. 2009),and Pmex = 0.2 (van Heerwaarden et al. 2011) for ModelIB. For both Models IA and IB, we inferred three parameters(↵, � and �), and, for Model II, we fixed tF = 6, 000 andtG = 4, 000 (Piperno 2006; Perry et al. 2006; Grobman et al.2012) and estimated the remaining four parameters (↵, �1, �2

and �).tF for model II is listed as 4,000 and 6,000 above. 6,000 is the number that matches

the lit best. is that what was used? if so, we should cite (Grobman et al. 2012) fixed

Differentiation between low- and highland popula-tions

We used our inferred demographic model to generate a nulldistribution of FST . As implemented in �a�i (Gutenkunst

4

Table 2 Inference of demographic parameters

Mexico Model I Model II

Likelihood �5592.80 Likelihood �4654.79

↵ 0.92 ↵ 1.5

� 0.38 � 0.76

� 1 � 1

South America Model I Model III

Likelihood �3855.28 Likelihood �8044.71

↵ 0.52 ↵ 1.0

� 0.97 �1 0.64

� 88 �2 0.95

� 54

Population structure

We performed a STRUCTURE analysis (Pritchard et al. 2000;Falush et al. 2003) of our landrace sample, varying the numberof groups from K = 2 to 6 (Figure 1, Figure S3). Most lan-draces were assigned to groups consistent with a priori popu-lation definitions, but admixture between highland and lowlandpopulations was evident at intermediate elevations (⇠ 1700m).Consistent with previously described scenarios for maize dif-fusion (Piperno 2006), we find evidence of shared ancestrybetween lowland Mexican maize and both Mexican highlandand S. American lowland populations. Pairwise FST amongpopulations reveals low overall differentiation (Table 1), andthe higher FST values observed in S. America are consistentwith decreased admixture seen in STRUCTURE. Archaeolog-ical evidence supports a more recent colonization of the high-lands in S. America (Piperno 2006; Perry et al. 2006; Grobmanet al. 2012), suggesting that the observed differentiation maybe the result of a stronger bottleneck during colonization of theS. American highlands.

Population differentiation under inferred demogra-phy

To provide a null expectation for allele frequency differentia-tion, we used the joint site frequency distribution (JFD) of low-land and highland populations to estimate parameters of twodemographic models using the maximum likelihood methodimplemented in �a�i (Gutenkunst et al. 2009). All models in-corporate a domestication bottleneck (Wright et al. 2005) andpopulation differentiation between lowland and highland popu-lations, but differ in their consideration of admixture and ascer-tainment bias (Figure 2; see Materials and Methods for details).

Estimated parameter values are listed in Table 2; while theobserved and expected JFDs were quite similar for both mod-els, residuals indicated an excess of rare variants in the ob-served JFDs in all cases (Figure 3). Under both models IA and

A

B

Lowlands

Hig

hlan

ds

Observation Expectation ResidualMexico

South America

40

–40

0

Model IA

Model IB

Density

Residual

10–4

0

10–310–210–1

Lowlands

Hig

hlan

ds

Observation Expectation Residual

40

–40

0

Model IA

Model II

Density

Residual

10–4

0

10–310–210–1

Figure 3 Observed and expected joint distributions of mi-nor allele frequencies in low- and highland populations in(A) Mexico and (B) S. America. Residuals are calculatedas (model � data)/

pmodel

IB, we found expansion in the highland population in Mexicoto be unlikely, but a strong bottleneck followed by populationexpansion is supported in S. American maize in both modelsIA and II. The likelihood value of model IB was higher thanthe likelihood of model IA by 850 units of log-likelihood (Ta-ble 2), consistent with analyses suggesting that introgressionfrom mexicana played a significant role during the spread ofmaize into the Mexican highlands (Hufford et al. 2013).

