CurriculumDONALD F. KLEIN, M.D. as of January, 2003

New York State Psychiatric InstituteCollege of Physicians & SurgeonsColumbia University

EDUCATION:

• BA, Colby College, Waterville, Maine, 1947• New York University Graduate School Program in Biology, 1947-1948• MD, State University of NY, College of Medicine, New York City, 1952• Doctor of Science (Hon.) State University of New York, Downstate Medical Center, 1998

INTERNSHIP & RESIDENCY:

• Rotating Internship, USPHS Hospital, Staten Island, NY, 1952-1953• Residency in Psychiatry, Creedmoor State Hospital, 1953-1954, and 1956-1958

MILITARY SERVICE:

• Senior Assistant Surgeon (R) USPHS Staff Psychiatrist USPHS Hospital, Lexington, Kentucky, 1954-1956

HONORS & AWARDS:

• Magna Cum Laude, 1947• Phi Beta Kappa, 1947• AE Bennett Neuropsychiatric Research Award, Third Place, 1964• National Association of Private Psychiatric Hospitals Research Award, 1965, 1971• Samuel W. Hamilton Award, APPA, 1980• Taylor Manor Hospital Psychiatric Award, 1985• Foundation's Fund Prize for Research in Psychiatry, 1988• William R. McAlpin Award for Research Achievement, N.A.M.H., 1988• The Society of Biological Psychiatry Gold Medal Award, 1990• Heinz E. Lehman Research Award, New York State, 1991• Paul Hoch Distinguished Service Award, ACNP, 1991• William A. Console, M.D. Award in Psychiatry, SUNY Alumni Society, 1992• Thomas W. Salmon Medal for Distinguished Service in Psychiatry, New York Academy of

Medicine, 1993.• Department of Veteran Affairs Certificate of Appreciation "Chairman VA/NIDA Review

Board", 1995• Society of Biological Psychiatry, Lifetime Achievement Award, 1996.• Exemplary Psychiatrist Award for 1997, National Alliance for the Mentally Ill• Columbia University, College of Physicians and Surgeons, Deans Distinguished Lectureship

in the Clinical Sciences, 1998• Castillo del Pino Prize for Achievement in Psychiatry, 1999• Office of Clinical Trials, Columbia University/New York Presbyterian Hospital,• Certificate for completion of course on Good Clinical Practices, 2000• Medical Society of the State of New York• Citation commemorating 50 years of dedication to medicine, 2002• Castle Connolly Medcal LTD

• America's Top Dotors & Top Doctors: New York Metro Area

BOARD STATUS:

• Qualified Psychiatrist, State of New York, 1959• Diplomate, American Board of Psychiatry and Neurology in Psychiatry, 1959• Diplomate, American Board of Clinical Pharmacology, 1992, Certificate #92109

TYPE OF PRACTICE:

• Psychiatry and Psychopharmacology

LICENSURE STATUS:

• Diplomate, National Board Medical Examiners, 1953• License # 73940, New York, 1953

PRESENT POSITIONS:

• Professor of Psychiatry, Columbia University, 1978-• Attending Psychiatrist, New York Presbyterian Hospital, 1977-• Director of Psychiatric Research, New York State Psychiatric Institute, 1976 -• Director of Department of Therapeutics, New York Psychiatric Institute, 1976-• Visiting Professor of Psychiatry, Albert Einstein College of Medicine, 1997-• Consultant, NIDA, 1990-• Special Advisory Board, Freedom From Fear, Staten Island, NY, 1992-• CPMC Clinical Research & Development Fund Committee, 1992-• Psychiatrist, Montefiore Medical Center, 1995-• Adjunct Professor of Psychology, Queens College, City University of New York, 1969-• Chairman of the Scientific Advisory Board, Vela Pharmaceuticals, 1999-• Consultant, Institute for Healthcare Quality, 1996-• ACNP Liaison Committee with Governmental Agencies and the Pharmaceutical Industry,

1999-• Visiting Professor of Psychiatry and Behavioral Sciences, 2001-• Assistant Treasurer of ASCP, 2001-• VivoMetrics Scientific Advisory Board Member, 2002-• Alexza Scientific Adviory Board Member, 2002-• The Scandinavian College of Neuro-Psychopharmacology, 2003-• Foreign Corresponding Member of SCNP, 2003-• ISI Highly Cited Member (Publication #A01827-2002X), 2003-

RELEVANT PAST POSITIONS:

• Consultant, Psychotherapeutic Medication Development Program, NIMH, 1992-96• Chairman, NIDA/VA Medication Development Review Group, 1991-96• Senior Science Advisor, ADAMHA, 1989-1990• Consultant, ADAMHA, 1988-1989• Chairman, Texas Department of Mental Health and Mental Retardation• Research Advisory Council, 1983-1985• Consultant, Long Island Jewish-Hillside Medical Center, 1976-1985• Full Attending Psychiatrist, Queens Hospital Center, 1972-1985• Lecturer, Columbia University, 1976-1978• Visiting Professor Psychiatry, Albert Einstein College of Medicine, 1976-1977• Visiting Professor, University of Hawaii, 1977, 1985, 1986, 1993• Professor of Psychiatry, State University of NY, College of Medicine, Stony Brook, 1972-

1976• Visiting Professor Psychiatry, University of Auckland, New Zealand, 1975• Psychiatrist-in-Chief, Queens Hospital Center, 1970-1971• Director, Research & Evaluation, Department of Psychiatry, Long Island Jewish-Hillside

Medical Center, 1972-1976• Chairman, Committee on Research & Publication, Long Island Jewish-Hillside Medical

Center, 1972-1975• Medical Director for Evaluation, Hillside Hospital, 1970-1971 Director of Research,• Hillside Hospital, 1965-1970• Senior Staff Psychiatrist (Research), Hillside Hospital, 1965 NIMH Mental Health• Career Investigator, Hillside Hospital, 1961-1964• Research Associate, Hillside Hospital, 1959-1964• Research Associate, Creedmoor Institute for Psychobiologic Studies, 1957-1959• Candidate NY Psychoanalytic Institute, 1957-1961

SOCIETIES:

• American Society of Clinical Psychopharmacology, Vice President, 1997- , President, 1992-1996

• National Foundation for Depressive Illness, President, 1983-• National Depressive and Manic Depressive Association, Scientific Advisory Board, 1986-

1999; Member 1986-• American Association for the Advancement of Science, 1983, Fellow, 1997-• American College of Neuropsychopharmacology - Life Fellow• Chairman Credentials Committee, 1976-1978• Program Committee, 1978• President-Elect, 1980, President, 1981• Chairman, Committee on Public Concern, 1983, 1987 and 1988; Consultant 1989-• Ad Hoc Awards Committee, 1984• Task Force for Creation of Statement of Principles (DF Klein & N Schooler), 1994• (accepted by ACNP Council, December 1995)• Nominating Committee, 1989; Chairman 1990-1991; Ex-Officio, 1992• Planning Group, Committee on Relations with Advocacy Groups• Chairman, Task Force for the Development of a Non-Profit• Foundation to Investigate Issues of Scientific Misconduct, 1989-1992• History Task Force, 1994-1996• Co-Chairman, Task Force on Ethical Issues in Controlled Clinical Trials, 1994-1996 Co-

Chairman Liaison Committee With Government Agencies & the Pharmaceutical Industry, 1994-1996; Member 1999-2001

• American Psychiatric Association - Life Fellow• DSM-III Task Force on Nomenclature & Statistics• DSM-III Anxiety and Dissociative Disorders Advisory Committee• DSM-III Personality Disorders Advisory Committee• DSM-III Impulse Control Disorders Advisory Committee• DSM-III-R Mood Disorders Advisory Committee• DSM-III-R Anxiety Disorders Advisory Committee• DSM-III-R Personality Disorders Advisory Committee• DSM-IV Mood Disorders Advisory Committee• Chairman, Task Force on Guidelines for the Protection of Human Subjects in• Psychiatric Research, 1977-1979; 1982-1984; Member, 1979-1981

• Consultant to APA Task Force on Treatment of Psychiatric Disorders, 1986-• Anxiety Disorders Association of America, Scientific Advisory Board, 1996-99• Task Force on Psychopharmacologic Criteria Development, 1977-1979• Chairman, Hofheimer Prize Board, 1973-1975• Task Force on Methadone & Narcotic Antagonist Evaluation,• Task Force on Nomenclature & Statistics, 1974-1979• American Psychopathological Association - Member• Treasurer, 1972-1975• Program Chairman, 1975, 1977-1079• Secretary, 1976• Vice-President, 1977• President-Elect, 1978-1979• President, 1979-1980• Councillor, 1980-1981• Collegium Internationale Neuro-Psychopharmacologicam (CINP), Fellow (1972)• International Neuropsychology Society, Executive Committee, 1967• Psychiatric Research Society, President, 1980• Information Exchange on Young Adult Chronic Patients, National Advisory Board, 1983-• Professional Board of Advisors, The Foundation of Thanatology Psychiatric Research

Society• Chairman, Steering Committee, 1977• Steering Committee, 1974-1976• Royal College of Psychiatrists - Founding Member, Fellow until 1996• Fellow Society of Life History Research in Psychopathology• Society of Biological Psychiatry, Senior Member• Society of Neuroscience• Society for Psychophysiological Research• Society for the Study of Social Biology• Association for Clinical Psychosocial Research - Fellow• American Society for Clinical Pharmacology and Therapeutics• European Brain and Behaviour Society• International Brain Research Organization• Society for Light Treatment and Biological Rhythms• Lyme Research Foundation, Inc., Scientific Advisory Council, 1993-• European Certificate in Anxiety and Mood Disorders, Board of Advisors, 1994- American

Statistical Association, 1994-• National Anxiety Disorders Screening Day, Scientific Advisory Board, 1994-• National Anxiety Foundation, Scientific Advisory Board, 1995-• Mental Illness Foundation, Medical Advisory Board, 1996-• American Association of Applied and Preventive Psychology, 1996-• International Academy for Biomedical and Drug Research, corresponding member, 1996-• International Society for the Advancement of Respiratory Psychophysiology, member, 1997-• American Psychological Society, 1997-• New York County Medical Society, 1953-• Global Alliance of Mental Illness Advocacy Networks (GAMIAN) Advisory Board, 1998-• III Congres de la Federation Internationale Francophone de Psychiatrie, Member, 2000 -• International Society for Research in Child & Adolescent Psychpathology, 2000-

FEDERAL CONSULTANTSHIPS:

• NIAAA Board of Scientific Counselors, 1996-1999• Consultant, Medical Research Council of New Zealand, 1986-• Affective and Anxiety Disorder Research Branch, NIMH, Workshop on Recommendations

for Future Research, 1986• Advisory Group, NIMH Depression Awareness, Recognition, and Treatment (D/ART)

Program, 1985• NIMH Workshop on Developing Guidelines for the Clinical Evaluation of Antidepressant

Drugs, 1985• Veterans Administration, Ad Hoc Scientific Review Committee for Clinical Research in

Alcoholism, 1984• National Institute of Health, Consultant to Clinical Center, 1983• Advisory Panel on Psychotherapy, Office of Technology Assessment, Wash. DC,• Background Paper #3: The Efficacy & Cost Effectiveness of Psychotherapy, 1980• Federal Hospital Council - Member, 1976-1980• Advisory Group, CRB-NIMH Psychotherapy of Depression Collaborative Research

Progam, 1979• National Institute of Education, Consultant, 1976• Clinical Psychopharmacology Study Section, NIMH, 1971-1975, Chairman, 1973-1975

EDITORIAL BOARDS:

• Center for Studies of Narcotic & Drug Abuse, 1973• Neuropharmacology Advisory Committee, Food & Drug Administration, 1971• Depression & Anxiety, 1993• Archives of General Psychiatry, 1975-• Comprehensive Psychiatry, 1977-• European Psychiatry 1992-• Evolutionary Psychology 2001-• Handbook of Anxiety (Roth, Noyes & Burrows, Eds.), 1985-• EDITORIAL BOARDS (Con't):• International Journal of Methods in Psychiatric Research, 1991- Journal of Clinical

Psychiatry, 1987-• Journal of Clinical Psychopharmacology, 1979-• Journal of Psychiatric Research, 1983- Journal of Abnormal Child Psychology, 1976-98• NYS District Branch Newsletter, 1975-1985• Health and Medical Horizons, Board of Advisers, 1982-97• Evolutionary Psychology 2001-

GRANTS:

• MH-4798 - NIMH Career Investigator - "Psychiatric Reaction Patterns to Psychotropic Drugs 7/1/61 - 6/30/64

• MH-08004 - NIMH "Development of Drug-Sensitive Behavioral Measures" 1/1/64 - 12/31/66

• Dreyfus Charitable Fund- "Psychotropic Effects of Dilantin" 1/1/66 - 12/31/66• MH-12237 - NIMH "Drug Pilot Study in Young Psychiatric Patients" 1/1/66 - 12/31/68• MH-145l4 - NIMH "Imipramine Treatment of School Phobia" 1/1/68 - 8/3/71• MH-18579 - NIMH "Comparative Drug Effects in Hyperkinetic Chi1dren" 9/1/70 - 8/31/73• MH-21337 - NIMH "Drugs in the Aftercare Treatment of Schizophrenia" 1/1/72 - 9/1/75• MH-23007 - NIMH "Imipramine Behavior Therapy & Phobia" 9/1/72 - 2/28/78• MH-18579 - NIMH "Methylphenidate and Behavior Modification in MBD Children" 9/1/73

- 8/31/78• MH-15144 - "Research Training in Depression and Schizophrenia", Associate Program

Director, 7/1/77-6/30/82• MH-30906 - NIMH "MHCRC-New York State Psychiatric Institute" 8/1/78 - 7/31/89,

8/1/89 - 7/31/94 & 8/1/94 - 7/31/99• MH-33422 - NIMH "Pharmacology & Physiology of Panic Disorder" 7/1/79 - 6/30/88• DACB1RO1DAO3836-01A1786-689, NIDA, "Treatment of Cocaine Abuse With

Imipramine" 7/86 - 6/89• MH-37592 - NIMH "Psychobiology, Genetics & Treatment of Anxiety Disorders" 9/1/83 -

4/30/00• Pfizer, Inc., "Sleep Apneic Threshold in Panic Disorder and Normals" 3/1/00 - 2/29/01• 2000 NARSAD Distinguished Investigator Award, "Investigation of Endogenous CO2

Sensitivity Using the Sleep Apneic Threshold in Panic and Depression Comorbid with Panic" 5/15/00 - 5/15/01

• Diagnosis & Drug Treatment of Psychiatric Disorders, Klein, DF, & Davis, JM, Baltimore, Maryland, Williams & Wilkins, 1969.

• Psychiatric Case Studies: Treatment, Drugs and Outcome, Baltimore, Maryland, Williams & Wilkins, 1972.

• Pharmacotherapy & Psychotherapy: Paradoxes, Problems & Progress, Group for the Advancement of Psychiatry, Vol. 9, Report #93, 1975. (Formulated by the Committee on Research: Members, Morris A. Lipton, Stanley H. Eldred, Louis A. Gottschalk, Donald F. Klein, Gerald L. Klerman, Ralph R. Notman, & Eberhard H. Uhlenhuth).

• Progress in Psychiatric Drug Treatment, Klein, DF, & Gittelman-Klein, R (Eds.), New York, Brunner/Mazel, Vol. I, 1975 and Vol II, 1976.

• Evaluation of Psychological Therapies: Psychotherapies, Behavior Therapies, Drug Therapies & Their Interactions, Spitzer, RL, & Klein DF (Eds.), Baltimore, Maryland, Johns Hopkins University Press, 1976.

• Estudios de Casos Psiquiatricos: Tratamiento, Drogas y Resultado, Spanish Edition of Klein (1972), Editorial Troquel S.A., Buenos Aires, 1977

• The Physicians Handbook on Depression. Project directed by Donald F. Klein, in consultation with Joseph Mendels & James G. Price, Pfizer, Inc., 1977.

• Critical Issues in Psychiatric Diagnosis. Spitzer, RL, & Klein, DF (Eds.), Raven Press, New York, 1978.

• Diagnosis & Drug Treatment of Psychiatric Disorders: Adults & Children (2nd Edition) Klein, DF, Gittelman, R, Quitkin, F & Rifkin A, Williams & Wilkins, Baltimore, Maryland,

• 1980.• Anxiety: New Research & Changing Concepts, Klein, DF, & Rabkin, JG (Eds.), Raven

Press, New York, NY, 1981.• Mind, Mood & Medicine: A Guide to The New Biopsychiatry. Wender, PH & Klein, DF,

Farrar Strauss & Giroux, New York, NY, 1981 and New American Library, New York, NY 1982. Japanese edition, 1990. Brazilian edition, 1990.

• Modern Problems of Pharmacopsychiatry (Vol. 22): Anxiety. Klein, DF, Liebowitz, MR, Fyer, AJ & Gorman, JM (Eds.), S. Karger A.G., Basel, Switzerland, 1987.

• Do You have a Depressive Illness? Klein, DF & Wender, PH, New American Library, New York, 1988.

• Understanding Depression. Klein, DF & Wender, PH, Oxford University Press, New York, 1993.

• Psychotherapeutic Drug Manual, Zito, JE (Ed.), John Wiley & Sons, Inc., New York, 1994. (Formulated by the New York State Office of Mental Health Committee on Therapeutics; Chairman: Robert Cancro; Secretary: Julie Magnum Zito; Members: Magda Campbell,

Thomas J. Craig, Donald F. Klein, Heinz E. Lehman, John Oldham, Kurt Patton, Zebulon Paintor, Herman van Praag, Jan Volavka.)

• The American Psychiatric Press Textbook of Psychopharmacology, Schatzberg, AF and Nemeroff, CB (Eds.), Klein, DF, section editor: Psychopharmacological Treatment. American Psychiatric Press, Washington, DC, 1995.

• Current Neurologic Drugs, Rowland, LP & Klein, DF (Eds.), Current Medicine, Philadelphia, PA, 1996.

• Current Psychotherapeutic Drugs, Klein, DF & Rowland, LP (Eds.), Current Medicine, Philadelphia, PA, 1996.

• The American Psychiatric Press Textbook of Psychopharmacology (Second Edition), Schatzberg, AF and Nemeroff, CB (Eds.), Klein, DF, section editor: Principles of Psychopharmacology. American Psychiatric Press, Washington, DC, 1998.

• 1. Whittier, JR, Klein, DF, Levine, G & Weiss, D: Mepazine (Pacatal): Clinical trial with• placebo control and psychological study. Psychopharmacologia 1:280-287, 1960.• 2. Whittier, JR, Korenyi, C, Klein, DF & Foley, W: Prevention of degenerative disease: A

controlled study of anticoagulant prophylaxis. J Chronic Dis 14:202-212, 1961.• 3. Blumberg, AG & Klein, DF: Severe papilledema associated with drug therapy. Am J

Psychiatry 118:168-170, 1961.• 4. Pollack, M, Karp, E, Krauthamer, G, Klein, DF & Fink, M: Neuropsychologic response

patterns of some psychotropic drugs. Neuropsychopharmacology 2:381-384, 1961.• 5. Kramer JC, Klein DF & Fink M: Withdrawal symptoms following discontinuation of

imipramine therapy. Am J Psychiatry 118:549-550, 1961.• 6. Klein DF & Fink M: Psychiatric reaction patterns to imipramine. Am J Psychiatry

119:432-438, 1962.• 7. Klein DF & Fink M: Behavioral reaction patterns with phenothiazines. Arch Gen

Psychiatry 7:449-459, 1962.• 8. Kramer, JC, Klein, DF & Fink, M: Imipramine as an adjunct to phenothiazine therapy.

Compr Psychiatry 3:377-380, 1962.• 9. Klein, DF & Fink, M: Multiple item factors as change measures in psychopharmacology.

Psychopharmacologia 4:43-52, 1963.• 10. Blumberg, AG, Klein, DF & Pollack, M: Age related changes in blood pressure with

chlorpromazine and imipramine. Excerpta Medica International Congress Series #57. Sixth International Congress of Gerontology, 1963.

• 11. Belmont I, Pollack, M, Willner, A, Klein, DF & Fink, M: The effects of imipramine and chlorpromazine on perceptual analytic ability, perceptual responsivity and memory as revealed in Rorschach response. J Nerv Ment Dis 137:42-50, 1963.

• 12. Gittelman, R, Klein, DF & Pollack, M: Effects of psychotropic drugs on long-term adjustment: A review. Psychopharmacologia 5:317-338, 1964.

• 13. Blumberg, AG, Klein, DF & Pollack, M: Effects of chlorpromazine and imipramine on systolic blood pressure in psychiatric patients: Relationships to age, diagnosis and initial blood pressure. J Psychiatry Res 2:51-60, 1964.

• 14. Belmont, I, Birch, HG, Klein, DF & Pollack, M: Perceptual evidence of CNS dysfunction in schizophrenia. Arch Gen Psychiatry 10:395-408, 1964.

• 15. Klein, DF: Management problems at Hillside Hospital 1960 and 1963. J Hillside Hosp 13:79-94, 1964.

• 16. Klein, DF: Delineation of two drug-responsive anxiety syndromes. Psychopharmacologia 5:397-408, 1964. Japanese version appeared in Archives of Psychiatric Diagnostic and Clinical Evaluation 4(16):505-508, 1993.

• 17. Klein, DF: Behavioral effects of imipramine and phenothiazines: Implications for a psychiatric pathogenetic theory and theory of drug action. Recent Adv Biol Psychiatry

7:273-287, 1964.• 18. Pollack M, Klein DF, Willner A, Blumberg AG & Fink, M: Imipramine-induced

behavioral disorganization in schizophrenic patients: Physiological and psychological correlates. Recent Adv Biol Psychiatry 7:53-61, 1964.

• 19. Fink, M, Pollack, M, Klein, DF, Blumberg, AG, Belmont, I, Karp, E, Kramer, JC & Willner A: Comparative studies of chlorpromazine and imipramine. I. Drug discriminating patterns. Neuropsychopharmacology 3:370-372, 1964.

• 20. Pollack, M, Karp, E, Belmont, I, Willner, A, Klein, DF, & Fink, M: Comparative studies of chlorpromazine and imipramine. II. Psychological performance profiles. Neuropsychopharmacology 3:374-376, 1964.

• 21. Klein, DF: Visual hallucinations with imipramine. Am J Psychiatry 121:911-914, 1965.• 22. Fink, M, Klein, DF & Kramer, JC: Clinical efficacy of chlorpromazine-procyclidine

combination, imipramine and placebo in depressive disorders. Psychopharmacologia 7:27-36, 1965.

• 23. Burnett, LL & Klein, DF: A guide for the psychiatric case study. J Hillside Hosp 14:54-68, 1965.

• 24. Blumberg, AG & Klein, DF: Methoxy-catecholamine excretion and the mecholyl test. J Psychiatric Res 3:239-254, 1965.

• 25. Levenstein, S, Pollack, M & Klein, DF: Follow-up study of formerly hospitalized psychiatric patients: Procedural considerations in data collection. J Hillside Hospital 15:(3-4)152-164, 1966.

• 26. Klein, DF: Chlorpromazine-procyclidine combination, imipramine and placebo in depressive disorders. Can Psychiatric Assoc J 11:Sl46-S149, 1966.

• 27. Levenstein, S, Klein, DF & Pollack, M: Follow-up study of formerly hospitalized voluntary psychiatric patients: The first two years. Am J Psychiatry 122:1102-1109, 1966.

• 28. Kennard, MA, Pollack, M & Klein, DF: The EEG qualities in a group of young adult hospitalized psychiatric patients. Recent Adv Biol Psychiatry 8:277-282, 1966.

• 29. Blumberg, AG & Klein, DF: Age, base blood pressure, diagnosis, and mecholyl test response. Psychosom Med 28:789-794, 1966.

• 30. Blumberg, AG & Klein, DF: Psychotropic drugs, mecholyl test and outcome. Excerpta Medica International Series 129:1212-1216, 1966.

• 31. Klein, DF: Diagnostic prediction of psychotropic drug effect: Global outcome. Excerpta Medica International Series 129:736-740, 1966.

• 32. Pollack, M, Levenstein, S & Klein, DF: A three year post-hospital follow-up of psychiatric patients: First hospitalization in adolescence vs. adulthood. Int J Child Psychiatry 33:224-225, 1966.

• 33. Klein, DF: Dilantin screening study in hospitalized psychiatric patients. 18th International Congress of Psychology, Symposium. 1966, pgs. 75-82.

• 34. Klein, DF & Cleary, TA: Platonic true scores and error in psychiatric rating scales. Psychol Bull 68: 77-80, 1967.

• 35. Klein, DF: Importance of psychiatric diagnosis in prediction of clinical drug effects. Arch Gen Psychiatry 16:118-126, 1967.

