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July 27, 2007

CURRICULUM VITAE

Richard Mayeux, MD, MSc Gertrude H. Sergievsky Professor of Neurology, Psychiatry and Epidemiology

Work Address: 630 West 168th Street New York, NY 10032 rpm2@columbia.edu Personal Data Date and Place of Birth: May 3, 1946, New Orleans, Louisiana Married: October 16, 1988 to Nancy S. Green, MD, 2 daughters, Naomi Beth and Sophie Ester Education: 1964 - 1968 Bachelor of Science, Mammalian Physiology, Oklahoma State University 1968 - 1972 Medical Doctor, Oklahoma University School of Medicine 1986 - 1991 Masters of Science in Epidemiology, Columbia University School of Public Health Post Graduate Training: 1972 - 1974 Internship & Residency: Boston City Hospital, Boston University, Internal Medicine. 1974 - 1977 Residency: Columbia Presbyterian Medical Center, Neurology, Columbia University,

College of Physicians and Surgeons 1977 - 1978 Fellowship: Behavioral Neurology and Aphasia, Boston Veteran's Administration

Hospital. 1984 & 1989 New England Epidemiology Institute 1994 Linkage Analysis. Columbia University 1996 Advanced Linkage Analysis, Columbia University 2005 Genetic Epidemiology and Molecular Biology (Summer Institute), Johns Hopkins Board Qualification: Neurology and Psychiatry, 1978 Medical License: New York # 118678, 1979 Chronology of Professional Employment: 1977 - 1978 Instructor in Neurology, Boston University School of Medicine 1978 - 1984 Assistant Professor of Clinical Neurology, College of Physicians and Surgeons

Assistant Attending: The Presbyterian Hospital (in New York City) 1984 - 1990 Associate Professor of Clinical Neurology, Associate Attending: The Presbyterian

Hospital (in New York City) 1985 - 1990 Associate Professor of Clinical Psychiatry 1986 - 1997 Associate Program Director, General Clinical Research Center College of Physicians

& Surgeons 1982 - 1999 Director, Division of Behavioral Neurology, Department of Neurology 1995 - 1999 Co-Director, Taub Alzheimer’s Disease Research Center

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Current: 1985 - Director, Memory Disorders Clinic, The New York State Psychiatric Institute 1990 - Professor of Neurology and Psychiatry, Columbia University, College of Physicians &

Surgeons. Attending Neurologist: The Presbyterian Hospital (in New York City) 1991 - Gertrude H. Sergievsky Professor of Neurology and Psychiatry and Director, Gertrude

H. Sergievsky Center 1993 - Gertrude H. Sergievsky Professor of Neurology, Psychiatry and Epidemiology. 2000 - Co-Director, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain. 2002 Gertrude H. Sergievsky Professor of Neurology, Psychiatry and Epidemiology (in the

Sergievsky Center and the Taub Institute). 2006 - Director, Human Genetic Resources Core, Columbia University Honors: 1971 Alpha Omega Alpha (third year) 1972 Distinguished Graduate of Oklahoma University School of Medicine 1992 Leadership and Excellence in Alzheimer’s Disease Award (LEAD), National Institute

of Aging 1997 Rita Hayworth Award, Alzheimer’s Association 1998 Dean’s Award, Columbia University, Distinguished Clinical Scientist

1999 Association of American Physicians

American Epidemiological Society 2001 Institute of Medicine, National Academies of Science 2002 Distinguished Achievement Award, Isabella Geriatric Nursing Center

2004 Fellow, New York Academy of Science 2005 Visiting Professor, Rockefeller University, Laboratory of Statistical Genetics 2007 Nancy R. McCune Research Award for Alzheimer’s Disease

Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology

Honorific Lectures: 1988 Joseph M. Foley, MD Lecturer, Case Western School of Medicine. 1991 Taylor Lecturer in Neurology and Psychiatry. University of Maryland. 1997 Bernard Siskind Lecturer, Lennox Hill Hospital, New York

Robert Aird Visiting Professor, University of California at San Francisco Emanuel Goldberg Lecture, University of Rochester

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1998 Decade of the Brain Plenary Presentation, American Academy of Neurology 2000 The JJ Silversides Lectureship in Clinical Neuroscience, University of Toronto 2001 Middelton-Goldsmith Lecture (New York Pathological Society) 2002 American Psychiatric Association, Frontiers in Science Lecture. 2005 Szabo Science Lecture, Hackley School, Tarrytown, New York 2006 Norman Geschwind Memorial Lecture, Harvard Medical School Boston, MA

Professional Organizations: 1977 - 1997 Associate, American Academy of Neurology. 1987 - 1995 Scientific Issues Committee, American Academy of Neurology 1990 - 1995 Clinical Research Subcommittee, American Academy of Neurology. 1990 - 1995 Parkinson's Disease Epidemiology Research Committee. 1995 - 1997 American Neurological Association, Ethical Affairs, Chairman 1997 - 1999 Counselor, American Neurological Association. 1990 - Society for Epidemiologic Research 1979 - Association for Research in Nervous and Mental Disease 1983 - Society for Neuroscience 1986 - American Neurological Association 1994 - International Genetic Epidemiology Society 1994 - Dana Brain Alliance Member 1995 - New York Academy of Medicine 1997 - Fellow, American Academy of Neurology Extramural Funding: Grants & Research Awards: Inactive: 1977 - 1978 Post Doctoral Fellowship Award, NS05773. 1981 - 1984 Clinical Investigator Award, AG02802 1984 - 1991 R0-1-AG-02802 Behavioral/Biochemical Correlation in Disease of Aging. Principal

Investigator 1987 - 1992 P50-MH43520 (HIV Center) HIV Center for Clinical and Behavioral Studies,

Neurology Core Director 1988 - 1991 Sigma Tau, L-acetyl carnitine in Alzheimer's Disease, Principal Investigator 1988 - 1992 R0-1-NS26179 Mechanisms and Syndromes of Dementia Related to Stroke, Co-

Principal investigator. 1985 - 1994 R0-1-AG-05433 rCBF in Alzheimer's Disease., co-principal Investigator 1989 - 1993 R0-1-AZ/MH44959, Behavioral Correlates of Magnetic Resonance Imaging in HIV,

Principal Investigator. 1993 - 1996 Dana Consortium on Memory. Principal Investigator, Changes in

Memory During Normal Aging. 1992 - 1997 U10-NS31321 Twin Studies in Parkinson's Disease. Co-Investigator . 1994 - 1997 Dana Consortium on the Recognition and Treatment of AIDS

Dementia and Related Disorders. Co-Principal Investigator. 1989 - 1999 R01-AG07370, Predictors of Disease Severity in Alzheimer's disease, Co-Principal

Investigator 1992 - 1999 R35-AG10963 Leadership and Excellence in Alzheimer's Disease. Gene-

Environment Interactions in Alzheimer's disease, Principal Investigator.

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1993 - 2000 R01-NS32527 Case-Control Study of Parkinson's Disease in the Elderly. Principal Investigator.

1999- 2003 P50-NS38370. Udall Parkinson’s Disease Research Center. Project 6, Principal Investigator. Gender and Ethnic Differences in Mortality for Parkinson’s Disease.

2000- 2004 R01-AG/ES18732 Genetic Epidemiology of Aging in a Multiethnic Community. Principal Investigator

2002 - 2005 P50 AG08702 Coordinator of the National Institute of Aging, Alzheimer’s Disease Genetic Initiative for Late-Onset Alzheimer’s Disease. Administrative Director.

2002 – 2005 Fine Mapping of Chromosomes 12 and 10 in Familial Alzheimer’s Disease. Principal Investigator. Alzheimer Association.

Active: Foundation 1983 - Charles Robertson Memorial Gift for Research in Alzheimer's Disease from the

Banbury Fund. 1995 - The Henry and Marilyn Taub Foundation. Taub Center for Alzheimer’s Disease

Research. Co-Director. 1995 - Blanchette Hooker Rockefeller Fund for Research In Alzheimer’s Disease. Principal

Investigator. National Institutes of Health 1989 - P01 AG07232 The Epidemiology of Dementia in an Urban Community, Principal

Investigator. 1989 - P50 AG08702 Alzheimer's Disease Research Center, Co-Director. 1998 - R37 AG15473 Genetic Epidemiology of Alzheimer’s Disease in Hispanics.

Principal Investigator. 2004 - U01 AG023749 Multicenter Study on Exceptional Survival in Families. Principal

Investigator 2005 - U24 AG026395-01 Genetic Consortium for Late Onset Alzheimer's Disease. Principal

Investigator Departmental, University & Hospital Committees: 1978 - 1992 Medical student faculty advisor 1981 - 1992 Executive and Residency Selection Committee, Department of Neurology 1985 - 1992 University Senate: Medical School Faculty 1986 - 1992 Internal Review Committee, General Center for Clinical Research

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1993 - 1994 Chairman, Search Committee Ophthalmology 1995 - 1996 Chairman, Search Committee Neurosurgery 1995 - 1997 Human Genome Project Committee, Columbia University 1995 - 1998 Tenure Review Advisory Committee, Columbia University 1992 - 2000 Member, Clinical Trials Committee 1998 - 2000 Chairman, Search Committee Biostatistics, School of Public Health 2000 - 2002 Chairman, Task Force on Human Genetics, Columbia University 2003 - 2004 Chairman, Search Committee Psychiatry Teaching Responsibilities: 1979 - 2001 Attending, Neurological Institute of New York, weekly Behavioral Neurology

rounds, Harlem Hospital Center Behavioral Neurology rounds (monthly) 1979 - 1994 Neuroscience course: Aphasia, Alexia and Apraxia lecture 1979 - 1994 Neuroscience Review Course: Language Disorders and Aphasia. 1987 - 1991 American Academy of Neurology, Course Director, Aging and Dementia. 1994 - 1998 American Academy of Neurology, Clinical Research Methods 1995 - 2001 Columbia University Medical School, Epidemiology (first-year) Fellows and Current Academic Positions: 1982 - 1984 Yaakov Stern, PhD., Professor in Neurology & Psychiatry, Columbia University+ 1987 - 1988 Mary Sano, Ph.D., Associate Professor in Neurology, Columbia University + 1987 Armondo Schmit. MD, Professor in Psychiatry, Director Geriatric Psychiatry, Brown

University 1986 - 1989 Karen Marder, MD,MPH, Associate Professor in Neurology Columbia University.+ 1988 - 1991 Karen Bell, MD, Assistant Professor in Neurology, Columbia University. 1988 - 1991 George Dooneief, MD,MPH, Assistant Professor in Neurology, Columbia University. 1989 Rafael Lantigua, MD, Professor in Clinical Medicine, Columbia University.+ 1992 - 1994 Ned Sacktor, MD, Instructor, Johns Hopkins School of Medicine+ 1992 - 1996 Peter William Schofield,BSc (Hons), MBBS, MSc, MD, FRACP, Associate Professor

of Psychiatry, University of Newcastle, Newcastle, Austrialia+ 1993 - 1995 Michael Chun, MD, University of Washington, Assistant Professor of Neurology. 1993 – 1997 Giancarlo Logroscino, MD, PhD. Associate Professor of Epidemiology. Harvard

chool of Public Health 1994 - 1995 Gayatri Devi, MD, Director, New York Memory Center 1994 - 1995 Elan Louis, MD, MSc, Assistant Professor, Columbia University, Department of

Neurology, Sergievsky Center + 1994 -1996 Veronica Hinton, Ph.D. , Assistant Professor of Neuropsychology (in Neurology and

the Sergievsky Center) , Columbia University. + 1995 -1998 Leo Stefanis, MD, Assistant Professor of Neurology. Application of tropic factors to

model systems of neuronal cell death.+ 1995 -1998 Carole Merchant, MD, MPH Assistant Professor of Neurology. 1996 -1998 Scott Small, MD, Assistant Professor of Neurology. Neurology.+ 1998 - 2000 Stavra Romas, MD. Assistant Professor of Neurology. Neurology. 2000 - 2002 Holly Posner, MD. Neuroepidemiology, Pfizer 2000 - 2002 Mark Albers, MD, PhD. Assistant Professor of Neurology+. 2002 - 2005 Christiana Reitz, MD. Vascular contribution to Alzheimer’s disease.