In addition to the parameters listed in Figure 2, we investi-gated the impact of varying the domestication bottleneck size(NB). Surprisingly, NB was estimated to be equal to NC , thepopulation size at the end of the bottleneck, and the likelihoodof NB < NC was much smaller than for alternative parame-terizations (Table 2, S2). This result appears to contradict ear-

7

Table 2 Inference of demographic parameters

Mexico Model I Model II

Likelihood �5592.80 Likelihood �4654.79

↵ 0.92 ↵ 1.5

� 0.38 � 0.76

� 1 � 1

South America Model I Model III

Likelihood �3855.28 Likelihood �8044.71

↵ 0.52 ↵ 1.0

� 0.97 �1 0.64

� 88 �2 0.95

� 54

Population structure

We performed a STRUCTURE analysis (Pritchard et al. 2000;Falush et al. 2003) of our landrace sample, varying the numberof groups from K = 2 to 6 (Figure 1, Figure S3). Most lan-draces were assigned to groups consistent with a priori popu-lation definitions, but admixture between highland and lowlandpopulations was evident at intermediate elevations (⇠ 1700m).Consistent with previously described scenarios for maize dif-fusion (Piperno 2006), we find evidence of shared ancestrybetween lowland Mexican maize and both Mexican highlandand S. American lowland populations. Pairwise FST amongpopulations reveals low overall differentiation (Table 1), andthe higher FST values observed in S. America are consistentwith decreased admixture seen in STRUCTURE. Archaeolog-ical evidence supports a more recent colonization of the high-lands in S. America (Piperno 2006; Perry et al. 2006; Grobmanet al. 2012), suggesting that the observed differentiation maybe the result of a stronger bottleneck during colonization of theS. American highlands.

Population differentiation under inferred demogra-phy

To provide a null expectation for allele frequency differentia-tion, we used the joint site frequency distribution (JFD) of low-land and highland populations to estimate parameters of twodemographic models using the maximum likelihood methodimplemented in �a�i (Gutenkunst et al. 2009). All models in-corporate a domestication bottleneck (Wright et al. 2005) andpopulation differentiation between lowland and highland popu-lations, but differ in their consideration of admixture and ascer-tainment bias (Figure 2; see Materials and Methods for details).

Estimated parameter values are listed in Table 2; while theobserved and expected JFDs were quite similar for both mod-els, residuals indicated an excess of rare variants in the ob-served JFDs in all cases (Figure 3). Under both models IA and

A

B

Lowlands

Hig

hlan

ds

Observation Expectation ResidualMexico

South America

40

–40

0

Model IA

Model IB

Density

Residual

10–4

0

10–310–210–1

LowlandsH

ighl

ands

Observation Expectation Residual

40

–40

0

Model IA

Model II

Density

Residual

10–4

0

10–310–210–1

Figure 3 Observed and expected joint distributions of mi-nor allele frequencies in low- and highland populations in(A) Mexico and (B) S. America. Residuals are calculatedas (model � data)/

pmodel

IB, we found expansion in the highland population in Mexicoto be unlikely, but a strong bottleneck followed by populationexpansion is supported in S. American maize in both modelsIA and II. The likelihood value of model IB was higher thanthe likelihood of model IA by 850 units of log-likelihood (Ta-ble 2), consistent with analyses suggesting that introgressionfrom mexicana played a significant role during the spread ofmaize into the Mexican highlands (Hufford et al. 2013).

In addition to the parameters listed in Figure 2, we investi-gated the impact of varying the domestication bottleneck size(NB). Surprisingly, NB was estimated to be equal to NC , thepopulation size at the end of the bottleneck, and the likelihoodof NB < NC was much smaller than for alternative parame-terizations (Table 2, S2). This result appears to contradict ear-