• 36. Klein, DF & Greenberg, IM: Behavioral effects of diphenylhydantoin in severe psychiatric disorders. Am J Psychiatry 124:847-849, 1967.

• 37. Klein, DF: Treatment of phobias characterized by separation anxiety. International Drug Therapy Newsletter 2:16, 1967.

• 38. Quitkin, FM & Klein, DF: Follow-up of treatment failure: Psychosis and character disorder. Am J Psychiatry 124:499-505, 1967.

• 39. Klein, DF: Discussion of psychotropic effect of diphenyl-hydantoin (DPH). Int J Neuropsychiatry 3:Suppl. 2,S63, 1967.

• 40. Pollack, M, Levenstein, S & Klein, DF: A three year post-hospital follow-up of adolescent and adult schizophrenics. Am J Orthopsychiatry 38:94-109, 1968.

• 41. Blumberg, AG & Klein, DF: Psychiatric diagnosis, activation and radioactive iodine uptake. Arch Gen Psychiatry 18:601-611, 1968.

• 42. Rosen, B, Klein, DF, Levenstein, S & Shahinian SP: Social competence and posthospital outcome. Arch Gen Psychiatry 19:165-170, 1968.

• 43. Klein, DF, Honigfeld, G & Feldman, S: Prediction of drug effect by diagnostic decision tree. Dis Nerv Syst Suppl 29:159-187, 1968.

• 44. Klein, DF: Psychiatric diagnosis and a typology of clinical drug effects. Psychopharmacologia 13:359-386, 1968.

• 45. Gittelman-Klein, R & Klein, DF: Marital status as a prognostic indicator in schizophrenia. J Nerv Ment Dis 147:289-296, 1968.

• 46. Feldman, S, Klein, DF & Honigfeld, G: A comparison of successive screening and discriminant function techniques in medical taxonomy. Biometrics 25:725-734, 1969.

• 47. Gittelman-Klein, R & Klein, DF: Premorbid asocial adjustment and prognosis in schizophrenia. J Psychiatric Res 7:35-53, 1969.

• 48. Quitkin, FM & Klein, DF: Two behavioral syndromes in young adults related to possible minimal brain dysfunction. J Psychiatric Res 7:131-142, 1969.

• 49. Rosen, B, Klein, DF, Levenstein, S & Shahinian SP: Social competence and posthospital outcome among schizophrenic and non-schizophrenic psychiatric patients. J Abnorm Psychol 74:401-404, 1969.

• 50. Honigfeld, G, Klein, DF & Feldman, S: Prediction of psychopharmacologic effect in man: Development and validation of a computerized diagnostic decision tree. Comput Biomed Res 2:350-361,1969.

• 51. Pollack, M, Woerner, MG, Goldberg, P & Klein, DF: Siblings of schizophrenic and non-schizophrenic psychiatric patients: Psychopathology and gender concordence. Arch Gen Psychiatry 20:652-658, 1969.

• 52. Blumberg, AG & Klein, DF: Chlorpromazine-procyclidine and imipramine: Effects on thyroid function in psychiatric patients. Clin Pharmacol Ther 10:350-354, 1969.

• 53. Mendel, JC & Klein, DF: Anxiety attacks with subsequent agoraphobia. Compr Psychiatry 10:190-195, 1969.

• 54. Rabiner, CJ & Klein, DF: Imipramine treatment of school phobia. Compr Psychiatry 10:387-390, 1969.

• 55. Klein, DF & Cleary, TA: Platonic true scores: Further comment. Psychol Bull 71(4):278-280, 1969.

• 56. Rosen, B, Klein, DF & Gittelman-Klein, R: Sex differences in the relationship between premorbid asociality and posthospital outcome. J Nerv Ment Dis 149(5):415-420, 1969.

• 57. Klein, DF: The prospective study of bereavement. Arch Foundation of Thanatology 1:13, 1969.

• 58. Pollack, M, Jaffe, R, Woerner, MG & Klein, DF: Fourteen- and-six-per-second positive spikes in adolescent and young adult psychiatric patients and their siblings. Proceedings of the American Psychological Assoc, 1969.

• 59. Klein, DF: Drugs and schizophrenia: Critical evaluations. Int J Psychiatry 8:734-739, 1969.

• 60. Glick, ID, Hauptman, B & Klein, DF: Pseudo-pregnancy treatment of periodic psychiatric illness: A pilot study. Psychiatr Quarterly 44:1-5, 1970.

• 61. Cohen, M & Klein, DF: Drug abuse in a young psychiatric population. Am J Orthopsychiatry 40(3):448-455, 1970.

• 62. Cohen, M, Klein, DF & Struve, F: Relationship between electroencephalographic and sociometric variables among psychiatric patients. Am J Psychiatry 127(1):137-141, 1970.

• 63. Gittelman-Klein, R & Klein, DF: Relationships of the mecholyl test, premorbid asocial functioning and long-term outcome in schizophrenia. J Nerv Ment Dis 150(4):301-306, 1970.

• 64. Klein, DF, Honigfeld, G, Burnett, LL, Steckler, M, Leader, M & Forman, M: Automating the psychiatric case study. Compr Psychiatry 11(6):518-523, 1970.

• 65. Klein, DF: Imipramine treatment of school phobia. Psychopharm Bull 6:32-33, 1970.• 66. Pollack, M, Woerner, M & Klein, DF: A comparison of twin and sibling studies for a

developmental theory of schizophrenia. Acta Geneticae Medical et Gamellologia 19:303-304, 1970.

• 67. Honigfeld, G & Klein, DF: The Hillside Hospital treatment evaluation program: Clinical and basic research. Suppl to Dis Nerv Syst 31:11, 1970.

• 68. Woerner, MG, Pollack, M & Klein, DF: Birth weight and length in schizophrenics, personality disorders and their siblings. Br J Psychiatry 118:461-464, 1971.

• 69. Rosen, B, Klein, DF & Gittelman-Klein, R: The prediction of rehospitalization: The relationship between age of first psychiatric treatment contact, marital status and premorbid asocial adjustment. J Nerv Ment Dis 152(1):17-22, 1971.

• 70. Rifkin, A, Quitkin, F, Carrillo, C & Klein, DF: Very high dosage fluphenazine for non-chronic treatment-refractory patients. Arch Gen Psychiatry 25:398-403, 1971.

• 71. Rosen, B, Engelhardt, DM, Freedman, N, Margolis, R & Klein, DF: The hospitalization proneness scale as a predictor of response to phenothiazine treatment: II. Delay of psychiatric hospitalization. J Nerv Ment Dis 152(6):405-411, 1971.

• 72. Cohen, M & Klein, DF: A measure of severity of multi-drug use. Intl Pharmacopsychiatry 6:83-91, 1971.

• 73. Blumberg, AG, Cohen, M, Heaton, AM & Klein, DF: Covert drug abuse among voluntary hospitalized psychiatric patients. JAMA 217(12):1659-166l, 1971.

• 74. Gittelman-Klein, R & Klein, DF: Controlled imipramine treatment of school phobia. Arch Gen Psychiatry 25:204-207, 1971.

• 75. Saraf, K & Klein, DF: The safety of a single daily dose schedule for imipramine. Am J Psychiatry 128(4):115-116, 1971.

• 76. Klein, DF: Youthful rebels - diagnosis and treatment. Adolescence 7(27):351-369, 1972.• 77. Struve, FA, Becka, DR & Klein, DF: B-Mitten EEG pattern and process and reactive

schizophrenia: A replication. Arch Gen Psychiatry 26:189-192, 1972.• 78. Rifkin, A, Levitan, SJ, Galewski, J & Klein, DF: Emotionally unstable character

disorder: A follow-up study I: Description of patients and outcome. Biol Psychiatry 4(1):65-79, 1972.

• 79. Rifkin, A, Levitan, SJ, Galewski, J & Klein, DF: Emotionally unstable character disorder: A follow-up study II: Prediction of outcome. Biol Psychiatry 4(1):81-88, 1972.

• 80. Struve, FA, Klein, DF & Saraf, KR: Electroencephalographic correlates of suicide ideation and attempts. Arch Gen Psychiatry 27:363-365, 1972.

• 81. Feldman, S, Klein, DF & Honigfeld, G: The reliability of a decision tree technique applied to psychiatric diagnosis. Biometrics 28:831-840, 1972.

• 82. Cohen, M & Klein, DF: Social values and drug use among psychiatric patients. Am J Psychiatry 128(8):1017-1019, 1972.

• 83. Cohen, M & Klein, DF: Age of onset of drug abuse in psychiatric inpatients. Arch Gen Psychiatry 26:(3)266-270, 1972.

• 84. Quitkin, F, Rifkin, A, Kaplan, J & Klein, DF: Phobic anxiety syndrome complicated by drug dependence and addiction: A treatable form of drug abuse. Arch Gen Psychiatry 27(2):159-162, 1972.

• 85. Rifkin, A, Quitkin, F, Carrillo, C, Blumberg, AG & Klein,DF: Lithium carbonate in emotionally unstable character disorders. Arch Gen Psychiatry 27:519-523, 1972.

• 86. Klein, DF: Logic in the use of psychiatric diagnosis. Psychotherapy and Social Science Review 6(11):21-23, 1972.

• 87. Quitkin, F, Rifkin, A & Klein, DF: Literature review and proposal for lithium prophylaxis studies. J Nat'l Assoc Private Psychiatric Hospitals 4(3)11-15, 1972.

• 88. Struve, FA, Becka, DR & Klein, DF: The B-Mitten EEG pattern in process and reactive schizophrenia and affective states. Clinical Electroencephalography 3(3):136-144, 1972.

• 89. Woerner, MG, Pollack, M & Klein, DF: Pregnancy and birth complications in schizophrenics, personality disorders and their siblings. Acta Psychiatrica Scandinavica 49(6):712-721, 1973.

• 90. Gittelman-Klein, R & Klein, DF: School phobia: Diagnostic considerations in the light of imipramine effects. J Nerv Ment Dis 156(3):199-215, 1973.

• 91. Rifkin, A, Kurtin, S, Quitkin, F & Klein, DF: Lithium-induced folliculitis. Am J Psychiatry 130(9):1018-1019, 1973.

• 92. Mendel, JG & Klein, DF: Utilization of the psychiatric consultation service in a large city hospital. Psychosomatics 14(1):57-58, 1973.

• 93. Quitkin, F, Rifkin, A, McKay, L & Klein, DF: Scapegoating in hospitalized adolescents: A behavioral phenomena associated with schizophrenia with premorbid asociality. Arch Gen Psychiatry 28(5):680-682, 1973.

• 94. Honigfeld, G & Klein, DF: Hillside Hospital Patient Progress Record: Explorations in clinical management by objective and exception. Evaluation. Special Mono #1:19-22, 1973.

• 95. Klein, DF & Rosen, B: Premorbid asocial adjustment and response to phenothiazine treatment among schizophrenic inpatients. Arch Gen Psychiatry 29:480-485, 1973.

• 96. Rifkin, A, Quitkin, F & Klein, DF: Organic brain syndrome during lithium carbonate treatment. Compr Psychiatry 4(3):251-254, 1973.

• 97. Hoffer, A, Cohen, M & Klein, DF: A classification of patient-peer interaction. Compr Psychiatry 14(3):255-262, 1973.

• 98. Klein, DF, Honigfeld, G, Feldman, S: Prediction of drug effect in personality disorders. J Nerv Mental Dis 156(3):183-97, 1973.

• 99. Saraf, KR, Klein, DF, Gittelman, R & Groff, S: Imipramine side effects in children. Psychopharmacologia 37(3):265-274, 1974.

• 100. Cohen, M & Klein, DF: Post-hospital adjustment of psychiatrically hospitalized drug users. Arch Gen Psychiatry 31:221-227, 1974.

• 101. Klein, DF: What should the package insert be? Arch Gen Psychiatry 31:735-741, 1974.• 102. Woerner, MG & Klein, DF: 14 and 6 per second positive spiking: Developmental and

clinical correlates in psychiatric patients and their siblings. J Nerv Ment Dis 159:356-361, 1974.

• 103. Klein, DF: Endogenomorphic depression: A conceptual and terminological revision. Arch Gen Psychiatry 31:447-451, 1974.

• 104. Klein, DF: Comment on "On molecular environment of the mind: An orthomolecular theory" by Linus Pauling. Am J Psychiatry 131:1263-1265, 1974.

• 105. Rifkin, A, Quitkin, F, Blumberg, AG & Klein, DF: The effect of lithium on thyroid functioning: A controlled study. J Psychiatric Res 10:115-120, 1974.

• 106. Quitkin, F, Gittelman, R, Rifkin, A & Klein, DF: Atypical signs of relapse in affective disorders. Dis Nerv Sys 36:145-146, 1975.

• 107. Klein, DF, Ross, DC & Feldman, S: Analysis and display of psychopharmacological data. J Psychiatric Res 12:125-147, 1975.

• 108. Quitkin, F, Rifkin, A, Kaplan, JH & Klein, DF: Treatment of acute schizophrenia with ultra-high dose fluphenazine: A failure at shortening time on a crisis intervention unit. Compr Psychiatry 16(3):279-283, 1975.

• 109. Rifkin, A, Quitkin, F, Howard, A & Klein, DF: A study of abrupt lithium withdrawal.

Psychopharmacologia 44:157-158, 1975.• 110. Prichep, L, Cohen, M, Kaplan, J, Karlin, E & Klein, DF: Psychiatric evaluation services

to court referred drug users. Am J Drug & Alcohol Abuse 2(2):197:213, 1975.• 111. Quitkin, F, Rifkin, A & Klein, DF: Very high dosage vs. standard dosage fluphenazine

in schizophrenia: A double-blind study of nonchronic treatment-refractory patients. Arch Gen Psychiatry 32(10):1276-1281, 1975.

• 112. Rifkin, A, Quitkin, F & Klein, DF: Akinesia: A poorly recognized drug-induced extrapyramidal behavior disorder. Arch Gen Psychiatry 32(5):672-674, 1975.

• 113. Klein, DF & Gittelman, R: Problems in the diagnosis of minimal brain dysfunction and hyperkinetic syndrome. International J Ment Health 4:45-60, 1975.

• 114. Gittelman-Klein, R & Klein, DF: Are behavioral and psychometric changes related in methylphenidate treated hyperactive children? International J Ment Health 4:182-198, 1975.

• 115. Katz, S, Saraf, K, Gittelman-Klein, R & Klein, DF: Clinical pharmacological management of hyperkinetic children. International J Ment Health 4(1-2):157-181, 1975.

• 116. Klein, DF: Indications for specific treatments of depressions. Psychopharm Bull 11(3):3-13, 1975.

• 117. Willner, AE, Rabiner, CJ, Wisoff, BG, Hartstein, M, Struve, F.A. & Klein, DF: Analogical reasoning and postoperative outcome: Predictions for patients scheduled for open heart surgery. Arch Gen Psychiatry 33(2):255-259, 1976.

• 118. Cohen, M, Howard, A, Klein, DF & Newfield, K: Evaluating outcome criteria used in methadone maintenance programs. International J Addictions 11(2):283-294, 1976.

• 119. Gittelman-Klein, R & Klein, DF: Methylphenidate effects in learning disabilities: Psychometric changes. Arch Gen Psychiatry 33(6):655-668, 1976.

• 120. Quitkin, F, Rifkin, A & Klein, DF: Prophylaxis of affective disorders: Current status of knowledge. Arch Gen Psychiatry 33(3):337-341, 1976.

• 121. Struve, FA & Klein, DF: Diagnostic implications of the B-Mitten EEG Pattern: Relationship to primary and secondary affective dysregulation. Biol Psychiatry 11(5):599-611, 1976.

• 122. Rosen, B, Katzoff, A, Carillo, C & Klein, DF: Clinical effectiveness of "short" vs "1ong" psychiatric hospitalization I: Inpatient results. Arch Gen Psychiatry 33(6):1316-1322, 1976.

• 123. Struve, FA, Saraf, KR, Arko, RS, Klein, DF & Becka, DR: Electroencephalographic correlates of oral contraceptive use in psychiatric patients. Arch Gen Psychiatry 33(6):741-750, 1976.

• 124. Quitkin, F, Rifkin, A & Klein, DF: Neurologic soft signs in schizophrenia and character disorders; Organicity in schizophrenia with premorbid asociality and emotionally unstable character disorders. Arch Gen Psychiatry 33(7):845-853, 1976.

• 125. Gittelman-Klein, R, Klein, DF, Katz, S, Saraf, K & Pollack, E: Comparative effects of methylphenidate and thioridazine in hyperkinetic children. Arch Gen Psychiatry 33(10):1217-1231, 1976.

• 126. Willner, AE, Rabiner, CJ, Wisoff, BG, Fishman, J, Rosen, B, Hartstein, M & Klein, DF: Analogy tests and psychopathology at follow-up after open heart surgery. Biol Psychiatry 11:687-696, 1976.

• 127. Gittelman-Klein, R, Klein, DF, Abikoff, H, Katz, S, Gloisten, AC & Katz, W: Relative efficacy of methylphenidate and behavior modification in hyperkinetic children: An interim report. J Abnorm Child Psychiatry 4:361-379, 1976.

• 128. Leader, M & Klein, DF: Reflections on instituting a computerized psychosocial history in a clinical facility. Compr Psychiatry 18(5):489-495, 1977.

• 129. Rifkin, A, Quitkin, F, Rabiner, CJ & Klein, DF: Fluphenazine decanoate, fluphenazine hydrochloride given orally, and placebo in remitted schizophrenics I: Relapse rates after one year. Arch Gen Psychiatry 34(1):43-47, 1977.

• 130. Quitkin, F, Rifkin, A, Gochfeld, L & Klein, DF: Tardive dyskinesia: Are first signs reversible? Am J Psychiatry 134:84-87, 1977.

• 131. Rifkin, A, Quitkin, F & Klein, DF: Fluphenazine decanoate,oral fluphenazine and placebo in treatment of remitted schizophrenics: II Rating scale data. Arch Gen Psychiatry 34(10):1215-1219, 1977.

• 132. Abikoff, H, Gittelman-Klein, R & Klein, DF: Validation of a classroom observation code for hyperactive children. J Consult & Clin Psychology 45(5):722-783, 1977.

• 133. Mattes, J, Rosen, B & Klein, DF: Comparison of the clinical effectiveness of "short" vs. "long" stay psychiatric hospitalization II: Results of a three year post hospital follow-up. J Nerv & Ment Dis 165(6):387-394, 1977.

• 134. Mattes, JA, Rosen, B, Klein, DF & Millan, D: Comparison of the clinical effectiveness of "short" vs "long" stay psychiatric hospitalization III: Further results of a three year post hospital follow-up. J Nerv & Ment Dis 165(6):395-401, 1977.

• 135. Klein, DF: Evaluation methodology. J Addictions 12(7):837-849, 1977.• 136. Saraf, KR, Klein, DF, Gittelman-Klein, R, Gootman, N & Greenhill, P: EKG effects of

imipramine treatment in children. J Acad Child Psych 17(1):60-69, 1978.• 137. Rifkin, A, Quitkin, F, Kane, J, Struve, F & Klein, DF: Are prophylactic antiparkinson

drugs necessary? A controlled study of procyclidine withdrawal. Arch Gen Psychiatry 35(4):483-489, 1978.

• 138. Kane, JM, Quitkin, F, Rifkin, A & Klein, DF: Comparison of incidence and severity of extrapyramidal side effects with fluphenazine enanthate and fluphenazine decanoate. Am J Psychiatry 135(12):1539-1542, 1978.

• 139. Quitkin, F, Rifkin, A & Klein, DF: Imipramine response in deluded depressive patients. Am J Psychiatry 135(7):806-811, 1978.

• 140. Zitrin, CM, Klein, DF & Woerner, MG: Behavior therapy, supportive psychotherapy, imipramine and phobias. Arch Gen Psychiatry 35(3):307-316, 1978.

• 141. Quitkin, F, Rifkin, A, Kane, J, Ramos-Lorenzi, JR & Klein, DF: Long-acting oral vs injectable antipsychotic drugs in schizophrenia: A one-year double-blind comparison in multiple episode schizophrenics. Arch Gen Psychiatry 35(7):889-892, 1978.

• 142. Quitkin, F, Rifkin, A, Kane, J, Ramos-Lorenzi, JR & Klein, DF: Prophylactic effect of lithium and imipramine in unipolar and bipolar II patients: A preliminary report. Am J Psychiatry 135(5):570-572, 1978.

• 143. Drues, J, Hargreaves, WA, Glick, ID & Klein, DF: Premorbid asocial adjustment and outcome in schizophrenia. J Nerv & Ment Dis 166(12):881-884, 1978.

• 144. Kane, J, Rifkin, A, Quitkin, F & Klein, DF: Extrapyramidal side effects with lithium treatment. Am J Psychiatry 135(7):851-853 1978.

• 145. Liebowitz, M, Neutzel, E, Bowser, A & Klein, DF: Phenelzine and delusions of parasitosis: A case report. Am J Psychiatry 135(12):1565-1566, 1978.

• 146. Ross, DC & Klein, DF: A comparison of analysis of covariance and the O technique as applied to illustrative psychopharmacological data. J Psychiatric Res 15:67-75, 1979.

• 147. Klein, DF: Comments on "Science and anti-science in confrontation: New responsibilities and new opportunities by Bernard Schoenberg," Man & Medicine 4(2):103-105, 1979 (Columbia University Press).

• 148. Quitkin, F, Rifkin, A & Klein, DF: Monoamine oxidase inhibitors: A review of antidepressant effectiveness. Arch Gen Psychiatry 36(7):749-760, 1979.

• 149. Mattes, J, Klein, DF, Millan, D & Rosen, B: Comparison of the clinical effectiveness of "short" vs "long" stay psychiatric hospitalization IV: Predictors of differential benefit. J Nerv & Ment Dis 167(3):175-181, 1979.

• 150. Kane, J, Rifkin, A, Quitkin, F, Nayak, D, Saraf, K, Ramos-Lorenzi, JR, Klein, DF & Sachar, EJ: Low dose fluphenazine decanoate in maintenance treatment of schizophrenics. Psychiatry Res 1:341-348, 1979.

• 151. Rifkin, A, Quitkin, F, Kane, J, Klein, DF & Ross, D: The effect of fluphenazine upon social and vocational functioning in remitted schizophrenics. Biol Psychiatry 14(3):499-508, 1979.

• 152. Liebowitz, MR & Klein, DF: Assessment and treatment of phobic anxiety. J Clin Psychiatry 40(11):486-492, 1979.

• 153. Dorsey, R, Ayd, F, Cole, J, Klein, DF, Simpson, G, Tupin, J & DiMascio, A: Psychopharmacological screening criteria development project. JAMA 241(10):1021-1031, 1979. Also in: Psychotropic Drugs O.B. Towery & A.B. Brands (Eds.): DHEW # (ADA) Publications, pp. 46-71, 1979.

• 154. Liebowitz, MR & Klein, DF: Hysteroid dysphoria. Psychiatric Clinics of North America 2(3):555-575, 1979.

• 155. Zitrin, C, Klein, DF & Woerner, M: Treatment of agoraphobia with group exposure in vivo and imipramine. Arch Gen Psychiatry 37(1):63-72, 1980.

• 156. Rifkin, A, Saraf, K, Kane, J, Ross, D & Klein, DF: Comparison of trimipramine and imipramine: A controlled study. J Clin Psychiatry 41(4):124-129, 1980.

• 157. Quitkin, F, Rifkin, A, Tsuang, M, Kane, J & Klein, DF: Can schizophrenia with premorbid asociality be genetically distinguished from the other forms of schizophrenia? Psychiatry Res 2:99-105, 1980.

• 158. Klein, DF: Psychosocial treatment of schizophrenia or psychosocial help for people with schizophrenia? Schizophrenia Bull 6(1):122-130, 1980.

• 159. Stewart, JW, Quitkin, F, Fyer, A, Rifkin, A, McGrath, P, Liebowitz, MR, Rosnick, L & Klein, DF: Efficacy of desipramine in endogenomorphically depressed patients. J Affective Disorders 2:165-176, 1980.

• 160. Klein, DF: A slippery slope. Perspectives in biology & medicine. Part 2, S115-S119, Winter, 1980.

• 161. Klein, DF: Anxiety reconceptualized. Compr Psychiatry 21(6):411-427, 1980.• 162. Abikoff, H, Gittelman, R & Klein, DF: Classroom observation code for hyperactive

children: A replication of validity. J Consult & Clin Psychiatry 48(5):555-565, 1980.• 163. Klein, DF & Rabkin, JG: Mental health policy; Implications for scientific research on

drugs. Annual Science and Technology Report to the Congress, National Science Foundation, Wash. DC, 1980.

• 164. Liebowitz, MR & Klein, DF: Drug therapy and/or psychotherapy for depression. The Female Patient 6:25-29, 1981.