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2005 - Beverly Johnson, MD. Doris Duke Fellow (Genetics of Alzheimer’s Disease)

(+) indicates successful independent funding for research. National Committees 1998 – 2000 Council Member, American Neurological Association 2001 – 2002 Long-Term Planning Committee, American Neurological Association 2004 - Scientific Program Advisory Committee, American Neurological Association Institute of Medicine 2001 – 2003 Gulf War and Health Committee II. Solvents and Pesticides, (Chair, Neurology

Section) 2003 – 2004 Gulf War and Health Committee III. Fuels, Combustion Products and Propellants,

(Chair, Neurology Section) 2004 Gulf War and Health Committee, Updated Review on Sarin 2005 - Gulf War and Health Committee IV. Physiologic, Psychologic and Psychosocial Effects of Deployment Stress (Chair) Post Traumatic Stress Disorder (Chair) 2005 - Membership committee, Section 7 (Neurology and Psychiatry) Masters Candidates in Epidemiology: 1993 - 1994 Giancarlo Logroscino, MD: Dietary Factors in Parkinson's Disease. 1993 - 1994 Susan Titlebaum, PhD: Smoking and Alzheimer's Disease. 1995 - 1996 Peter William Schofield, MSc. Head Injury and Alzheimer’s Disease. 2001 – 2004 Elena Hoskins Doctor of Public Health Candidate in Epidemiology: 1995 - 1997 Giancarlo Logroscino, MD, PhD: Parkinson’s Disease. Editorial Boards: 1985 - 1990 Movement Disorders 1992 - 1998 Annals of Neurology 1988 - 1998 Behavioral Neurology 1989 - Dementia 1994 - Neuroepidemiology 2001- Journal of Clinical Investigation Bibliography: An asterisk after the citation denotes Dr. Mayeux as the senior author. Original Articles:

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1) Mayeux R, Brandt J, Rosen J, Benson F: Interictal memory and language impairment in temporal lobe epilepsy. Neurology 1980; 30: 120-6. 2) Mayeux R, Stern Y, Rosen Y, Leventhal J: Depression, intellectual impairment and Parkinson disease. Neurology 1981; 31:645-50.* 3) Matison R, Mayeux R, Rosen J, Fahn S: Tip-of-the-tongue phenomenon in Parkinson disease. Neurology 1982; 32:567-70. 4) Mayeux R, Stern Y, Rosen J, Benson DF: Subcortical dementia: A recognizable clinical entity. Trans Am Neuro Assoc 1981; 106:313-16. 5) Stern Y, Mayeux R, Rosen J, Ilson J: Perceptual motor dysfunction in Parkinson's disease. J Neurol, Neurosurg, Psych 1983; 46: 145-51.* 6) Reed E, Lewison A, Mayeux R, Such-Foca N: HLA antigens in Parkinson's disease. Tissue Antigens 1983; 21:161-3. 7) Reed E, Lewison A, Mayeux R, Sucin-Foca N: HLA antigens in Alzheimer's disease. Tissues Antigens 1983; 164-7. 8) Mayeux R, Stern Y, Rosen J. Benson DF: Is "subcortical dementia" a recognizable clinical entity? Ann Neurol 1983; 14:278-83. 9) Stern Y, Mayeux R, Ilson J, Fahn S, Cote L: Pergolide treatment of Parkinson's disease: Neurobehavioral changes. Neurology 1984; 34:201-3.* 10) Nerl C, Mayeux R, O'Neill JG: HLA-linked complement markers in Alzheimer's and Parkinson's disease: C4 variant (C4B2) a possible marker for senile dementia of the Alzheimer's type. Neurology 1984; 34:310-14.* 11) Mayeux R, Cote L, Stern Y, Williams JBW: Altered serotonin metabolism in depressed patients with Parkinson's disease. Neurology 1984; 34: 642-46.* 12) Stern Y, Mayeux R, Cote L: Reaction time and vigilance in Parkinson's disease: possible role of altered norepinephrine metabolism. Arch Neurol 1984; 41:1086-9.* 13) Stern Y, Mayeux R, Rosen J: Contribution of perceptual motor dysfunction to construction and tracing disturbances in Parkinson's disease. J Neurol Neurosurg Psychiat 1984; 47:983-94.* 14) Mayeux R, Stern Y, Spanton S: Heterogeneity in dementias of the Alzheimer type: Evidence for subgroups. Neurology 1985;35:453-6l.* 15) Kaplan JG, Katzman R, Horoupian BS, Fuld PA, Mayeux R, Hays AP: Progressive dementia, visual deficits, amyotrophy and micro infarcts. Neurology 1985, 35:789-96. 16) Mayeux R, Stern Y, Mulvey R, Cote L: A reappraisal of temporary Levodopa withdrawal ("Drug

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Holiday") in Parkinson's disease. N Engl J Med 1985;313:724-8.* 17) Mayeux R, Stern Y, Williams JBW, Cote L, Frantz A, Dreyenfurth I. Clinical and biochemical features of depression in Parkinson's disease. Am J Psychiatry, 1986; 143:756-9.* 18) Mayeux R, Stern Y, Hermann A, Greenbaum L, Fahn S: Correlates of early disability in Huntington's disease. Ann Neurol 20:727-31, 1986.* 19) Mayeux R, Stern Y, Sano M. Heterogeneity and prognosis in dementia of the Alzheimer type. Clin Neurosi Bull 1985; 50:7-10.* 20) Mayeux R, Albert M, Jenike M. Physostigmine-induced myoclonus in Alzheimer's disease. Neurology. 1987;37:345-6.* 21) Whitehouse PJ, Vale WW, Zweig RM, Singer H, Mayeux R, Kuhar MY, Price OL, DeSoaza EB: Reductions in corticotropin releasing factor-like immunoreactivity in cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy. Neurology 1987;37:905-9. 22) D'Amato RJ, Zweig RM, Whitehouse PJ, Wenk GL, Singer HS, Mayeux R, Price DL, Snyder SH: Aminergic systems in Alzheimer's disease and Parkinson's disease. Ann Neurology 1987;22:229-36. 23) Stern Y, Sano M, Mayeux R. Effects of oral physostigmine in Alzheimer's disease. Ann Neurol 1987;22:306-10.* 24) Stern Y, Mayeux R, Sano M, Hauser WA, Bush T: Predictors of disease course in patients with probable Alzheimer's disease. Neurology 1987;37:1649-53.* 25) Mayeux R, Stern Y, Sano M, Cote L, Williams DSW: Clinical and biochemical correlates of bradyphrenia in Parkinson's disease. Neurology 1987;37:1130-4.* 26) Dickson DW, Davies P, Mayeux R, Crystal H, Horoupian DS, Thompson A, Goldman JE: Diffuse Lewy Body Disease, neuropathological and biochemical studies of six patients. Acta Neuropathol (Berl) 1987;75:8-15. 27) Mayeux R, Stern Y, Rosenstein R, Marder K, Hauser A, Cote L, Fahn S: An Estimate of the prevalence of dementia in idiopathic Parkinson's disease. Arch Neurol 1988;45:260-2.* 28) Prohovnik I, Mayeux R, Sackheim H, Smith G, Stern Y, Alderson P: Cerebral Perfusion as a Diagnostic Marker of Early Alzheimer's Disease. Neurology 1988;38:931-7.* 29) Stern Y, Mayeux R, Hermann A, Rosen J: Prism adaptation in Parkinson's disease. J Neurol Neurosurg Psychiat 1988;51:1584-7.* 30) Duffy P, Mayeux R, Kupsky W: Familial Alzheimer's Disease with Myoclonus and "Spongy Change." Arch Neurol 1988;45: 1097-1103.* 31) Devanand DP, Sackeim HA, Mayeux R. Psychosis, Behavioral Disturbance and the Use of Neuroleptics in Dementia. Comp Psychiatry 1988; 29: 387-401.*

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32) Mayeux R, Stern Y, Sano M, William JBW, Cote L. The relationship of serotonin to depression in Parkinson's disease. Movement Dis 1988;3: 237-44.* 33) Stern Y, Sano M, Mayeux R. Long-term Administration of oral physostigmine in Alzheimer's disease. Neurology, 1988;38: 1837-41.* 34) Mayeux R, Stern Y, Hesendorf D, Sano M. Noncognitive manifestations of Alzheimer's disease. Bull Clin Neuroscience 1988; 53:10-4.* 35) Prohovnik I, Smith G, Sackeim HA, Mayeux R, Stern Y. Gray-matter degeneration in presenile Alzheimer's disease. Ann Neurol 1989; 25: 117-24.* 36) Dal Pan G, Sano M, Stern Y, Mayeux R. Clock drawing in neurological disorders. Behav Neurology 1989; 2: 39-48.* 37) Devanand D, Sackeim HA, Brown RP, Mayeux R. A pilot study of haloperidol treatment of psychosis and behavioral disturbance in Alzheimer's disease. Arch Neurol 1989; 46: 854-7.* 38) Zweig RM, Jankel WR, Hedreen JC, Mayeux R, Price DL. The pedunculopontine nucleus in Parkinson's disease. Ann Neurol 1989;26:41-6. 39) Sano M, Stern Y, Williams J, Cote L, Rosenstein R, Mayeux R. Co-existing dementia and depression in Parkinson's disease. Arch Neurol 1989; 46:1284-7.* 40) Mayeux R, Sano M, Chen J, Tatemichi T, Stern Y. Heredity as a risk factor for Alzheimer's disease. New Trends in Clin Neuropharm 1989; 3: 217-23.* 41) Marder K, Flood P, Cote L, Mayeux R. A pilot study of risk factors for dementia in Parkinson's disease. Movement Dis 1990; 5: 156-61.* 42) Stern Y, Hesdorffer D, Sano M, Mayeux R. Measurement and prediction of functional capacity in Alzheimer's disease. Neurology 1990; 40: 8-13.* 43) Sano M, Stern Y, Marder K, Mayeux R. A controlled trial of Piracetam in intellectually impaired patients with Parkinson's disease. Movement Dis 1990; 5:230-234.* 44) Palmert MR, Usiak M, Mayeux R, Raskind M, Tourtelotte W, Younkin SG. The soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: Alterations in normal aging and in Alzheimer's disease. Neurology 1990; 40: 1028-34. 45) St George-Hyslop PH, Haines JL, Farrer LA, Plinsky R, Van Broeckhoven C, Goate A, Crapper-Mclachlan CR, Orr H, Bruni AC, Sorbi S, Rainero I, Foncin JF, Pollon D, Cantu J-M, Tupler R, Voskesenskaya N, Mayeux R, and others. Genetic linkage studies suggest that Alzheimer's disease is not a single homogenous disorder. Nature 1990; 347: 194-7. 46) Mayeux R, Chen J, Mirabello E, Marder K, Bell K, Dooneief G, Stern Y. An estimate of the incidence of dementia in patients with idiopathic Parkinson's disease. Neurology 1990; 40: 1513-7.*

