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MIRACUM Consortium: Medical Informatics in Research and Care in University Medicinefirst results and outlook

Dr. Tim HerrmannInstitute for Biometrics and Medical Informatics OVG University MagdeburgData Integration Center Magdeburg

19.11.2019 MEDICA 2019

Medical Health IT Forum

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Greifswald

Dresden

MII Consortia & Coverage of the MIRACUM consortium

Image source: http://www.medizininformatik-initiative.de/en/node/5

http://www.medizininformatik-initiative.de/en/node/5

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MIRACUM Data Integration Center Reference-Architecture & Data Flow

Federation

Consent-Management

Local ID-Manage-

ment

ID-/Consent-Management

Sourcesystem 1

Comm-Server

Sourcesystem 2

Clinicaldata

repository

Routinebusiness

intelligence

Clinical Module

ClinicalDecisionSupport

Enrichment

Researchqueries

Research datalongtermarchive

Research Module

Researchdata

repository

Harmoni-zation

Researchqueries

ProjectTracking

TrialRegistry

Authenti-cation

Vocabulary MDR Mapping

Harmoni-zation

NLPPheno-typing

Enrichment

MIRACOLIX

Medical Informatics ReusAble eCo-system of Open source Linkable and Interoperable software tools – X

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R-ScriptSQL-

Statement

„Bring the analysis to the data“

Federated MIRACUM DIC architecture:

MIRACUM Structure

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R-ScriptSQL-

Statement

„Bring the analysis to the data“

SQL / R

SQL / R

SQL / R

SQL / R

SQL / R

SQL / R

SQL / R

SQL / R

OMOP OMOPOMOPOMOP

OMOP OMOPOMOP OMOP

MIRACUM Structure

Federated MIRACUM DIC architecture:

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R-ScriptSQL-

Statement

„Bring the analysis to the data“

SQL / R

SQL / R

SQL / R

SQL / R

SQL / R

SQL / R

SQL / R

SQL / R

OMOP OMOPOMOPOMOP

OMOP OMOPOMOP OMOP

aggregated results

First clinical analysis:

• Stroke / ThrombectomyAnalysis of the guideline adherence

• Colorectal cancerAnalysis of therapy patterns

• MII demonstrator studiesRare diseases and comorbidities

Federated MIRACUM DIC architecture:

MIRACUM Structure

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MIRACUM Use Cases

Patient Recruitmentfor Clinical Trials

Predictive Toolfor Asthma/COPD

andNeurooncology

MolecularTumor Board

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Laboratory Medicine in MIRACUM

Provision of uniform and cross-location laboratory parameters for research questions (studies, etc.)

Basis: Logical Observation Identifiers Names and Codes (LOINC)

LOINC solves problem of proprietary codes of the laboratory instrument manufacturers and local configurations

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Top-300 LOINC-listed laboratory results

Laboratory Medicine in MIRACUM

Stakeholder TOP-300:

• Andreas Bietenbeck

• Michael Neumaier

• Thomas Ganslandt

• Sebastian C. Semler

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MIRACUM aim 2020: Workflow support for research projects• Metadaten / Datamap: Überblick über verfügbare Daten

MIRACUM Research PortalPreview of the first data treasures ...

MIRACUM Research Portal Content

Research Portal

Register Data Map Feasibility

Machine Learning

MetadataRepository

ProjectProposal

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• Metadaten / Datamap: Überblick über verfügbare Daten

MIRACUM Research Portal Content

Research Portal

Register Data Map Feasibility

MachineLearning

MetadataRepository

ProjectProposal

11MIRACUM Research Portal Content

Connected University Hospitals:10Patients:3.034.243

- incl. Biomaterial 18.012- incl. Images 25.143- consented Data Use 0- consented Biomaterial Use 0

Encounters: 9.124.543Diagnosis:35.321.765

*the above mentioned numbers are fictive values

Research Portal

MIRACUM aim 2020: Workflow support for research projects

MIRACUM Research PortalPreview of the first data treasures ...

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Thank you for attention