• 165. Rifkin, A, Klein, DF, Dillon, D & Levitt, M: Blockade by imipramine or desipramine of panic induced by sodium lactate. Am J Psychiatry 138(5):676-677, 1981.

• 166. Gorman, JM, Fyer, AF., Gliklich, J, King, D & Klein, DF: Effect of sodium lactate on panic disorder patients with mitral valve prolapse. Am J Psychiatry 138(2):247-249, 1981.

• 167. Halbreich, U, Weinberg, U, Stewart, JW, Klein, DF & Quitkin, F: An inverse correlation between serum levels of desmethylimipramine and melatonin-like immunoreactivity in DMI-responsive depressives. Psychiatry Res 4:109-113, 1981.

• 168. Liebowitz, MR & Klein, DF: Interrelationship of hysteroid dysphoria and borderline personality disorder. Psychiatric Clinics of North America 4(l):67-87, 1981.

• 169. McGrath, PJ, Quitkin, F, Stewart, JW, Liebowitz, MR, Fyer, A, Davies, S & Klein, DF: Novel antidepressants: A clinical trial of mianserin. Psychopharm Bull 17(1):2l-23, 1981.

• 170. Stewart, JW, Quitkin, F, Liebowitz, MR, McGrath, PJ & Klein, DF: Efficacy of desipramine in mildly depressed patients: A double-blind placebo-controlled trial. Psychopharm Bull 17(1):136-138, 1981.

• 171. Gorman, JM, Fyer, AJ, Gliklich, J, King, D & Klein, DF: Effect of imipramine on the prolapsed mitral valves of patients with panic disorder. Am J Psychiatry 138(7):977-978, 1981.

• 172. Liebowitz, MR, Fyer, AJ, McGrath, PJ & Klein, DF: Clonidine treatment of panic disorder. Psychopharm Bull 17(3):122-123, 1981.

• 173. Liebowitz, MR & Klein, DF: Differential diagnosis and treatment of panic attacks and phobic states. The Annual Review of Medicine 32:583-599, 1981.

• 174. Liebowitz, MR, Quitkin, FM, Stewart, JW, McGrath, PJ, Harrison, W, Schwartz, D, Rabkin, J, Tricamo, E & Klein, DF: Phenelzine and imipramine in atypical depression. Psychopharm Bull 17(3):159-16l, 1981.

• 175. Quitkin, FM, Schwartz, DG, Liebowitz, MR, Stewart, JW, McGrath, PJ, Halpern, F, Puig-Antich, J, Tricamo, E, Harrison, W, Sacher, EJ & Klein, DF: Atypical depressives: A preliminary report of antidepressant response and sleep patterns. Psychopharm Bull 18(1):78-80, 1981.

• 176. Quitkin, F, Kane, JM, Rifkin, A, Ramos-Lorenzi, J, Saraf, K, Howard, A & Klein, DF: Lithium and imipramine in the prophylaxis of unipolar and bipolar II depression: A prospective placebo-controlled comparison. Psychopharm Bull 17(1):142-144, 1981.

• 177. Kane, JM, Quitkin, F, Rifkin, A, Ramos-Lorenzi, J, Saraf, K, Howard, A & Klein, DF: Prophylactic lithium with and without imipramine for bipolar I patients: A double-blind study. Psychopharm Bull 17(l):144-145, 1981.

• 178. Wender, PH & Klein, DF: The promise of biological psychiatry. Psychology Today, pp. 25-41, Feb. 1981.

• 179. Strain, JJ, Liebowitz, MR, Klein, DF: Anxiety and panic attacks in the medically ill. Psychiatric Clinics of North America 4(2):333-50, 1981.

• 180. Halbreich, U, Sachar, EJ, Asnis, GM, Quitkin, F, Nathan, RS, Halpern, FS & Klein, DF: Growth hormone response to dextroamphetamine in depressed patients and normal subjects. Arch Gen Psychiatry 39(2):189-192, 1982.

• 181. Frances, A & Klein, DF: DSM-III Case Studies - Anxious, precise, demanding man seeks help soon after marriage. Hosp Comm Psychiatry 33(2):89-90, 1982.

• 182. Karoum, F, Chuang, L, Eisler, T, Calne, DS, Liebowitz, MR, Quitkin, FM, Klein, DF & Wyatt, RJ: Metabolism of (-) deprenyl to amphetamine and methamphetamine may be responsible for deprenyl's therapeutic benefit: A biochemical assessment. Neurology 32:503-509, 1982.

• 183. Klein, DF: Panic, separation anxiety, and endorphins. Behvrl and Brn Sciences 3:436-437, 1982.

• 184. Klein, DF: Editorial. Diagnosis and treatment prescription: Psychiatry's special value. Psychosom 23(8):791-795, 1982.

• 185. Klein, DF: Medication in the treatment of panic attacks and phobic states. Psychopharm Bull 18(4):85-90, 1982.

• 186. Liebowitz, MR & Klein, DF: Unresolved issues in the treatment of agoraphobia with panic attacks. Psychopharm Bull 18(4):109-114, 1982.

• 187. Stewart, JW, Quitkin, FM, McGrath, PJ, Liebowitz, MR & Klein, DF: Efficacy of mianserin in mildly depressed patients. Psychopharm Bull 18(1):68-70, 1982.

• 188. McGrath, PJ, Quitkin, FM, Blood, D, Liebowitz, MR, Stewart, J, Fyer, AJ & Klein, DF: The effect of mianserin on cardiac conduction: A controlled study. Psychopharm Bull 18(1):71-72, 1982.

• 189. Gittelman, R, Klein, DF & Feingold, I: Children with reading disorders II: Effects of methylphenidate in combination with reading remediation. J Child Psychol & Psychiatry 24(2):193-212, 1983.

• 190. Zitrin, CM, Klein, DF, Woerner, MG & Ross, DC: Treatment of Phobias: I. Comparison of imipramine hydrochloride and placebo. Arch Gen Psychiatry 40(2):125-138, 1983.

• 191. Klein, DF, Zitrin, CM, Woerner, MG & Ross, DC: Treatment of Phobias: II. Behavior therapy and supportive psychotherapy: Are there any specific ingredients? Arch Gen Psychiatry 40(2):139-145, 1983.

• 192. Stewart, JW, Quitkin, FM, Liebowitz, MR, McGrath, PJ, Harrison, WM & Klein, DF: Efficacy of desipramine in depressed outpatients: Response according to research diagnostic criteria diagnoses and severity of illness. Arch Gen Psychiatry 40(2):202-207, 1983.

• 193. Liebowitz, MR, Karoum, F, Quitkin, FM, Davies, SO, Stewart, JW, McGrath, PJ, Harrison, W, Schwartz, D, Levitt, M, Linnoila, M, Wyatt, R, Palij, M & Klein, DF: Biochemical effects of deprenyl. Psychopharm Bull 19(3):336-339, 1983.

• 194. Liebowitz, MR , Fyer, AJ , Appleby, I, Levitt, M, Gorman, J, Dillon, D, Levy, G, Anderson, S, Davies, SO, Palij, M & Klein, DF: Lactate provocation of panic attacks. Psychopharm Bull 19(3):476-478, 1983.

• 195. Harrison, W, Cooper, TB, Quitkin, FM, Liebowitz, MR, McGrath, PJ, Stewart, JW & Klein, DF: Tyramine sulfate excretion test in depressive illness. Psychopharm Bull 19(3):503-504, 1983.

• 196. Klein, DF: Is the anti-panic activity of antidepressant medication a reflection of antidepressant effects? Integrative Psychiatry 1(1):26-27, 1983.

• 197. Kass, F, Charles, E, Klein, DF & Cohen, P: Discordance between the SCL-90 and therapists' psychopathology ratings: Implications for clinical assessment. Arch Gen Psychiatry 40(4):389-393, 1983.

• 198. Fyer, A, Liebowitz, MR, Gorman, JM, Davies, SO & Klein, DF: Sodium lactate reinfusion of recovered lactate-vulnerable panic disorder patients. 21st Annual Meeting of the ACNP - 1982 Poster Session. Psychopharm Bull 19(4):576-577, 1983.

• 199. Gorman, JM, Levy, G, Liebowitz, MR, McGrath, P, Appleby, I, Dillon, D, Davies, SO & Klein, DF: Intravenous propranolol during sodium lactate infusion. 21st Annual Meeting of the ACNP - 1982 Poster Session. Psychopharm Bull 19(4):577-578, 1983.

• 200. Klein, DF: Editorial. The specificity of psychotherapy. Biol Psychiatry 18(10):1105, 1983.

• 201. Gorman, JM, Levy, G, Liebowitz, MR, McGrath, P, Appleby, IL, Dillon, DJ, Davies, SO & Klein, DF: Effect of acute beta-adrenergic blockade on lactate-induced panic. Arch Gen Psychiatry 40(10):1079-1082, 1983.

• 202. Liebowitz, MR, Quitkin, FM, Stewart, JW, McGrath, P, Harrison, W, Rabkin, J, Tricamo, E, Markowitz, JS & Klein, DF: Phenelzine vs imipramine in atypical depression: A preliminary report. Arch Gen Psychiatry 41:(7)669-677, 1984.

• 203. Lindemann, CG, Zitrin, C & Klein, DF: Thyroid dysfunction in phobic patients. Psychosomatics 25(8):603-606, 1984.

• 204. Harrison, W, Cooper, TB, Stewart, JW, Quitkin, FM, McGrath, PJ, Liebowitz, MR, Rabkin, JR, Markowitz, JS & Klein, DF: The tyramine challenge test as a marker for melancholia. Arch Gen Psychiatry 41(7):681-685, 1984.

• 205. Liebowitz, MR, Gorman, JM, Fyer, AJ, Dillon, DJ & Klein, DF: Effects of naloxone on patients with panic attacks. Am J Psychiatry 141(8):995-997, 1984.

• 206. Liebowitz, MR, Quitkin, FM, Stewart, JW, McGrath, PJ, Harrison, W, Rabkin, JG, Tricamo, E, Markowitz, JS & Klein, DF: Psychopharmacological validation of atypical depression. J Clin Psychiatry 45[7 Sect. 2]:22-25, 1984.

• 207. Gorman, JM, Martinez, JM, Liebowitz, MR, Fyer, AJ & Klein, DF: Hypoglycemia and panic attacks. Am J Psychiatry 141(3):101-102, 1984.

• 208. Liebowitz, MR, Fyer, AJ, Gorman, JM, Dillon, D., Appleby, IL., Levy, G, Anderson, S, Levitt, M, Palij, M, Davies, SO & Klein, DF: Lactate provocation of panic attacks: I. Clinical & behavioral findings. Arch Gen Psychiatry 41(8):764-770, 1984.

• 209. McGrath, PJ, Quitkin, FM, Harrison, W & Klein, DF: Treatment of melancholia with tranylcypromine. Am J Psychiatry 141(2):288-289, 1984.

• 210. Halperin, JM, Gittelman, R, Klein, DF & Rudel, RG: Reading-disabled hyperactive children: A distinct subgroup of attention deficit disorder with hyperactivity? J Abn Child Psychol 12(1):1-14, 1984.

• 211. Gittelman-Klein, R & Klein, DF: Relationship between separation anxiety and panic and agoraphobic disorders. VII World Congress of Psychiatry. Vienna, Austria, July, 1983. Psychopathology 17(1):56-65, 1984.

• 212. Fyer, AJ, Gorman, JM, Martinez, J, Levitt, M, Liebowitz, MR & Klein, DF: Sodium lactate infusion, panic attacks and ionized calcium. Biol Psychiatry 19(10):1437-47, 1984.

• 213. Liebowitz, MR, Gorman, J, Fyer A, Levitt, M, Levy, G, Dillon, D, Appleby, I, Anderson, S, Palij, M, Davies, SO, & Klein, DF: Biological accompaniments of lactate-induced panic. Psychopharm Bull 20(1):43-44, 1984.

• 214. Klein, DF & Gorman. J: Panic disorders and mitral valve prolapse. J Clin Psychiatry, Monograph Series 2(1):14-17, 1984.

• 215. Liebowitz, MR, Fyer, AJ, Gorman, JM, Dillon, D, Appleby, IL, Levy, G, Anderson, S, Levitt, M, Palij, M, Davies, SO & Klein, DF: Provocation of panic attacks by sodium lactate infusion. J Clin Psychiatry, Monog Ser 2(1):18-20, 1984.

• 216. Gorman, JM, Askanazi, J, Liebowitz, MR, Fyer, AJ, Stein, J, Kinney, JM & Klein, DF: Response to hyperventilation in a group of patients with panic disorder. Am J Psychiatry 141(7):857-861, 1984.

• 217. Klein, DF: Psychopharmacologic treatment of panic disorder. Psychosomatics 25(10):32-36, 1984.

• 218. Liebowitz, MR, Quitkin, FM, Stewart, JM, McGrath, P, Harrison, W, Rabkin, JG & Klein, DF: Psychopharmacological dissection of nonendogenous depression. Psychopharm Bull 20(3):390-392, 1984.

• 219. Gorman, JM, Liebowitz, MR, Stein, J, Fyer, AJ & Klein, DF: Insulin levels during lactate infusion. Am J Psychiatry 141(12):1621-1622, 1984.

• 220. Garakani, H, Zitrin, CM & Klein, DF: Treatment of panic disorder with imipramine alone. Am J Psychiatry 141(3):446-448, 1984.

• 221. Fyer, AJ, Liebowitz, MR, Gorman, JM, Davies, SO & Klein, DF: Lactate vulnerability of remitted panic patients. Psychiatry Res 14:143-148, 1985.

• 222. Liebowitz, MR, Gorman, JM, Fyer, AJ, Levitt, M, Dillon, D, Levy, G, Appleby, IL, Anderson, S, Palij, M, Davies, SO & Klein, DF: Lactate provocation of panic attacks: II. Biochemical and physiological findings. Arch Gen Psychiatry 42(7):709-719, 1985.

• 223. Liebowitz, MR, Gorman, JM, Fyer, AJ & Klein, DF: Social phobia: Review of a neglected anxiety disorder. Arch Gen Psychiatry 42:(7)729-736, 1985.

• 224. Liebowitz, MR, Fyer, AJ, Gorman, JM, Dillon, D, Davies, S, Stein, J, Cohen, BS & Klein, DF: Specificity of lactate infusions in social phobia vs panic disorders. Am J Psychiatry 142(8):947-949, 1985.

• 225. Liebowitz, MR, Quitkin, FM, Stewart, JW, McGrath, PJ, Harrison, W, Rabkin, JR, Tricamo, E, Markowitz, JS & Klein, DF: Effect of panic attacks on the treatment of atypical depressives. Psychopharm Bull 21(3):558-562, 1985.

• 226. Liebowitz, MR, Gorman, J, Fyer, A, Campeas, R, Levin, A, Davies, S & Klein, DF: Psychopharmacological treatment of social phobia. Psychopharm Bull 21(3):610-6l4, 1985.

• 227. Gorman, J Liebowitz, MR, Fyer, AJ, Levitt, M, Baron, M, Davies, S & Klein, DF: Platelet monoamine oxidase activity in patients with panic disorder. Biol Psychiatry 20(8):852-857, 1985.

• 228. Gorman, JM, Fyer, AJ, Ross, DC, Cohen, BS, Martinez, JM, Liebowitz, MR & Klein, DF: Normalization of venous pH, pCO, and bicarbonate levels after blockade of panic attacks. Psychiatry Res 14:57-65, 1985.

• 229. Gorman, JM, Liebowitz, MR, Fyer, AJ, Dillon, D, Davies, SO, & Klein, DF: Lactate infusions in obsessive-compulsive disorder. Am J Psychiatry 142(7):864-866, 1985.

• 230. Gorman, JM, Dillon, D, Fyer, AJ, Liebowitz, MR & Klein, DF: The lactate infusion model. Psychopharm Bull 21(3):428-433, 1985.

• 231. Gorman, JM, Liebowitz, MR, Fyer, AJ, Campeas, R & Klein, DF: Treatment of social

phobia with atenolol. J Clin Psychopharm 5(5):298-301, 1985.• 232. Gittelman, R & Klein, DF: Hillside behavior rating scale (Behavior during testing).

Psychopharm Bull 21(4):898-899, 1985.• 233. Liebowitz, MR, Gorman, JM, Fyer, AJ, Dillon, D, Levitt, M, & Klein, DF: Possible

mechanisms for lactate's induction of panic. Am J Psychiatry 143(4):495-502, 1986.• 234. Janowsky, DS, Glick, ID, Lash, L, Mitnick, L, Klein, DF, Goodwin, FK, Hanin, I,

Nemeroff, C & Robins, L: Psychobiology and psychopharmacology: Issues in clinical research training. J Clin Psychopharm 6(1):1-7, 1986.

• 235. Liebowitz, MR, Fyer, AJ, Gorman, JM, Campeas, R, Levin, A, Davies, SO, Goetz, D & Klein, DF: Alprazolam in the treatment of panic disorders. J Clin Psychopharm 6(l):13-20, 1986.

• 236. Klein, DF & Quitkin, FM: Problems with and promises of monoamine oxidase inhibitors. Psychopharm Bull 22(1):7-1l, 1986.

• 237. Gorman, JM, Shear, MK, Devereux, RB, King, DL & Klein, DF: Prevalence of mitral valve prolapse in panic disorder: Effect of echocardiographic criteria. Psychosom Med 48(3/4):167-171, 1986.

• 238. Mannuzza, S, Fyer, AJ, Klein, DF & Endicott, J: Schedule for affective disorders and schizophrenia-lifetime version modified for the study of anxiety disorders (SADS-LA): Rationale and conceptual development. J Psychiatric Res 20(4):317-325, 1986.

• 239. Kahn, JP, Stevenson, E, Topol, P & Klein, DF: Agitated depression, alprazolam and panic anxiety. Am J Psychiatry 43(9):1172-1173, 1986.

• 240. Gorman, JM, Cohen, BS, Liebowitz, MR, Fyer, AJ, Ross, D, Davies, SO & Klein, DF: Blood gas changes and hypophosphatemia in lactate-induced panic. Arch Gen Psychiatry 43(11):1067-1075, 1986.

• 241. Liebowitz, MR, Gorman, JM, Fyer, AJ, Dillon, D & Klein, DF: L'induction pharmacologique des crises de Les nouveaux aspects de l'anxiete, Symposium International. Actualities Medicales Internationales en Psychiatrie, supplement 22:29-34, 1986.

• 242. Levin, AP, Fyer, AJ, Gorman, JM, Liebowitz, MR & Klein, DF: Troubles paniques. Les nouveaux aspects de l'anxiete, Symposium International. Actualities Medicales Internationales en Psychiatrie, supplement 22:90-96, 1986.

• 243. Liebowitz, MR, Fyer, AJ, Gorman, JM & Klein, DF: Recent developments in the understanding and pharmacotherapy of panic attacks. Psychopharm Bull, 22(3):792-796, 1986.

• 244. Gorman, JM, Liebowitz, MR, Fyer, AJ & Klein, DF: Possible respiratory abnormalities in panic disorder. Psychopharm Bull, 22(3):797-801, 1986.

• 245. Rabkin, JG, Markowitz, JS, Stewart, J, McGrath, P, Harrison, W, Quitkin, FM & Klein, DF: How blind is blind? Assessment of patient and doctor medication guesses in a placebo-controlled trial of imipramine and phenelzine. Psychiatric Res 19:75-86, 1986.

• 246. Gorman, JM, Liebowitz, MR, Fyer, AJ, Goetz, D, Campeas, R, Fyer, MR, Davies, SO & Klein, DF: An open trial of fluoxetine in the treatment of panic attacks. J Clin Psychopharm 7(5):329-332, 1987.

• 247. Kahn, JP, Drusin, RE & Klein, DF: Idiopathic cardiomyopathy and panic disorder: Clinical association in cardiac transplant candidates. Am J Psychiatry 44(10):1327-1330, 1987.

• 248. Levin, AP, Doran, AR, Liebowitz, MR, Fyer, AJ, Gorman, JM, Klein, DF & Paul, SM: Pituitary adrenocortical unresponsiveness in lactate-induced panic. Psychiatric Res 21(1):23-32, 1987.

• 249. Fyer, AJ, Liebowitz, MR, Gorman, JM, Campeas, R, Levin, A, Davies, SO, Goetz, D & Klein, DF: Discontinuation of alprazolam treatment in panic patients. Am J Psychiatry 144(3):303-308, 1987.

• 250. Dillon, DJ, Gorman, JM, Liebowitz, MR, Fyer, AJ & Klein, DF: The measurement of

lactate-induced panic and anxiety. Psychiatric Res 20:97-105, 1987.• 251. Klein, DF, Ross, DC & Cohen, P: Panic and avoidance in agoraphobia: Application of

PATH analysis to treatment studies. Arch Gen Psychiatry 44(3):377-385, 1987.• 252. Klein, DF & Gorman, JM: A model of panic and agoraphobic development. Acta

Psychiatr Scand, 76 (suppl 335):87-95, 1987.• 253. Gorman, JM, Liebowitz, MR, Dillon, D, Fyer, AJ, Cohen, BS, & Klein, DF: Antipanic

drug effects during lactate infusion in lactate-refractory panic patients. Psychiatric Res 21:205-212, 1987.

• 254. Gorman, JM, Davies, M, Steinman, R, Liebowitz, MR, Fyer, AJ, Coromilas, J & Klein, DF: An objective marker of lactate-induced panic. Psychiatric Res 22:341-348, 1987.

• 255. Papp, LA, Klein, DF & Gorman, JM: Commentary: Hyperventilation, anxiety, and panic. Integrative Psychiatry 5:289-291, 1987.

• 256. Fyer, MR, Klein, DF, Liebowitz, MR, Fyer, AJ & Gorman, JM: CO2 challenge of patients with panic disorder. Am J Psychiatry 144(8):1080-1082, 1987.

• 257. McGrath, PJ, Stewart, JW, Markowitz, J, Liebowitz, MR, Gorman, JM, Quitkin, FM & Klein, DF: Lactate provocation of panic attacks in depressed outpatients. Psychiatric Res 25:41-47, 1988.

• 258. Klein, DF: Cybernetics, activation, and drug effects. Acta Psychiatrica Scandinavica, The Netherlands, 77(341): 126-137, 1988.

• 259. Liebowitz, MR, Quitkin, FM, Stewart, JW, McGrath, PJ, Harrison, WM, Markowitz, JS, Rabkin, JG, Tricamo, E, Goetz, DM & Klein, DF: Antidepressant specificity in atypical depression. Arch Gen Psychiatry 45(2):129-137, 1988.

• 260. Ross, DC & Klein, DF: Group matching: Is this a research technique to be avoided? Educational and Psychological Measurement 48:281-295, 1988.

• 261. Gorman, JM, Goetz, RR, Martinez, J, Uy, J, Ross, D, Fyer, AJ, Liebowitz, MR & Klein, DF: Hyperventilation occurs during lactate-induced panic. J Anxiety Disorders 2:193-202, 1988.

• 262. Wager, SG & Klein, DF: Drug therapy strategies for treatment resistant depression. Psychopharm Bull 24(1):69-74, 1988.

• 263. Klein, DF & Klein, HM: The status of panic disorder. Current Opinion in Psychiatry 1:177-183, 1988.

• 264. Gorman, JM, Goetz, RR, Fyer, MR, King, DL, Fyer, AJ, Liebowitz, MR & Klein, DF: The mitral valve prolapse-panic disorder connection. Psychosomatic Medicine 50(2):114-l22, 1988.

• 265. Klein, RG, Landa, B, Mattes, JA & Klein, DF: Methylphenidate and growth in hyperactive children: A controlled withdrawal study. Arch Gen Psychiatry 45(12):1127-1130, 1988.

• 266. Quitkin, FM, Stewart, JW, McGrath, PJ, Liebowitz, MR, Harrison, WM, Tricamo, E, Klein, DF, Rabkin, JG, Markowitz, JS & Wager, SG: Phenelzine versus imipramine in the treatment of probable atypical depression: Defining syndrome boundaries of selective MAOI responders. Am J Psychiatry 145(3):306-31l, 1988.

• 267. Kahn, JP, Puertollano, MA, Schane, MD & Klein, DF: Adjunctive alprazolam for schizophrenia with panic anxiety: Clinical observation and pathogenetic implications. Am J Psychiatry 145(6):742-744, 1988.

• 268. Stewart, JW, Quitkin, FM, McGrath, PJ, Rabkin, JG, Markowitz, J, Tricamo, E & Klein, DF: Social functioning in chronic depression: Effect of six-weeks of antidepressant treatment. Psychiatric Res 25:213-222, 1988.

• 269. Papp, LA, Gorman, JM, Liebowitz, MR, Fyer, AJ, Cohen, B& Klein, DF: Epinephrine infusions in patients with social phobia. Am J Psychiatry l45(6):733-736, 1988.