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47) Stern Y, Marder K, Bell K, Chen J, Dooneief G, Goldstein S, Mindry D, Richards M, Sano M, Williams J, Gorman J, Ehrhardt A, Mayeux R. Multidisciplinary baseline assessment of gay men with and without HIV infection: III. neurological and neuropsychological findings. Arch Psychiatry 1991; 48:131-8.* 48) Gorman J, Kertzner R, Todak G, Goetz R, Williams JBW, Rabkin J, Meyer-Bahlburg H, Mayeux R. Stern Y, Lange M, Dobkin J, Spitzer R, Ehrhardt AA. Multidisciplinary baseline assessment of gay men with and without HIV infection: I: Overview of Study Design. Arch Psychiatry 1991; 48:120-3.* 49) Mayeux R, Sano M, Chen J, Tatemichi T, Stern Y. Risk of dementia in first-degree family members of patients with Alzheimer's disease and related disorders. Arch Neurol 1991; 48: 269-73.* 50. Marder K, Leung D, Tang M, Bell K, Dooneief G, Cote L, Stern Y, Mayeux R. Are demented patients with Parkinson's disease accurately reflected in prevalence surveys? A survival analysis. Neurology 1991; 41: 1240-4.* 51. Sano M, Stanley M, Lawton A, Cote' L, Williams JBW, Stern Y, Marder K, Mayeux R. 3H-Imipramine binding: a peripheral marker for serotonin in Parkinson's disease. Arch Neurology 1991; 48: 1052-4.* 52. Chen J, Stern Y, Sano M, Mayeux R. Cumulative risk of developing extrapyramidal signs, psychosis, and myoclonus in the course of Alzheimer's disease. Arch Neurology 1991; 48: 1141-6.* 53. Richards M, Marder K, Bell K, Dooneief G, Mayeux R, Stern Y. Interrater reliability of extrapyramidal signs in a group assessed for dementia. Arch Neurology 1991; 48: 1147-9.* 54. Gorman JM, Kertzner R, Cooper T, Goetz RR, Lagomasino I, Novacenko H, Williams JBW, Stern Y, Mayeux R, Ehrhardt AA: Glucocorticoid level and neuropsychiatric symptoms in homosexual men with HIV infection. Am J Psychiatry 1991; 148: 41-5. 55. Dooneief G, Bello J, Todak G, Mun I, Hilal S, Gorman J, Stern Y, Mayeux R. A prospective study of magnetic resonance imaging in Human Immunodeficiency Virus. Arch Neurol 1992; 49:38-43.* 56. Devanand DP, Miller L, Richards M, Marder K, Bell K, Mayeux R, Stern Y. The Columbia University Scale for Psychopathology in Alzheimer's Disease. Arch Neurol 1992; 49: 371-376.* 57. Dooneief G, Mirabello E, Bell K, Marder K, Stern Y, Mayeux R. An Estimate of the Incidence of Depression in Idiopathic Parkinson's Disease. Arch Neurol 1992; 49: 305-7.* 58) Stern Y, Andrews H, Pittman J, Sano M, Tatemichi T, Lantigua R, Mayeux R. Diagnosis of dementia in a heterogenous population: Development of a neuropsychological paradigm and quantified correction for education. Arch Neurol 1992; 49: 453-60.* 59) Pittman J, Andrews H, Tatemichi T, Link B, Struening E, Stern Y, Mayeux R. Diagnosis of dementia in a heterogeneous population: A comparison of paradigm based diagnosis and physician's diagnosis. Arch Neurol 1992; 49: 461-7.*

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60) Mayeux R, Denaro J, Hemenegildo N, Marder K, Tang MX, Cote LJ, Stern Y. A Population-Based Investigation of Parkinson's Disease with and without Dementia: Relationship to age and gender. Arch Neurol 1992; 49: 492-497.* 61) Tatemichi T, Desmond D, Mayeux R, Paik M, Stern Y, Sano M, Remien R, Williams JBM, Mohr J, Hauser A, Figueroa M. Dementia after Stroke: Prevalence, risks, and baseline clinical features in a hospitalized cohort. Neurology 1992; 42; 1185-1193.* 62) Stern Y, Alexander G, Prohovnik I, Mayeux R. Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease. Ann Neurol 1992; 32: 371-375.* 63) Sano M, Bell K, Cote L, Dooneief G, Lawton A, Legler L, Marder K, Naini A, Stern Y, Mayeux R. Double-blind parallel design pilot study of Acetyl-l-Carnitine in patients with Alzheimer's disease. Arch Neurol 1992; 49:1137-1141.* 64) Marder K, Stern Y, Malouf R, Tang M-X, Bell K, Dooneief G, el Sadr W, Goldstein S, Gorman J, McMurtry C, Richards M, Sano M, Sorrell S, Todak G, Ehrhardt A, Mayeux R. Early neurological and neuropsychological manifestations of HIV infection in a cohort of intravenous drug users. Arch Neurol 1992; 49: 1169-1175.* 65) Mayeux R, Stern Y, Tang M-X, Todak G, Marder K, Sano M, Richards M, Stein A, Ehrhardt A, Gorman J. Mortality Risks in Gay Men with Human Immunodeficiency Virus infection and Cognitive Impairment. Neurology 1993; 43: 176-182.* 66) Gorman JM, Mayeux R, Stern Y, Williams JBW, Rabkin J, Goetz RR, Ehrhardt AA. The effect of zidovudine on neuropsychiatric measures in HIV infected men. Am J Psychiatry 1993; 150: 505-507. 67) Richards M, Stern Y, Marder K, Cote L, Mayeux R. Relationships between extrapyramidal signs and cognitive function in a community-dwelling cohort of patients with Parkinson's disease and normal elderly individuals. Ann Neurol 1993; 267-274.* 68) Mayeux R, Ottman R, Tang M-X, Noboa-Bauza L, Marder K, Gurland B, Stern Y. Genetic Susceptibility and Head Injury as Risk Factors for Alzheimer's Disease Among Community-Dwelling Elderly Persons and their First-Degree Relatives. Ann Neurol 1993; 33:494-501.* 69) Tatemichi T, Desmond D, Paik M, Figueroa M, Gropen TI, Stern Y, Sano M, Remien R, Williams JBM, Mohr J, Mayeux R. Clinical determinants of dementia related to stroke. Ann Neurol 1993; 33:568-575.* 70) Stern Y, Marder K, Tang M-X, Mayeux R. Antecedent clinical features associated with dementia in Parkinson's disease. Neurology 1993; 46:1690-1693.* 71) Richards M, Bell K, Dooneief G, Marder K, Sano M, Mayeux R, Stern Y. Patterns of neuropsychological performance in Alzheimer's disease patients with and without extrapyramidal signs. Neurology 1993; 46: 1708-1711.* 72) Stern Y, Richards M, Sano M, Mayeux R. Comparison of cognitive changes in patients with Alzheimer's and Parkinson's disease. Arch Neurol 1993; 50: 1040-1045.*

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73) Mayeux R, Stern Y, Ottman R, Tatemichi TK, Tang M-X, Maestre G, Ngai C, Tycko B, Ginsberg H. The apolipoprotein ε4 allele in patients with Alzheimer's disease. Ann Neurol 1993; 34:752-754.* 74) Richards M, Stern Y, Mayeux R. Subtle extrapyramidal signs can predict the development of dementia in elderly individuals. Neurology 1993; 43: 2184-2188.* 75) Richards M, Marder K, Cote L, Mayeux R. Interrater reliability of the United Parkinson's disease Rating Scale. Mov Disorders 1994; 9:89-91.* 76) Mayeux R, Tang M-X, Marder K, Cote LJ, Stern Y. Smoking and Parkinson's disease. Mov Disorders 1994; 9: 207-212.* 77) Stern Y, Gurland B, Tatemichi TK, Tang M-X, Wilder D, Mayeux R. Influence of education and occupation on the incidence of dementia. JAMA 1994; 271:1004-1010.* 78) Marder K, Maestre G, Cote LJ, Mejia H, Alfaro B, Halim A, Tang M-X, Tycko B, Mayeux R. The apolipoprotein-ε4 allele in Parkinson's disease with and without dementia. Neurology 1994; 44 1330-1331.* 79) Schupf N, Dapell D, Lee J, Ottman R, Mayeux R. Increased risk for Alzheimer's disease in mothers of adults with Down syndrome. Lancet 1994; 344:353-356.* 80) Lynch T, Sano M, Marder KS, Bell KL, Foster NL, Defendini RF, Sima AAF, Koehane C, Nygaard TG, Fahn S, Mayeux R, Rowland LP, Wilhelmsen KC. Clinical Characteristics of a family with chromosome 17-linked disinhibition-dementia-parkinsonism-amyotrophy complex. Neurology 1994; 44:1878-1884. 81) Tatemichi TK, Paik M, Bagiella E, Desmond DW, Stern Y, Sano M, Hauser WA, Mayeux R. Risk of dementia after stroke in a hospitalized cohort: Results of a longitudinal study. Neurology 1994; 44: 1885-1891.* 82) Sano M, Rosen W, Stern Y, Rosen J, Mayeux R. Simple reaction time as a measure of global attention in Alzheimer's disease. JINS 1995; 1: 56-61. 83) Stern Y, Alexander G, Prohovnik I, Stricks L, Link B, Lennon MC, Mayeux R. Relationship between lifetime occupation and parietal flow: Implications for a reserve against Alzheimer's disease pathology. Neurology 1995; 55-60.* 84) Schofield PW, Mosesson RE, Stern Y, Mayeux R. The age at onset of Alzheimer's disease and the intracranial area measurement: a relationship. Arch Neurol 1995; 52: 95-98.* 85) Marder K, Liu X, Dooneief G, Bell K, Schofield P, Sacktor N, Todak G, Friedman R, Ehrhardt A, Stein Z, Gorman J, Mayeux R. Neurological signs and symptoms in a cohort of gay men followed for 4.5 years. Neurology 1995;45: 261-267.* 86) Maestre G, Ottman R, Stern Y, Gurland B, Chun M, Tang M-X, Shelanski M, Tycko B, Mayeux R. Apolipoprotein-Ε and Alzheimer's Disease: Ethnic Variation in Genotypic Risks. Ann Neurol 1995; 37:

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254-259.* 87) Mayeux R, Ottman R, Maestre G, Ngai C, Tang M-X, Ginsberg H, Chun M, Tycko B, Shelanski MS. Synergistic effects of Traumatic Head Injury and Apolipoprotein-ε4 in Patients with Alzheimer's Disease. Neurology 1995; 45:555-557.* 88) Gurland B, Wilder D, Cross P, Lantigua R, Teresi J, Bolivar M, Barret V, Mayeux R. Relative rates of dementia by multiple case definitions, over two prevalence periods, in three cultural groups. Am J Geriatric Psych 1995; 3:6-12.* 89) Stern Y, Tang M-X, Denaro J, Mayeux R. Increased Risk of Mortality in Alzheimer’s Disease patients with more advanced educational and occupational attainment. Ann Neurol 1995; 37: 590-595.* 90) Sacktor N, Prohovnik I, Van Heertum RL, Dooneief G, Gorman J, Marder K, Todak G, Stern Y, Mayeux R. Cerebral Tc-99m HMPAO SPECT abnormalities in HIV-1-infected gay men without cognitive impairment. Arch Neurol 1995; 52: 607-611.* 91) Sacktor N, Liu X, Popescu M, Marder K. Stern Y, Mayeux R. Serum neopterin predicts HIV-related mortality but not progression to AIDS or development of neurological disease in gay men and parenteral drug users. Arch Neurol 1995; 52:676-679.* 92) Marder K, Tang M-X, Cote LJ, Stern Y, Mayeux R. The frequency and associated risk factors for dementia in patients with Parkinson' s disease. Arch Neurol 1995; 52:695-701.* 93) Gurland BJ, Wilder DE, Chen J, Lantigua R, Mayeux R, Van Nostrand J. A flexible system of detection for Alzheimer’s disease and related dementias. Aging Clin Exp Res 1995; 7: 165-172. 94) Jacobs DM, Marder K, Cote LJ, Sano M, Stern Y, Mayeux R. Neuropsychological characteristics of preclinical dementia in Parkinson’s disease. Neurology 1995; 45: 1691-1696.* 95) Mayeux R, Marder K, Cote LJ, Denaro J, Hemenegildo N, Mejia H, Tang M-X, Lantigua R, Wilder D, Gurland B, Hauser A. The frequency of idiopathic Parkinson's disease among middle-aged and elderly Black, Hispanic and White men and women in northern Manhattan 1988 to 1993. Am J Epidemiol 1995; 142: 820-827.* 96) Alexander GE, Prohovnik I, Sackeim HA, Stern Y, Mayeux R. Cortical perfusion and gray-matter weight in frontal lobe dementia. J Neuropschiat Clin Neurosci 1995;7:188-196.* 97) Sacktor N, Van Heertum RL, Dooneief G, Gorman J, Khandji A, Marder K, Nour R, Todak G, Stern Y, Mayeux R. A comparison of cerebral SPECT abnormalities in HIV-positive homosexual men with and without cognitive impairment. Arch Neurol 1995; 52; 1170-1173.* 98) Louis ED, Marder K, Cote LJ, Pullman, Ford B, Wilder D, Tang M-X, Lantigua R, Gurland B, Mayeux R. Difference in the prevalence of essential tremor among elderly African-Americans, Whites and Hispanics in Northern Manhattan, NY. Arch Neurol 1995; 52; 1201-1205.* 99) Tang M-X, Tsai W-Y, Marder K, Mayeux R. Linear rank tests for doubly censored data. Statistics Medicine 1995; 14: 2555-2563.*