7

lowlands

high

land

s

landrace genomes to test colonization and genetic load●

●●●●●

●●

●

●

●●●

●●●●● ●

●

●●

●

●

●

●

●

●

●

●

●

−10

0

10

20

30

−110 −100 −90 −80 −70longitude

latit

ude

population●

●

●

●

●

●

AndesGua_HighlandMex_HighlandMex_LowlandSA_LowlandSW_US

distribution of samples

32 genomes, 20X coverage

Li Wang, Iowa State

phylogenetic conservation identifies deleterious alleles

GERP = neutral - observed substitution rate

Davydov et al., 2010; Rodgers-Melnick et al., 2015

phylogenetic conservation identifies deleterious alleles

GERP = neutral - observed substitution rate

Davydov et al., 2010; Rodgers-Melnick et al., 2015

GERP≤0 mutation neutral

phylogenetic conservation identifies deleterious alleles

GERP = neutral - observed substitution rate

Davydov et al., 2010; Rodgers-Melnick et al., 2015

GERP≤0 mutation neutral

GERP>0 mutation deleterious

GERP consistent with population genetic predictions of deleterious alleles

r = -0.8, P value < 0.01

Allele Frequency Recombination Quantiles

GER

P

GER

P

● ●

75000

100000

125000

150000

175000

Andes SA_Low MexHigh MexLow SW_US GuaHigh

sum

leng

th o

f RO

Hs(

kb)

popAndesGua_HighlandMex_HighlandMex_LowlandSA_LowlandSW_US

●

●

●

●

190000

210000

230000

Andes SA_Low MexHigh MexLow SW_US GuaHigh

load

popAndesGua_HighlandMex_HighlandMex_LowlandSA_LowlandSW_US

gene

tic lo

ad (

GER

P)

runs

of h

omoz

ygos

ityrecently bottlenecked Andean populations

show increased load

●

●

●

●

190000

210000

230000

Andes SA_Low MexHigh MexLow SW_US GuaHigh

load

popAndesGua_HighlandMex_HighlandMex_LowlandSA_LowlandSW_US

Piperno 2006; Perry et al. 2006; Piperno et al. 2009

domestication in Mexico lowland

9,000 BP

highland colonization led to mexicana sympatry

Piperno 2006; Perry et al. 2006; Piperno et al. 2009

Mexico highland6,000 BP

domestication in Mexico lowland

9,000 BP

PhotobyPesachLubinsky

mexicanamaize

highland colonization led to mexicana sympatry

introgressed teosinte haplotypes have lower load

Hufford et al. 2013

% in

trogr

esse

d

chromosome position (Mb)

introgressed teosinte haplotypes have lower load

Introgressed Not introgressed

% S

NPs

with

GER

P>0

Hufford et al. 2013

% in

trogr

esse

d

chromosome position (Mb)

maize demography similar to other systems

Henn 2015

maize demography similar to other systems

Henn 2015 Marsden 2016

heterosis drives change in fitness (yield) in maize

Springer and Stupar 2007 Crow 1998

P1 P2F1

Photo: Peter Yang

East 1936; Shull 1948

Dominant Model

East 1936; Shull 1948

Dominant Model Overdominant Model

Crow 1948; Gowen 1952

East 1936; Shull 1948

Dominant Model Overdominant Model

Crow 1948; Gowen 1952

Crow 1998 Charlesworth and Willis 2009

33

Krieger et al, 2010 Yao et al 2013

evidence inconsistent with simple dominance

photo: Jim Birchler

experimentally evaluate heterosis

3 years, 7 phenotypes + BPH

Better-Parental Heterosis (BPH)

12 inbred lines: 66 hybrids

Rita Mumm U Illinois

Jinliang Yang UC Davis

yangjl.com

whole-genome resequencing: 13.8M SNPs 500K SNPs at sites with GERP > 0

phenotypes and sequence

Yield

HeightFlowering

Time

whole-genome resequencing: 13.8M SNPs 500K SNPs at sites with GERP > 0

phenotypes and sequence

GBLUP estimate additive and dominance effects of GERP SNPs

additive effect of jth SNP

0-1-2 coding of genotype

0-1-0 coding of genotype

dominance effect of jth SNP

BLUE value of the ith hybrid

GERP score correlates with effect size for fitness-related traits

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

β!=0β=0

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

Fl. Time

Height

Yield

GERP score GERP score

Add

itive

effe

ct

Dom

inan

t effe

ct

deleterious SNPs are more recessive for fitness

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

eβ!=0β=0

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

Fl. Time

Height

Yield

Dom

inan

ce (

k) o

f be

nefic

ial a

llele

GERP score

deleterious SNPs are more recessive for fitness

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

eβ!=0β=0

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

Fl. Time

Height

Yield

Dom

inan

ce (

k) o

f be

nefic

ial a

llele

GERP score

Phadnis and Fry 2005

but larger-effect loci do not contribute more to phenotypic variance0.