• 270. Klein, DF: Rheostat and cybernetic issues. Comments on "The Current Status of the Dopamine Hypothesis of Schizophrenia". Neuropsychopharmacology 1(3):187-188, 1988.

• 271. Liebowitz, MR, Fyer, AJ, Gorman, JM, Campeas, RB, Sandberg, DP, Hollander, E, Papp, LA & Klein, DF: Tricyclic therapy of the DSM-III anxiety disorders: A review with implications for further research. J Psychiatric Res 22(1):7-31, 1988.

• 272. Fyer, AJ, Liebowitz, MR, Gorman, JM, Campeas , R, Levin, A, Sandberg, D, Fyer, M, Hollander, E, Papp, LA, Goetz, D & Klein, DF: Effects of clonidine on alprazolam discontinuation in panic patients: A pilot study. J Clin Psychopharm 8(4):270-274, 1988.

• 273. Gewirtz, GR, Malaspina, D, Hatterer, JA, Feureisen, S, Klein, DF & Gorman, JM: Occult thyroid dysfunction in patients with refractory depression. Am J Psychiatry 145(8):1012-1014, 1988.

• 274. McGrath, PJ, Cooper, TB, Quitkin, FM & Klein, DF: Effects of imipramine and phenelzine on plasma phenylethylamine (PEA) levels. Psychiatric Res 26:239, 1988.

• 275. Gorman, JM, Fyer, MR, Goetz, R, Askanazi, J, Liebowitz, MR, Fyer, AJ, Kinney, J & Klein, DF: Ventilatory physiology of patients with panic disorder. Arch Gen Psychiatry 45(1):31-39, 1988.

• 276. Mannuzza, S, Fyer, AJ, Martin, LY, Gallops, MS, Endicott, J, Gorman, JM, Liebowitz, MR & Klein, DF: Reliability of Anxiety Assessment: I. Diagnostic agreement. Arch Gen Psychiatry 46(12):1093-1101, 1989.

• 277. Fyer, AJ, Mannuzza, S, Martin, LY, Gallops, MS, Endicott, J, Schleyer, B, Gorman, JM, Liebowitz, MR & Klein, DF: Reliability of Anxiety Assessment: II. Symptom agreement. Arch Gen Psychiatry 46(12):1102-1110, 1989.

• 278. Hollander, E, Liebowitz, MR, Winchel, RW, Klumker, A & Klein, DF: Treatment of body-dysmorphic disorder with serotonin reuptake blockers. Am J Psychiatry 146(6):768-770, 1989.

• 279. Papp, LA, Goetz, R, Cole, R, Klein, DF, Jordan, F, Liebowitz, MR, Fyer, AJ, Hollander, E & Gorman, JM: Hypersensitivity to carbon dioxide in panic disorder. Am J Psychiatry 146(6):779-781, 1989.

• 280. Hollander, E, Liebowitz, MR, Gorman, JM, Cohen, B, Fyer, AJ, & Klein, DF: Cortisol and sodium lactate-induced panic. Arch Gen Psychiatry 46(2):135-140, 1989.

• 281. Klein, DF & Klein, HM: The substantive effect of variations in panic measurement and agoraphobia definition. J of Anxiety Disorders 3:45-56, 1989.

• 282. Gorman, JM, Battista, D, Goetz, RR, Dillon, DJ, Liebowitz, MR, Fyer, AJ, Kahn, JP, Sandberg, D & Klein, DF: A comparison of sodium bicarbonate and sodium lactate infusion in the induction of panic attacks. Arch Gen Psychiatry 46(2):145-150, 1989.

• 283. Nunes, EV, Quitkin, FM & Klein, DF: Psychiatric diagnosis in cocaine abuse. Psychiatric Res 28(1):105-114, 1989.

• 284. Quitkin, FM, McGrath, PJ, Stewart, JW, Harrison, W, Wager, SG, Nunes, E, Rabkin, JG, Tricamo, E, Markowitz, J & Klein, DF: Phenelzine and imipramine in mood reactive depressives: Further delineation of the syndrome of atypical depression. Arch Gen Psychiatry 46(9):787-793, 1989.

• 285. Hollander, E, Liebowitz, MR, Cohen, B, Gorman, JM, Fyer, AJ, Papp, LA & Klein, DF: Prolactin and sodium lactate-induced panic. Psychiatric Res 28(2):181-191, 1989.

• 286. Klein, DF & Klein, HM: The utility of the panic disorder concept. European Archives of Psychiatry & Neurological Sciences 238:268-279, 1989.

• 287. Papp, LA, Martinez, JM, Klein, DF, Ross, D, Liebowitz, MR, Fyer, AJ, Hollander, E & Gorman, JM: Arterial blood gas changes in panic disorder and lactate-induced panic. Psychiatric Res 28:171-180, 1989.

• 288. Goetz, RR, Gorman, JM, Dillon, DJ, Papp, LA, Hollander, E, Fyer, AJ, Liebowitz, MR & Klein, DF: Do panic disorder patients indiscriminately endorse somatic complaints? Psychiatric Res 29(2):207-213, 1989.

• 289. Klein, DF: Schizophrenia and bipolar affective disorders: Likenesses and differences. Grand Rounds presentation, Hillside Hospital, Glen Oaks, NY, February 17, 1988. Hillside J

Clin Psychiatry 11(l):3-15, 1989.• 290. Schneier, FR, Martin, LY, Liebowitz, MR, Gorman, JM, Klein, DF & Fyer, AJ: Alcohol

abuse in social phobia. J Anxiety Disorders 3:15-23, 1989.• 291. Hollander, E, Nunes, E, DeCaria, C, Quitkin, F, Cooper, T, Wager, S & Klein, DF:

Dopaminergic sensitivity and cocaine abuse: Response to apomorphine. Psychiatric Res 33:161-169, 1990.

• 292. Klein, DF: Pharmacotherapy of obsessive compulsive disorder. L'Encephale XVI:331-4, 1990.

• 293. Kahn, JP, Gorman, JM, King, DL, Fyer, AJ, Liebowitz, MR, & Klein, DF: Cardiac left ventricular and chamber dilatation in panic disorder patients: Implications for idiopathic dilated cardiomyopathy. Psychiatric Res 32(1):55-61, 1990.

• 294. Fyer, AJ, Mannuzza, S, Gallops, MS, Martin, LY, Aaronson, C, Gorman, JM, Liebowitz, MR & Klein, DF: Familial transmission of simple phobias and fears: A preliminary report. Arch Gen Psychiatry 47(3):252-256, 1990.

• 295. Hollander, E, DeCaria, C, Schneier, F, Schneier, H, Liebowitz, MR & Klein, DF: Fenfluramine augmentation of serotonin reuptake blockade antiobsessional treatment. J Clin Psychiatry 51(3):119-123, 1990.

• 296. Schneier, F, Liebowitz, MR, Fairbanks, J, Hollander, E, Campeas, R & Klein, DF: Fluoxetine in panic disorder. J Clin Psychopharm 10(2):119-121, 1990.

• 297. Rabkin, JG, McGrath, PJ, Quitkin, FM, Tricamo, E, Stewart, JW & Klein, DF: Effects of pill giving on maintenance of placebo response in patients with chronic mild depression. Am J Psychiatry 147(12):1622-1626, 1990.

• 298. Klein, DF: Psychotropic drug development: Challenge and Promise (Editorial) Biol Psychiatry 27:1061-1064, 1990.

• 299. Quitkin, FM, McGrath, PJ, Stewart, JW, Harrison, W, Tricamo, E, Wager, SG, Ocepek-Welikson, K, Nunes, E, Rabkin, JG & Klein, DF: Atypical depression, panic attacks, and response to imipramine and phenelzine: A replication. Arch Gen Psychiatry 47(10):935-941, 1990.

• 300. Hollander, E, Liebowitz, MR, DeCaria, C, Fairbanks, J, Fallon, B & Klein, DF: Treatment of depersonalization with serotonin reuptake blockers. J Clin Psychopharm 10(3):200-203, 1990.

• 301. Gorman, JM, Goetz, RR, Dillon, D, Liebowitz, MR, Fyer, AJ, Davies, S & Klein, DF: Sodium d-lactate infusion of panic disorder patients. Neuropsychopharmacology 3(3):181-189, 1990.

• 302. Mannuzza, S, Fyer, AJ, Liebowitz, MR & Klein, DF: Delineating the boundaries of social phobia: Its relationship to panic disorder and agoraphobia. J Anxiety Disorders 4:41-59, 1990.

• 303. Hollander, E, DeCaria, CM, Aronowitz, B, Klein, DF, Liebowitz, MR & Shaffer, D: A pilot follow-up study of childhood soft-signs and the development of adult psychopathology. J Neuropsych & Clin Neurosciences 3(2):186-189, 1991.

• 304. Hollander, E, DeCaria, C, Nitescu, A, Cooper, T, Stover, B, Gully, R, Klein, DF & Liebowitz, MR: Noradrenergic function in obsessive compulsive disorder: Behavioral and neuroendocrine responses to clonidine and comparison to healthy controls. Psychiatry Res 37:161-177, 1991.

• 305. Hollander, E, Mullen, L, DeCaria, C, Skodol, A, Schneier, F, Liebowitz, MR & Klein, DF: Obsessive-compulsive disorder, depression, and fluoxetine. J Clin Psychiatry 52(10):418-422, 1991.

• 306. Quitkin, FM, Rabkin, JG, Stewart, JW, McGrath, PJ, Harrison, W, Ross, DC, Tricamo, E, Fleiss, J, Markowitz, J & Klein, DF: Heterogeneity of clinical response during placebo treatment. Am J Psychiatry 148(2):193-196, 1991.

• 307. Quitkin, FM, McGrath, PJ, Rabkin, JG, Stewart, JW, Harrison,W, Ross, DC, Tricamo,

E, Fleiss, J, Markowitz, J & Klein, DF: Different types of placebo response in patients receiving antidepressants. Am J Psychiatry 148(2):197-203, 1991.

• 308. Klein, DF: Improvement of phase III psychotropic drug trials by intensive phase II work. Neuropsychopharmacology 4(4):251-258, 1991.

• 309. Klein, DF: Reply to commentaries: Improvement of phase III psychotropic drug trials by intensive phase II work. Neuropsychopharmacology 4(4):269-271, 1991.

• 310. Hollander, E, DeCaria, C, Nitescu, A, Gulley, R, Cooper, TB, Gorman, JM, Klein, DF & Liebowitz, MR: Effects of chronic fluoxetine treatment on behavioral and neuroendocrine response to m-CPP in obsessive-compulsive disorder. Psychiatry Res 36:1-17, 1991.

• 311. Vinar, O, Klein, DF, Potter, WZ & Gause, EM: A survey of psychotropic medications not available in the United States. Neuropsychopharmacology 5(4):201-217, 1991.

• 312. Quitkin, FM, Harrison, W, Stewart, JW, McGrath, PJ, Tricamo, E, Ocepek-Welikson, K, Rabkin, JG, Wager, SG, Nunes, E & Klein, DF: Response to phenelzine and imipramine in placebo responders with atypical depression: A new application of the crossover design. Arch Gen Psychiatry 48(4):319-323, 1991.

• 313. Klein, DF: Scientific fraud and misconduct. (Editorial) J Clin Psychopharm 11(6):337-338, 1991.

• 314. Klein, DF: Commentary on "Psychology and Pharmacology in the Treatment of Anxiety Disorders: Cooperation or Confrontation?" by H.C. Middleton, M.D. J of Pharmacol 5(4):299-300, 1991.

• 315. Schneier, FR, Fyer, AJ, Martin, LY, Ross, D, Mannuzza, S, Liebowitz, MR, Gorman, JM & Klein, DF: A comparison of phobic subtypes within panic disorder. J Anxiety Disorders 5:65-75, 1991.

• 316. Shear, MK, Fyer, AJ, Ball, G, Josephson, S, Fitzpatrick, M, Gitlin, B, Frances, A, Gorman, J, Liebowitz, M and Klein, DF: Vulnerability to sodium lactate in panic disorder patients given cognitive-behavioral therapy. Am J Psychiatry 148(6):795-797, 1991.

• 317. Liebowitz, MR, Schneier, F, Campeas, R, Hollander, E, Hatterer, J, Fyer, AJ, Gorman, J, Papp, L, Davies, S, Gully, R & Klein, DF: Phenelzine vs. atenolol in social phobia: A placebo controlled comparison. Arch Gen Psychiatry 49(4):290-300, 1992.

• 318. Mannuzza, S, Fyer, AJ, Endicott, J, Gallops, MS, Martin, LY, Reich, T & Klein, DF: An extension of the acquaintanceship procedure in family studies of mental disorder. J Psychiatric Res 26(1):45-57, 1992.

• 319. Hollander, E, DeCaria, C, Nitescu, A, Gully, R, Suckow, RF, Cooper, TB, Gorman, JM, Klein, DF & Liebowitz, MR: Serotonergic function in obsessive compulsive disorder: Behavioral and neuroendocrine responses to oral m-CPP and fenfluramine in patients and healthy volunteers. Arch Gen Psychiatry 49(1):21-28, 1992.

• 320. Stewart, JW, Quitkin, FM & Klein, DF: The pharmacotherapy of minor depression. Am J Psychotherapy XLVI(1):23-36, 1992.

• 321. Coplan, JD, Liebowitz, MR, Gorman, JM, Fyer, AJ, Dillon, DJ, Campeas, RB, Davies, SO, Martinez, J & Klein, DF: Noradrenergic function in panic disorder effects of intravenous clonidine pretreatment on lactate induced panic. Biol Psychiatry 31:135-146, 1992.

• 322. Klein, DF, Mannuzza, S, Chapman, T & Fyer, AJ: Child panic revisited. J Am Acad of Child & Adolesc Psychiatry 31(1):112-116, 1992.

• 323. Coplan, JD, Gorman, JM & Klein, DF: Serotonin related functions in panic-anxiety; A critical overview. Neuropsychopharmacology 6(3):189-200, 1992.

• 324. McGrath, PJ, Stewart, JW, Harrison, WM, Ocepek-Welikson, K, Rabkin, JG, Nunes, E, Wager, S, Tricamo, E, Quitkin, FM & Klein, DF: Predictive value of symptoms of atypical depression for differential drug treatment outcome. J Clin Psychopharm 12(3):197-202, 1992.

• 325. Stein, JM, Papp, LA, Klein, DF, Cohen, S, Simon, J, Ross, D, Martinez, J & Gorman,

JM: Exercise tolerance in panic disorder patients. Biol Psychiatry 32:281-287, 1992.• 326. Klein, DF & Klein, RG: Methodologic issues in maintenance therapy clinical trials; A

commentary. International J of Methods in Psych Res 2(3):107-109, 1992.• 327. Mannuzza, S, Aronowitz, B, Chapman, T, Klein, DF & Fyer, AJ: Panic disorder and

suicide attempts. J Anxiety Disorders 6:261-274, 1992.• 328. Stein, DJ, Hollander, E, Anthony, D, Schneier, FR, Fallon, BA, Liebowitz, MR &

Klein, DF: Serotonergic medications for sexual obsessions, sexual addictions and paraphilias. J Clin Psychiatry 53:267-271, 1992.

• 329. Klein, DF: Commentary on "Panic disorder-old wine in new bottles" by Leo E. Hollister. Integrative Psychiatry 8(2):85-86, 1992.

• 330. Fyer, AJ, Mannuzza, S, Chapman, T, Liebowitz, MR & Klein, DF: A direct interview family study of social phobia. Arch Gen Psychiatry 50(4):286-293, 1993.

• 331. Goetz, RR, Klein, DF, Gully, DJ, Kahn, J, Liebowitz, MR, Fyer, AJ, & Gorman, JM: Panic attacks during placebo procedures in the laboratory: Physiology and symptomatology. Arch Gen Psychiatry 50(4):280-285, 1993.

• 332. McGrath, PJ, Stewart, JW, Nunes, E, Ocepek-Welikson, K, Rabkin, JG, Quitkin, FM & Klein, DF: A double-blind crossover trial of imipramine and phenelzine for outpatients with treatment-refractory depression. Am J Psychiatry 150(1):118-123, 1993.

• 333. Klein, DF & Ross, DC: Reanalysis of the National Institute of Mental Health Treatment of Depression Collaborative Research Program General Effectiveness Report. Neuropsychopharmacology 8(3):241-252, 1993.

• 334. Klein, DF: The utility of the super-normal control group in psychiatric genetics. Psychiatric Genetics 3(1):17-19, 1993.

• 335. Klein, DF: False suffocation alarms, spontaneous panics, and related conditions; An integrative hypothesis. Arch Gen Psychiatry 50(4):306-317, 1993.

• 336. Quitkin, FM, Stewart, JW, McGrath, PJ, Nunes, E, Ocepek-Welikson, K, Tricamo, E, Rabkin, J, Ross, D & Klein, DF: Loss of drug effects during continuation therapy. Am J Psychiatry 150(4):562-565, 1993.

• 337. Quitkin, FM, Stewart, JW, McGrath, PJ, Nunes, E, Ocepek-Welikson, K, Tricamo, E, Rabkin, JG & Klein, DF: Further evidence that a placebo response to antidepressants can be identified. Am J Psychiatry 150(4):566-570, 1993.

• 338. Chapman, TF, Fyer, AJ, Mannuzza, S & Klein, DF: A comparison of treated and untreated simple phobia. Am J Psychiatry 150:816-818, 1993.

• 339. Hollander, E, DeCaria, CM, Saoud, JB, Klein, DF & Liebowitz, MR: A pilot study of biological predictors of treatment outcome in obsessive-compulsive disorder. Biol Psychiatry 33:747-749, 1993.

• 340. Klein, DF: Clinical psychopharmacologic practice: The need for developing a research base. Arch Gen Psychiatry 50(6):491-494, 1993.

• 341. Papp, LA, Klein, DF, Martinez, J, Schneier, F, Cole, R, Liebowitz, MR, Hollander, E, Fyer, AJ, Jordan, F & Gorman, JM: Diagnostic and substance specificity of carbon-dioxide-induced panic. Am J Psychiatry 150(2):250-257, 1993.

• 342. Papp, LA, Klein, DF & Gorman, JM: Carbon dioxide hypersensitivity, hyperventilation and panic disorder. Am J Psychiatry 150(8):1149-1157, 1993.

• 343. Klein, DF: Mixed anxiety depression: For and against. (Proceedings of the Eighth International Thematic Meeting Paris, November 27, 1992.) L'Encephale XIX:493-495, 1993.

• 344. Hollander, E, Cohen, LJ, DeCaria, C, Saoud, JB, Stein, DF, Cooper, TB, Islam, MN, Liebowitz, MR & Klein, DF: Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD. Biol Psychiatry 34:407-413, 1993.

• 345. Mannuzza, S, Fyer, AJ & Klein, DF: Assessing psychopathology. International J of Methods in Psych Res 3:157-165, 1993.

• 346. Fallon, BA, Nields, JA, Parsons, B, Liebowitz, MR & Klein, DF: Psychiatric manifestations of Lyme Borreliosis. J Clin Psychiatry 54(7):263-268, 1993.

• 347. Quitkin, FM, Stewart, JW, McGrath, P.J., Tricamo, E., Rabkin, JG, Ocepek-Welikson, K, Nunes, E, Harrison, W & Klein, DF: Columbia atypical depression: A sub-group of depressives with better response to MAOI than to tricyclic antidepressants or placebo. Br J Psychiatry 163(Suppl.21):30-34, 1993.

• 348. Klein, DF: Should the government assure scientific integrity? Academic Medicine 68(9, Suppl.):S56-S59, 1993.

• 349. Fallon, BF, Liebowitz, MR, Salman, E, Schneier, F, Jusino, C, Hollander, E & Klein, DF: Fluoxetine for hypochondriacal patients without major depression. J Clin Psychopharm 13(6):438-441, 1993.

• 350. Gorman, JM, Papp, LA, Coplan, J, Martinez, J, Liebowitz, MR & Klein, DF: The effect of acetazolamide on ventilation in panic disorder patients. Am J Psychiatry 150(10):1480-1484, 1993.

• 351. Klein, DF: Identified placebo treatment? Neuropsychopharmacology 10(4):271-272, 1994.

• 352. Klein, DF: The utility of guidelines and algorithms for practice. Psychiatric Annals 24(7):362-367, 1994.

• 353. Klein, DF: The treatment of atypical depression. European Psychiatry 8(5):251-255, 1993.

• 354. Stein, DJ, Hollander, E, Chan, S, DeCaria, CM, Hilal, S, Liebowitz, MR, Klein, DF: Computed tomography and neurological soft signs in obsessive-compulsive disorder. Psych Res 50 (3):143-150, 1993.

• 355. Lipsitz, JD, Martin, LY, Mannuzza, S, Chapman, TF, Liebowitz, MR, Klein, DF & Fyer, AJ: Childhood separation anxiety disorder in patients with adult anxiety disorders. Am J Psychiatry 151(6):927-929, 1994.

• 356. Klein, DF: Testing the suffocation false alarm theory of panic disorder. Anxiety 1:1-7, 1994.

• 357. Goetz, RR, Klein, DF & Gorman, JM: Consistencies between recalled panic and lactate induced panic. Anxiety 1:31-36, 1994.

• 358. Chapman, T, Fyer, AJ, Mannuzza & Klein, DF: Effects of informant mental disorder on psychiatric family history data. Am J Psychiatry 151(4): 574-579, 1994.

• 359. Pine, DS, Weese-Mayer, DE, Silvestri, JM, Davies, M, Whitaker, A & Klein, DF: Anxiety and Congenital Central Hypoventilation Syndrome. Am J Psychiatry 151(6): 864-870, 1994.

• 360. Stein, DJ, Hollander, E & Klein, DF: Biological markers of depression and anxiety. Medicographia 16(1): 18-21, 1994.

• 361. Gorman, JM, Papp, LA, Coplan, JD, Martinez, JM, Lennon, S, Goetz, RR, Ross, D & Klein, DF: Anxiogenic effects of CO2 and hyperventilation in patients with panic disorder. Am J Psychiatry 151(4): 547-553, 1994.

• 362. Liebowitz, MR, Salman, E, Jusino, CM, Garfinkel, R, Street, L, Cardenas, D, Silvestre, J, Fyer, AJ, Carrasco, JL, Davies, S, Guarnaccia, P & Klein, DF: Ataque de nervios and panic disorder. Am J Psychiatry 151(6): 871-875, 1994.

• 363. Klein, DF: Pregnancy and panic disorder (Commentary). J Clin Psychiatry 55(7):293-294, 1994.

• 364. Mannuzza, S, Schneier, FR, Chapman, TF, Liebowitz, MR, Klein, DF & Fyer, AJ: Generalized social phobia: Reliability and validity. Arch Gen Psychiatry 52:230-237, 1995.

• 365. Papp, LA, Martinez, JM, Klein, DF, Coplan, J & Gorman, JM: Rebreathing tests in panic disorder. Biol Psychiatry 38(4): 240-245, 1995.

• 366. Nunes, EV, McGrath, PJ, Quitkin, FM, Ocepek-Welikson, K, Stewart, JW, Koenig, T, Wager, S & Klein, DF: Imipramine treatment of cocaine abuse: Possible boundaries of

efficacy. Drug and Alcohol Dependence 39:185-195, 1995.• 367. Fyer, AJ, Mannuzza, S, Chapman, TF, Martin, LY & Klein, DF: Specificity in familial

aggregation of phobic disorders. Arch Gen Psychiatry 52(7): 564-573, 1995.• 368. Klein, DF, Skrobala, A & Garfinkel, RS: Preliminary look at the effects of pregnancy

on the course of panic disorder. Anxiety 1(5): 227-232, 1995.• 369. Mannuzza, S, Chapman, TF, Klein, DF & Fyer, AJ: Familial transmission of panic

disorder: Effect of major depression comorbidity. Anxiety 1:180-185, 1994/1995.• 370. Klein, DF: Improving medication and legislation by controlled experimentation.

Psychiatric Annals 25(1):67-69, 1995.• 371. Klein, DF: Psychopharmacological practice and health reform. Psychiatric Annals

25(2):79-83, 1995.• 372. Klein, DF. Response to critique of suffocation alarm theory. Anxiety 1(3):145-148,

1995.• 373. Klein, DF: Treatment of panic disorder, agoraphobia and social phobia. Clinical

Neuropharmacology 18 (suppl. 2):S45-S51, 1995.• 374. Resschke, AH, Mannuzza, S, Chapman, TF, Lipsitz, JD, Liebowitz, MR, Gorman, JM,

Klein, DF, Fyer, AJ: Sodium lactate response and familial risk for panic disorder. Am J Psychiatry 152(2):277-279, 1995.

• 375. Glick, ID, Lecrubier, Y, Montgomery, SA, Vinar, O & Klein, DF: Efficacious and safe psychotropics not available in the United States. Psychiatric Annals 26:354-361, 1996.