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100) Schofield PW, Tang M-X, Marder K, Bell K, Dooneief G, Lantigua R, Wilder D, Gurland B, Stern Y, Mayeux R. Consistency of clinical diagnosis in a community-based longitudinal study of dementia and Alzheimer's disease. Neurology 1995; 45: 2159-2164.* 101) Albert SM, Gurland B, Maestre G, Jacobs DM, Stern Y, Mayeux R. APOE Genotype influences functional status among elderly without dementia. Am J Med Genet (Neuropsychiatr Genet) 1995; 60:583-587.* 102) Louis ED, Marder K, Cote L, Wilder D, Tang M-X, Lantigua R, Gurland B, Mayeux R. Prevalence of a history of shaking in persons 65 years of age and older: diagnostic and functional correlates. Mov Disord 1996; 11: 63-69.* 103) Logroscino G, Marder K, Cote LJ, Tang M-X, Mayeux R. Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control study. Ann Neurol 1996; 39: 89-94.* 104) Tang M-X, Maestre G, Tsai W-Y, Liu X-H, Feng L, Chung W-Y, Chun M, Schofield P, Stern Y, Tycko B, Mayeux R. Relative Risk of Alzheimer’s Disease and Age-at-Onset Based on APOE Genotypes Among Elderly African-Americans, Caucasians and Hispanics in New York City. Am J Hum Genetics 1996; 58: 554-574.* 105) Devanand D, Sano M, Tang M-X, Taylor S, Gurland BJ, Wilder D, Stern Y, Mayeux R. Depressed mood and the incidence of Alzheimer's disease in the community elderly. Arch Gen Psychiatry. 1996; 53: 175-182.* 106) Dooneief G, Marlink R, Bell K, Marder K, Renjifo B, Stern Y, Mayeux R. Neurologic consequences of HTLV-II infection in injection-drug users. Neurology 1996; 46: 1556-1560.* 107) Marder K, Tang M-X, Alfaro B, Cote L, Louis E, Groves J, Mayeux R. Risk of Parkinson’s disease among first-degree relatives: A community-based study. Neurology. 1996; 47: 155-160.* 108) Ramachandran G, Marder K, Tang M-X, Schofield PW, Chun MR, Devanand DP, Stern Y, Mayeux R. Apolipoprotein-Ε genotype and psychiatric manifestations of Alzheimer's disease. Neurology 1996; 47: 256-259.* 109) Tang M-X., Jacobs D, Stern Y, Marder K, Schofield P, Andrews H, Gurland B, Mayeux R. Effect of oestrogen during menopause on risk and age-at-onset of Alzheimer’s disease. Lancet 1996; 348:429-432.* 110) Tycko B, Nguyen L, Feng L, Chung W-Y, Tang M-X, Stern Y, Mayeux R. Polymorphisms in the Human Apolipoprotein-J/Clusterin Gene: Ethnic Variation and Distribution in Alzheimer's Disease. Human Genetics 1996; 98: 430-6.* 111) Dana Consortium on Therapy for HIV Dementia and Related Cognitive Disorders. Clinical confirmation of the American Academy of Neurology algorithm for HIV 1-associated cognitive/motor disorder. Neurology 1996; 47:1274-1253. 112) Schupf N, Kapell D, Zigman W, Canto B, Tycko B, Mayeux R. Onset of dementia is associated

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with Apolipoprotein ε4 in Down syndrome. Ann Neurol 1996; 40: 799-801.* 113) Liu X, Stern Y, Marder K, Stern Y, Dooneief G, Bell K, Todak G, Joseph M, El Sadr W, Williams JBW, Ehrhardt A, Stein Z, Mayeux R. Gender differences in HIV-related neurological progression in a cohort of injecting drug users followed for 3.5 years. J Neuro-AIDS; 1996:17-30.* 114) Dooneief GH, Bello JA, Todak GG, Tang M-X, Marder KS, Stern Y, Mayeux R. Serial MRI in HIV infection with and without neurologic impairment. J Neuro-AIDS 1996; 1: 49-57.* 115) Schofield PW, Tang M-X, Marder K, Bell K, Dooneief G, Chun M, Sano M, Stern Y, Mayeux R. Alzheimer’s disease following remote head injury: an incidence study. J Neurol, Neurosurg, Psychiatry 1997; 62: 119-124.* 116) Slooter AJC, Tang M-X, van Duijn C, Stern Y, Ott A, Bell K, Breteler MMB, Van Broeckhoven C, Tatemichi TK, Tycko B, Hofman A, Mayeux R. Apolipoprotein E4 increases the risk of dementia within patients with stroke. A population-based investigation. JAMA 1997; 277: 818-821.* 117) Evans DA, Beckett LA, Field TS, Feng L, Albert MA, Bennet DA, Tycko B, Mayeux R. Apolipoprotein E4 and incidence of Alzheimer’s disease in a community population of older persons. JAMA 1997; 277: 822-824.* 118) Louis ED, Marder K, Cote LJ, Tang M, Mayeux R. Mortality from Parkinson’s disease. Arch Neurol 1997; 54: 260-264.* 119) Stern Y, Brandt J, Albert M, Jacobs DM, BellK, Marder K, Sano M, Albert S, Castenada CDC, Bylsma F, Tycko B, Mayeux R. The absence of the apolipoprotein-Ε ε4 allele is associated with a more aggressive form of Alzheimer’s disease. Ann Neurol 1997; 41: 615-620.* 120) Wilhelmsen K, Mirel D, Marder K, Bernstein M, Naini A, Leal S, Tang M-X, Freyer G, Graziano J, Mayeux R. Is There a Genetic Susceptibility Locus for Parkinson's Disease on Chromosome 22ql3 ? Ann Neurol 1997; 41: 813-817.* 121) Logroscino G, Marder K, Graziano J, Freyer G, Slavkovich V, LoIacono N, Cote L, Mayeux R. Altered systemic iron metabolism in Parkinson's disease. Neurology 1997; 49: 714-717.* 122) Farrer LA, Cupples LA, Haines JL, Hyman BT, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM, APOE and Alzheimer’s Disease Meta Analysis Consortium. Effects of age, gender and ethnicity on the association between apolipoprotein-E genotype and Alzheimer’s disease. JAMA 1997; 278:1349-1356.* 123) Hirano M, Shtilbans A, Mayeux R, Davidson MM, DiMauro S, Knowles JA, Schon EA. Apparent mtDNA heteroplamsy in Alzheimer’s disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes. Proc Nat Acad Sci 1997; 94: 14894-14899. 124) Pablos-Mendez A, Mayeux R, Ngai C, Shea S, Bergland L. Association of apo-E polymorphism with plasma lipid levels in a multi-ethnic elderly population. Atherioscler ThombVasc Biol 1997; 17:3534-3541.

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125) Jacobs DM, Tang M-X, Stern Y, Sano M, Marder K, Bell KL, Schofield P, Dooneief G, Gurland B, Mayeux R. Cognitive function in nondemented older women who took estrogen after menopause. Neurology 1998;50:368-373.* 126) Marder K, Logroscino G, Alfaro B, Mejia H, Halim A, Louis E, Cote L, Mayeux R. Environmental risk factors for Parkinson’s disease in an urban multi-ethnic community. Neurology 1998; 50:279-281.* 127) Mayeux R, Saunders AM, Shea S, Mirra S, Evans D, Roses AD, Hyman BT, Crain B, Tang M-X, Phelps CH, the Alzheimer’s Disease Centers Consortium on APOE and Alzheimer’s Disease. Utility of the APOE Genotype in the Diagnosis of Alzheimer’s Disease. New Engl J Med 1998; 338; 506-511.* 128) Tang M-X, Stern Y, Marder K, Bell K, Gurland B, Lantingua R, Andrews H, Tycko B, Mayeux R. APOE Risks and the Frequency of Alzheimer’s Disease Among African-Americans, Caucasians and Hispanics. JAMA 1998; 279:751-755.* 129) Schupf N, Kapell D, Nightingale B, Rodriquez A, Tycko B, Mayeux R. Eariler onset of Alzheimer’s disease in men with Down syndrome. Neurology 1998; 50: 991-995.* 130) Marder K, Logroscino G, Tang M-X, Graziano J, Cote L, Louis E, Alfaro B, Mejia H, Slavkovich V, Mayeux R. Systemic iron metabolism and mortality from Parkinson’s disease. Neurology 1998; 50; 1138-1140.* 131) Marder K, Tang M-X, Alfaro B, Mejia H, Cote L, Jacobs D, Stern Y, Sano M, Mayeux R. Postmenopausal estrogen use and Parkinson’s disease with and without dementia. Neurology 1998; 50; 1141-1143.* 132) Devi G, Marder K, Schofield PW, Tang M-X, Stern Y, Mayeux R. Validity of family history for the diagnosis of dementia among siblings of patients with late-onset Alzheimer’s disease. Genet Epidemiol 1998; 15: 215-223.* 133) Mirel DB, Marder K, Graziano J, Freyer G, Zhao Q, Mayeux R, Wilhelmsen KC. Characterization of the human mitochondrial aconitase gene (ACO2). Gene 1998; 213: 205-218. 134) Devanand DP, Marder K, Michaels KS, Sackeim HA, Bell K, Sullivan MA, Cooper TB, Pelton GH, Mayeux R. A randomized, placebo-controlled dose-comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer’s disease. Am J Psychiatry 1998; 151:1512-1520.* 135) Tanner CM, Ottman R, Goldman SM, Ellenberg J, Chan P, Mayeux R, Langston JW. Parkinson’s disease in twins: An etiologic study. JAMA 1999: 281:341-346. 136) Xu Y, Berglund L, Ramakrishnan R, Mayeux R, Ngai C, Holleran S, Tycko B, Leff T, Shachter NS. A common Hpa I RFLP of apolipoprotein C-I increases gene transcription and exhibits an ethnically distinct pattern of linkage disequilibrium with the alleles of apolipoprotein E. Lipid Res 1999; 40:50-58. 137) Marder K, Tang MX, Alfaro B, Mejia H, Cote L, Louis E, Stern Y, Mayeux R. Risk of Alzheimer's disease in relatives of Parkinson's disease patients with and without dementia. Neurology 1999; 52:719-724.*

