curriculum vitae brent w. weston, m.d. october 25, 2013 2014-02-19آ  curriculum vitae brent w....

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    CURRICULUM VITAE BRENT W. WESTON, M.D. October 25, 2013 Associate Professor of Pediatrics Division of Hematology – Oncology University of North Carolina at Chapel Hill EDUCATION: Fellowship and lecturer Pediatric Hematology/Oncology, Mott Children's Hospital, University of Michigan Medical Center, Ann Arbor, MI, 1988-1992. Postgraduate Pediatric internship and residency, University of North Carolina at Chapel Hill, NC, 1985-1988. Medical MD, Duke University School of Medicine, 1981-1985. Epidemiology and biostatistics research track, 1984-1985. Cancer Epidemiology summer internships, 1982 and 1983. Undergraduate BA, English, Duke University, Durham, NC Graduated magna cum laude, 1977-1981. New College, Oxford University, summer 1979 Senior thesis, Duke University, 1980-1981. EMPLOYMENT: Associate Professor of Pediatrics, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, 1999 - current Assistant Professor of Pediatrics, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, July, 1992-1999. LICENSURE AND CERTIFICATIONS: Board-certified in Pediatric Hematology/Oncology, Certificate #001054, 01/01/07-12/31/2016. Board-certified in Pediatric Hematology/Oncology, 1999-2006. Board-certified in General Pediatrics, 1999-2006.

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    Board-certified in Pediatric Hematology/Oncology, 1992-1999. Board-certified in General Pediatrics, 1989-1999. State of North Carolina Medical License, 1986-date, License #30578, registered annually. State of Michigan Medical License, 1988-1992.

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    HONORS AND AWARDS: Patients’ Choice Award, American Registry LLC, 2013 North Carolina Make-A-Wish Physician of the Year (Shooting Star Award), 2011. Consumers’ Research Council of America, Guide to America’s Top Oncologists, inclusion starting in 2009-date. Top-rating, MDX Medical Vitals.Com Physician Ratings, 2006-date. Consumers’ Research Council of America, Guide to America’s Top Pediatricians, inclusion starting in 2004. Consumers’ Research Council of America, Guide to America’s Top Physicians, inclusion starting in 2004. Veterans of Foreign Wars (VWF) Research Award, 2001. Council for Tobacco Research (CTR) Scholar Award, 1997-2000. University of North Carolina at Chapel Hill Junior Faculty Development Award, 1996-1997. Edward Curnen Book award for academic achievement, University of North Carolina at Chapel Hill, 1988. William Webb award for hematology/oncology patient care, University of North Carolina at Chapel Hill, 1987. Phi Beta Kappa, Duke University, 1980. Angier B. Duke Memorial Scholar, Duke University, 1977-1981. Early Identification Program, Duke University Medical School, 1978. BIBLIOGRAPHY: Selected publications in peer-reviewed journals:

    1. Smitherman AB, Weston BW. Catheter-associated thrombosis in children: single institution experience and review of pediatric thromboembolic disease. J Infus Nurs., in press, 2013.

    2. Weston BW, Monahan PE. Congenital deficiency of vitamin K-dependent clotting factors. Haemophilia , in press, 2013.

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    3. Chu Y, Liu Z, Weston B, Wang, B. Synthesis and evaluation of a fluorescent conjugate sLex- selective bisboronic acid for imaging applications. Bioorg Med Chem Lett, 23: 6307-6309, 2013. 4. Weston BW, Hayden MA, Roberts KG, Bowyer S, Hsu J, Fedoriw G, Rao KW, Mullighan CG. Tyrosine Kinase Inhibitor Therapy Induces Remission in a Patient With Refractory EBF1- PDGFRB–Positive Acute Lymphoblastic Leukemia. J Clin Oncol. 2013 Sep 1;31(25):e413-6. doi: 10.1200/JCO.2012.47.6770. Epub July, 2013. 5. Blatt J, Weston B, Gold S. Fatigue and Irritability as Markers of Thrombocytopenia in Childhood Idiopathic Thrombocytopenic Purpura. Pediatr Hematol Oncol 27: 65-67, 2010. 6. Taylor-Cousar JL, Zariwala MA, Burch LH, Pace RG, Drumm ML, Calloway H, Fan H, Weston BW, Wright FA, Knowles MR; Gene Modifier Study Group. Histo-blood group gene polymorphisms as potential genetic modifiers of infection and cystic fibrosis lung disease severity. PloS ONE 4: e4270, 2009. 7. Weston BW, Monahan PE. Familial deficiency of vitamin K-dependent clotting factors. Haemophilia 14: 1209-1213, 2008. 8. Yang W, Fan H, Gao X, Gao S, Karnati V, Ni W, Hooks WB, Carson J, Weston B, and Wang B. The first fluorescent diboronic acid sensor specific for hepatocellular carcinoma cells expressing sialyl Lewis X. Chem. & Biol., 11: 439-448, 2004. 9. Cakir B, Heiss G, Pankow JS, Salomaa V, Sharrett RA, Couper D, Bray M, Weston BW. Association of the Lewis genotype with cardiovascular risk factors and subclinical carotid atherosclerosis: the ARIC study. J. Int. Med., 255: 40-51, 2004. 10. Cakir B, Pankow JS, Salomaa V, Couper D, Morris TL, Brantley KR, Hiller KM, and Weston BW. Distribution of Lewis (FUT-3) genotype and allele frequencies in a bi-ethnic U.S. population: the ARIC study. Ann. Hematol., 81: 558-565, 2002. 11. Yang W, Gao S, Gao X, Karnati V, Ni W, Wang B, Hooks WB, Carson J, and Weston B. Diboronic acids as fluorescent probes for cells expressing sialyl Lewis x. Bioorgan & Med Chem Let, 12: 2175-2177, 2002. 12. Richardson MW, Funkhouser WK, Senior B, and Weston BW. Spindle cell lesions of the head and neck mimicking rhabdomyosarcoma in children. Pediatr. Hematol. Oncol., 19: 129- 134, 2002. 13. Blatt, J, Weston, B, Belhorn, T, Hamrick, H, and Maia, D. Childhood non-Hodgkin's lymphoma presenting as hemophagocytic syndrome. Pediatr. Hematol. Oncol., 19: 45-49, 2002. 14. Weston, BW, Lin, JL, Muenzer, J, Cameron, HS, Arnold, RR, Seydewitz, HH, Mayatepek,E, Van Schaftingen, E, Veiga-Da-Cunha, M, Matern, D, and Chen, YT. Glucose-6-phosphatase mutation G188R confers an atypical glycogen storage disease type 1b phenotype. Pediatr. Res.,