• 376. Klein, DF: Response to Rothman and Michels on placebo-controlled clinical trials. Psychiatric Annals 25(7):401-403, 1995.

• 377. Marshall, RD & Klein, DF: Pharmacotherapy in the treatment of posttraumatic stress disorder. Psychiatric Annals 25(10):588-597, 1995.

• 378. Papp, LP, Welkowitz, LA, Martinez, JM, Klein, DF, Browne, S & Gorman, JM. Instructional set does not alter outcome of respiratory challenges in panic disorder. Biological Psychiatry 38(12):826-830, 1995.

• 379. Klein, DF. What's new in DSM-IV? Psychiatric Annals 25(8):461-474, 1995.• 380. Klein, DF: Counterevidence from psychopharmacology, psychopathology, and

psychobiology. Behav Brain Sci 18(2):302-3, 1995.• 381. Klein, DF: Forword: Controversies and conventions in panic disorder: questions and

answers in recognition and treatment. European Psychiatry 10 (suppl. 2):55s, 1995.• 382. Klein, DF: Recognising panic disorder. European Psychiatry 10 (suppl. 2):61s-63s,

1995.• 383. Liebowitz, MR, Coplan, JD, Martinez, J, Fyer, AJ, Dillon, DJ, Campeas, RB, Davies,

SO, Gorman, JM, & Klein, DF: Effects of intravenous diazepam pretreatment on lactate-induced panic. Psychiatry Research 58:127-138, 1995.

• 384. Martinez, JM, Papp, LA, Anderson, DE, Mueller, CM, Klein, DF, Coplan, JD & Gorman, JM. Ambulatory monitoring of respiration in anxiety. Anxiety 2:296-302, 1996.

• 385. Quitkin, FM, McGrath, PJ, Stewart, JW, Ocepek-Welikson, K, Taylor, BP, Nunes, E, Deliyannides, D, Agosti, V, Donovan, SJ, Petkova, E & Klein, DF: Chronological milestones to guide drug change: When should clinicians switch antidepressants? Arch Gen Psychiatry 53(9):785-792, 1996.

• 386. Schwartz, GE, Goetz, RR, Klein, DF, Endicott, J & Gorman, JM: Tidal volume of respiration and "sighing" as indicators of breathing irregularities in panic disorder patients. Anxiety 2/3:145-148, 1996.

• 387. Quitkin, FM, McGrath, PJ, Stewart, JW, Taylor, BP & Klein, DF: Can the effects of antidepressants be observed in the first two weeks of treatment? Neuropsychopharmacology 15(4):390-394, 1996.

• 388. Fyer, AJ, Mannuzza, S, Chapman, TF, Lipsitz, J, Martin, LY& Klein, DF: Panic

disorder and social phobia: Effects of comorbidity on familial transmission. Anxiety 2:173-178, 1996.

• 389. Klein, DF: Preventing hung juries about therapy studies. J Consulting and Clinical Psychology 64(1):81-87, 1996.

• 390. Goetz, RR, Klein, DF & Gorman, JM: Symptoms essential to the experience of sodium lactate-induced panic. Neuropsychopharmacology 14(5):355-366, 1996.

• 391. Klein, DF: Discussion of "Methodological Controversies in the Treatment of Panic Disorder" by McNally. Behaviour Research and Therapy 34(11/12):849-853, 1996.

• 392. Klein, DF: Critiquing McNally's reply. Behaviour Research and Therapy 34(11/12):859-863, 1996.

• 393. Klein, DF: Comments on "Integrity and Misconduct in Research". Psychiatric Annals 26(10):669-675, 1996.

• 394. Klein, DF: Panic disorder and agoraphobia: Hypothesis hothouse. J Clin Psychiatry 57(suppl 6):21-27, 1996.

• 395. Papp, LA, Martinez, JM, Klein, DF, Coplan, JD, Norman, RG, Cole, R, de Jesus, MJ, Ross, D, Goetz, R, Gorman, JM: Respiratory psychophysiology of panic disorder: Three respiratory challenges in 98 subjects. Am J Psychiatry 154(11):1557-1565, 1997.

• 396. Coplan, JD, Papp, LA, Pine, D, Martinez, J, Cooper, T, Rosenblum, LA, Klein, DF & Gorman, JM: Clinical improvement with fluoxetine therapy and noradrenergic function in patients with panic disorder. Arch Gen Psychiatry 54(7):643-648, 1997.

• 397. Donovan, SJ, Susser, ES, Nunes, EV, Stewart, JW, Quitkin, FM & Klein, DF: Divalproex treatment of disruptive adolescents: A report of 10 cases. J Clin Psychiatry 58(1):12-15, 1997.

• 398. Klein, DF, Smith, LB. A psychotherapeutic context for pharmacotherapy trials is promising, but manualization is not. Arch Gen Psychiatry 54(10):929-930, 1997.

• 399. Papp, LA, Schneier, FR, Fyer, AJ, Liebowitz, MR, Gorman, JM, Coplan, JD, Saoud, J, Campeas, R, Fallon, B, Jusino, C, Klein, DF: Clomipramine treatment of panic disorder: Pro's and con's. J Clin Psychiatry 58(10):423-425, 1997.

• 400. Gorman, JM, Browne, ST, Papp, LA, Martinez, J, Welkowitz, L, Coplan, JD, Goetz, RR, Kent, J, Klein, DF: Effect of antipanic treatment on response to carbon dioxide. Biol Psychiatry 42:982-991, 1997.

• 401. Klein, DF: Control groups in pharmacotherapy and psychotherapy evaluations. Prevention and Treatment, http://journals.apa.org/treatment/vol1/97_a1.html, posted 9/22/97.

• 402. Fallon, BA, Liebowitz, MR, Campeas, R, Schneier, FR, Marshall, R, Davies, S, Goetz, D, Klein, DF: Intravenous clomipramine for obsessive compulsive disorder refractory to oral clomipramine: A placebo controlled study. Arch Gen Psychiatry 55(10):918-924, 1998.

• 403. Heimberg, RG, Liebowitz, MR, Schneier, FR, Hope, DA, Holt, CS, Welkowitz, LA, Juster, HR, Campeas, R, Bruch, MA, Cloitre, M, Fallon, B, Klein, DF: Cognitive-behavioral group therapy vs phenelzine therapy for social phobia: 12-week outcome. Arch Gen Psychiatry 55(12):1133-1141, 1998.

• 404. Stewart, JW, Garfinkel, R, Nunes, EV, Donovan, S, Klein, DF: Atypical features and treatment response in the National Institute of Mental Health Treatment of Depression Collaborative Research Program. J Clin Psychopharm 18(6):429-434, 1998.

• 405. Klein, RG, Pine, DS, Klein, DF: Mania is mistaken for ADHD in prepubertal children. A debate (against). J Am Acad Child Adolesc Psychiatry 37(10):1093-1096; 1098-1099, 1998.

• 406. Quitkin, FM, McGrath, PJ, Stewart, JW, Ocepek-Welikson, K, Taylor, BP, Nunes, E, Deliyannides, D, Agosti, V, Donovan, SJ, Ross, D, Petkova, E, & Klein, DF: Placebo run-in period in studies of depressive disorders; Clinical, heuristic and research implications. Br J Psychiatry 242-248, 1998.

• 407. Salman, E, Liebowitz, MR, Guarnaccia, PJ, Jusino, CM, Garfinkel, R, Street, L, Cardenas, DL, Silvestre, J, Fyer, AJ, Carrasco, JL, Davies, SO, & Klein, DF. Subtypes of ataques de nervios: The influence of coexisting psychiatric diagnosis. Culture, Medicine and Psychiatry 22(2):231-244, 1998.

• 408. Simpson, HB, Schneier, FR, Campeas, RB, Marshall, RD, Fallon, BA, Davies, S, Klein, DF, Liebowitz, MR: Imipramine in the treatment of social phobia. J Clin Psychopharmacology 18(2):132-135, 1998.

• 409. Klein, DF: The significance of panic in general medicine (Editorial). J Psychosomatic Research 44(1):17-19, 1998.

• 410. Pine, DS, Coplan, JD, Papp, LA, Klein, RG, Martinez, JM, Kovalenko, P, Tancer, N, Moreau, D, Dummit, ES, Shaffer, D, Klein, DF, Gorman, JM: Ventilatory physiology of children and adolescents with anxiety disorders. Arch Gen Psychiatry 55(2):123-129, 1998.

• 411. Coplan, JD, Goetz, R, Klein, DF, Papp, LA, Fyer, AJ, Liebowitz, MR, Davies, SO, Gorman, JM: Plasma cortisol concentrations preceding lactate-induced panic; Psychological, biochemical, and physiological correlates. Arch Gen Psychiatry 55(2):130-136, 1998.

• 412. Klein, DF: Commentary: The treatment of panic. Psychopharm Bull 34(2):197, 1998.• 413. Martinez, JM, Coplan, JD, Browne, ST, Goetz, R, Welkowitz, LA, Papp, LA, Klein,

DF, Gorman, JM: Hemodynamic response to respiratory challenges in panic disorder. J Psychosom Res 44(1):153-161, 1998.

• 414. Klein, DF: Listening to meta-analysis but hearing bias. Prevention and Treatment• http://journals.apa.org/prevention/volume1/pre0010008r.html, posted 6/26/98.• 415. Klein, DF: Reply to Kirsch's rejoinder regarding antidepressant meta-analysis.

Prevention and Treatment. http://journals.apa.org/prevention/volume1/pre0010008r.html, posted 11/20/98.

• 416. Knowles, JA, Fyer, AJ, Vieland, VJ, Weissman, MM, Hodge, SE, Heiman, GA, Haghighi, F, de Jesus, GM, Rassnick, H, Preud'homme-Rivelli, X, Austin, T, Cunjak, J, Mick, S, Fine, LD, Woodley, KA, Das, K, Maier, W, Adams, PB, Freimer, NB, Klein, DF, Gilliam, TC: Results of a genome-wide genetic screen for panic disorder. American Journal of Medical Genetics (Neuropsychiatric Genetics) 81:130-147, 1998.

• 417. Klein, DF: Panic and phobic anxiety: Phenotypes, endophenotypes, and genotypes. Am J Psychiatry 155(9):1147-1149, 1998.

• 418. Lipsitz, JD, Mannuzza, S, Klein, DF, Ross, DC, Fyer, AJ. Specific phobia 10-16 years after treatment. Depression & Anxiety 10:105-111, 1999.

• 419. Klein, DF: Harmful dysfunction, disorder, disease, illness, and evolution. J Abnorm Psychol 108(3):421-429, 1999.

• 420. Klein, DF: Dealing with the effects of therapy allegiances. Clin Psychol: Sci & Practice 6:124-126, 1999.

• 421. Klein, DF: Evidence for the Validity of the Concept of Panic Disorder. European Neuropsychopharmacology 8(supl 2) S57-60, 1998.

• 422. Hamilton, SP, Heiman, GA, Haghigi, FG, Mick, S, Klein, DF, Hodge, SE, Weissman, MM, Fyer, AJ, Knowles, JA. Lack of genetic linkage or association between a functional serotonin transporter polymorphism and panic disorder. Psychiatric Genetics 9:1-6, 1999.

• 423. Klein, DF, Smith, LB: Organizational requirements for effective clinical effectiveness studies. Prevention and Treatment http://journals.apa.org/prevention/volume2/pre0020002a.html, posted March 21, 1999.

• 424. Klein, DF: (Commentary) The report by the Institute of Medicine and Postmarketing Surveillance. Arch Gen Psychiatry 56(4):353-354, 1999.

• 425. Coplan, JD, Tamir, H, Calaprice, D, de Jesus, MJ, de la Nuez, M, Pine, D, Papp, LA, Klein, DF & Gorman, JM: Plasma anti-serotonin and serotonin anti-idiotypic antibodies are elevated in panic disorder. Neuropsychopharmacology 20(4):386-391, 1999.

• 426. Sinha, SS, Coplan, JD, Pine, DS, Martinez, JA, Klein, DF & Gorman, JM: Panic

induced by carbon dioxide inhalation and lack of hypothalamic-pituitary-adrenal axis activation. Psychiatry Res 86:93-98, 1999.

• 427. Breslau, N & Klein, DF: Smoking and panic attacks: An epidemiologic investigation. Arch Gen Psychiatry 56(12):1141-1147, 1999.

• 428. Sinha, SS, Goetz, R, Klein, DF: Non-fearful panic induction in normals with naloxone pretreatment of lactate infusion. Submitted Psychiatry Research.

• 429. Liebowitz, MR, Heimberg, RG, Schneier, FR, Hope, DA, Davies, S, Holt, CS, Goetz, D, Juster, HR, Lin, S-H, Bruch, MA, Marshall, RD, Klein, DF: Cognitive-behavioral group therapy versus phenelzine in social phobia: Long term outcome. Depression and Anxiety 10:89-98, 1999.

• 430. Hamilton, SP, Haghighi, F, Heiman, GA, Klein, DF, Hodge, SE, Fyer, AJ, Weissman, MW, Knowles, JA: Investigation of dopamine receptor (DRD4) and dopamine transporter (DAT) polymorphisms for genetic linkage or association to panic disorder. In preparation.

• 431. Fyer, AJ, Mannuzza, S, Chapman, TF, Martin, LY, Lipsitz, J, Zhang, ZD, Leptou, H, Klein, DF: Effects of specific phobia comorbidity on the familial transmission of panic disorder. Submitted Am J Med Genetics (11/99).

• 432. Quitkin, FM, Petkova, E, McGrath, PJ, Nunes, EV, Taylor, B, Beasley, C, Stewart, J, Amsterdam, J, Fava, M, Rosenbaum, J, Reimherr, F, Fawcett, J, Klein, DF: New fluoxetine effects occur until the 12th treatment week: Clinical and biologic implications. Submitted 1999.

• 433. Goetz, RR, Klein, DF, Papp, LA, Martinez, JM, Gorman, JM: Acute panic inventory symptoms during CO2 inhalation and room-air hyperventilation among panic disorder patients and normal controls. Depression and Anxiety 14(2)123-136, 2001.

• 434. Petkova, E, Quitkin, FM, McGrath, P, Stewart, J, Klein, DF: A method to quantify rater bias in antidepressant trials. Neuropsychopharmacology 22(6):559-565, 2000.

• 435. Pine, DS, Klein, RG, Coplan, JD, Papp, LA, Hoven, CW, Martinez, J, Kovalenko, P, Mandell, DJ, Moreau, D, Klein, DF, Gorman, JM: Differential carbon dioxide sensitivity in childhood anxiety disorders and non-ill comparison group. Arch Gen Psychiatry 57(10):960-967, 2000.

• 436. Olfson, M, Guardino, M, Struening, E, Schneier, FR, Klein, DF: Barriers to the treatment of social anxiety. Am J Psychiatry 157(4):521-527, 2000.

• 437. Kent, JM, Papp, LA, Martinez, JM, Browne, ST, Coplan, JD, Klein, DF, Gorman, JM: Specificity of panic response to CO2 inhalation in panic disorder: A comparison with major depression and premenstrual dysphoric disorder. Am J Psychiatry 158(1):58-67, 2001.

• 438. Quitkin, F, Rabkin, JG, Gerald, J, Davis, JM, Klein, DF: Validity of clinical trials of antidepressants. Am J Psychiatry 157(3):327-337, 2000.

• 439. Klein, DF: Flawed meta-analyses comparing psychotherapy with pharmacotherapy. Am J Psychiatry 157(8):1204-1211, 2000.

• 440. McGrath, PJ, Stewart, JW, Janal, MN, Petkova, E, Quitkin, FM, Klein, DF: A placebo- controlled study of fluoxetine versus imipramine in the acute treatment of atypical depression. Am J Psychiatry 157(3):344-350, 2000.

• 441. Hamilton, SP, Slager, S, Helleby, L, Heiman, GA, Klein, DF, Hodge, SE, Weissman, ME, Fyer, AJ, Knowles, JA: No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder. Molecular Psychiatry, 6:59-65, 2001.

• 442. Quitkin, FM, Klein, DF: What conditions are necessary to assess antidepressant efficacy? Arch Gen Psychiatry 57(4): 323-324, 2000.

• 443. Martinez, JM, Coplan, JD, Browne, ST, Papp, LA, Fyer, AJ, Klein, DF, Gorman, JM: Respiratory variability in panic disorder. Depression and Anxiety 14:232-237, 2001.

• 444. Quitkin, FM, Stewart, JW, McGrath, PJ, Taylor, BP, Tisminetzky, MS, Petkova, E, Klein, DF: Gender and antidepressant response. Submitted Am J Psychiatry. 2001

• 445. Johnson, JG, Cohen, P, Pine, DS, Klein, DF, Kasen, S, Brook, JS: Association between cigarette smoking and anxiety disorders during adolescence and early adulthood. JAMA 284(19):2348-2351, 2000.

• 446. Preter, M, Martinez, J, Ross, DC, Klein, DF: Hematologic alterations and CO2• hypersensitivity in male panic disorder patients and normal controls: Similarities to high

altitude hypoxia and chronic lung disease. Depression and Anxiety 14(2)153-154, 2001.• 447. Glick, ID, Janowsky, DS, Zisook, S, Lydiard, RB, Oesterheld, JR, Ward, NG, Ellison, J,

Halper, J, Shear, MK, Doraiswamy, PM, Preven, DW, Ross, P, Klein, DF: How should we teach psychopharmacology to residents? Results of the initial experience with the ASCP Model Curriculum. Academic Psychiatry, 25 (2):90-97, 2001.

• 448. Sheikh, JI, Leskin, GA, Klein, DF: Gender differences in Panic Disorder: Findings from the National Comorbidity Survey. Am J Psychiatry 159: 55-58, 2002.

• 449. Donovan, SJ, Stewart, JW, Nunes, EV, Quitkin, FM, Parides, M, Daniel, W, Susser, E, Klein, DF: Divalproex treatment for youth with explosive temper and mood lability: A double-blind, placebo-controlled crossover design. Am J Psychiatry 157(5):818-820, 2000.

• 450. Klein, DF, Thase, M, Endicott, J, Adler, L, Glick, I, Kalali, A, Levanter, S, Mattes, J, Ross, P, Bystritsky, A: Improving clinical trials: American Society of Clinical Psychopharmacology Recommendations. Arch Gen Psychiatry 59: 272-278, 2002.

• 451. Hamilton S, Slager S, Heiman G, Deng Z, Klein DF, Hodge S, Weissman M, Fyer A, Knowles J: Evidence for a Susceptibility Locus for Panic Disorder near the Catechol-O-Methyltransferase Gene on Chromosome 22. Biological Psychiatry 51:591-601, 2002.

• 452. Marshall R, Blanco C, Printz D, Liebowitz M, Klein DF, Coplan J: A Pilot Study of Noradrenergic and HPA axis Functioning in PTSD vs. Panic Disorder. Psychiatric Research 110 (3) 219-30, 2002.

• 453. Klein, DF, Lipsitz, J, Fyer, A, Paternitti, A: Emetophobia: Preliminary Results of an• Internet Survey. Depresion and Anxiety 14(2) 149-152, 2001.• 454. Klein, DF, Preter, M: Panic, Suffocation False Alarms, Seperation Anxiety and

Endorphins• Submitted: Behavioral and Brain Sciences 11/01.• 455. Mannuza, S., Klein, R., Moulton, J., Scarfone, N., Malloy, P., Vosburg, S. & Klein, D:

Anxiety sensitivity among children of parents with anxiety disorders: a controlled high-risk study. Journal of Anxiety Disorders 16:135-148, 2002.

• 456. Mannuza, S., Klein, R., Klein, R., Bessler, A. & Shrout, P: Accuracy of adult recall of childhood attention deficit hyperativity disorder. American Journal of Psychiatry 159:1882-1888, 2002.

• 457. Ross, D., Quitkin, F. & Klein, D: A Typological Model for Estimation of Drug and Placebo Effects in Depression. Journal of Clinical Psychopharmacology 22:414-418, 2002.

• 458. Slattery, M, Klein, DF, Mannuzza, S, Moulton, J, Pine, D & Klein, RG: Relationship Between Separation Anxiety Disorder, Parental Panic Disorder, and Atopic Disorders in Children: A Controlled High-Risk Study. J Am Acad Adolesc Psychiatry 41(8):947-954, 2002.

• 459. Quitkin, F, Stewart, J, McGrath, P, Taylor, B, Tisminetzky, M, Petkova, E, Chen, Y, Ma, G & Klein, D: Are there differences between women's and men's antidepressant responses? Am J Psychiatry 159:1848-1854, 2002.

• 460. Hamilton, S, Slager, S, de Leon, A, Heiman, G, Klein, D, Hodge, S, Weissman, M, Fyer, A, & Knowles, J: Evidence for Genetic Linkage between a Polymorphism in the Adenosine 2A Receptor (ADORA2A) and Panic Disorder. Submitted Neuropsychopharmacology 11/02.

• 461. Klein, D: Historical Aspects of Anxiety. Submitted Dialogues in Clinical Neuroscience.11/02

• 462. Klein, D: (Commentary) Identifying Adaptation by Dysfunction (Andrews et al;

Adaptation-How to Carry Out an Exaptationist Program) Submitted Behavioral and Brain Science 11/02.

• 463. Quitkin F, Petkova E, McGrath P, Taylor B, Beasley C, Stewart J, Amsterdam J, Fava M, Rosenbaum J, Reimherr F, Fawcett J, Chen Y, Klein D: When Should a Trial of Fluxetine for Major Depression be Declared Failed? Submitted American Journal of Psychiatry 12/02.

• 464. Klein D: (Editoral) Fostering Treatment Advances. Journal of Clinical Psychopharmacology 22: 541-2, 2002.

• 465. Hamilton, S., Slager, S., Mayo, D., Heiman, G., Klein, D., Hodge, S., Fyer, A., Myrna, W. & Knowles, J: Investigation of Polymorphisms in the CREM gene in Panic Disorder. Submitted Neuropsychiatric Genetics 2/03.

• C. 1. Klein, DF: Behavioral effects of imipramine and phenothiazines: Implications for a psychiatric pathogenic theory and theory of drug action. In Joseph Wortis (Ed.) Volume VII Recent Advances in Biological Psychiatry. Plenum Press, New York, 1964, pp. 273-287.

• C. 2. Klein, DF: Diagnosis and pattern of reaction to drug treatment: Clinically derived formulations. In Katz, NM, Cole, JO & Barton, WE (Eds.): The Role and Methodology of Classification in Psychiatry and Psychopathology. NIMH, 1968, pp. 466-483.

• C. 3. Gittelman-Klein, R & Klein, DF: Long-term effects of antipsychotic agents: A review. In Efron, DH (Ed.): Psychopharmacology: A Review of Progress, 1957-1967. Government Printing Office, Wash. DC, 1968, pp. 1119-1153.

• C. 4. Klein, DF, Honigfeld, G & Feldman, S: Prediction of drug effect by a successive screening decision tree diagnostic technigue. In May, PRD & Wittenborn, JR (Eds.): Psychotropic Drug Responses: Advances in Prediction. Charles C. Thomas, 1969, pp. 45-91.

• C. 5. Klein, DF: Psychopharmacological treatment of bereavement and its complications. In Kutscher, AH (Ed.): Death and Bereavement. Charles C. Thomas, 1969, pp. 299-304.

• C. 6. Woerner, MG, Pollack, M, Rogalski, C, Pollack, Y & Klein, DF: A comparison of childhood characteristics of schizophrenics, personality disorders and their siblings. In Roff, M & Ricks, D (Eds.): Life History Research in Psychopathology. Univ. of Minnesota Press, 1970, pp. 208-225.

• C. 7. Klein, DF, Feldman, S & Honigfeld, G: Can univariate measures of drug effect reflect clinical descriptions of change? In Wittenborn, JR, Goldberg, SC & May, PRA (Eds.): Psychopharmacology and the Individual Patient. Raven Press, 1970, pp. 189-225.

• C. 8. Klein, DF: The importance of diagnosis: An analysis and program. In Rothman, T (Ed.): Changing Patterns in Psychiatric Care. Crown Publications, 1970, pp. 229-244.

• C. 9. Rosen, B, Levenstein, S, Shahinian, SP & Klein, DF: Social competence and posthospital outcome. In Rothman, T (Ed.): Changing Patterns in Psychiatric Care. Crown Publications, 1970, pp. 245-255.

• C. 10. Klein, DF: Psychotropic drugs and the regulation of behavioral activation in psychiatric illness. In Smith, WL (Ed.): Drugs and Cerebral Function. Charles C. Thomas, 1970, pp. 69-81.

• C. 11. Klein, DF: Constraints on psychiatric treatment research produced by the organization of clinical services. In Merlis, S (Ed.): Non-Scientific Constraints on Medical Research. Raven Press 1970, pp. 69-90.