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138) Small SA, Perera M, DeLaPaz R, Mayeux R, Stern Y. Differential regional activation of the hippocampal formation among elderly with memory decline. Ann Neurol 1999; 45: 466-472. 139) Small SA, Stern Y, Tang M-X, Mayeux R. Selective decline in memory function among healthy elderly followed prospectively. Neurology 1999; 52: 1392-1396.* 140) Merchant C, Tang M-X, Albert S, Manly J, Stern Y, Mayeux R. The influence of smoking on the risk of Alzheimer’s disease. Neurology 1999; 52: 1408-1412.* 141) Moroney J, Tang M-X, Stern Y, Lerglund L, Small S, Merchant C, Bell K, Mayeux R. Low-density lipoprotein cholesterol and the risk of dementia with stroke. JAMA 1999; 282:254-260.* 142) Gurland BJ, Wilder DE, Lantigua R, Stern Y, Chen J, Killeffer EH, Mayeux R. Rates of dementia in three ethnoracial groups. Int J Geriatr Psychiatry 1999 14:481-93.* 143) Romas S, Tang M-X, Berglund L, Mayeux R. APOE genotype, plasma lipids, lipoproteins and Alzheimer’s disease in northern Manhattan elderly. Neurology. 1999; 53:517-521.* 144) Mayeux R, Tang M-X, Jacobs DM, Manly J, Bell K, Merchant C, Small SA, Stern Y, Wisniewski HM, Mehta PD. Plasma amyloid β peptide 1-42 and incipient Alzheimer’s disease. Ann Neurol 1999; 46: 412-415.* 145) Devi G, Ottman R, Tang M-X, Marder K, Stern Y, Tycko B, Mayeux R. Influence of Apolipoprotein E genotype on familial aggregation of Alzheimer’s disease among Caucasians, African Americans and Carribean Hispanics in Northern Manhattan. Neurology 1999; 53: 789-794.* 146)Teresi JA, Albert SM, Homes D, Mayeux R. Use of latent class analyses for the estimation of prevalence of cognitive impairment, and signs of stroke and Parkinson’s disease among African-Americans elderly of central Harlem: Results of The Harlem Aging Project. Neuroepidemiology. 1999; 18:309-318.* 147) Massoud F, Devi G, Stern S, Lawton A, Goldman JE, Liu Y, Chin SS, Mayeux R. A clinicopathological comparison of community-based and clinic-based cohorts of patients with dementia. Arch Neurol 1999; 56: 1368-1377.* 148) Devi G, Ottman R, Tang M-X, Marder K, Stern Y, Mayeux R. Familial aggregation of Alzheimer’s disease among Whites, African Americans and Caribbean Hispanics in Northern Manhattan. Arch Neurol 2000; 57: 72-77.* 149) Simon DK, Mayeux R, Marder K, Kowall NW, Beal MF, Johns DR. Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson’s disease. Neurology 2000; 54: 703-709. 150) Romas SN, Mayeux R, Rabinowitz D, Tang M-T, Rondon H, Lantigua R, Medrano M, Tycko B, Knowles J. The deletion polymorphism in α-2-macroglobulin is associated with Alzheimer Disease in Caribbean Hispanics. Neurosci Let 2000; 279:133-136.* 151) Manly JJ, Merchant CA, Jacobs DM, Small SA, Bell K, Ferin M, Mayeux R. Endogenous estrogen

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levels and Alzheimer’s disease among postmenopausal women. Neurology 2000; 54: 833-837. 152) Kline J, Kinney A, Levin B, Mayeux R, Schupf N, Warburton D. Alzheimer's disease in the parents of women with trisomic spontaneous abortions. NeuroReport 2000; 11: 795-9. 153) Romas SN, Mayeux R, Tang M-T, Tycko B, Knowles J. No association between a presenilin-1 polymorphism and Alzheimer’s disease. Arch Neurol 2000; 57: 699-702.* 154) Devanand, DP, Michaels-Marston KS, Liu X, Pelton GH, Padilla M, Marder K, Bell K, Stern Y, Mayeux R. Olfactory deficits in mild cognitive impairment predict Alzheimer’s disease on follow-up. Am J Psychiatry 2000; 157: 1399-1405. * 155) Devi G, Fotiou A, Jyrinji D, Tycko B, DeArmand S, Rogaeva E, Song Y, Medieros H, Liang Y, Orlacchio A, Williamson J, St George-Hyslop P, Mayeux R. Novel Presenilin 1 mutations Associated with Early Onset of Dementia in a Family with Both Early and Late Onset Alzheimer’s disease. Arch Neurol 2000; 57: 1454-7. * 156) Massoud F, Devi G, Moroney JT, Stern Y, Lawton A, Bell K, Marder K, Mayeux R. The role of routine laboratory studies and neuroimaging in the diagnosis of dementia: a clinicopathological study. J Am Geriatric Soc 2000; 48: 1204-10.* 157) Small SA, Wu EX, Bartsch D, Perera GM, Lacefield CO, DeLaPaz R, Mayeux R, Stern Y, Kandel ER. Imaging Physiologic Dysfunction of Individual Hippocampal Subregions in Humans and Genetically Modified Mice. Neuron 2000; 28: 653-64. 158) Tang M-X, Cross P, Andrews , Jacobs DM, Small S, Bell K, Merchant C, Lantigua R, Costa R, Stern Y, Mayeux R. Incidence Rates for Alzheimer’s Disease Among Black, Caribbean Hispanic and White Elderly Living in Northern Manhattan. Neurology 2000; 56 (1): 49-56. * 159) Schupf N, Patel B, Silverman W, Zigman WB, Zhong N, TyckoB, Mehta PD, Mayeux R. Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome. Neurosci Lett 2001; 301:199-203.* 160) Small SA, Nava AS, DeLaPaz R, Mayeux R, Stern Y. Circuit mechanisms underlying memory encoding and retrieval in the long axis of the hippocampal formation. Nature Neuroscience 2001; 4: 442-9. 161) Hyman BT, Smith C, Buldyrev I, Whalen C, Brown H, Tang M-X, Mayeux R. Autoantibodies to Alzheimer disease related Aß. Ann Neurol 2001; 49:808-10.* 162) Mayeux R, Small SA, Tang M-X, Tycko B, Stern Y. Memory Performance in Healthy Elderly Without Alzheimer’s Disease: Effects of time and Apolipoprotein-ε4. Neurobiology Aging 2001; 22: 683-9.* 163) Rogaeva EA, Fafel KC, Song YQ Medeiros H, Sato C, Liang Y, Richard E, Rogaev EI, Frommelt P, Sadovnick AD, Meschino W, Boss M, Mayeux R, St George-Hyslop PH. Screening for PS1 mutations in a referral-based series of Alzheimer's Disease cases: 21 Novel mutations. Neurology 2001; 57: 621-5.

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164) Lee J, Tang M-X, Schupf N, Stern Y, Jacobs DM, Tycko B, Mayeux R. Mortality and apolipoprotein E in Hispanics, African-Americans and Caucasians. Am J Medical Genetics 2001; 103: 121-7.* 165) Luchsinger JA, Tang M-X, Stern Y, Shea S, Mayeux R. Diabetes and risk of Alzheimer’s disease and dementia with stroke in a multiethnic cohort. Am J Epidemiology 2001; 154: 635-41.* 166) Schupf N, Kapell D, Nightengale B, Lee JH, Mohlenhoff J, Bewley S Ottman R, Mayeux R. Specificity of the fivefold increase in AD in mothers of adults with Down Syndrome. Neurology 2001; 57: 979-85.* 167) Athan E, Williamson J, Ciappa A, Santana V, Romas SN, Lee JH, Zadroga HR, Lantigua R, Medrano M, Torres M, Arawaka S, Rogaeva E, Song Y, Sato C, Kawarai T, Stern Y, St George-Hyslop P, Tycko B, Mayeux R. A Novel Founder Mutation in Presenilin 1 Causing Early-Onset Alzheimer’s Disease in Unrelated Caribbean Hispanic Families. JAMA 2001; 286: 1-7.* 168) Khokhar SR, Stern Y, Bell K, Anderson K, Noe E, Mayeux R, Albert SM. Persistent mobility deficit in the absence of ADL deficit: A risk factor for mortality. J Am Geriatrics Soc 2001; 45: 1539-43. 170) Mayeux R, Lee JH, Romas SN, Mayo D, Santana V, Williamson J, Ciappa A, Rondon HZ, Estevez P, Lantigua R, Medrano M, Torres M, Stern Y, Tycko B, Knowles JA. Chromosome 12 mapping of Late-Onset Alzheimer Disease Among Caribbean Hispanics. Am J Human Genetics 2002: 70: 237-44.* 171) Romas SN, Santana V, Williamson J, Ciappa A, Lee JH, Rondon HZ, Estevez P, Lantigua R, Medrano M, Torres M, Stern Y, Tycko B, Mayeux R. Familial Alzheimer Disease among Caribbean Hispanics. Arch Neurology; 2002; 59:87-91. * 172) Rodriguez C, Mendez-Pablos A, Palmas W, Lantigua R, Mayeux R, Bergland L. Comparison of modifiable determinants of lipids and lipoprotein levels among African-Americans, Hispanics and Non-Hispanic Caucasians >65 years of age and living in New York City. Am J Cardiology 2002; 89: 178-83. 173) Tanner CM, Goldman SM, Aston DA, Ottman R, Ellenberg J, Mayeux R, Langston JW. Smoking and Parkinson’s disease in twins. Neurology 2002; 58: 581-8. 174) Small SA, Nava SA, Tsai W-Y, DeLaPaz R, Mayeux R, Stern Y. Imaging hippocampal function across the human life span: is memory decline normal or not? Ann Neurol 2002; 51: 290-5. 175) Posner HB, Tang M-X, Luchsinger J, Lantigua R, Stern Y, Mayeux R. The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function. Neurology 2002; 58:1175-81.* 176) Albert SM, Glied S, Andrews H, Stern Y, Mayeux R. Primary Care Expenditures for Newly Diagnosed Alzheimer’s Disease among White, African-American, and Hispanic Elders Living in New York City. Neurology 2002; 59: 573-8.* 177) Luchsinger JA, Tang M-X, Stern Y, Shea S, Mayeux R. Caloric intake and risk of Alzheimer’s disease among elderly African-Americans, Caribbean Hispanics and Whites in New York City. Arch

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Neurol 2002; 59; 1258-63.* 178) Athan ES, Lee JH, Mayeux R, Tycko B. Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer’s disease. Arch Neurol 2002; 59: 1793-9. 179) Pressley JC, Louis ED, Tang MX, Cote LJ, Cohen PD, Glied S, Mayeux RM. The Impact of Comorbid Disease and Injuries on Resource Use and Expenditures in Parkinsonism. Neurology 2003;60:87-93.* 180) ) Luchsinger JA, Tang M-X, Stern Y, Shea S, Mayeux R. Antioxidant vitamin intake and risk of Alzheimer’s disease among elderly African-Americans, Caribbean Hispanics and Whites in New York City. Arch Neurol 2003; 60: 203-8.* 181) Louis E, Luchsinger JA, Tang M-X, Mayeux R. Parkinsonian Signs in a Community Population of Older People: Prevalence and Associations with Smoking and Coffee Consumption. Neurology 2003; 61: 24-8.* 182) Clark LN, Levy G, Tang M-X, Mejia-Santana H, Ciappa A, Tycko B, Cote LJ, Louis LD, Mayeux R, Marder K. The Saitohin ‘Q7R’ Polymorphism and Tau Haplotype in Multi-ethnic Alzheimer Disease and Parkinson’s Disease Cohorts. Neurosci Letters 2003; 347: 17-20. 183) Schupf N, Pang D, Patel BN, Silverman W, Schubert R, Lai F, Kline JK, Stern Y, Ferin M, Tycko B, Mayeux R. Onset of dementia is associated with age at menopause in women with Down syndrome. Ann Neurol 2003; 54: 433-8. * 184) Davis HP, Small SA, Stern Y, Mayeux R, Feldstein SN, Keller FR. Acquisition, recall, and forgetting of verbal information in long-term memory by young, middle-aged, and elderly individuals. Cortex 2003; 39:1063-91. 185) Mayeux R, Honig L, Tang M-X, Manly J, Stern Y, Mehta PD. Plasma amyloid Aβ40 and Aβ42 and Alzheimer’s disease: Relation to stage of disease, age and mortality. Neurology* 2003 11;61:1185-1190. 186) Honig LS, Tang M-X, Albert S, Costa R, Stern Y, Manly JJ, Mayeux R. Stroke and the risk of Alzheimer's disease. Arch Neurol 2003; 1707-12.* 187) Hoskin E, Tang M-X, Manly J, Mayeux R. Elevated Sex Hormone Binding Globulin in Elderly Women with Alzheimer’s Disease. Neurobiol Aging. 2004; 25:141-7.* 188) Patel BN, Pang D, Stern Y, Silverman W, Kline JK, Mayeux R, Schupf N. Obesity enhances verbal memory in postmenopausal women with Down syndrome. Neurobiol Aging. 2004; 25:159-66. 189) Devi G, Williamson J, Massoud F, Anderson K, Stern Y, Devanand DP, Mayeux R. A comparison of family history of psychiatric disorders among patients with early- and late-onset Alzheimer's disease. J Neuropsychiatry Clin Neurosci. 2004;16:57-62.* 190) Louis ED, Tang M-X, Mayeux R. Factor structure of parkinsonian signs in the community-dwelling elderly. Mov Disord. 2004; 19: 268-72.*