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    48: 329-334, 2000. 15. Salomaa V, Pankow J, Heiss G, Cakir B, Eckfeldt JH, Ellison, C., Myers, R., Hiller KM, Brantley KR, Morris TL, and Weston BW. Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI family heart study. J. Int. Med., 247: 689-698, 2000. 16. Hiller, K.M., Mayben, J.P., Bendt, K.M., Manousos, G.A., Singer, K., Cameron, H.S., and Weston, B.W. Transfection of alpha(1,3)fucosyltransferase antisense sequences impairs the proliferative and tumorigenic ability of human colon carcinoma cells. Mol. Carcinog., 27: 280- 288, 2000. 17. Weston BW, Hiller KM, Mayben JP, Manousos GA, Nelson CM, Klein MB, and Goodman JL. A cloned CD15s-negative variant of HL60 cells is deficient in expression of FUT7 and does not adhere to cytokine-stimulated endothelial cells. Eur. J. Haematol., 63: 42-49, 1999. 18. Weston, BW, Hiller, KM, Mayben, JP, Manousos, GA, Bendt, KM, Liu, R, and Cusack, JC, Jr. Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin- mediated adhesion and liver metastasis of colon carcinoma cells. Cancer Res., 59: 2127-2135, 1999. 19. Goodman JL, Nelson CM, Klein MB, Hayes SF, and Weston BW. Leukocyte infection by the granulocytic ehrlichiosis agent is linked to expression of a selectin ligand. J. Clin. Invest., 103: 407-412, 1999. 20. Weston BW and Lauria M. Patient advocacy in the 1990s. N Engl J Med, 334: 543-544, 1996. 21. Cameron HS, Szczepaniak DA, and Weston BW. Expression of human chromosome 19p alpha(1,3)fucosyltransferase genes in normal tissues: alternative splicing, polyadenylation, and isoforms. J Biol Chem, 270: 20112-20122, 1995. 22. McCurley RS, Recinos A, Olsen, A, Gingrich, J, Szczepaniak DA, Cameron HS, Krauss R, and Weston BW. Physical maps of human alpha(1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. Genomics, 26: 142-146, 1995. 23. Mollicone R, Reguigne I, Kelly RJ, Fletcher A, Watt J, Chatfield S, Aziz A, Cameron HS, Weston BW, Lowe JB, and Oriol R. Molecular basis for Lewis alpha(1,3/1,4) fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian Pedigrees. J Biol Chem, 269: 20987-20994, 1994. 24. Mollicone R, Reguigne I, Fletcher A, Aziz A, Rustam M, Weston BW, Kelly RJ, Lowe JB, and Oriol R. Molecular basis for plasma alpha(1,3) fucosyltransferase gene deficiency (FUT6). J Biol Chem, 269: 12662-12671, 1994. 25. Weston BW, Smith PL, Kelly RJ, Lowe JB. Molecular cloning of a fourth member of a

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    human alpha(1,3)fucosyltransferase gene family: multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes. J Biol Chem 267: 24575-24584, 1992. 26. Wong CH, Dumas DP, Ichikawa Y, Koseki K, Danishefsky SJ, Weston BW, Lowe JB. Specificity, inhibition, and synthetic utility of a recombinant human alpha(1,3)fucosyltransferase. J Am Chem Soc 114: 7321-7322, 1992. 27. Ball GE, O'Neill R, Schultz JE, Lowe JB, Weston BW, Nagy JO, Brown EG, Hobbs C, Bednarski MD. Synthesis and structural analysis using 2-D NMR of sialyl Lewis x (SLex) and Lewis x (Lex) oligosaccharides: Ligands related to E-selectin [Elam-1] binding. J Am Chem Soc 114: 5449-5451, 1992 28. Weston BW, Nair RP, Larsen RD, Lowe JB. Isolation of a novel human alpha(1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha(1,3/1,4)fucosyltransferase gene. Syntenic, homologous, non-allelic genes encoding enzymes with distinct acceptor substrate specificities. J Biol Chem 267: 4152-4160, 1992. 29. Ross CW, Schnitzer B, Weston BW, Hanson CA. Chronic active Epstein-Barr virus infection and virus-associated hemophagocytic syndrome. Arch Pathol Lab Med 11

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