• C. 12. Klein, DF: Approaches to measuring the efficacy of drug treatment of personality disorders: An analysis and program. In Principles and Problems in Establishing the Efficacy of Psychotropic Agents. US Dept. of Health, Education & Welfare, Public Health Service, #2138 1971, pp. 187-204.

• C. 13. Gittelman-Klein, R & Klein, DF: School phobia: Diagnostic considerations in the light of imipramine effects. In Smith, L (Ed.): Drugs, Development and Cerebral Function. Charles C. Thomas, 1972, pp. 200-223.

• C. 14. Quitkin, F, Rifkin, A & Klein, DF: Lithium in other psychiatric disorders. In Gershon, S & Shopsin, B (Eds.): Lithium: Its Role in Psychiatric Research and Treatment. Plenum

Press, 1972, pp. 295-315.• C. 15. Klein, DF: Methodology for study of bereavement. In Goldberg, IK, Malitz, S &

Kutscher, AH (Eds.): Psychopharmacological Agents for the Terminally Ill and Bereaved. Columbia University Press, 1973, pp. 318-319.

• C. 16. Klein, DF: Drug therapy as a means of syndromal identification and nosological revision. In Cole, JO, Freedman, AM & Friedhoff, AJ (Eds.): Psychopathology and Psychopharmacology. The Johns Hopkins Press, 1973, pp. 143-160.

• C. 17. Klein, DF, Honigfeld, G & Feldman, S: Prediction of drug effect in personality disorders. In Smith, L (Ed.): Drugs, Development and Cerebral Function. Charles C. Thomas, 1972, pp. 248-269. Also J Nerv & Ment Dis 156(3):183-198, 1973.

• C. 18. Klein, DF & Gittelman-Klein, R: Diagnosis of minimal brain dysfunction and hyperkinetic syndrome. In Conners, K (Ed.): Clinical Use of Stimulant Drugs in Children. The Hague, Excerpta Medica, 1974, pp. 1-10.

• C. 19. Klein, DF: Who should not be treated with neuroleptics, but often are? In Ayd, F (Ed.): Rational Psychopharmacotherapy and the Right to Treatment. Ayd Medical Communications, Lts., 1974, pp. 29-36.

• C. 20. Klein, DF: Endogenomorphic depression. In Angst, J: Classification and Prediction of Outcome of Depression. Symposia Medica Hoechst, Stuttgart, KK, Schattauer Verlag, 1974, pp. 289-300.

• C. 21. Honigfeld G & Klein, DF: Computerized translatable psychiatric history form. In Turan, I (Ed.): Transcultural Neuropsychopharmacology. M. Bozak Publications, Istanbul, 1975.

• C. 22. Klein, DF: Psychopharmacology and the borderline patients. In Mack, JG (Ed.): Borderline State in Psychiatry. Gruen & Stratton, Inc., 1975 pp. 75-91.

• C. 23. Rifkin, A, Quitkin, F & Klein, DF: Longterm use of antipsychotic drugs. In Klein, DF & Gittelman-Klein, R (Eds.): Progress in Psychiatric Drug Treatment. Brunner/Mazel, 1975, pp. 387-396.

• C. 24. Quitkin, F, Rifkin, A & Klein, DF: Prophylaxis of affective disorders: A review. In Klein, DF, & Gittelman-Klein, R (Eds.): Progress in Psychiatric Drug Treatment. Brunner/Mazel, 1975, pp. 226-279.

• C. 25. Klein, DF: Differential diagnosis and treatment of the dysphorias. In Simpson, GM, & Gallant, DM (Eds.): Depression: Behavioral, Biochemical, Clinical and Treatment Concepts. Spectrum Press, 1975, pp. 127-154.

• C. 26. Schildkraut, JJ & Klein, DF: The classification and treatment of depressive disorders. In Shader, RI (Ed.): Manual of Psychiatric Therapeutics: Practical Psychopharmacology & Psychiatry. Little Brown & Company, 1975, pp. 39-61.

• C. 27. Klein, DF: Treating anxiety. In Anxiety: Decision at the Synapse. New York, Medcom, 1975, pp. 31-33.

• C. 28. Klein, DF: Clinical phenomena of anxiety. In Anxiety: Decision at the Synapse. New York, Medcom, 1975, pp. 10-13.

• C. 29. Kane, J, Rifkin, A, Quitkin, F & Klein, DF: Antidepressant drug blood levels, pharmacokinetics and clinical outcome. In Klein, DF, & Gittelman-Klein, R (Eds.): Progress in Psychiatric Drug Treatment. Volume 2. Brunner/Mazel, 1976, pp. 136-158.

• C. 30. Rifkin, A, Quitkin, F, Kane, J & Klein, DF: Longterm use of antipsychotic drugs. In Klein, DF & Gittelman-Klein, R (Eds.): Progress in Psychiatric Drug Treatment II. Brunner/Mazel, 1976, pp. 322-329.

• C. 31. Zitrin, CM, Klein, DF, Lindemann, C, Toback, P, Rock, M, Kaplan, JH & Ganz, VH: Comparison of short-term treatment regimens in phobic patients. In Spitzer, RL & Klein, DF (Eds.): Evaluation of Psychological Therapies. The Johns Hopkins Press, 1976, pp. 233-250.

• C. 32. Klein, DF: Diagnosis of anxiety and differential use of anti-anxiety drugs. In Simpson, L (Ed.): Drug Treatment of Mental Disorders. Raven Press, 1976, pp. 61-72.

• C. 33. Kane, J, Rifkin, A, Quitkin, F & Klein, DF: Antipsychotic drug blood levels and clinical outcome. In Klein, DF, & Gittelman-Klein, R (Eds.): Progress in Psychiatric Drug Treatment II. Brunner/Mazel, 1976, pp. 399-408.

• C. 34. Quitkin, F, Rifkin, A, Kane, J & Klein, DF: Amine biochemistry and treatment of depression. In Klein, DF & Gittelman-Klein, R (Eds.): Progress in Psychiatric Drug Treatment II. Brunner/Mazel, 1976, pp. 79-86.

• C. 35. Klein, DF & Shader, RI: The borderline state: Psychopharmacologic treatment approaches to the undiagnosed case. In Shader, RI (Ed.): Manual of Psychiatric Therapeutics: Practical Psychopharmacology in Psychiatry. Little Brown & Co., 1975, pp. 281-293. & Shagass, C (Eds.): Psychopathology and Brain Dysfunction. Raven Press, 1977, pp. 199-221.

• C. 36. Klein, DF: Psychotropic drugs and the pregnant patient. In Rovinsky, J (Ed.): Medical, Surgical, & Gynecological Complications of Pregnancy. Williams & Wilkins, 1977.

• C. 37. Klein, DF: Psychopharmacological treatment and delineation of borderline disorders. In Hartocollis, P (Ed.): Borderline Personality Disorders: The Concept, the Syndrome, the Patient. International Universities Press, Inc., 1977, pp. 365-383.

• C. 38. Struve, FA, Saraf, KR, Arko, RS, Klein, DF & Becka, R: Relationship between paroxysmal electroencephalographic dysrhythmia and suicide ideation and attempts in psychiatric patients. In Gershon, S & Shagass, C (Eds.): Psychopathology and Brain Dysfunction. Raven Press, 1977, pp. 199-221.

• C. 39. Klein, DF: A proposed definition of mental illness. In Spitzer, R & Klein, DF (Eds.): Critical Issues in Psychiatric Diagnosis. Raven Press, 1978, pp. 41-71.

• C. 40. Klein, DF & Gittelman-Klein, R: Drug treatment of separation anxious and depressive illness in children. In: Mendlewicz, J (Ed.): Advances in Biological Psychiatry. Karger, Basel, 2:50-60, 1978.

• C. 41. Klein DF, Zitrin, CM & Woerner, M: Antidepressants, anxiety, panic and phobia. In Lipton, MA, DiMascio, A & Killman, K (Eds.): Psychopharmacology: A Generation of Progress. Raven Press, 1978. pp. 1401-1410.

• C. 42. Klein, DF: The pharmacotherapy of anxious and phobic states. In Levine, J (Ed.): Contemporary Standards for the Pharmacotherapy of Mental Disorders. Vol. XII. Futura Publishing Co., Mt. Kisco, NY, 1978, pp. 185-204.

• C. 43. Klein, DF: General discussion. In Bellak, L (Ed.): Psychiatric Aspects of Minimal Brain Dysfunction in Adults. Grune & Stratton, Inc., 1979, pp. 151-157.

• C. 44. Klein, DF: Discussion. Clinical and biological aspects of depression in the elderly. In Cole, JO & Barrett, JE (Eds.): Psychopathology in the Aged. Raven Press, 1980, pp. 197-203. Proceedings of APPA Meeting, 1979.

• C. 45. Gittelman-Klein, R, Abikoff, H, Pollack, E, Klein, DF, Katz, S & Mattes, J: A controlled trial of behavior modification and methylphenidate in hyperactive children. In Whalen, C & Henker, B (Eds.): Hyperactive Children: The Social Ecology of Identification and Treatment. Acadamic Press, 1980, pp.221-243.

• C. 46. Gittelman, R & Klein, DF: Separation anxiety in school refusal and its treatment with drugs. In Hersov, L (Ed.): Out of School. John Wiley & Sons, 1980, pp. 321-341.

• C. 47. Klein, DF: Anxiety reconceptualized; Gleaning from pharmacological dissection-early experience with imipramine and anxiety. In Klein, DF & Rabkin JG (Eds.): Anxiety: New Research & Changing Concepts. Raven Press, 1981, pp. 235-262; also in Anxiety (volume 22 of Modern Problems of Pharmacopsychiatry), series editors Ban, TA, Pichot, P, Poldinger, W, volume editor, Klein, DF, Karger, Basel, 1987, pp. 1-35.

• C. 48. Zitrin, CM, Woerner, MG & Klein, DF: Differentiation of panic anxiety from anticipatory anxiety and avoidance behavior. In Klein, DF & Rabkin, JG (Eds.): Anxiety: New Research & Changing Concepts. Raven Press, 1981, pp. 27-46.

• C. 49. Gorman, JM, Fyer, AF, Gliklich, J, King, DL & Klein, DF: Mitral valve prolapse and panic disorders: Effects of imipramine. In Klein, DF & Rabkin, JG (Eds.): Anxiety: New Research & Changing Concepts. Raven Press, 1981, pp. 317-326.

• C. 50. Appleby, IL, Klein, DF, Sachar, EJ & Levitt, M: Biochemical indices of lactate-induced panic: A preliminary report. In Klein, DF & Rabkin, JG (Eds.): Anxiety: New Research and Changing Concepts. Raven Press, 1981, pp. 411-423.

• C. 51. Liebowitz, MR & Klein, DF: Differential diagnosis and treatment of panic attacks and phobic states. In Creger, WP, Coggins, CH & Hancock, EW (Eds.): Annual Review of Medicine: Selected Topics in the Clinical Sciences. Vol. 32, 1981, pp. 583-599.

• C. 52. Dillon, DJ, Levitt, M, Klein, DF & Danielson, E: Some physiological, biochemical and psychological concomitants of lactate induced panic: A preliminary report. In Neuropsychology & Cognition, Vol. II, Sijthoff & Noordhoff Int'l Publications, Alphen, Aan den Rijn, The Netherlands, 1981, pp. 651-660.

• C. 53. Strain, JJ, Liebowitz, MR & Klein, DF: Anxiety and panic attacks in the medically ill. In Strain, JJ, (Ed.): The Medical1y Ill Patient. Psychiatric Clinics of North America, Saunders, Philadelphia, PA, 1981, 4(2):333-351.

• C. 54. Liebowitz, MR & Klein, DF: Agoraphobia: Clinical features, pathophysiology & treatment. In Chambless, DL & Goldstein, A (Eds.): Agoraphobia: Contextual Analysis and Treatment. John Wiley & Sons, 1982, pp. 153-181.

• C. 55. Liebowitz, MR & Klein, DF: Uses of MAO inhibitors for borderline patients. In RO Friedel (Ed.): The Borderline Patient: Diagnosis and Treatment, 1981, pp. 22-28. Proceedings from the Annual Meeting of the APA, San Francisco, 1980.

• C. 56. Klein, DF & Liebowitz, MR: Psychotherapeutic attitudes in the drug treatment of anxiety and phobic reactions. In Greenhill, & Gralnick, A (Eds.): Psychopharmacology and Psychotherapy. The Free Press, 1982, pp. 145-163.

• C. 57. Liebowitz, MR, Quitkin, FM, Stewart, JW, McGrath, PJ, Harrison, W, Karoum, F, Wyatt, R, Levitt, M, Rabkin, J & Klein, DF: Efficacy of deprenyl in atypical depression: A preliminary report. Symposium on Deprenyl. Hungary, 1982.

• C. 58. Quitkin, FM, Schwartz, D, Liebowitz, MR,Stewart, JR, McGrath, PJ, Harrison, W, Halpern, F, Puig-Antich, K, Tricamo, E, Sachar, EJ & Klein, DF: Atypical depressives: A preliminary report of antidepressant response, sleep patterns, and cortisol secretion. In Clayton, PJ & Barrett, JE (Eds.): Treatment of Depression: Old Controversies and New Approaches; New York, Raven Press, 1982, pp. 253-263.

• C. 59. Klein, DF: Psychopharmacology: Special considerations. In Pepper, B & Ryglewicz, H (Eds.): New Directions for Mental Health Services: The Young Adult Chronic Patient. No. 14, Jossey-Bass, San Francisco, June 1982.

• C. 60. Rabkin, JG & Klein, DF: The biological therapies. In Lewis, J & Usdin, G (Eds.): Treatment Planning in Psychiatry. American Psychiatric Association, Washington, D.C., 1982, Chap. 3, p.87.

• C. 61. Potter, WZ, Agren, H, Carlsson, A, Cowdry, RW, Delini-Stula, A, Emrich, HM, Herz, A, Kehr, W, Klein, DF, Maj, J & Svensson, TH: Neurotransmission. In Angst, J (Ed.): The Origins of Depression: Current Concepts and Approaches. Dahlem Konferenzen, Berlin, Heidelberg, New York, Tokyo: Springer-Verlag, 1983, pp. 447-457.

• C. 62. Klein, DF: A personal view of psychopharmacology for non-psychotic adolescents. In Golombek, H & Garfinkel, BD (Eds.): The Adolescent and Mood Disturbance. International Universities Press, 1983, pp. 239-247.

• C. 63. McGrath, PJ & Klein, DF: Heuristically important mood altering drugs. In Angst, J (Ed.): The Origins of Depression: Current Concepts and Approaches. Dahlem Konferenzen. Berlin, Heidelberg, New York & Tokyo, Springer-Verlag, 1983, pp. 331-349.

• C. 64. Rabkin, JG, Klein, DF & Quitkin, FM: Somatic treatment of acute depression. In Rifkin, A (Ed.): Schizophrenia & Affective Disorders. Wright - PSJ Inc., Littleton, Mass.,

1983, pp. 35-78.• C. 65. Klein, DF: Critique. In Cooper, JR, Altman, F, Brown, BS & Czechowicz, D (Eds.):

Research on the Treatment of Narcotic Addiction: State of the Art. Nat'l Inst. of Drug Abuse, pp. 149-157, 1983.

• C. 66. Quitkin, FM & Klein, DF: Effectiveness of monoamine oxidase inhibitors: A review. In Habig, RL (Ed.): The Brain, Biochemistry and Behavior. Proceedings of the Sixth Arnold O. Beckman Conference in Clinical Chemistry; Washington, DC. The American Association for Clinical Chemistry, Tarpon Springs, Fla., pp. 125-169, 1983.

• C. 67. Quitkin, FM, Schwartz, D, Liebowitz, MR, Stewart, JR, McGrath, PJ, Harrison, W, Halpern, F, Puig-Antich, J, Tricamo, E, Sachar, EJ & Klein, DF: Atypical depressives: A preliminary report of antidepressant response, sleep patterns and cortisol secretion. In Clayton, PJ, and Barrett, JE, (Eds.): Treatment of Depression: Old Controversies and New Approaches. New York, Raven Press, pp. 253-263, 1983.

• C. 68. Rabkin, JG, Klein, DF & Quitkin, FM: Somatic treatment of acute depression. Rifkin, A (Ed.): Biology and Drug Treatment of Schizophrenia and Affective Disorders. Wright-PSG, New York, 1983, pp. 35-78.

• C. 69. Liebowitz, MR, Klein, DF, Quitkin, FM, Stewart, JW & McGrath, PJ: Clinical implications of diagnostic subtypes of depression. In Post, RM & Ballenger, JC (Eds.): Neurobiology of Mood Disorders. Williams & Wilkins, Vol. 1, pp. 107-120, 1983.

• C. 70. Klein DF & Rabkin, JG: Specificity and strategy in psychotherapy research and practice. In Williams, J & Spitzer, R (Eds.): Psychotherapy Research: Where are We and Where Should We Go? New York, The Guilford Press, 1984, pp. 306-331.

• C. 71. Levin, AP, Liebowitz, MR, Fyer, AJ, Gorman, JM & Klein, DF: Lactate induction of panic: Hypothesized mechanisms and recent findings. In Biology of Agoraphobia. APA Monograph, pp. 81-97, 1984.

• C. 72. Klein, DF: Introduction to the Anxiety Disorders Program. In Grinspoon, L (Ed): Psychiatry Update American Psychiatric Association Annual Review, Vol .3, American Psychiatric Press Inc, Washington, D.C., 1984 pp. 390-392.

• C. 73. Klein, DF: Unresolved questions. In Grinspoon, L (Ed.): Psychiatry Update American Psychiatric Annual Review, Vol 3. American Psychiatric Press Inc, Washington, D.C. 1984 pp. 519-525.

• C. 74. Liebowitz, MR, Karoum, F, Quitkin, FM, Stewart, J, McGrath, PJ, Harrison, W, Davies, SO & Klein, DF: Biochemical effects and antidepressant mechanisms of l-deprenyl. In Boulton, AA, Baker, GB, Dewhurst, WG & Sandler, M (Eds.): Neurobiology of Trace Amines. Humana Press, Clifton, New Jersey, 1984, pp. 581-587.

• C. 75. Klein, DF: Boundaries between DSM-III, anxiety and affective disorders. Xanax Cross National Collaborative Panic Studies Training Workshop. In Proceedings, DSM-III Meeting, Florence, Italy, Nevember, 1983, and I confini tra i disturbi I'ansia e i disturbi affettivi nel DSM-III (1). In Cassano, G.B. Il DSM-III in Italia, Diagnose e Classificazione dei Disturbi Affettivi, Masson Italia Editori, pp. 51-55, 1985.

• C. 76. Fyer, A & Klein, DF: Agoraphobia, social phobia, and simple phobia. Kavenar, JO (Ed.): In Psychiatry. Philadelphia, JB Lippincott, Vol. 1, chapter 33, pp. 1-14, 1985.

• C. 77. Klein, DF, Rabkin, J & Gorman, JM: Etiological and pathophysiological inferences from the pharmacological treatment of anxiety. In Maser, JD & Tuma AA (Eds.): Anxiety and the Anxiety Disorders, Hillsdale, NJ, Erlbaum Publishing, pp. 501-532, 1985.

• C. 78. Rabkin, JG, Stewart, J & Klein, DF: Overview on the relevance of the Dexamethasone Suppression Test to differential diagnosis. In Hirschfeld, RMA, Koslow, SH, Kupfer, DJ: Clinical Utility of the Dexamethasone Suppression Test. U.S. Department of Health & Human Services, Rockville, MD, 1985.

• C. 79. Liebowitz, MR, Fyer, AJ, Gorman, JM, Campeas, R, Levin, A, Davies, SO & Klein, DF: Alprazolam in the treatment of panic disorders. In Lader, MH & Davies, HC (Eds.):

Drug Treatment of Neurotic Disorders: Focus on Alprazolam. Churchill Livingston, 1985, pp. 173-177.

• C. 80. Gittelman, R & Klein, DF: Childhood separation anxiety and adult agoraphobia. In Tuma, AH & Maser, JD (Eds): Anxiety and the Anxiety Disorders. Lawrence Erlbaum Assoc., Inc., 1985, pp. 389-411.

• C. 81. Liebowitz, MR, Quitkin, FM, Stewart, JW, McGrath, PJ, Harrison, W, Rabkin, J, Tricamo, E, Markowitz, JS & Klein, DF: Treatment of atypical depression: Phenelzine, imipramine and placebo. In Hippius, H, Klerman G & Matussek, N (Eds): New Results in Depression Research. Springer-Verlag, Heidelberg, pp. 112-117, 1986.

• C. 82. Rabkin, JG & Klein, DF: The clinical measurement of depressive disorders. In Marsella, A, Hirschfeld, R & Katz, M (Eds.): The Measurement of Depression. Guilford Press, New York, 1987, pp 30-83.

• C. 83. Klein, DF: Depression and Anhedonia. In Clark, DC & Fawcett, J (Eds.): Anhedonia and Affect Deficit States. PMA Publishing Corp., New York, 1987.

• C. 84. Klein, DF: Sexual disorders and medication. In Kaplan-Singer, H: Sexual Aversion, Sexual Phobias, and Panic Disorder. Brunner/Mazel, Inc., New York, 1987.

• C. 85. Nunes, EV & Klein, DF: Research issues in cocaine abuse: Future directions. In Spitz, HI and Rosecan, JS (Eds.): Cocaine Abuse: New Directions in Treatment Research. Brunner/Mazel, New York, 1987.

• C. 86. Gorman, JM, Fyer, MR, Liebowitz, MR, Klein, DF: Pharmacologic provocation of panic attacks. In HY Meltzer (Ed): The Third Generation of Progress. Raven Press, New York1987, pp. 985-993.

• C. 87. Klein, RG & Klein, DF: Adult anxiety disorders and childhood separation anxiety. In Roth, M, Noyes, R, Jr. & Burrows, GD (Eds.): Handhook of Anxiety, Volume 1: Biological Clinical and Cultural Perspectives. Amsterdam, Elsevier Science Publishers, 1988, pp. 213-229.

• C. 88. Cooper, TB, Harrison, WM, Stewart, JW & Klein, DF: Decreased tyramine conjugation in melancholia: A trait marker. In Boulton, AA, Juorio, AV & Downer, RGH (Eds.): Trace Amines: Comparative and Clinical Neurobiology. Humana Press, Inc., New Jersey, 1988, pp. 379-386.

• C. 89. Hollander, E, Fay, M, Klein, DF & Liebowitz, MR: Catecholaminergic and monoaminergic effects in obsessive-compulsive disorder. In Belmaker, RH, Sandler, M, Dahlstrom, A (Eds.): Progress in Catecholamine Research, Part C: Clinical Aspects. Alan R. Liss, Inc., New York, 1988, pp. 377-383.

• C. 90. Klein, DF & Klein, HM: The definition and psychopharmacology of spontaneous panic and phobia: A critical review I. In Tyrer, PJ (Ed.): Psychopharmacology of Anxiety. Oxford University Press, New York, 1989, pp. 135-162.

• C. 91. Klein, DF & Klein, HM: The nosology, genetics and theory of spontaneous panic and phobia: A critical review II. In Tyrer, PJ (Ed.): Psychopharmacology of Anxiety. Oxford University Press, New York, 1989, pp. 163-195.

• C. 92. Hollander, E & Klein, DF: Medication. In Lindemann, C (Ed.): Handbook of Phobia Therapy: Rapid Symptom Relief in Anxiety Disorders. Jason Aronson, Inc., Northvale, New Jersey, 1989, pp. 405-425.

• C. 93. Klein, DF: The pharmacological validation of psychiatric diagnosis. In Robbins, LN & Barrett, J (Eds.): Validity of Psychiatric Diagnosis. Raven Press Ltd., New York, 1989, pp. 203-216.

• C. 94. Hollander, E & Klein, DF: Differential diagnosis of anxiety disorders. In Kielholz, P and Adams, C (Eds.): Panic Anxiety States. Deutscher Arzte-Verlag, Koln, 1989, pp. 17-26. Also in Kielholz, P and Adams, C (Eds.): The Kaleidoscope of Anxiety Disorders (English version) and Die Vielfalt von Angstzustanden (German version), Deutscher Arzte-Verlag, Koln, 1989, pp. 150-159.

• C. 95. Hollander, E, Hatterer, J & Klein, DF: Antidepressants for the treatment of panic and agoraphobia. In Noyes, R, Roth, M, Burrows, GD (Eds.): Handbook of Anxiety Disorders Vol. 4. The Treatment of Anxiety, Elsevier Science Publishers, B.V. Amsterdam, 1990, pp. 207-232.

• C. 96. Fyer, AJ, Liebowitz, MR & Klein, DF: Treatment trials, comorbidity, and syndromal complexity. In Maser, JD, & Cloniger, CR (Eds.): Comorbidity of Anxiety and Depression. American Psychiatric Press, 1990, pp.669-679.

