DRUG STUDYNAME

Generic:PREDNISONE

Brand:Apo-prednisone

Classification:Corticosteroid;Glucocorticoid

MODE OF ADMINISTRATION

Form:Tablet

Route:Oral

Dosage:50 mg

ACTIONMechanism of Action:Immediate-acting synthetic analog of hydrocortisone. Effect depends on biotransformation to prednisolone, a conversion that may be impaired in patient with liver dysfunction. Less mineralocorticoid activity than hydrocortisone, but sodium retention and potassium depletion can occur.INDICATION

*May be used as a single agent or conjunctively with antineoplastics in cancer therapy; also used in treatment of myasthenia gravis and inflammatory conditions and as an immunosuppressant.

INTERACTION

*Drug: BARBITURATES,phenytoin,rifampinincrease steroid metabolismincreased doses of prednisone may be needed;amphotericin B,DIURETICSincrease potassiumloss;ambenonium,neostigmine,pyridostigminemay cause severe muscle weakness in patients with myasthenia gravis; may inhibit antibody response toVACCINES,TOXOIDS.CONTRAINDICATION

*Systemic fungal infections and known hypersensitivity; cataracts; pregnancy (category C).

CAUTIOUS USE

* Patients with infections; nonspecific ulcerative colitis; diverticulitis; active or latent peptic ulcer; renal insufficiency; coagulopathy; psychosis; seizure disorders; thromboembolic disease; hypertension; osteoporosis; myasthenia gravis.ADVERSE EFFECT

CNS:Euphoria, headache, insomnia, confusion, psychosis.CV:CHF, edema.GI:Nausea, vomiting, peptic ulcer.Musculoskeletal:Muscle weakness, delayed wound healing, muscle wasting, osteoporosis, aseptic necrosis of bone, spontaneous fractures.Endocrine:Cushingoid features, growth suppression in children, carbohydrate intolerance, hyperglycemia.Special Senses:Cataracts.Hematologic:Leukocy-tosis.Metabolic:Hypokalemia.RESPONSIBILITIES

NAME: RafaelDate:Diagnosis:Pneumonia II, Congenital Heart DiseasePhysician:Santiaga L. Balayon, M.D.

DRUG STUDYNAME

Generic:CEFTRIAXONE SODIUM

Brand:Rocephin

Classification:Antibiotic;Third generation Cephalosporin

MODE OF ADMINISTRATION

Form:Injection

Route:Intravenous through tubing

Dosage:1 gm

ACTIONMechanism of Action:Semisynthetic third-generation cephalosporin antibiotic. Preferentially binds to one or more of the penicillin-binding proteins (PBP) located on cell walls of susceptible organisms. This inhibits third and final stage of bacterial cell wall synthesis, thus killing the bacterium.INDICATION

* Infections caused by susceptible organisms in lower respiratory tract, skin and skin structures, urinary tract, bones and joints; also intra-abdominal infections, pelvic inflammatory disease, uncomplicated gonorrhea, meningitis, and surgical prophylaxis.

INTERACTION

*Drug: Probeneciddecreases renal elimination of ceftriaxone;alcoholproduces disulfiram reaction; effect ofwarfarinmay be increased.CONTRAINDICATION

* Hypersensitivity to cephalosporins and related antibiotics; viral infections; neonates with hyperbilirubinemia, premature neonates.

CAUTIOUS USE

* Coagulopathy, GI disease, colitis; renal disease, renal impairment; pregnancy (category B).ADVERSE EFFECT

Body as a Whole: Pruritus, fever, chills, pain, induration at IM injection site; phlebitis (IV site).GI:Diarrhea,abdominal cramps,pseudomembranous colitis,biliary sludge.Urogenital:Genital pruritus; moniliasis.RESPONSIBILITIES

NAME:RafaelDate:Diagnosis:Pneumonia II, Congenital Heart DiseasePhysician: Santiaga L. Balayon, M.D.

DRUG STUDYNAME

Generic:CEFTRIAXONE SODIUM

Brand:Rocephin

Classification:Antibiotic;Third generation Cephalosporin

MODE OF ADMINISTRATION

Form:Injection

Route:Intravenous through tubing

Dosage:1 gm

ACTIONMechanism of Action:Semisynthetic third-generation cephalosporin antibiotic. Preferentially binds to one or more of the penicillin-binding proteins (PBP) located on cell walls of susceptible organisms. This inhibits third and final stage of bacterial cell wall synthesis, thus killing the bacterium.INDICATION

* Infections caused by susceptible organisms in lower respiratory tract, skin and skin structures, urinary tract, bones and joints; also intra-abdominal infections, pelvic inflammatory disease, uncomplicated gonorrhea, meningitis, and surgical prophylaxis.

INTERACTION

*Drug: Probeneciddecreases renal elimination of ceftriaxone;alcoholproduces disulfiram reaction; effect ofwarfarinmay be increased.CONTRAINDICATION

* Hypersensitivity to cephalosporins and related antibiotics; viral infections; neonates with hyperbilirubinemia, premature neonates.

CAUTIOUS USE

* Coagulopathy, GI disease, colitis; renal disease, renal impairment; pregnancy (category B).ADVERSE EFFECT

Body as a Whole: Pruritus, fever, chills, pain, induration at IM injection site; phlebitis (IV site).GI:Diarrhea,abdominal cramps,pseudomembranous colitis,biliary sludge.Urogenital:Genital pruritus; moniliasis.RESPONSIBILITIES

NAME:RafaelDate:Diagnosis:Pneumonia II, Congenital Heart DiseasePhysician: Santiaga L. Balayon, M.D.