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191) Lee JH, Flaquer A, Stern Y, Tycko B, Mayeux R. The Heritability of Memory as a Phenotypic Component of Alzheimer’s Disease. Neurology 2004;62: 414-21. * 192) Luchsinger JA, Tang M-X, Shea S, Mayeux R. Alcohol intake and risk of dementia. JAGS 2004; 52: 540-6.* 193) Reitz C, Tang M-X, Luchsinger J, Mayeux R. Relation of Plasma Lipids to Alzheimer’s Disease and Vascular Dementia. Arch Neurol 2004 ;61: 705-14. 194) Li Q, Athan ES, Yuan E, Rice SL, Vonsattel J-P, Mayeux R, Tycko B. TP73 allelic expression in human brain and allele frequencies in Alzheimer's disease. BMC Medical Genetics 2004; 5:14. 195) Luchsinger JA, Tang M-X, Shea S, Miller J, Green R, Mayeux R. Plasma homocysteine levels and risk of Alzheimer’s disease. Neurology 2004; 62: 1972-76*. 196) Clark LN, Afridi S, Mejia-Santana H, Harris J, Louis ED, Cote LJ, Andrews H, Singleton A, De-Vrieze FW, Hardy J, Mayeux R, Fahn S, Waters C, Ford B, Frucht S, Ottman R, Marder K. Analysis of an early-onset Parkinson’s disease cohort for DJ-1 mutations. Mov Disord 2004; 19: 796-800. 197) Lee JH, Flaquer A, Estrada-Nadal L, Costa R, Andrews H, Cross P, Lantigua R, Mayeux R. Genetic influences on life span and survival among elderly African-Americans, Caribbean Hispanics and Caucasians. Am J Med Gene 2004: 128A: 159-64.* 198) Louis ED, Tang M-X, Mayeux R. Parkinsonian signs in older people in a community-based study: Risk of incident dementia. Arch Neurol 2004; 61: 1273-6. * 199) Tycko B, Lee JH, Ciappa A, Saxena A, Li C-M, Lin Feng L, Arriaga A, Stern Y, Lantigua R, Yang L, Shachter NS Mayeux R. APOE and APOC1 promoter polymorphisms and Alzheimer’s disease in African-Americans and Caribbean Hispanics. Arch Neurol 2004; 61: 1434-9.* 200) Luchsinger JA, Tang M-X, Shea S, Mayeux R. Hyperinsulinemia and risk of Alzheimer’s disease. Neurology 2004; 63:1187-92. * 201) Lee JH, Mayeux R , Mayo D, Santana V, Williamson J, Flaquer A, Ciappa A, Rondon HZ, Estevez P, Lantigua R, Kawari T, Toulina A, Medrano M, Torres M, Stern Y, Tycko R, Rogaeva E, St George-Hyslop, Knowles JA. Fine mapping of 10q and 18q for familial Alzheimer disease in Caribbean Hispanics. Mol Psychiatry 2004; 9:1042-51.* 202) Pressley JC, Tang MX, Marder K, Cote LJ, Mayeux R. Disparities in the recording of Parkinson's disease on death certificates. Mov Disord 2004 ; 20:315-321.* 203) Schupf N, Costa R, Tang M-X, Andrews H, Tycko B, Lee JH, Mayeux R. Preservation of cognitive and functional ability as markers of longevity. Neurobio Aging 2004; 25:1231-40* 204) Honig L, Kukul B, Mayeux R. Atherosclerosis and AD: Analysis of data from the US national Alzheimer’s Coordinating Center. Neurology 2005; 64: 494-500.*

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205) Louis ED, Tang MX, Schupf N, Mayeux R. Functional correlates and prevalence of mild parkinsonian signs in a community population of older people. Arch Neurol. 2005; 62:297-302. * 206) Schupf N, Costa R, Luchsinger J, Tang MX, Lee JH, Mayeux R. Relationship between plasma lipids and all-cause mortality in nondemented elderly. J Am Geriatr Soc. 2005;53:219-26. *

207) Reitz C, Luchsinger J, Tang MX, Manly J, Mayeux R. Impact of plasma lipids and time on memory performance in healthy elderly without dementia. Neurology. 2005; 64: 1378-83.* 208) Louis ED, Schupf N, Manly J, Marder K, Tang MX, Mayeux R. Association between mild parkinsonian signs and mild cognitive impairment in a community. Neurology. 2005; 64: 1157-61.* 209) Devanand DP, Pelton GH, Zamora D, Liu X, Tabert MH, Goodkind M, Scarmeas N, Braun I, Stern Y, Mayeux R. Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment. Arch Neurol. 2005; 62 :975-80.* 210) Clark LN, Nicolai A, Afridi S, Harris J, Mejia-Santana H, Strug L, Cote LJ, Louis ED, Andrews H, Waters C, Ford B, Frucht S, Fahn S, Mayeux R, Ottman R, Marder K. Pilot association study of the beta-glucocerebrosidase N370S allele and Parkinson's disease in subjects of Jewish ethnicity. Mov Disorders 2005; 20:100-3. 211) Luchsinger J, Reitz C, Honig LS, Tang M-X, Mayeux R. Aggregation of vascular risk factors and risk of Alzheimer’s disease. Neurology; 2005: 65: 545-51.* 212) Reitz C, Luchsinger J, Tang MX, Mayeux R. Effect of smoking and time on cognitive function in the elderly without dementia. Neurology. 2005; 65: 870-5. * 213) Albert SM, Simone B, Brassard A, Stern Y, Mayeux R. Medicaid home care services and survival in New York City. Gerontologist. 2005; 45: 609-16.* 214) Schupf N, Tang MX, Albert SM, Costa R, Andrews H, Lee JH, Mayeux R. Decline in cognitive and functional skills increases mortality risk in nondemented elderly. Neurology 2005; 65:1218-26.* 215) Manly JJ, Bell-McGinty S, Tang M-X, Schupf N, Stern Y, Mayeux R. Implementing diagnostic criteria and estimating frequency of Mild Cognitive Impairment in an urban community. Arch Neurol. 2005;62:1739-46.* 216) Rippon GA, Tang M-X, Lee JH, Lantigua R, Mayeux R.Familial Alzheimer Disease in Caribbean Hispanics: Interaction Between Stroke, Estrogen Replacement and APOE. Neurology 2006; 66:35-40.* 217) Shibata N, Kawarai T, Lee JH, Shibata E, Salehi-Rad S, Sato C, Morgan A, Mayeux RP, Rogaeva E, St George-Hyslop PH. Genetic study of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease. Neuroscience Letters 2006; 391:142-6. 218) Reitz C, Luchsinger JA, Tang MX, Manly J, Mayeux R. Stroke and memory performance in elderly persons without dementia. Arch Neurol 2006; 63:571-6.

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219) Scarmeas N, Stern Y, Tang M-X, Mayeux R, Luchsinger JA. Mediterranean diet and risk of Alzheimer’s disease. Ann Neurol 2006; 59: 912-21. 220) Honig LS, Schupf N, Lee JH, Flores I, Tang M-X, Mayeux R. Short telomere repeat length is associated with mortality and dementia. Ann Neurol. 2006; 60: 181-7. 221) Schupf N, Winsten S, Patel B, Pang D, Ferin M, Zigman WB, Silverman W, Mayeux R. Bioavailable estradiol and age at onset of Alzheimer's disease in postmenopausal women with Down syndrome. Neuroscience Letters 2006; 406: 298-302. 222) Olarte L, Schupf N, Lee JH, Tang M-X, Santana V, Williamson J, Tycko B, Maramreddy P, Mayeux R. APOE-ε4 and Age-At-Onset of Sporadic and Familial Alzheimer Disease in Caribbean Hispanics. Arch Neurology 2006; 63: 1586-90.* 223) Lee JH, Cheng R, Santana V, Williamson J, Lantigua R, Medrano M, Arriaga A, Stern Y, Tycko B, Rogaeva E, Wakutani Y, Kawarai T, St George-Hyslop P, Mayeux R. Expanded Genome-Wide Scan Implicates a Novel Locus at 3q28 Among Caribbean Hispanics with Familial Alzheimer’s Disease. Arch Neurology 2006; 63: 1591-8. * 224) Elbaz A, Nelson L, Payami H, Ioannidis JPA, Fiske BK, Annesi G, Carmine A, Factor SA, Ferrarese C, Hadjigeorgiou GM, Higgins D, Kawakami H, Krueger P, Marder K, Mayeux R, Mellick G, Nutt J, Ritz B, Samii A, Tanner CM, Van Broeckhoven C, Van Den Eeden SK, Wirdefeldt K, Zabetian CP, Dehem M, Montimurro JS, Myers RM, Southwick A, Trikalinos TA. Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study. Lancet Neurology 2006; 5:917-23. 225) Luchsinger JA, Miller J, Green R, Tang M-X, Mayeux R. Higher folate intake is related to lower risk of Alzheimer’s disease in the elderly. Arch Neurol 2007; 64: 86-92. 226) Scarmeas N, Stern Y, Mayeux R, Luchsinger JA. Mediterranean diet, Alzheimer's disease and vascular mediation. Arch Neurol. 2006; 63: 1707-17. 227) Rogaeva E, Meng Y, Lee JH, Gu Y-J, Kawarai T, Katayama T, Erlich P, Baldwin CT, Cheng R, Tycko B, Hasegawa H, Chen F, Shibata N, Lunetta K, Cupples LA, Green RC, Sato C, Ruan X, Salehi-Rad S, Liang Y, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Hampe W, Bujo H, Song Y, Fraser PE, Westaway D, Schmitt-Ulms G, Mayeux R, Farrer LA, St George-Hyslop P. The sortilin-related receptor SORLA is functionally and genetically associated with Alzheimer's disease. Nat Genetics 2007; 39:168-177. 228) Devanand DP, Pradhaban G, Liu X, Khandji A, De Santi S, Segal S, Rusinek H, Pelton GH, Honig LS, Mayeux R, Stern Y, Tabert MH, de Leon MJ. Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease. Neurology. 2007; 68 :828-36. 229) Luchsinger JA, Patel B, Tang MX, Schupf N, Mayeux R. Measures of adiposity and dementia risk in elderly persons. Arch Neurol 2007; 64: 392-8. * 230) Lee JH, Cheng R, Schupf N, Manly JJ, Lantigua R, Stern Y, Rogaeva E, Wakutani Y, Farrer L St George-Hyslop P , Mayeux R. The Association Between Genetic Variants in SORL1 and Alzheimer's

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Disease in an Urban, Multiethnic, Community-Based Cohort. Arch Neurol; 64:501-6.* 231) Luchsinger JA, Reitz C, Patel B, Tang MX, Mayeux R. Relation of diabetes to mild cognitive impairment. Arch Neurol; 64:570-5.* 232) Luchsinger JA, Tang MX, Miller J, Green R, Mehta PD, Mayeux R. Relation of plasma homocysteine to plasma amyloid beta levels. Neurochem Res 2007; 32:775-81* 233) Reitz C, Patel B, Tang MX, Manly J, Mayeux R, Luchsinger JA. Relation between vascular risk factors and neuropsychological test performance among elderly persons with Alzheimer's disease. J Neurol Sci. 2007 Jun 15;257(1-2):194-201. 234) Reitz C, Brickman AM, Luchsinger JA, Wu WE, Small SA, Tang M-X, Mayeux R. Frequency of subclinical heart disease in elderly persons with dementia. AJGC 2001; 16:183-8.* 235) Shibata N, Kawarai T, Meng Y, Lee JH, Shibata E, Sato C, Sorbi S, Bruni AC, Duara R, Mayeux R, Farrer LA, St George-Hyslop P, Rogaeva E. Association studies between the plasmin genes and late-onset Alzheimer's disease. Neurobiol Aging 207; 28: 1041-3.

