College of Pharmacy College of Pharmacy Research ActivitiesResearch Activities

University of Illinois at Chicago College of PharmacyUIC

University of Illinois at ChicagoUniversity of Illinois at Chicago

University of Illinois at Chicago College of PharmacyUIC

Where are we?Where are we?

University of Illinois at Chicago College of PharmacyUIC

Medical CampusMedical Campus

University of Illinois at Chicago College of PharmacyUIC

College of PharmacyCollege of Pharmacy

Then:

Now:

University of Illinois at Chicago College of PharmacyUIC

Research SuccessResearch Success

UIC ranks in the top five nationally out of 83 colleges of pharmacy

Between 1998 and 2002 the College expanded research grants and contracts by an average of 11.6% per year 5

6

7

8

9

10

11

12

13

14

15

1995 1996 1997 1998 1999 2000 2001 2002

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Aw

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Fiscal YearFiscal Year

The College of Pharmacy continues to enhance its research baseThe College of Pharmacy continues to enhance its research base

Source: Comparative 2002 Survey, Research-Intensive Colleges of PharmacySource: Comparative 2002 Survey, Research-Intensive Colleges of Pharmacy

University of Illinois at Chicago College of PharmacyUIC

Research – Source of Funds – FY 2002Research – Source of Funds – FY 2002

68%

10%

8%

3%

11%

NIH

Other Gov

Illinois

Private

Private Non Profit

$14.3M total in awards -$14.3M total in awards - NCI is $5.3M of $9.6M NIH totalNCI is $5.3M of $9.6M NIH total

Source: COP external awards databaseSource: COP external awards database

University of Illinois at Chicago College of PharmacyUIC

COP Research CapabilitiesCOP Research Capabilities

Research Disciplines Drug discovery / natural products Drug development / natural products Drug delivery Molecular target discovery Pharmacogenomics Biotechnology / biodefense Pharmacoeconomics / Patient outcome management

Disease States Cancer Cardiovascular Infectious diseases Neurosciences / neurodegenerative diseases Immunology / Transplant medicine

University of Illinois at Chicago College of PharmacyUIC

OrganizationOrganization

Andrew DonnellyAndrew DonnellyDirectorDirector

Hosp. Pharm Srv.Hosp. Pharm Srv.

Jerry BaumanJerry BaumanDeanDean

Jan EngleJan EngleHeadHead

Pharmacy Pharmacy PracticePractice

Nicholas PopovichNicholas PopovichHeadHead

Pharmacy Pharmacy AdministrationAdministration

William BeckWilliam BeckHeadHead

Biopharmaceutical Biopharmaceutical SciencesSciences

Judith BoltonJudith BoltonActing HeadActing Head

Medicinal Chemistry Medicinal Chemistry and Pharmacognosyand Pharmacognosy

Steve SwansonSteve SwansonActing Associate Acting Associate

Dean forDean forResearch and Research and

Graduate EducationGraduate Education

James FischerJames FischerDirectorDirector

Ciln. Res. Lab.Ciln. Res. Lab.

Ken WitteeKen WitteeDirectorDirector

Amb. Care Srv.Amb. Care Srv.

Norman FarnsworthNorman FarnsworthDirectorDirector

PCRPS & PCRPS & Botanical Ctr.Botanical Ctr.

Michael JohnsonMichael JohnsonDirectorDirector

Ctr. Pharm. Ctr. Pharm. Biotech.Biotech.

Departments & UnitsDepartments & Units

Services & CentersServices & Centers

Institutes & CentersInstitutes & Centers

Scott FranzblauScott FranzblauDirectorDirector

ITRITR

Glen SchumockGlen SchumockDirectorDirector

Ctr. Pharmco-Ctr. Pharmco-economics Res.economics Res.

Mary MoodyMary MoodyDirectorDirector

Drug. Info. Ctr.Drug. Info. Ctr.

University of Illinois at Chicago College of PharmacyUIC

Degree ProgramsDegree Programs

Doctor of Pharmacy (Pharm. D.) Joint Programs

Pharm.D./Ph.D. Pharm.D./M.B.A. M.D./Ph.D.

Doctor of Philosophy Ph.D. in Pharmacy (Administration) Ph.D. in Biopharmaceutical Sciences Ph.D. in Pharmacognosy Ph.D. in Medicinal Chemistry

Master of Science M.S. in Forensic Science

University of Illinois at Chicago College of PharmacyUIC

Infectious Diseases (e.g., HIV/AIDS) Cardiology Transplantation Renal Ophthalmic Central Nervous System/Epilepsy Pediatrics Pharmacoeconomics and Outcomes Research Clinical Use of Natural Products Oncology Others

Pharmacy Practice (No Graduate Program)Pharmacy Practice (No Graduate Program)

University of Illinois at Chicago College of PharmacyUIC

Patient Outcomes Research

Health Care Policy

Comparative Health Care Systems

Consumer Behavior

Consumer Medication Use Safety

Pharmacoeconomics and Management

Pharmacists and Pharmacy Services

Professional Educational Research and Instructional Methodologies

Ph.D. in Pharmacy AdministrationPh.D. in Pharmacy Administration

University of Illinois at Chicago College of PharmacyUIC

Drug Delivery (Pharmaceutics)

Pharmacokinetics (Drug Disposition)

Pharmacodynamics (Drug Action)

Molecular target discovery

Pharmacogenomics (Genetics of individualized drug response; targeted drug action)

Toxicology/Pharmacogenomics

Forensic Science (Unique nationally recognized program)

Ph.D. in Biopharmaceutical SciencesPh.D. in Biopharmaceutical Sciences

University of Illinois at Chicago College of PharmacyUIC

Biopharmaceutical SciencesBiopharmaceutical Sciences

University of Illinois at Chicago College of PharmacyUIC

Ph. D. in Medicinal Chemistry or Ph. D. in Medicinal Chemistry or PharmacognosyPharmacognosy

Synthetic chemistry (neurodegenerative and oncologic diseases)

Computational Approaches to Drug Design

Chemical Toxicology and Biological Mechanisms

Synthetic Development of Enzyme Inhibitors and Low Molecular Weight Catalysts

Natural Product Structure Elucidation

Cancer Chemoprevention / Dietary Antioxidants

Dietary Supplements for Women’s Health

Method Development for Analysis of Botanicals

Analytical Support (MS, NMR, etc)

University of Illinois at Chicago College of PharmacyUIC

MDCH-PCOGMDCH-PCOG

University of Illinois at Chicago College of PharmacyUIC

M.S. in Forensic ScienceM.S. in Forensic Science

Criminalistics Forensic toxicology

University of Illinois at Chicago College of PharmacyUIC

Actively Managed or Marketed InventionsActively Managed or Marketed Inventions

Over 70 active inventions reside in the portfolio in the areas of:

Alzheimer’s Disease Anti-Infectives Blood Substitutes Cancer Avoiding Drug

Confusion

Almost half have been exclusively licensed

Drug DeliveryDrug Delivery MenopauseMenopause Natural ProductsNatural Products PainPain Research Tools (e.g., Research Tools (e.g.,

vectors, cell lines)vectors, cell lines)

University of Illinois at Chicago College of PharmacyUIC

Laboratory FacilitiesLaboratory Facilities

University of Illinois at Chicago College of PharmacyUIC

Laboratory Facilities (Cont.)Laboratory Facilities (Cont.)