Data, Outcomes, and Evidence: Data Science in The Life Cycle of Evidence Based Medicine

Johannes Starlinger

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 2

Important notice: Several slides contained in the original, oral

presentation which showed copyrighted material and/or unpublished results have

been redacted/removed.

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 3

About me

Studied Medicine

Studied Computer

Science

PhD Computer

Science

Biomedical Data

Researcher

Clinical Data

Researcher

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 4

About me

Studied Medicine

Studied Computer

Science

PhD Computer

Science

[Health]Data

Software

Freelance

[Health]Data

Software

Biomedical Data

Researcher

Clinical Data

Researcher

Start-up

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 5

About me

Studied Medicine

Studied Computer

Science

PhD Computer

Science

[Health]Data

Software

Freelance

[Health]Data

Software

Biomedical Data

Researcher

Clinical Data

Researcher

Start-up

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 6

The Life Cycle of Evidence Based Medicine

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 7

The Life Cycle of Evidence Based Medicine

Assessment SOPs Care Planning Care Pathways Outcomes

Observations

New Evidence Clinical Studies Hypothesis Geneartion Outcome Analysis

Summarization Synthesis of Recommendations COI Assessment Consensus Process Evidence Rating Evidence Review

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Approval Storage Versioning Archival Indexing Publication Searchability

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 8

The Life Cycle of Evidence Based Medicine

Assessment SOPs Care Planning Care Pathways Outcomes

Observations

New Evidence Clinical Studies Hypothesis Geneartion Outcome Analysis

Summarization Synthesis of Recommendations COI Assessment Consensus Process Evidence Rating Evidence Review

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Approval Storage Versioning Archival Indexing Publication Searchability

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 9

The Life Cycle of Evidence Based Medicine

Assessment SOPs Care Planning Care Pathways Outcomes

Observations

New Evidence Clinical Studies Hypothesis Geneartion Outcome Analysis

Summarization Synthesis of Recommendations COI Assessment Consensus Process Evidence Rating Evidence Review

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Approval Storage Versioning Archival Indexing Publication Searchability

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 10

The Life Cycle of Evidence Based Medicine

Assessment SOPs Care Planning Care Pathways Outcomes

Observations

New Evidence Clinical Studies Hypothesis Geneartion Outcome Analysis

Summarization Synthesis of Recommendations COI Assessment Consensus Process Evidence Rating Evidence Review

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

`

Approval Storage Versioning Archival Indexing Publication Searchability

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 11

The Life Cycle of Evidence Based Medicine

Assessment SOPs Care Planning Care Pathways Outcomes

Observations

New Evidence Clinical Studies Hypothesis Geneartion Outcome Analysis

Summarization Synthesis of Recommendations COI Assessment Consensus Process Evidence Rating Evidence Review

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

`

Approval Storage Versioning Archival Indexing Publication Searchability

Clinical Practice

Guidelines

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 12

The Life Cycle of Evidence Based Medicine

Assessment SOPs Care Planning Care Pathways Outcomes

Observations

Approval Storage Versioning Archival Indexing Publication Searchability

New Evidence Clinical Studies Hypothesis Geneartion Outcome Analysis

Summarization Synthesis of Recommendations COI Assessment Consensus Process Evidence Rating Evidence Review

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

`

Clinical Practice

Guidelines

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 13

The Life Cycle of Evidence Based Medicine

Assessment SOPs Care Planning Care Pathways Outcomes

Observations

Approval Storage Versioning Archival Indexing Publication Searchability

New Evidence Clinical Studies Hypothesis Geneartion Outcome Analysis

Summarization Synthesis of Recommendations COI Assessment Consensus Process Evidence Rating Evidence Review

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Clinical Practice

Guidelines

`

Data Science?

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 14

The Life Cycle of Evidence Based Medicine

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

`

Clinical Practice

Guidelines

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 15

The Life Cycle of Evidence Based Medicine

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

`

Future

Clinical Practice

Guidelines

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 16

The Life Cycle of Evidence Based Medicine

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Clinical Practice

Guidelines

`

Data

Future

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 17

The Life Cycle of Evidence Based Medicine

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Clinical Practice

Guidelines

`

Data

Future

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 18

The Life Cycle of Evidence Based Medicine

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Clinical Practice

Guidelines

`

Data

Future

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 19

The Life Cycle of Evidence Based Medicine

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Clinical Practice

Guidelines

`

Data

Future

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 20

The Life Cycle of Evidence Based Medicine

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Clinical Practice

Guidelines

`

Data

Future

DataScience!

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 21

The Life Cycle of Evidence Based Medicine

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Clinical Practice

Guidelines

`

Data

Future

Data

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 22

Weber et al. Finding the Missing Link for Big Biomedical Data, JAMA June 25, 2014, Volume 311, Number 24, pp. 2479

About the patient

Graphic and commentary removed, please refer to

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 23

Evidence Personalized Based Medicine

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 24

Evidence Personalized Based Medicine

Co

ho

rt S

ize

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Evidence Personalized Based Medicine

Co

ho

rt S

ize

Number of Features

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 26

Evidence Personalized Based Medicine

Co

ho

rt S

ize

Number of Features

DataScience!

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 27

Unpublished example removed

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 28

Evidence Personalized Based Medicine

Co

ho

rt S

ize

Number of Features

DataScience!

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 29

Evidence Personalized Based Medicine

Co

ho

rt S

ize

Number of Features

DataScience!

DataScience!

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 30

Evidence Personalized Based Medicine

Co

ho

rt S

ize

Number of Features

DataScience!

DataScience!

DataScience!

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 31

Unpublished example removed

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 32

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Clinical Practice

Guidelines

`

Data

DataScience!

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 33

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Clinical Practice

Guidelines

`

Data

DataScience!

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 34

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Clinical Practice

Guidelines

`

Data

DataScience!

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 35

Analysis

Intensive Care

Anesthesia

Routine Care

Notes, letters, reports

DataScience!

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 36

Plotting

Analysis

Intensive Care

Anesthesia

Routine Care

Prep

Notes, letters, reports

DataScience!

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 37

Plotting

Analysis

Intensive Care

Anesthesia

Routine Care

Prep

Notes, letters, reports

Created by Freepik

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 38

Plotting

Analysis

Intensive Care

Anesthesia

Routine Care

Prep

Notes, letters, reports

Created by Freepik

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 39

Plotting

Analysis

`

Intensive Care

Anesthesia

Routine Care

Prep

Notes, letters, reports

OutcomesResearch

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Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Clinical Practice

Guidelines

`

Data

DataScience!

Johannes Starlinger – Data Science in the Life Cycle of Evidence Based Medicine – 2019 41

Synth

esis

Managem

ent

Im

plem

enta

tion

Evaluation

Clinical Practice

Guidelines

`

Data

DataScience!