236) Luchsinger JA, Tang MX, Mayeux R. Glycemic Load and Risk of Alzheimer's Disease. J Nutr Health Aging 2007; 11:238-41.* 237) Schupf N, Patel B, Pang D, Zigman WB, Silverman W, Mehta PD, Mayeux R Elevated plasma amyloid β-peptide Aβ42, incident dementia and mortality in Down syndrome. Arch Neurol 2007; 64:1007-13. Invited Reviews: 1) Mayeux R. Parkinson's disease and dementia. Current Opinion Neurol Neurosurg 1988; 1: 279-283.* 2) Mayeux R. Therapeutic strategies in Alzheimer's disease. Neurology 1990; 40; 175-80.* 3) Mayeux R. Parkinson's disease: a review of cognitive and psychiatric disorders. J Neuropsych Neuropsychiatr Behav Neuro 1990; 3:3-14.* 4) Mayeux R. Extrapyramidal Disorders and Dementia. Current Opinion in Neurology 1990; 3: 98-102.* 5) Mayeux R. A neurologist's view of a registry for Alzheimer's disease. Aging 1990; :97-9.* 6) Mayeux R. Diagnostic problems in nursing home patients with dementia: Why we should and how we can improve accuracy. Alzheimer Disease and Related Disorders 1994: 8: S184-S187.* 7) Chun MR, Mayeux R. Alzheimer's Disease. Current Opinion in Neurology 1994; 7: 299-304.* 8) Spencer S, Davis P, DeAngelis L, Denckla M, Mayeux R, Meador K, Price R. Status of Clinical Research in neurology. Neurology 1995; 45:839-845.

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9) Mayeux R, Schupf N. Apolipoprotein-Ε and Alzheimer's disease: The implications of progress in molecular medicine. Am J Public Health 1995; 85: 1280-1284.* 10) American College of Medical Genetics Working Group on APOE Testing in Alzheimer’s Disease. Statement on the Use of Apolipoprotein E Testing For Alzheimer’s disease. JAMA 1995; 274:1627-1629. 11) National Institute on Aging/Alzheimer’s Association Working Group. Apolipoprotein E genotyping in Alzheimer’s Disease. Lancet 1996; 347: 1091-1095. 12) Mayeux R. Development of a national prospective study of Alzheimer’s disease. Alzheimer’s Disease and Related Disorder. Alzheimer Disease and Associated Disorders 1996; 10 (suppl.1): 38-44.* 13) Mayeux R. Evaluation and use of diagnostic tests in Alzheimer’s disease. Neurobiol Aging 1998; 19: 139-143.* 14) Logroscino G, Marder K, Graziano J, Freyer G, Slavkovich V, Lojacono, Cote LJ, Mayeux R. Dietary iron, animal fat and risk of Parkinson’s disease. Movement Disord 1998; 13: (S1) 13-16.* 15) Mayeux R. Gene-environment interaction in late-onset Alzheimer disease: the role of apolipoprotein-ε4. Alzheimer Dis Assoc Disord 1998;12 Suppl 3:S10-5 16) Small SA, Mayeux R. A clinical approach to memory decline. J Practical Psychiatry and Behavioral Health 1999; 5:87-94.* 17) Mayeux R, Sano M. Drug Therapy: The treatment of Alzheimer’s Disease. New Engl J Med 1999; 341:1670-79.* 18) Honig LS, Mayeux R. Natural history of Alzheimer’s disease. Aging Clin Exp Res 2001; 13: 171-82. 19) Mayeux R. Epidemiology of Neurodegenerative Diseases. Annual Review of Neuroscience. 2003; 26: 81-104. 20) Kennedy JL, Farrer LA, Andreasen NC, Mayeux R, St George-Hsylop P. The Genetics of Common Adult-onset Neuropsychiatric Disease: Complexities and Conundra? Science 2003; 302:822-6. 21) Lee JH, Mayeux R. Genetics and its use in Alzheimer’s disease. Trends in Evidence-Based Neuropsychiatry 2003; 5(3): 41-47. 22) Mayeux R. Biomarkers: Potential Uses and Limitations. NeuroRx 2004; 1: 182-8. 23) Luchsinger JA, Mayeux R. Cardiovascular risk factors and Alzheimer’s disease. Curr Atheroscler Rep 2004; 6: 261-6. 24) Luchsinger JA, Mayeux R. Dietary factors and Alzheimer’s disease. The Lancet Neurology 2004; 3: 579-87.

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25) Mayeux R. Mapping the new frontier: complex genetic disorders. J Clin Invest 2005; 115:1404-1407. 26) Mayeux R. Genetic Epidemiology of Alzheimer Disease. Alzheimer Dis Assoc Disord. 2006 July/September;20 Suppl 2:S58-S62. 27) Luchsinger JA, Mayeux R. Adiposity and Alzheimer’s disease. Current Alzheimer Research 2007; 4: 127-134. Chapters: 1) Mayeux R. Disorders of speech and learned movements: Aphasia and Apraxia. In: Principals of Neural Science. Kandel, Eric R., Schwartz, James H., (Eds). Elsevier North-Holland, New York, Volume I 1981, pps. 593-598. 2) Mayeux R. Depression and Dementia in Parkinson's disease. In: Movement Disorders. Butterworths International Medical Reviews, Marsden CD, and Fahn S (Eds), London, Butterworth Scientific, pps. 75-99, 1982.* 3) Ilson J, Fahn S, Mayeux R, Cote L: Pergolide in Parkinson's disease. Lisuride and other dopamine agonists. Calne D, Horowski R, MacDonald RJ, Wuttke W, (Eds), Raven Press. New York; 1983:443-45l. 4) Ilson J, Fahn S, Mayeux R, Cote L, Snider S: Pergolide treatment of Parkinsonism. Experimental therapeutics of movement disorders. Fahn S, Calne D, Shoulson I, (Eds), Raven Press. New York; 1983:85-94. 5) Mayeux R. Emotional Changes Associated with Basal Ganglia Disorders. In: Neuropsychology of Human Emotion. Heilman KM, Satz P, (Eds). Guilford Press, New York; 1983;141-164.* 6) Mayeux R, Stern Y: Intellectual dysfunction and dementia in Parkinson's disease. In: The Dementias. Mayeux R, Rosen W, (Eds). Raven Press, New York; 1983:211-227.* 7) Mayeux R, Williams JBW, Stern Y, Cote L: Depression and Parkinson's disease. In: Parkinson-specific Motor and Mental disorders. Hassler RG, Christ JF (Eds). Adv Neurol 1984; New York: Raven Press, 40: 241-250.* 8) Mayeux R. Behavioral manifestations of movement disorders: Parkinson's disease and Huntington's disease. In Jankovic J (Ed) Movement Disorders. Neurological Clinics 1984; 2:527-540. Philadelphia:Saunders.* 9) Mayeux R and Kandel ER: Natural language, disorders of language and other localizable disorders of cognitive functioning. In: Principals of Neural Science. Kandel ER, Schwartz JH, (Eds). Elsevier North-Holland, New York, Second Edition, 1985, pps. 688-702. 10) Mayeux R, Stern Y: Clinical Heterogeneity in patients with dementia of the Alzheimer type. Alzheimer's and Parkinson's Disease. Fisher, Hanin, Lachman (eds), New York: Raven Press, pps 129-134.

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11) Stern Y, Mayeux R. Possible dopaminergic basis for perceptual motor dysfunction. Alzheimer's and Parkinson's Disease. Fisher, Hanin, Lachman (eds), New York: Raven Press, pps 185-190.* 12) Prohovnik I, Smith G, Sackeim HA, Mayeux R, Stern Y: The early stages of presenile and senile Alzheimer's disease: Initial studies of disease severity and cerebral blood flow. Alzheimer's and Parkinson's Disease. Fisher, Hanin, Lachman (eds), New York: Raven Press, pps 233-240.* 13) Stern Y, Mayeux R. Intellectual Impairment in Parkinson's disease. Parkinson's Disease. Yahr & Bergman (Eds). Raven Press, New York, pps 405-409.* 14) Mayeux R, Stern Y: Depression and Parkinson's disease. Parkinson's Disease. Yahr & Bergman (Eds). Raven Press, New York, pps 451-456.* 15) Mayeux R. The Mental State. Handbook of Parkinson's Disease. Koller WA (Ed), New York, Dekker, pps 125-146. 1987.* 16) Marder K, Mayeux, R. Recognition and management of major behavior problems in Parkinson's disease. The Comprehensive Management of Parkinson's disease. Stern MB, Hurtig HI (eds). New York: PMA Publishing Co. 1988.* 17) St.George-Hyslop P., Haines J, Farrer L, Tanzi R, Hobbs W, Polinsky RJ, Nee L, Sorbi S, Piacentini S, Amaducci L, Heston L, Orr H, Fish S, Crapper-McLachlan D, Percy M, Frommelt P, Foncin J-F, Bruni A, Wexler N, Mayeux R, and others: Molecular Genetics of Autosomal Dominant Familial Alzheimer's Disease. The Molecular Biology of Alzheimer's Disease. Finch CE, Davies P (Eds), Cold Spring Harbor, NY, Cold Spring Harbor Lab. Publications, pps 159-68, 1988. 18) Mayeux R. The epidemiology of major forms of dementia in the United States. In: Sinha KK, Chandra P (eds), Progress in Clinical Neurosciences. Ranchi, India: Catholic Press, 1988; 1:335-347.* 19) Mayeux R. A current analysis of behavioral problems in patients with idiopathic Parkinson's disease. Movement Dis 1989; 4: 26-37 (Supplement).* 20) Mayeux R. Alzheimer's Disease. Principles of Geriatric Medicine. Hazzard WR, Andres R, Bierman EL, Blass JP (eds). New York: McGraw-Hill 1989, pps. 934-48.* 21) Mayeux R. The "serotonin" hypothesis for depression in Parkinson's disease. Adv Neurol 1990; 53:163-166).* 22) Gurland BJ, Mayeux R, Meyers BS. The effectiveness of intervention for the mental health of the elderly. In: Kane RL, Evans JG, Macfadyen D.(ed): Improving the Health in Older People: A World View. London, Oxford University, 1990;(16)262-272. 23) Mayeux R. The "Genetics" of Alzheimer's disease. in: Merritt's Textbook of Neurology, Update 7, Rowland LP (ed), 1991, Lea & Febiger, pps 3-10.* 24) Mayeux R, Kandel E. Disorders of Language: The Aphasias. In: Kandel E, Schwartz J, Jessell TM. Principles of Neural Science. Third Edition, 1991. Elsevier, New York, pps:839- 851. 25) Marder K, Mayeux R. The Epidemiology of Dementia in Patients with Parkinson's Disease. In: The

