crimean congo hemorrhagic fever - who
TRANSCRIPT
Crimean Congo hemorrhagic Fever
Epidemiology and clinical manifestations of CCHF
Global Situation of CCHF, published by WHO 2013
Nr
of
Cases
%
1956
Zai
re (D
RC) 2
1958
–197
7 Ugan
da
1983
-200
4 M
aurit
ania
1983
Burk
ina
Faso
1981
–201
8 South
Afric
a
1986
Tan
zania
2000
Ken
ya
2008
–201
0 Sudan
1
10
100
1000
0
20
40
60
80
100
Cases
Case fatality
Nr
of
Cases
%
1965
–199
7 Chin
a
1948
–200
0 Khaz
akhst
an
1943
–201
0 Taj
ikis
tan
1976
–200
0 Pak
ista
n
2011
India
1979
–199
5 Unite
d Ara
b Em
irate
s
1990
Sau
di Ara
bia
1995
–199
7 Om
an
1979
–198
0 Iraq
2000
–201
5 Iran
2008
–201
2 Afg
hanis
tan
2002
–201
8 Turk
ey
1
10
100
1000
10000
100000
0
20
40
60
80
100Cases
Case fatality
Nr
of
Cases
%
Crim
ea 1
944
1953
–196
3 Ast
rakh
an
1953
–196
8 Sta
vropol
1963
–196
9 Rost
ov
1953
–200
9, 2
012-
2019
Bulg
aria
1995
–201
8 Koso
vo
1999
–200
8 Russ
ia
2001
–200
6 Alb
ania
2008
Gre
ece
2016
-201
8 Spai
n
1
10
100
1000
10000
0
20
40
60
80
100Cases
Case fatality
South Africa
CCHF CASES PER PROVINCE
SOURCE OF INFECTION
FATALITY RATE
0102030405060708090
100
Laboratory confirmed cases in southern Africa
total of >200 cases 1981- to date • 46.8% tick bite or squashing ticks • 36.8% contact with fresh blood or other tissues
of livestock and/or ticks • 3.5% nosocomial infections arose from contact
with blood or fomites of known CCHF patients, • 12.9% no direct evidence of contact but patients
lived in or visited a rural area
T HE HISTORY OF CCHF IN SOUTH AFRICA
Turkey
2004
2014
2015
2017
https://hsgm.saglik.gov.tr/tr/zoonotikvektorel-kkka/zoonotikvektorel-kkka-istatistik
Seroprevalance
Yagci-Caglayik D, J Med Virol. 2014
https://hsgm.saglik.gov.tr/tr/zoonotikvektorel-kkka/zoonotikvektorel-kkka-istatistik
IRAN Iran J Public Health, Vol. 48,
IRAN
Nr
of
Cases
%
2009
2010
2011
2012
2013
2014
2015
0
100
200
300
15
20
25
30
Cases
Mortality %
Tadjikistan
366 patients diagnosed with CCHF: 78 died, mortality rate 21.3%.
When analysing transmission routes: 14 (3.8%) - cases through contact with infected cows;256 (70%) - cases in the result of tick bite; 96 (26.2%) - cases in the result of contact with CCHF infected humans
KOSOVO
Seroprevalence
Nr
of
Cases
%
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
0
10
20
30
40
50
0
50
100
150Cases
Mortality
Kosovo
YearN
r o
f C
ases In
cid
en
ce
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
0
10
20
30
40
50
0.0
0.5
1.0
1.5
2.0
2.5Cases
Incidence
Bulgaria
BulgariaC
ases
Incid
en
ce
2012
2013
2014
2015
2016
2017
2018
2019
0
2
4
6
8
10
0.0
0.2
0.4
0.6
0.8
1.0Cases
Incidence
Nr
of
Cases
%
2012
2013
2014
2015
2016
2017
2018
2019
0
2
4
6
8
10
0
20
40
60Nr of cases
Mortality
CCHFV seroprevalence in Bulgaria
CCHFV seroprevalence in Greece
Gaps• Lack of systematic epidemiological data from all endemic countries
• Difficult to calculate attack rate in most of endemic countries.
• NO knowledge about the Re-infection!