• C. 97. Klein, DF & Klein, HM: Clinical validation of anxiety syndromes. In Sartorius, N (Ed.): Anxiety: Psychobiological and Clinical Perspectives. Hemisphere Publishing Corporation, Washington, D.C., 1990.

• C. 98. Gorman, JM, Papp, L & Klein, DF: Biological models of panic disorder. In Burrows, GD, Roth, M, Noyes, R Jr. (Eds.): Handbook of Anxiety, Vol. 3, The Neurobiology of Anxiety. Elsevier, Amsterdam, NY, Oxford, 1990.

• C. 99. Klein, DF, Coplan, JD & Gorman, JM: Bases for serotonin related drug use in spontaneous panic behaviour. In Cassano, GB and Akiskal, HS (Eds.): Serotonin-Related Psychiatric Syndromes: Clinical and Therapeutic Links, Royal Society of Medicine Services International Congress and Symposium Series No. 165, Royal Society of Medicine Services Limited, London, 1991, pp.93-97.

• C. 100. Fyer, AJ, Sandberg, D & Klein, DF: Pharmacological treatment of panic disorder and agoraphobia. In Walker, JR, Norton, R, Ross, C: Panic Disorder and Agoraphobia: A Guide for the Practitioner. Brooks/Cole Publishing Co., Pacific Grove, California, 1991, pp. 211-251.

• C. 101. Stewart, JW, Rabkin, JG, Quitkin, FM, McGrath, PJ & Klein, DF: Atypical depression. In Dunner, DL (Ed.): Current Psychiatric Therapy, WB Saunders, Philadelphia, PA, 1993, pp. 215-220.

• C. 102. Klein, DF: Foreword. In Hollander, E (Ed.) Obsessive Compulsive Related Disorders, American Psychiatric Press, Inc., Washington, DC, 1993, pp. xi-xvii.

• C. 103. Vieland, VJ, Knowles, JA, Fyer, AJ, Stefanovich, M, Freimer, NF, Lish, J, Adams, P, Woodley, K, Rassnick, H, Heiman, GA, White, P, Das, K, Klein, DF, Ott, J, Weissman, MM & Gilliam, TC: Linkage study of panic disorder: A preliminary report. In Gershon, ES & Cloninger, CR (Eds.) Genetic Approaches to Mental Disorders, American Psychiatric Press, Inc., Washington, DC, 1994, pp. 345-354.

• C. 104. Laska, EM, Klein, DF, Lavori, PW, Levine, J & Robinson, DS: Design issues for the clinical evaluation of psychotropic drugs. In Prien, RF & Robinson, DS (Eds.) Clinical Evaluation of Psychotropic Drugs: Principles and Guidelines, Raven Press, New York, 1994.

• C. 105. Klein, DF, Liebowitz, MR, Gorman, JM & Lewis, CP: Evaluation of psychotropic drug treatment of panic-related disorders and social phobia. In Prien, RF & Robinson, DS (Eds.) Clinical Evaluation of Psychotropic Drugs: Principles and Guidelines, Raven Press, New York, 1994.

• C. 106. Klein, DF: Panic may be a misfiring suffocation alarm. In Montgomery, SA (Ed.) Psychopharmacology of Panic, Oxford Medical Publications, New York, NY, 1993, pp. 67-73.

• C. 107. Stewart, JW, McGrath, PJ, Quitkin, FM & Klein, DF: The treatment of atypical depression. In The Proceedings of the International Committee for Prevention and Treatment of Depression (March 5-6, 1993).

• C. 108. Klein, DF: La physiologie et les troubles anxieux (Physiology and the anxiety disorders). In Chneiweiss, L & Albert E (Eds.) Stress Et Anxiete: Les Faux-Semblants, Upjohn, 1993, pp. 93-114.

• C. 109. Klein, DF: Closing comments. In Friedman, S (Ed.) Anxiety Disorders in African Americans, Springer Publishing Company, 1994, pp. 227-231.

• C. 110. Coplan, JD, Wolk, SI & Klein, DF: Anxiety and the serotonin1A receptor. In Bloom,

FE & Kupfer, DJ (Eds.) Psychopharmacology: The Fourth Generation of Progress, New York; Raven Press, Ltd, 1995, pp. 1301-1310.

• C. 111. Klein, DF, Schneier, FR & Liebowitz, MR: Novel therapeutic approaches to social phobia. Current Therapeutic Approaches to Panic and Other Anxiety Disorders, Basel, Switzerland;S. Karger AG, 1994, pp. 187-191.

• C. 112. Stein, DJ, Hollander, E & Klein, DF: Anxiodepression: Evolution des Idees (Anxio-Depression: Evolution of Ideas). In Olie, JP, Poirier, MF & Loo, H (Eds.) Les Maladies Depressives (The Depressive Disorders), Paris, France;Flammarion, 1995, pp. 159-164.

• C. 113. Glick, ID, Lecrubier, Y, Montgomery, SA, Vinar, O & Klein, DF: Promising psychopharmacological agents available in Europe. In Schatzberg, AF & Nemeroff, CB (Eds.) The American Psychiatric Press Textbook of Psychopharmacology, Washington, DC; American Psychiatric Press, 1995, pp. 839-846.

• C. 114. Coplan, JD & Klein, DF: Pharmacological probes in panic disorder. In Westenberg, H.G.M., DenBoer, H, & Murphey, D (Eds.) Advances in the Neurobiology of Anxiety Disorders, Chichester, England; John Wiley & Sons, Ltd., 1996, pp. 173-196.

• C. 115. Rabkin, JG, Stewart, JW, Quitkin, FM, McGrath, PJ, Harrison, WM & Klein, DF: Should atypical depression be included in DSM-IV? A review of the research evidence. Prepared for the DSM-IV Committee on Affective Disorders. In Widiger, T (Ed.): APA Sourcebook, (Volume 2) Washington, DC;American Psychiatric Press, Inc., chapter 10, pp. 239-260, 1996.

• C. 116. Klein, DF: The development of nosological concepts in anxiety disorders. In Ackenheil, M, Bondy, B, Engel, R, Ermann, M & Nedopil, N (Eds.) Implications of Psychopharmacology to Psychiatry; Biological, Nosological, and Therapeutical Concepts, Springer Verlag, Berlin Heidelberg, 1996, pp. 89-100.

• C. 117. Schneier, FS, Liebowitz, MR, Beidel, DC, Fyer, AJ, George, MS, Heimberg, RG, Holt, CS, Klein, DF, Leven, AP, Lydiard, RB, Mannuzza, S, Martin, LY, Nardi, AE, Terril, DR, Spitzer, RL, Turner, SM, Uhde, TW, Figueroa, IV and Versiani, M. Social Phobia. In Widiger, T (Ed.): APA Sourcebook, (Volume 2) Washington, DC;American Psychiatric Press, Inc., chapter 17, pp. 507-548, 1996.

• C. 118. Stewart, J & Klein, DF: Chronic (and Hysteroid) Dysphorias. In Akiskal, HS & Cassano, GB (Eds.), Dysthymia and the Spectrum of Chronic Depressions, New York;Guilford Press, 1997, pp. 174-182.

• C. 119. Klein, DF: Anxiety disorders. In Breslau, N, Roth, T. The Status of Research on Selected Mental Disorders: A Report to The Ethel and James Flinn Family Foundation. Henry Ford Health Sciences Center, Detroit, MI, February 1997, pp. 52-79.

• C. 120. Klein, DF & Hurowitz, G: Irene: A case of bipolar disorder. In Halgin, RG & Whitbourne, SK (Eds.) A Casebook in Abnormal Psychology; From the Files of Experts, New York;Oxford University Press,1998, pp. 144-165.

• C. 121. Preter, M, Klein, DF: Panic disorder and the suffocation false alarm theory: Current state of knowledge and further implications for neurobiologic theory testing. In Bellodi, L & Perna, G (Eds.). International Workshop on the Panic-Respiration Connection MDM Medical Media, Srl:Milan, Italy, 1998, pp.1-24.

• C. 122. Klein, DF: Introduction. In Sheffield, A. How You Can Survive When They're Depressed; Living and Coping with Depression Fallout New York:Harmony, 1998, pp. ix-xiii.

• C. 123. Klein, DF: Studying the respective contributions of pharmacotherapy and psychotherapy: Toward Collaborative Controlled Studies. In Weissman, S, Sabshin, M, Eist, H (Eds.) Psychiatry in the New Millenium, Washington, DC:American Psychiatric Press, 1999, pp. 217-235.

• C. 124. Klein, DF: A checklist for developing and reviewing comparative treatment evaluations in the areas of psychotherapy and pharmacotherapy. In Janowsky, DS (Ed.)

Psychotherapy Indications and Outcomes, Washington, DC:American Psychiatric Press, Inc., 1999, pp. 367-381.

• C. 125. Marshall, R, Klein, DF: Diagnostic classification of anxiety disorders: Historical context and implications for neurobiology. In Charney, DS, Nestler, EJ, Bunney, BS (Eds.) Neurobiology of Mental Illness, New York;Oxford University Press, 1999, pp. 437-450.

• C. 126. Klein, DF: The current utility and future development of algorithms. In Fawcett, J, Stein, DJ, Jobson, KO (Eds) Textbook of Treatment Algorithms in Psychopharmacology, Chichester, England;John Wiley & Sons, Ltd, 1999, pp. 33-36.

• C. 127. Klein, DF: New ideas for testing treatments-What's wrong and how to fix it. In Weissman, MM (Ed.) Treatment of Depression; Bridging the 21st Century, Washington, DC; American Psychiatric Press, 2001, pp. 197-211.

• C. 128. Klein, DF: Introduction. In Griez, EJL, Faravelli, C, Nutt, D, Zohar, J (Eds) The European Certificate Textbook of Anxiety Disorders. Chichester, England;John Wiley & Sons, Ltd, 2001, pp. xv-xxii.

• C. 129. Marshall, RD; Klein, DF: Conceptual Antecedents of the Anxiety Disorders. In press. Nutt, D. and Ballinger, J. (Eds) Anxiety Disorders.

• C. 130. Wender, P; Klein, DF: What we don't know: What's blocking progress? What to do?• Understanding Depression Second Edition (Last Chapter) Submitted 1/03•• PA 1. Gorman, JM, Liebowitz, MR & Klein, DF: Panic disorder and agoraphobia. Current• Concepts, 40 pages. The Upjohn Company, Kalamazoo, Michigan, 1984.• PA 2. Gorman, JM, Liebowitz, MR & Klein, DF: Disturbo da Attacchi di Panico e

Agorafobia. Manoscritto Pre-Publicazione (pre-publication manuscript, Italian edition)• PA 3. Gorman, JM, Liebowitz, MR & Klein, DF: Panik-Syndrom und Agoraphobie. (pre-

publication manuscript, German edition)• PA 4. Gorman, JM, Liebowitz, MR & Klein, DF: Trastornos de Angustia y Agorafobia. (pre-

publication manuscript, Spanish edition)• PA 5. Gorman, JM, Liebowitz, MR & Klein, DF: Trouble: Panique et Agoraphobie (pre-

publication manuscript, French edition)• PA 6. Klein, DF: Panic attacks and agoraphobia. Merrell Dow Pharmaceuticals, Inc.• PA 7. Friedel, RO, Klerman, GL, Spitzer, RL & Klein, DF: Charter Quarterly Review 3. A

summary of a symposium on anxiety, panic and phobia held on May 17, 1985.

SCHEDULES & MANUALS

• SM 1. Fyer, AJ, Endicott, J, Mannuzza, S & Klein, DF: Schedule for Affective Disorders and Schizophrenia Lifetime Version (Modified for the Study of Anxiety Disorders, SADS-LA). Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, New York. March, 1985.

• SM 2. Mannuzza, S, Fyer, AJ & Klein, DF: SADS-LA Rater Manual. Anxiety Disorders Clinic, York State Psychiatric Institute, New York, New York. May, 1985.

• SM 3. Mannuzza, S, Fyer, AJ, Endicott, J & Klein, DF: Family Informant Schedule and Criteria (FISC). Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, New York. May, 1985.

•• AB 1. Klein, DF & Markoff, RA: Our atomic war on disease. Electronics Illustrated 7:55-

59, 1961.• AB 2. Pollack, M, Woerner, M & Klein, DF: I.Q. differences between hospitalized

schizophrenic and personality disorder patients and their normal siblings. Proceedings of the 76th Annual American Psychological Association Convention. San Francisco, 1968.

• AB 3. Klein, DF, Honigfeld, G & Feldman, S: Prediction of drug effect in personality disorders. Psychopharm Bull 7:89, 1971.

• AB. 4. Klein, DF, Ross, DC, Honigfeld, G & Feldman, S: Detection and analysis of behavioral change patterns. 16th Annual Veterans Administration Research Conference on Chemotherapy in Psychiatry. Houston, Texas. March, 1971.

• AB 5. Klein, DF, Ross, DC, Honigfeld, G & Feldman, S: Detection of behavioral change patterns. Proceedings of the XXth International Congress of Psychology, Tokyo, Japan, 1972.

• AB 6. Gittelman-Klein, R & Klein, DF: Short and long-term effects of methylphenidate on cognitive performance in learning disability children. Proceedings of the XXth International Congress of Psychology, Tokyo, Japan, 1972.

• AB 7. Chen, M, Blumberg, AG, Klein, DF & Heaton, AM: Relationship between history of drug abuse and covert drug use in a psychiatric hospital. Proceedings of the 80th Annual Convention of the American Psychiatric Association, 1972, pg. 415-416.

• AB 8. Klein, DF, Ross, DC, Honigfeld, G & Feldman, S: Exploration and analysis of change patterns. Psychopharm Bull 8:18-19, 1972.

• AB 9. Klein, DF: Imipramine treatment of school phobia. Psychopharm Bull (Special Issue) Vol. 19, 1973.

• AB 10. Klein, DF & Gittelman-Klein, R: Comparative drug effects in hyperkinetic children. Psychopharm Bull 19:20-21, 1973.

• AB 11. Klein, DF & Cohen, M: A 6-month follow-up of drug abusing psychiatric inpatients. Proceedings of the American Psychiatric Association Meetings, Honolulu, 1973.

• AB 12. Struve, F, Saraf, K, Arko, RS, Klein, DF & Becka, DR: Further investigation of electroencephalographic correlates of suicide ideation and attempts: Preliminary results. Proceedings of the 4th Annual Conferences of the Indian Psychiatric Society. West Zone, Bombay, India, 1973.

• AB 13. Gittelman-Klein, R & Klein, DF: The relationship between behavioral and psychological test changes in hyperkinetic children. Psychopharm Bull 10(4):34, 1974.

• AB 14. Klein, DF: Pharmacological response as a basis for syndrome identification. Psychopharm Bull 10(4):48-49, 1974.

• AB 15. Klein, DF: Comparative drug effects in hyperkinetic children. Psychopharm Bull 10(2):62-63, 1974.

• AB 16. Zitrin, CM & Klein, DF: Imipramine behavior therapy and phobia. Psychopharm Bull 11(4):41-42, 1975.

• AB 17. Gittelman-Klein, R, Klein, DF, Abikoff, H, Katz, S, Gloisten, A, Kates, W & Saraf, K: Methylphenidate vs. behavior therapy in hyperkinetic children. Proceedings of the 128th Annual Meeting of American Psychiatric Association, Anaheim, California, 1975.

• AB 18. Klein, DF: A new classification of depressive disorders...excerpts from an informal interview with Donald F. Klein, M.D. Psychiatric Research Interview, Depression Notes No. 16, Merrell-National Laboratories 5-8608-A (7626), September, 1975.

• AB 19. Klein, DF, Zitrin, CM & Woerner, MG: Imipramine and phobia. Psychopharm Bull 12(2):24-27, 1977.

• AB 20. Rifkin, A, Quitkin, F, Kane, J & Klein, DF: Fluphenazine decanoate, oral fluphenazine and placebo in the treatment of remitted schizophrenics II. Rating scale data. Psychopharm Bull 13(2):49-50, 1977.

• AB 21. Klein, DF, Zitrin, CM & Woerner, MG: Imipramine and phobia. Psychiatry Digest, August 1977, pg. 47-48.

• AB 22. Quitkin, F, Rifkin, A & Klein, DF: A one-year double-blind comparison of long acting (Penfluridol) vs. long acting injectable (Fluphenazine decanoate) antipsychiatric drugs in multiple-episode schizophrenics. Psychopharm Bull 13(3):27-29, 1977.

• AB 23. Rifkin, A, Quitkin, F, Kane, J & Klein, DF: Is prophylactic procyclidine necessary? Psychopharm Bull 13(3):33-34, 1977.

• AB 24. Rifkin, A, Quitkin, FM, Kane, J & Klein, DF: Long-term antipsychotic medication

in schizophrenics in aftercare clinic. Psychopharm Bull, 1977.• AB 25. Klein, DF: Differential diagnosis of anxiety states. Abstracts VI World Congress of

Psychiatry, page 16 (No. 74), 1977.• AB 26. Klein, DF: Testimony: Proposals to expand coverage of mental health under

medicare-medicaid. Hearing before the subcommittee on Health Committee on Finance. 98th Congress (Second Session). U.S. Printing Office, 1978, pp. 44-52.

• AB 27. Klein, DF & Gittleman-Klein, R: Neuropsychopharmacology of hyperkinetic children. 11th C.I.N.P. Congress, July 9-14, 1978, Vienna, Austria, pp. 130-131.

• AB 28. Kane, J, Rifkin, A, Quitkin, F & Klein, DF: A pilot study of "low-dose" fluphenazine decanoate in outpatient schizophrenics. Psychopharm Bull 15(2):78-80, 1979.

• AB 29. Quitkin, F, Rifkin, A, Kane, J & Klein, DF: The prophylactic effect of lithium and imipramine in bipolar II and unipolar patients: A preliminary report. Psychopharm Bull 15(2):35-39, 1979.

• AB 30. Klein, DF: Behavior therapy, supportive therapy and imipramine in different classes of phobics. Psychopharm Bull 16(2):62-64, 1980.

• AB 31. Liebowitz, MR & Klein, DF: Antidepressant pharmacotherapyfor agoraphobia phobias and panic states. Int'l Drug Therapy Newsletter 15(8):31-32, 1980.

• AB 32. Quitkin, FM & Klein, DF: The utility of antidepressants in outpatient depressive disorder. Abstracts of the 12th CINP Congress, Goteburg, #547, pp. 290-291, June, 1980.

• AB 33. Klein, DF & Liebowitz, MR: Uses of MAO inhibitors for borderline patients. Printed in The Borderline Patient: Diagnosis and Management, Robert O. Friedel, M.D., Program Chairman & Editor. Proceedings of the annual meeting of the American Psychiatric Association, San Francisco, California, May 5, 1980, pp. 24-31.

• AB 34. Liebowitz, MR, Fyer, AJ, McGrath, P & Klein, DF: Clonidine treatment of panic disorder. Psychopharm Bull 17(3)122, 1981.

• AB 35. Klein, DF: Boston State Hospital: An update and comment. The Bulletin 23(8)1-3, June, 1981.

• AB 36. Klein, DF: Psychotherapeutic Drug Manual (2nd Edition). Committee Member New York State Office of Mental Health Committee on Therapeutics. Albany, N.Y., 1981.

• AB 37. Klein, DF: Working at an unaccredited facility. Questions & Answers. Hospital & Community Psychiatry 33:(3)185, 1982.

• AB 38. McGrath, PJ, Quitkin, FM, Blood, D, Liebowitz, MR, Stewart,JW, Fyer, A & Klein, DF: The effect of mianserin on cardiac conduction: A controlled study. Psychopharm Bull, 18(1):71-72, 1982.

• AB 39. Quitkin, FM & Klein, DF: Atypical depressive disorder; A depressive subtype which selectively responds to MAOI. Presentation for C.I.N.P. Congress, 1984.

• AB 40. Klein, DF: Psychopharmacology and the classification of anxiety disorders - use of antidepressants. Presented at the 14th C.I.N.P. Congress. Clinical Neuropharmacology 7 Suppl., 1984.

• AB 41. Liebowitz, MR, Fyer, AJ, Gorman, JM & Klein, DF: Biological findings during lactate induced panic attacks. Presented at the 14th CINP Congress, Florence, Italy, 1984.

• AB 42. Liebowitz, MR, Quitkin, FM & Klein, DF: Diagnosis and treatment of atypical depression. Currents 3(6):5-7, 1984.

• AB 43. Levitt, M, Danielson, E, Dillon, D, Liebowitz, M, Cohen, B & Klein, DF: Plasma catecholamine effects in lactate-provoked panic attacks. Presented at ASPET-ACS DMC. Boston, Massachusetts, 1985.

• AB 44. Davis, JM & Klein, DF: Citation classic: Diagnosis and drug treatment of psychiatric disorders. Current Contents, page 22, May, 1985.

• AB 45. Klein, DF: Conceptual overview and diagnosis of panic disorders. Panic Disorders: Current Perspectives. The Tufts University School of Medicine New England Medical Center Symposium, pages 3-4.

• AB 46. Klein, DF: A personal view: Hypothesis on pleasure and mental illness. New York State Psychiatric Institute Newsletter 6(4):4-6, 1986.

• AB 47. Klein, DF: ACNP past president statement on the evolution and emerging trends in neuropsychopharmacology, for 1986 Annual Meeting. Printed in the ACNP Anniversary Anthology, 1961-1986 25 Years of Progress, pages 42-43.

• AB 48. Klein, DF: The master psychiatrist. Masters in Psychiatry, The Upjohn Company, pages 2-8, 1986.

• AB 49. Wender, PH & Klein, DF: Psychiatry returns to biology: Evidence mounts for physiological basis of mental disorders. Congressional Record - Senate, Si0637-Si0638, 1986.

• AB 50. Klein, DF: Anti-anxiety agents. Presented at the Japanese Society of Psychopharmacology meeting in Yokohama Japan, 1987.

• AB 51. Klein, DF: Masters in neuroscience. An interview. On Target, Newsletter of Freedom From Fear, Inc., 1(1):2, 2988.

• AB 52. Klein, DF: Recent research and advances in the treatment of anxiety disorders. Psychiatric News XXIV(15):3, August 4, 1989.

• AB 53. Klein, DF: Diagnosis & treatment of panic disorders. Presented at the Japan Upjohn Ltd. Symposium on Anxiety and Anxiety Disorders, Tokyo Japan, July 8, 1989.

• AB 54. Hollander, E, Nunes, E, DeCaria, C, Quitkin, F, Cooper, T & Klein, DF: Dopamine sensitivity and cocaine abuse: Endocrine and behavioral response to apomorphine. Presented at the annual meeting of the Society of Biological Psychiatry, 1990.

• AB 55. Hollander, E, DeCaria, C, Aronowitz, B, Klein, DF & Shaffer, D: Follow-up of soft-signs and anxiety disorders into adulthood. Presented at the annual meeting of the Society of Biological Psychiatry, 1990.

• AB 56. Klein, DF: The pathophysiology of panic anxiety. J Psych Res 24(S1):49, 1990.• AB 57. Klein, DF: The pathophysiology of panic anxiety. J Clin Psychiatry 52(2, suppl.):10-

11, 1991.• AB 58. Klein, DF: Improving psychopharmacological response. NARSAD Research

Newsletter, May, 1991, pp. 12-13.• AB 59. Klein, DF: From psychoanalysis to metapsychopharmacology.Abstracts of the

Proceedings of the Royal College of Psychiatrists, Annual Meeting, 1991. Supplement 4 to the Psychiatric Bulletin.

• AB 60. Klein, DF: The formation of the American Society of Clinical Psychopharmacology. Progress Notes (Newsletter of the ASCP) 3(2):1-2, 1992.

• AB 61. Klein, DF: Commentary: What we should do to counteract the greying of the science profession. The Scientist 6(22):10-13, 1992.

• AB 62. Quitkin, FM, Stewart, JW, McGrath, PJ, Ocepek-Welikson, K & Klein, DF: Do self-rating scales demonstrate the efficacy of antidepressant treatment? A comment on Greenberg et al. Progress Notes (Newsletter of the ASCP) 4(1):3, 1993.

• AB 63. Klein, DF: Depression; How to spot it; How to beat it. Health Confidential 7(10):7-8, 1993.

• AB 64. Klein, DF: Physiological, hormonal and environmental determinants of anxiety. Neuropsychopharmacology 9(2S):1S, 1993.

• AB 65. Schwartz, GE, Goetz, RR, Gorman, JM, Endicott, J & Klein, DF: Breathing irregularities in panic disorder patients. Presented at the ACNP Annual Meeting, December 14, 1993, Honolulu, Hawaii.

• AB 66. Klein, DF (Interview): The suffocation false alarm hypothesis: Panic disorder as the smothering response gone awry. Currents XIII(1):5-13, 1994.