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Basal Forebrain. Napier TC, et al (eds). New York: Plenum Press, 1991, pps.439-45.* 26) Sano R, Mayeux R. The Biochemistry of Depression in Parkinson's Disease. In: Parkinson's Disease. Neurobehavioral Aspects. Huber SJ, Cummings JL (eds), New York: Oxford University Press, 1992, pps. 229-239.* 27) Mayeux R, Foster N, Rossor M, Whitehouse PJ. The clinical evaluation of patients with dementia. In: Whitehouse PJ (ed), Dementia, Philadelphia: FA Davis, 1992, pps 92-117.* 28) Civil R, Whitehouse PJ, Lanska D, Mayeux R. Degenerative Dementias. In: Whitehouse PJ (ed), Dementia, Philadelphia: FA Davis, 1992, pps.167-214. 29) Mayeux R, Tatemichi TK, Sacktor N. The Other Dementias. In: Current Therapy in Neurologic Disease. Johnson RT, Griffin JW (eds). St. Louis: Decker BC, 1993, pps. 296-301.* 30) Tatemichi TK, Sacktor N, Mayeux R. Dementia Associated with Cerebrovascular Disease, Other Degenerative Diseases and Metabolic Disorders. In: Katzman R, Terry R, Bick K (eds), Alzheimer's Disease. New York: Raven Press,1994, pps. 123-166.* 31) Mayeux R, Chun MR. Acquired and Hereditary Dementias. In: Rowland LP (ed), Merritt's Textbook of Neurology. Ninth edition (1994), pps 677-685.* 32) Sacktor N, Mayeux R. Dementia and Delirium. In: Rowland LP (ed), Merritt's Textbook of Neurology. Ninth edition (1994), pps 1-8.* 33) Maestre G, Schofield P, Chun M, Tang M-X, Tycko B, Mayeux R. Ethnic Variation in the Association Between APOE-ε4 and Alzheimer’s Disease: A Follow-up Study. In: Roses AD, Weisgaber K, Christen Y (eds). Apolipoprotein E and Alzheimer’s Disease. Berlin: Springer-Verlag. 1996, pps 170-179.* 34) Mayeux R, Marder K. Putative Clinical and Genetic Antecedents of Dementia Associated with Parkinson's Disease. Dementia With Lewy Bodies. New York: Churchill Livingstone, 1996, pps. 33-45.* 35) Tang, M-X, Maestre G, Tsai W-Y, Liu X-H, Feng L, Chung W-Y, Chun M, Schofield P, Stern Y, Tycko B, Mayeux R. Effect of age, ethnicity and head injury on the association between APOE genotypes and Alzheimer’s disease. In: Relkin NR, Khachaturian ZS, Gandy S (eds) Apolipoprotein E Gentoyping in Alzheimer’ s Disease. Annals of the New York Academy of Sciences 1996; 802: 6-15.* 36) Chun MR, Schofield P, Stern Y, Mayeux R. The Epidemiology of Dementia Among the Elderly: Experience from a Community-Based Registry. Association for Research in Nervous and Mental Disease. Washington D.C., American Psychiatric Press, 1998, pps.1-26.* 37) Schofield P, Mayeux R. Alzheimer’s Disease: Clinical features, Diagnosis and Epidemiology. In: Markesberry W. The Neuropathology of Dementing Disease. New York: Oxford University Press, 1998, pps. 89-105.* 38) Manly JJ, Jacobs DM, Mayeux R. Alzheimer Disease Among Different Ethnic and Racial Groups. In: Terry RD, Katzman R, Bick KL, Sisodia SS (eds), Alzheimer's Disease. Philadelphia: Lippincott

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Williams and Wilkins,1999, pps. 117-132.* 39) Mayeux R, Gandy S. Alzheimer’s Disease. In Goldman MB, Hatch MC(eds) Women and Health. San Diego: Academic Press, 1999 pps. 1227-1238.* 40) Jacobs DM, Stern Y, Mayeux R. Dementia in Parkinson disease, Huntington disease, and other degenerative conditions. In Feinberg TE, Farah MJ, eds. Patient-Based Approaches to Cognitive Neuroscience. Cambridge: MIT Press, 2000, pp. 375-383.* 41) Mayeux R. Alzheimer’s Disease. The Dana Guide to Brain Health and Disorders. The Dana Press. 42)Mayeux R. Apolipoprotein-E and the Epidemiology of Alzheimer’s Disease. In: Khoury MJ, Little J, Burke W. Human Genome Epidemiology: Scientific Basis for Using Genetic Information to Improve Health and Prevent Disease. Oxford University Press, 2003, pps 365-82. 43) Mayeux R. Alzheimer’s Disease: Epidemiology. In: Kurtzke JF. Neuroepidemiology. Encyclopedia of the Neurological Sciences. Aminoff MJ, Daroff RB (Eds). Academic Press, 2003. 44) Mayeux R. The Influence of α-tocopherol, Caloric Restriction and Genes on Life Span. In: Rosenberg R, Prusiner S, DiMauro S, Barchi R and Nestler E (eds), The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Third Edition. Butterworth-Heinemann, Woburn, Mass, 2003, pps. 693-8. 45) Manly JJ, Mayeux R. Ethnic differences in dementia and Alzheimer's disease. In N. A. Anderson, R. A. Bulatao, and B. Cohen (Eds.) Critical perspectives on racial and ethnic differentials in health in late life. Washington, DC: National Academies Press. 2004, pps. 95-141.

Case Reports: 1) Mayeux R, Fahn S: Strokes and ulcerative colitis. Neurology 1978; 28:571-4. 2) Latovitzki N, Abrams G, Clark C, Mayeux R, Ascherl G, Sciarra D: Cerebral cysticercosis. Neurology 1978; 28:838-42. 3) Mayeux R, Leuders H: Complex partial status epilepticus: case report and proposal for diagnostic criteria. Neurology 1978; 28:957-62. 4) Mayeux R. Sexual intercourse and transient global amnesia. (Letter) New Eng J Med 1979; 300:854. 5) Mayeux R, Hunter S, Fahn S: More on myoclonus in Alzheimer disease. Ann Neurol 1980; 8:200. 6) Mayeux R, Benson DF: Phantom limb and multiple sclerosis. Neurology 1979; 29:724-26. 7) Mayeux R, Alexander M, Benson F, Brandt J, Rosen J: Poriomania. Neurology 1979; 29: 1616-19. 8) Miranda A, DiMauro S, Eastwood AB, Hays A, Johnson WG, Olarte M, Whitlock R, Mayeux R, Rowland LP: Lipid Storage myopathy, ichthyosis, steatorrhea. Muscle Nerve 1979; 2:1-13.

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9) Fahn S, Mayeux R. Unilateral Parkinson's disease and contralateral tardive dyskinesia: A unique case with successful therapy that may explain the pathophysiology of these two disorders. Neural Trans (Supplement) 1980; 16:179-85. 10) Burke R, Fahn S, Mayeux R, Weinberg H, Louis K, Wilner JH: Neuroleptic malignant syndrome due to dopamine-depleting drugs in a patient with Huntington disease. Neurology 1981; 31:1022-6. 11) Mayeux R, Fahn S: Paroxysmal dystonic choreoathetosis in a patient with familial ataxia. Neurology 1982; 32:1184-6. 12) Shale H, Fahn S, Mayeux R. Tics in a patient with Parkinson's disease. Movement Disorders. 1986; 1:79-83. Edited Volumes: 1) Mayeux R, Rosen W: The Dementias. Raven Press, New York; 1983, Volume 38, Advances in Neurology. 2) Agnoli A, Cahn J, Lassen N, Mayeux R. Senile Dementias. London: John Libbey, 1988. 3) Fahn S, Mayeux R. Progress in Parkinson's disease. Movement Disorders, 4 (Supplement), 1989. 4) Surgeon General Report on Tobacco Use, 1995. 4) Mayeux R, Christen Y. Epidemiology of Alzheimer’s disease: From gene to prevention. Research and Perspectives in Alzheimer’s Disease. Springer Berlin Heidelberg 1999 5) Hofman A and Mayeux R. Investigating Neurological Disease: Epidemiology for Clinical Neurology. Cambridge University Press 2001. 6) Institute of Medicine Report. Gulf War and Health: Insecticides and Solvents. The National Academies Press, Washington DC. 2003. 7) Institute of Medicine Report. Gulf War and Health: Updated Literature Review of Sarin. The National Academies Press, Washington DC. 2004. Editorials and Commentaries: 1) Mayeux R. Understanding Alzheimer’s disease: Expect more genes and other things. Ann Neurol 1996; 39: 689-690. 2) Mayeux R, Ottman R. Alzheimer’s disease genetics: home runs and strike outs. Ann Neurol 1998; 44: 716-719. 3) Grodstein F, Mayeux R, Stampfer MJ. Tofu and cognitive function: food for thought J Am Coll Nutr

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2000; 19: 207-9. 4) Mayeux R, Small SA. Finding the beginning or predicting the future? Arch Neurol 2000; 57: 783-4. 5) Mayeux R. Evil forces and vulnerable brains. Neurology 2000; 28:1428-9. 6) Mayeux R. Can estrogen or selective estrogen-receptor modulators preserve cognitive function in elderly women? N Engl J Med 2001; 344: 1242-4. 7) Mayeux R. Apolipoprotein E, African Americans and Alzheimer’s Disease. Arch Neurol 2003; 60:161-3. 8) Mayeux R. Dissecting the relative influences of genes and the environment in Alzheimer's disease. Ann Neurol. 2004;55:156-8. 9) Green NS, Mayeux R. The long and short of it: telomeres and the brain. Lancet Neurology 2006; 5:999-1000. Relevant Brief Notes: 1) Sano M, Stern Y, Mayeux R, Hartman S, Devanand DP. A standardized technique for establishing the onset symptoms of probable Alzheimer's disease. J Clin Exp Neuropsychol 1987:9;65. 2) Stern Y, Sano M, Paulson J, Mayeux R. Modified Mini-Mental State Examination: Validity and Reliability. Neurology 37 (Supp 1); 1987:179. 3) Richards M, Stern Y, Mayeux R. Subtle extrapyramidal signs and incident dementia: A follow-up analysis. Neurology 1995; 45: 1942. 4) Mayeux R. Apolipoprotein ε4 and head trauma: Synergistic or additive risks? Neurology 46: 889-892. 5) Rosenberg RN, Pedley TA, Baringer JR, Fahn S, Lisak RP, Mayeux R, Olson SF, Ringel SP, Rowland LP, Selzer ME. At jeopardy: the NIH as we know it. Arch Neurol. 2003; 60:1191-2 Manuscripts In Press or submitted: 1) Reitz C, Tang M-X, Mayeux R, Luchsinger JA. Incident Dementia is preceded by Increases in Systolic Blood Pressure in the Elderly. (submitted) 2) Mayeux R. Alzheimer’s disease: Epidemiology. (The Handbook of Clinical Neurology, 3rd Series). 3) Luchsinger JA, Patel B, Tang MX, Schupf N, Mayeux R. Body mass index, dementia, and mortality in the elderly. (J Nutr Health Aging). 4) Muller M, Tang MX, Schupf N, Manly JJ, Mayeux R, Luchsinger JA. Metabolic syndrome and

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dementia risk in a multiethnic elderly cohort. (Dement Geriatr Cogn Disord). 5) Johnson B, Santana V, Schupf N, Tang M-X, Stern Y, Mayeux R, Lee JH. The Heritability of Abstract Reasoning in Caribbean Latinos with Familial Alzheimer Disease. (Dement Geriatr Cogn Disord). 6) Moreno H, Wu WE, Lee T, Brickman A, Mayeux R, Brown TR, Small SA. Imaging the Aβ-related neurotoxicity of Alzheimer’s disease (Arch Neurol). 7) Scarmeas N, Luchsinger JA, Mayeux R, Stern Y. Mediterranean diet and Alzheimer's disease mortality. (Neurology). 8) Williamson J, Goldman JS, Mayeux R. Genetic research and genetic testing in Alzheimer's disease: a view from the bridge. (Nat Clin Pract Neurol).* 9) Lee JH, Cheng R, Honig LS, Vonsattel JP, Clark L, Mayeux R. The association between genetic variants in SORL1 and autopsy-confirmed Alzheimer’s disease. (Neurology)* 10) Lee JH, Cheng R, Rogaeva E, Meng Y, Stern Y, Santana V, Lantigua R, Medrano M, Jimenez-Velazques I, Farrer LA, St George-Hyslop P , Mayeux R. The chromosome 12p13 locus for late-onset Alzheimer’s disease. (submitted)* 11) Lee JH, Barral S, Cheng R, Chacon I, Santana V, Williamson J, Lantigua R, Medrano M, Ivonne Jimenez-Velazques, Stern Y, Tycko B, Rogaeva E, Wakutani Y,Kawarai T, St George-Hyslop P , Mayeux R. Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer’s disease. (submitted)*