010.

020.

03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

β!=0β=0

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Effe

ct3e−0

64e−0

65e−0

66e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Addi

tive

Varia

nce

0.00

0.01

0.02

0.03

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Effe

ct0e

+00

5e−0

71e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Dom

inan

t Var

ianc

e

0.0

0.1

0.2

0.3

0.4

0.0 0.5 1.0 1.5 2.0GERP Score

Deg

ree

of D

omia

nce

(k)

4.5e−0

65.

0e−0

65.

5e−0

66.

0e−0

6

0.0 0.5 1.0 1.5 2.0GERP Score

Tota

l Var

ianc

e

Fl. Time

Height

YieldD

omin

ance

Var

Tota

l Var

Add

itive

Var

GERP scoreGERP scoreGERP score

increasing heterosis

Height Yield

dominant

additive

recessive

Flow. Time

incomplete dominance important for fitness, heterosis

genomic prediction to test dominance models

genomic prediction to test dominance models

BLUE value of the ith hybrid regression

coefficient for jth haplotype

block

weighted GERP scores under 3

models

Heterosis (BPH)Trait per se

Height Yield

Heterosis increasing

Flowering Time Height Yield

Heterosis increasing

Flowering Time

Incomplete Dominance

Complete Dominance

Additive

incomplete dominance explains more variance

5-fold cross-validation improves prediction by

build model

5-fold cross-validation improves prediction by

build model

predict

5-fold cross-validation improves prediction by

*

** *

Height Yield

Heterosis increasing

Flowering Time

Heterosis (BPH)Trait per se

Height Yield

Heterosis increasing

Flowering Time

observed shuffled

concluding thoughts on deleterious alleles

• demographic change impacts purifying selection and effects on diversity at linked sites

• demographic impacts differ for alleles of different freqs

• deleterious alleles contribute substantially to phenotypic variation

• a simple incomplete dominance model can largely explain observed patterns of heterosis

Acknowledgments

Maize Diversity Group Peter Bradbury

Ed Buckler John Doebley Theresa Fulton

Sherry Flint-Garcia Jim Holland

Sharon Mitchell Qi Sun

Doreen Ware

Collaborators Matt Hufford (Iowa State)

Li Wang (Iowa State) Rita Mumm (U Illinois)

Ross-Ibarra Lab Tim Beissinger (USDA-ARS, MU)

Kate Crosby (Monsanto) Arun Durvasula (Vienna Biocenter)

Jinliang Yang (←hire this guy!) Sofiane Mezmouk (KWS)

removing hard/soft sweeps

Title Text Title Text

top 10% and bottom 10% quantile mean GERP scores

hard sweep at tga1

sing

leto

n di

vers

ity

distance to nearest substitution (cM)

singletons still show now effect of hard sweeps

Title Text Title Text

1e+05

1e+07

1e+09

100 1000 10000years

effe

ctive

pop

ulat

ion

size

MSMC results support model

non equilibrium dynamics in teosinte, still different from maize

non equilibrium dynamics in teosinte, still different from maize

Sattah et al. 2011 PLoS Gen. Williamson et al. 2014 PLoS Gen Hernandez et al. 2011 Science

Sattah et al. 2011 PLoS Gen. Williamson et al. 2014 PLoS Gen Hernandez et al. 2011 Science

Sattah et al. 2011 PLoS Gen. Williamson et al. 2014 PLoS Gen Hernandez et al. 2011 Science

dive

rsity

Ne diploids

s selection coefficient

selection is effective if 2Nes > 1

Ne diploids

s selection coefficient

selection is effective if 2Nes > 1

Ne ~ 150,000 Ne ~ 10,000

Ne ~ 2,000,000 Ne ~ 600,000

Ne diploids

s selection coefficient

selection is effective if 2Nes > 1

Ne ~ 150,000 Ne ~ 10,000

Ne ~ 2,000,000 Ne ~ 600,000

20% nonsyn. subs 10% nonsyn. subs

50% nonsyn. subs 40% nonsyn. subs