• AB 67. Klein, DF: Commonly asked questions about anxiety disorder. On Target, Newsletter of Freedom From Fear, Inc., Staten Island, NY. 5(3):5-6, 1994.

• AB 68. Coplan, J, Pine, D, Goetz, R, Rosenblum, L, Papp, L, Klein, DF & Gorman, JM: Monoamine and HPA function in panic: Clinical and preclinical approaches. Neuropsychopharmacology 10(3S/Part 1):919S, 1994.

• AB 69. Papp, L, Coplan, J, Klein, DF & Gorman, JM: Respiratory neurobiology of panic disorder. Neuropsychopharmacology 10(3S/Part 1):922S, 1994.

• AB 70. Klein, DF: Response to Rothman & Michels on placebo-controlled clinical trials. Progress Notes (Newsletter of the ASCP) 6(1):3-4, 1995.

• AB 71. Klein, DF: Testing the suffocation false alarm theory of panic disorder. Psychiatric Times XII(4):14, 1995.

• AB 72. Klein, DF: Response to Freedman, Price and Masters. ASCAP (Newsletter of the Society for Sociophysiological Integration) 8(5):7-9, 1995.

• AB 73. Klein, DF: (Interview) Point/Counterpoint. Are panic attacks caused by a false suffocation alarm? Physicians Weekly XII(32), August 28, 1995.

• AB 74. Klein, DF: Chairman's commentary. European Psychiatry 10 (suppl. 2):69s, 73s-74s & 76s, 1995.

• AB 75. Klein, DF: Off-label use of tricyclic antidepressants for panic disorder. Progress Notes (Newsletter of the ASCP) 7(2):6-7, 1996.

• AB 76. Klein, DF: Current obstacles to drug development. Psychiatric Times XIV(6):58-60, 1997.

• AB 77. Papp, LA, Klein, DF: Medication management of anxiety disorders. Psychiatry: The State of the Art 1997, Hillside Hospital's 70th Anniversary Academic Symposium, pages 1-12 (9:15 to 10:05 a.m.) November 16, 1997.

• AB 78. Klein, DF: 28 million Americans now take antidepressants; Should you be one of them? Bottom Line Health 11(12):1-2, 1997.

• AB 79. Klein, DF, Thase, M: Medication vs psychotherapy for depression. Progress Notes 8(2):41-47, 1997.

• AB 80. Klein, DF: Current obstacles to drug development. Progress Notes 9(1):6, 1998.• AB 81. Bouwer, C, Stein, DJ, Papp, LA, Martinez, JM, Klein, DF: Breath of panic. Harvard

Mental Health Letter 14(10):6-7, 1998.• AB 82. Klein, DF: Panic and depression. European Neuropsychopharmacology 8 (suppl

2):S57, 1998.• AB 83. Klein, DF: Point/Counterpoint: Is the efficacy of antidepressants primarily a placebo

effect? Physicians Weekly XVI(15):1, 1999.• AB 84. Klein, DF: Review of recent developments in anxiety disorders and survey of topical

issues in psychiatry. An interview with Donald F. Klein, M.D. Currents in Affective Illness XVIII (7):5-10, 1999.

• AB 85. Klein, DF: Waller's view of depression. The ASCAP Newsletter 13(1):13-14, 2000.• AB 86. Klein, DF: Comments on Kripke's views on "Do no harm". Biol Rhythms Bull

1(4):6, 1999.• AB 87. Klein, DF: Chance, the prepared mind and the appropriate setting. Milestones at the

Millenium: Panic Disorder. In conjunction with the Anxiety Disorders Association of America's 20th National Conference, Washington, DC, March 24, 2000.

• AB 88. Klein, DF: Diagnosis and treatment of depression. Best Doctors• http://bestdoctors.com/en/conditions/d/depression/depression_051900.htm• AB 89. Klein, DF: A Breif Review of the Development of Clinical

Neruopsychopharmacology.• Amercian College of Neuropsychopharmacology. Nobel Laureate Celebration of ACNP

members. July 18, 2001, Washington, DC. Pg 4-8.• AB 90. Klein, DF: Institute for Alternative Futures Forsight Seminars on Health and

Innovation.

• Foresight Seminar on the Future of Brain Research Policy. March 15, 1983.• AB 91. Klein, DF and Sinha, Smit: HPA Inhibition in the Acute Panic of Panic Disorder• Columbia University, NY.• AB 92. Klein, DF, Stewart, J, Quitkin, F, McGrath, P: Cortisol in A typical Depression.• Columbia University, NY.• AB 93. Klein, DF: Study of Squential Treatment of Depression. CINP Symposium;

Hiroshima,• Japan. October 3, 2001.• AB 94. Klein, DF: Suffocation false alarm theory: Update. International Society for the

Advancement of Respiratory Psychophysiology; Washington DC. October 2, 2002.• BR 1. Klein, DF: Review of Psychopharmacology. Dimensions and Perspectives. Ed. by• CRB Joyce (Tavistock Publication, London, 1968).• BR 2. Klein, DF: Review of Clinical Handbook of Psychopharmacology. Ed. by DiMascio,

A. and Shader (R.I. Science House, New York, 1970).• BR 3. Klein, DF: Review of Experimental Approaches to Psychiatric Diagnosis Ed. by Ban,

TA and Lehmann, HE. (C.C. Thomas, Springfield, 1971).• BR 4. Klein, DF: Review of Agoraphobia: Nature and Treatment. Ed. by Mathews, AM,

Gleder, MC, and Johnson, DW (Guilford Press, New York, 1981). Am J PSYCHIATRY 139(4):534-5, 1982.

• BR 5. Klein, DF: Review of Models for Clinical Psychopathology. Ed. by Carl Eisdorfer, et al. (SP Medical & Scientific Books, 1981). CONT PSYCHOL 27(2):121-122, 1982.

• BR 6. Klein, DF: Review of The Biology of Anxiety. Ed. by Matthew, RJ (Brunner/Mazel, New York, 1982). PSYCHOSOM MED 45(2):181-182, 1983.

• BR 7. Klein, DF: Review of The Agoraphobic Syndrome: Behavioral Approaches to Evaluation and Treatment. Ed. by Thorpe, GL and Burns, LE (John Wiley & Sons). Am J PSYCHIATRY 141(8):1006-1007, 1984.

• BR 8. Klein, DF: Review of Surviving Schizophrenia: A Family Manual. Ed. by Torrey, EF (Harper and Row, New York, 1983). HOSP AND COMM PSYCHIATRY 35(5):500, 1984.

• BR 9. Klein, DF: Review of Antianxiety Agents: Drugs in Psychiatry, Vol. 2. Ed. by Burrows, GD, Norman, TR & Davies, B (Elsevier, Amsterdam, 1984). Am J PSYCHIATRY 143(11):1480-1481, 1986.

• BR 10. Klein, DF: Review of Panic and Phobias, written by Wittchen, H & Hand, I (Springer-Verlag, Germany, 1986). COMP PSYCHOL 32(5):474-475, 1987.

• BR 11. Klein, DF: Review of Psychiatry, volume 7, Ed. by Frances, AJ & Hules, RE (American Psychiatric Press, Washington DC, 1988). AM J PSYCHIATRY 146(2):263-264, 1989.

• BR 12. Klein, DF: Review of Panic: Psychological Perspectives, Ed. by Rachman, S & Maser, JD (Lawrence Erlbaum Associates, Hillsdale, NJ, 1988). CANADIAN PSYCHOLOGY/PSYCHOLOGIE CANADIENNE 31(2):182-183, 1990.

• BR 13. Klein, DF: Review of Panic and Phobias 2: Treatments and Variables Affecting Course and Outcome, edited by Hand, I & Wittchen, H-U (Springer-Verlag, New York, 1988). AM J PSYCHIATRY 147(8):1085-1086, 1990.

• BR 14. Klein, DF: Review of Lexicon of Psychiatry, Neurology, and the Neurosciences by Ayd, Jr., FJ, (Williams & Wilkins, Baltimore, MD, 1995). J NERV MENT DIS 183(11):722, 1995.

• BR 15. Klein, DF: Review of Exiles From Eden by Kalman Glantz and John K. Pearce (W. W. Norton & Company, New York, NY, 1989). HUMAN ETHOLOGY BULLETIN 11(3):18-20, 1996.

• BR 16. Klein, DF: Review of The Treatment of Anxiety Disorders: Clinicians Guide to Patient Manuals by Gavin Andrews, Rocco Crino, Caroline Hunt, Lisa Lampe, Andrew Page

(Eds.) AM J PSYCHIATRY 155(1):143-4, 1998.• BR 17. Klein, DF, Quitkin, F: Review of From Placebo to Panacea: Putting Psychiatric

Drugs to the Test by Seymour Fisher and Roger P. Greenberg (Eds.) (Wiley; New York, 1997) CONT PSYCHOL 43(9):628-630, 1998.

• BR 18. Klein, DF: Review of Studying the Clinician by Howard N. Garb, (American Psychological Association;Washington, DC, 1998). AM J PSYCHIATRY 156(7):1108, 1999.

• BR 19. Klein, DF: Review of Practical Management of the Side Effect of Psychotropic Drugs by Richard Balon (Ed.), (Marcel Dekker, Inc.; New York, 1999) AMER J PSYCHIATRY 157(1):144, 2000.

• BR 20. Klein, DF: Review of Lexicon of Psychiatry, Neurology and the Neurosciences, 2nd E. (Phildaelphia: Lippincott Williams & Wilkins, 2000) J NERV MENT DIS 189(5): 339-340, 2001.

• BR 21. Klein, DF: Review of Pharmacotherapy for Mood, Anxiety, and Cognitive Disorders, edited by Uriel Halbreich, M.D. and Stuart A. Montgomery, M.D., 159(1): AM J PSYCHIATRY 165-166, 2002.

• BR 22. Klein, DF: Review of Comprehensive Handbook of Psychopathology,edited by Henry E. Adamns and Patricia B. Sutker, Accepted AM J PSYCHIATRY, March, 2002.

• BR 23. Klein, DF: Review of Creation of Psychopharmacology, by David Healy (Harvard University Press, Cambridge Massachusetts 2002) Human Nature 2:534-539 http://human-nature.com/nibbs/02/healy.html, 2002.

• L 1. Klein, DF: CNS effects of mitral commissurotomy. JAMA 188(12):1017, 1964.• L 2. Klein, DF: Application of computer techniques to medical data. JAMA 194(4):240-241,

1965.• L 3. Pollack, M & Klein, DF: Schizophrenic children and maternal speech facility. Am J

Psychiatry 123(2):232, 1966.• L 4. Klein, DF & Davis, JM: The drug treatment of depression. JAMA 212(1l):1962-1963,

1970.• L 5. Blumberg, AG, Klein, DF, Cohen, M & Heaton, AM: Covert drug abuse. N Engl J Med

286(l0):547, 1972.• L 6. Rifkin, A, Quitkin, FM & Klein, DF: Long-acting amitriptyline. Br J Psychiatry

121:457, 1972.• L 7. Rifkin, A, Quitkin, F & Klein, DF: Plasma-nortriptyline levels in depression. The

Lancet, 1(7814):1258-1259, 1973.• L 8. Rifkin, A, Klein, DF & Quitkin, F: Sane: Insane. JAMA 224(12):1646, 1973.• L 9. Klein, DF, Rifkin, A & Quitkin, F: Sane: Insane. JAMA 226(13):1569, 1973.• L10. Klein, DF: Pathophysiology of depressive syndromes. Biol Psychiatry 8:1, 1974.• L11. Klein, DF: Pharmacotherapeutic investigation: time for change. Am J Psychiatry

132(9):974, 1975.• L12. Rifkin, A, Quitkin, F, Tieman, D & Klein, DF: Fluphenazine decanoate. The Lancet,

February 1976, pg. 364.• L13. Quitkin, F, Rifkin, A, Klein, DF & Davis, JM: On prophylaxis in unipolar affective

disorder. Am J Psychiatry 133(9):1091-1092, 1976.• L14. Rifkin, A, Quitkin, F & Klein, DF: Withdrawal reaction of diazepam. JAMA

236(19):2172-2173, 1976.• L15. Rifkin, A, Klein, DF & Quitkin, F: Withdrawal from diazepam. JAMA 238(4):306,

1977.• L16. Klein, DF: New psychopharmacological programs at New York State Psychiatric

Institute. NCDEU Intercom 7(1):2-4, 1977.• L17. Klein, DF: Controlled trials for ill-defined syndromes. Drug Therapy 12(120):32, 1980.• L18. Klein, DF: Children's unestablished rights. Hastings Center Report, February, 1981, p.

24.• L19. Klein, DF: Boycott: Solution to problems of institutional practice? Am J Psychiatry

138(2):259, 1981.• L20. Klein, DF & Liebowitz, MR: Comment on hysteroid dysphoria. Am J Psychiatry

139(11):1520, 1982.• L21. Klein, DF: Mitral valve prolapse and imipramine. Am J Psychiatry 139(2):259-260,

1982.• L22. Klein, DF: Malady causes confusion. Hastings Center Report 12(4):46, 1982.• L23. Klein, DF, Gittelman, R, Quitkin, F & Rifkin, A: Theories must be tested. Am

Psychologist 37(7):863-864, 1982.• L24. Klein, DF: Question the experts. J Clin Psychopharm 2(6):12S-14S, 1982.• L25. Klein, DF: Controlled trials for poorly defined syndromes. Drug Therapy 8(1):13,

1983.• L26. Klein, DF: Experience and efficacy. Dr. Klein replies. Psychosomatics 24(6):588-589,

1983.• L27. Klein, DF: Imipramine and agoraphobia. Br J Psychiatry 143:309, 1983.• L28. Kass, F, Charles, E, Klein, DF & Cohen, P: Misuse of the symptom checklist 90. A

reply. Arch Gen Psychiatry 40(10):1152-1153, 1983.• L29. Klein, DF: A study of the reliability of reported premorbid adjustment in schizophrenic

patients. Biol Psychiatry 19(2):203-222, 1984.• L30. Quitkin, F, Klein, DF & Rifkin, A: Schizophrenia with good and poor outcome. Reply.

Br J Psychiatry 147:445-446, 1985.• L31. Klein, DF: An update on panic disorders. An interview with Donald F. Klein, M.D.

Currents IV(10):5-10, 1985.• L32. Klein, DF: A cybernetic theory of how psychotropic drugs work. Comment on

"Overview: Toward a dysregulation hypothesis of depression", (September, 1985 issue). Am J Psychiatry 143(5):685, 1986.

• L33. Klein, DF & Ross, DC: Response of panic patients and normal controls to lactate infusions. Psychiatry Res 19 (2):163-164, 1986.

• L34. Klein, DF: Psychodynamics vs. biology. Clinical Psychiatry News 14(12):4, 1986.• L35. Klein, DF: Drug therapy for agoraphobia; A reply. Arch Gen Psychiatry 45:387-388,

1988.• L36. Klein, DF: The cause and treatment of agoraphobia; A reply. Arch Gen Psychiatry

45:388-392, 1988.• L37. Klein, DF: Nottingham study of neurotic disorder. The Lancet 2(8618):1015, 1988.• L38. Klein, DF: Treatments for neurotic disorders. The Lancet 2(8625):1418, 1988.• L39. Klein, DF: The Osheroff case: A rebuttal. Psychiatric News XXIV(7):26, April 7, 1989.• L40. Klein, DF: Prodromal symptoms in agoraphobia and panic disorder. Am J Psychiatry

146(6):812-813, 1989.• L41. Klein, DF: Psychiatry panic & poetry. New York County District Branch Newsletter,

Amer. Psych. Assoc., XII(3):2, Summer, 1989.• L42. Klein, DF: Repeated observations of yawning, clitoral engorgement, and orgasms

associated with fluoxetine administration. J Clin Psychopharm 9(5):384, 1989.• L43. Klein, DF: Views on how to get science into elementary schools and how to activate

minority students. Submitted Science, 1989.• L44. Hollander, E, Liebowitz, MR, DeCaria, C & Klein, DF: Fenfluramine, cortisol and

anxiety. Psychiatry Res 31:211-213, 1990.• L45. Klein, DF: Further discussion of article on prodromal symptoms in panic disorder. Am

J Psychiatry 147(11):1581, 1990.• L46. Klein, DF: NIMH collaborative research on treatment of depression. Arch Gen

Psychiatry 47(7):682-684, 1990.• L47. Klein, DF & Klein, RG: Does panic disorder exist in childhood? J Am Academy of

Child & Adolescent Psych 29(5):834, 1990.• L48. Hollander, E, DeCaria, C, Liebowitz, MR & Klein, DF: Body dysmorphic disorder; a

response. Am J Psychiatry 147(6):817, 1990.• L49. Klein, DF: Comments on bulimia. Am J Psychiatry 147(9):1253-1254, 1990.• L50. McGrath, PJ, Stewart, JW, Quitkin, FM, Ocepek-Welikson, K & Klein, DF: Does

imipramine worsen atypical depression? J Clin Psychopharm 11(4):270-272, 1991.• L51. Hollander, E, DeCaria, CM, Saoud, JB, Klein, DF & Liebowitz, MR: Neurologic soft

signs in obsessive-compulsive disorder. A reply. Arch Gen Psychiatry 48(3):278-279, 1991.• L52. Klein, DF: Independent misconduct inquiries could be the answer. J NIH Research

3(8):14, 1991.• L53. Klein, DF: Scientific misconduct investigations: Who should conduct them? Science

254:918, 1991.• L54. Klein, DF: Re: Deltito & Rifkin. Comp Psychiatry 33(3):220, 1992.• L55. Klein, DF: Correlational versus experimental studies. Biol Psychiatry 31:1183, 1992.• L56. Klein, DF: Psychotherapy. The Psychiatric Times IX(2):6-7, 1992.• L57. Klein, RG & Klein, DF: Women and scientific thought. Br J Psychiatry 161:280, 1992.• L58. Klein, DF: Reader response corner. Response to article in last issue abstracting

suffocation alarm theory. Anxiety Newsletter 10(2):5, 1992.• L59. Fallon, BA, Liebowitz, MR, Klein, DF. Taking chronic fatigue syndrome seriously. Am

J Psychiatry 149(12): 1756, 1992.• L60. Klein, DF: Conflict of interest. Science 262(5141):1802, 1993.• L61. Klein, DF: On managed care. NYSPA The Bulletin, American Psychiatric Association-

Area II, 35(6):5, 1993.• L62. Klein, DF; Panic disorder with agoraphobia. Br J Psychiatry, 163:835-836, 1993.• L63. Klein, DF: Klein's suffocation theory of panic; In reply. Arch Gen Psychiatry

51(6):506, 1994.• L64. Klein, DF. Boundary violations. Psychiatric News XXIX(6):23, 1994.• L65. Klein, DF: Cognitive therapy: Reply. Br J Psychiatry 165(6):838, 1994.• L66. Klein, DF: Prescribing privileges. Psychiatric Times February, 1994.• L67. Klein, DF & Wender, PH: Understanding Depression. Am J Psychiatry 152(4):652,

1995.• L68. Klein, DF: Response to Cholst and Kelwala. Psychiatric Times XII(7):6-7, 1995.• L69. Papp, LA, Weiss, JR, Greenberg, HE, Rifkin, A, Scharf, SM, Gorman, JM & Klein,

DF: Sertraline for chronic obstructive pulmonary disease and comorbid anxiety and mood disorders. Am J Psychiatry 152(10):1531, 1995.

• L70. Gorman, JM & Klein, DF: Questions and Answers: Respiration disorders in panic attacks. JAMA 274(19):1504, 1995.

• L71. McGrath , PJ, Quitkin, FM & Klein, DF: Bromocriptine treatment of relapses seen during selective serotonin re-uptake inhibitor treatment of depression. J Clin Psychopharm 15(4):289-291, 1995.

• L72. Klein, DF: The Office of Research Integrity Biannual Report 1991-1992. Biol Psychiatry 37(7):491, 1995.

• L73. Klein, DF: Panic attacks: Klein's false suffocation alarm, Taylor and Rachman's data, and Ley's dyspneic-fear theory. Arch Gen Psychiatry 53(1):83-85, 1996.

• L74. Klein, DF: Psychotropic drug action. Am J Psychiatry 154(3):440, 1997.• L75. Quitkin, FM, Stewart, JW, McGrath, PJ, Nunes, EV, Klein, DF: The identification and

validation of distinct depressive syndromes in a population-based sample of female twins. Arch Gen Psychiatry 54(10):970-972, 1997.

• L76. Klein, DF: Placebo comparisons. Clin Psychiatry News 25(7):10, 1997.• L77. Klein, DF: In reply to Ley. Arch Gen Psychiatry 54(7):678, 1997.• L78. Quitkin, FM, McGrath, PF, Stewart, JW, Taylor, BP, Klein, DF: Can the effects of

antidepressants be observed in the first two weeks of treatment? Response. Neuropsychopharmacology 17(2):113-115, 1997.

• L79. Klein, DF: Supraventricular distinctions, tachycardia, and panic disorder. Arch Internal Med 157(13):1505, 1997.

• L80. Klein, DF, Ross, DC: Clomipramine treatment and behaviour therapy with agoraphobic women. Can J Psychiatry 42(8):881, 1997.

• L81. Klein, DF: In reply to Kellner and Wiedemann. Arch Gen Psychiatry 54(1):86, 1998.• L82. Klein, DF: Wilson critique. The ASCAP Newsletter 11(1):4-5, 1998.• L83. Quitkin, FM, Klein, DF: Antidepressant quandaries. Br J Psychiatry 173:181, 1998.• L84. Klein, DF: Response to Lewis. Am J Psychiatry 156(6):976-7,1999.• L85. Quitkin, FM, Klein, DF: "From Placebo to Panacea" by Fisher & Greenberg. Submitted

N Engl J Med.• L86. Klein, DF: Panic disorder. Lancet 353 (9149): 326-7, 1999.• L87. Klein, DF: Comments on Kripke's views on "Do No Harm". In press, Society for Light

Therapy Research Bulletin, 1999.• L88. Hamilton, SP, Slager, SL, Heiman, GA, Haghighi, F, Klein, DF, Hodge, SF, Weissman,

MM, Fyer, AJ, Knowles, JA: No genetic linkage or association between a functional promoter polymorphism in the monoamine oxidase-A gene and panic disorder. Molecular Psychiatry 5:465-6, 2000.

• L89. Quitkin, FM, Stewart, J, McGrath, P, Klein, DF: On "Classifying Depression" by Parker G. Am J Psychiatry 158(8):1332-3, 2001

• L90. Klein, DF: Asthma and Psychiatric Illness, JAMA 285 (7) 881-2, 2001.• L91. Klein, DF; Reply to Davies: D-Lactate and the false suffocation alarm. Arch Gen.

Psychiatry 59: 287-8, 2002.• L92. Klein, DF: In reply: Flawed meta-analyses comparing psychotherapy with

pharmacotherapy. Am J Psychiatry, in press.• L93. Johnson, JG; Cohen, P; Klein, DF; Kasem, S; Pine, DS; Brook, JS: In reply: Cigarette

Smoking and Anxiety Disorders. JAMA 285(6): 732-3, 2001.• L94. Klein, DF: Reply to Gorman. Archives of General Psychiatry 59:567-9, 2002.• L95. Klein, DF: Dr. Klein replies. (Responds to Dr. Gould) Am J of Psychiatry 158(8):1165-• 6, 2001.• L96. Klein, DF: Letter to the Editor: Improving scientific publication and public trust.• Neuropsychopharmacology 26(5): 696-7, 2002.• L97. Klein, DF, Garb, H, & Grove, W: Comparison of Medical and Psychological Tests.• American Psychologist 57 (2) 137-8, 2002.• L98. Klein, DF: Dodo Deliberations. Clinical Psychology: Science and Practice 9: 28-29,

2002.• L99. Klein, DF: Letter to the Editor: Peer Review and Data Access.Cortex 38:412, 2002.• L100. Klein, DF: You Slice, We'll Dice: Dan's Letter's. Dan's Papers Special Section: Home

Guide August 9th: 110, 2002.• R 1. Klein, DF, member of the Advisory Panel on Psychotherapy. The implications of cost-

effectiveness analysis of medical technology. Background paper #3: The efficacy and cost effectiveness of psychotherapy. Congress of the United States, Office of Technology Assessment, October, 1980. Library of Congress Catalog Card Number 80-600161.

• R 2. Klein, DF: New therapies for alcoholism, drug abuse, and mental illness; Issues and opinions. Report to Administrator of ADAMHA 6/19/89.

AUTOBIOGRAPHICAL STATEMENT

• The Psychopharmacologists; Interviews by David Healy, Chapman and Hall, London, 1996, pp. 329-352.

• I 1. Norton PJ, Asmundson GJG, Cox BJ, Norton GR: Future Directions in Anxiety Disorders: Profiles and Perspectives of Leading Contributors: JAMA, 14(1): 69-95, 2000.