CollaborativeResearchonAddictionatthe

National InstitutesofHealthUpdate2016

MARGARETM.MURRAY,PH.D.

SUSANR.B. WEISS, PH.D.

CRAN MissionCollaborativeResearchonAddictionatNIH

“…toprovideastrongcollaborativeframeworktoenabletheNationalInstituteonAlcoholAbuseandAlcoholism(NIAAA),theNationalInstituteonDrugAbuse(NIDA),andtheNationalCancerInstitute(NCI)tointegrateresourcesandexpertisetoadvancesubstanceuse,abuse,andaddictionresearchandpublichealthoutcomes.”

http://addictionresearch.nih.gov/

TheCRANBlogSavinga“LostGeneration”:TheNeedtoPreventDrugandAlcoholAbuseinMidlife

Dr.NoraVolkowandDr.GeorgeKoob Jan28,2016

CollaborativeResearchonAddictionatNIH

• GranteeMeeting(SupplementAwardees)• SocialMediaFOA• DevelopmentofNewProgramAnnouncements

____________________________

• JointT32TrainingReview• CRANStrategicPlan

Ø 80attendeesincludingseniorandjunior investigators,NIAAA,NIDA,NCIprogramstaff,coveringdiverseareasof research.

SelectDiscussionSummary

§ PanelistsdescribedtheneedtoeducatereviewersinbothtranslationalresearchandCRANresearch,theneedtohaveanappropriatestructureinplace,moreconversationbetweenpreclinicalandclinicalinvestigatorsaboutpolysubstanceabuse,morefocusontheclinicaldilemmasregardingthemosteffectivetreatmentregimen.

§ CRANhasbeengoodbecauseithasprovidedaframeworkforbothpreclinicalandclinicalresearch,butperhapsmostimportantly,ithaselevatedthestatusofpolysubstancework,oftennotseenbeforeasvaluable.

§ CRANmaybemoreimportantforclinicalanddeliverysciencethanotherareasofsubstanceabuseresearch.BecauseofCRAN,barriershavebeenremovedandinvestigatorscanstudythingssuchase-cigarettes(bigepidemicinadolescentmedicine),co-morbiddepression,andprescriptiondrugs,alongwithalcohol.

§ Allpanelistsfeltthatmoreinterdisciplinarytrainingisneeded.

MoreDiscussionComments• Thereneeds tobeastudysectionputtogether lookingatcollaborationacross

thefieldofaddiction.• IfreviewersareunawareofNIHinterestinthisfunctional integration, thenit

becomeschallenging.• Itiscriticaltochangethewaybothsides(programandinvestigators)think

andoperateforresearch.• CRANmentorshipprogramisneeded.• FosterthetranslationalresearchinterestwithinCRANvianewmechanisms.• CRANgranteescouldworktogetheronreviewarticles.• Institutescouldpublishguidelines formulti-substance research.• Asystematicreviewofmultisubstanceinstrumentsandmeasuresisneeded.• CRANsymposiaatmajorscientificmeetingswouldhelp.

RFA-CA-14-008/009:UsingSocialMediatoUnderstandand

AddressSubstanceUseandAddictionACRANInitiative

CurrentActivities

June10,2015:GranteeIntroductionWebinarJune22-23,2016:GranteeMeeting

UsingSocialMediatoAddressSubstanceUseandAddiction -CA14-008/009GoalsoftheRFAweretwo-fold:

• Observationalstudiesusingsocialmediainteractionsassurveillancetoolstounderstandtheepidemiology,riskfactors,attitudes,andbehaviorsassociatedwithalcohol,tobaccoandotherdruguseandaddiction.

• Interventionresearchmeasuringthereach,engagement,andbehavioralandhealthimpactofsocialmedia-basedinterventionsforscreening,prevention,andtreatment.

• ElevenawardsmadeinSeptember2014- sevenR01’sandfourR21’s.

SocialMediaRFAGrantees&*RelatedProjectsPIName,Grant# ProjectTitle

Kim,AnniceR01CA192240

UsingSocialMediaDataforE-CigaretteSurveillanceandPolicyResearch

Oesterle,SabrinaR21DA039466

UsingFacebooktoRecruit ParentstoaParentingProgramtoPreventTeenDrugUse

Schulte, MaryaR21DA039459

PURPOSE:ASocialMediaInterventionforParentSupport

Vrieze,ScottR01AA023974

SocialMedia,OnlineMeasures,&SubstanceUseDevelopmentinAdolescent Twins

Weitzman,Elissa*R21AA023901

Detecting YouthDrinkingandAssociationswithAlcoholPolicies viaSocialMedia

Young,SeanR21DA039458

AdaptingtheHopeSocialMediaIntervention toReducePrescription DrugAbusef

PIName,Grant# ProjectTitleBerg,CarlaR21CA198455

Policy,advertisingandsocialmediarelated toe-cigarette consumerbehavior

Bickel,WarrenR01DA039456

TheSocialInteractome ofRecovery:SocialMediaAsTherapyDevelopment

Cavazos-Rehg,PatriciaR01DA039455

Implications ofSocialMediaContent andEngagementForAlcoholAndMarijuanaUse

Carlson,Robert*R56DA038366

NIDANational EarlyWarningSystemNetwork(IN3)

Curtis,BrendaR01DA039457

Predicting AODRelapseandTreatment CompletionfromSocialMediaUse

Daniulaityte, RamintaR01DA039454

Trending:SocialMediaAnalysistoMonitor CannabisAndSyntheticCannabinoid Use

Ge,YongR21AA023975

MiningPatternsofSubstancebyYoungAdultswithSocialMediaData

Graham,AmandaR01CA192345

SocialDynamicsOfSubstanceUseinOnlineSocialNetworksforSmokingCessation

FY15FundingOpportunitiesNovelTargetstoImproveAdolescentSubstanceAbuseTreatmentandPrevention(PA:R34,R01)AdolescentBrainCognitiveDevelopment(ABCD)Study(RFAs:U01,U24)

NovelTargetstoImproveAdolescent(andYoungAdult)SubstanceAbuseTreatmentandPreventionAimedatunderstandingmechanismsaswellasdevelopingnoveltreatmentsandpreventioninterventionsthattargetbehavioralmechanismsrelevanttosubstanceuseandabuse,including:impulsivity,risk-takingpropensity,sensationseeking,distresstolerance,delaydiscounting,self-regulation,andstressreactivity.

• PA15-035-ResearchAimedatNovelBehavioralTargetstoImproveAdolescentSubstanceAbuseTreatmentandPreventionInterventions(R34)1/5/2015-1/8/2018(changedtoincludeyoungadultsuptoage25).

• PA-15-036 - ResearchAimedatNovelBehavioralTargetstoImproveAdolescentSubstanceAbuseTreatmentandPreventionInterventions(R01)1/5/2015– 1/8/2018(Changedtoincludeyoungadultsuptoage25).

DevelopingFundingOpportunities

WorkgroupsFormingtoDevelopProgramAnnouncementsinthefollowingareas:§ ImplementationofSystem-LevelChangestoImproveSubstance

AbuseTreatmentandPrevention§ LoriDucharme,NIAAA;TishaWiley,NIDA;LizGinexi,NCI

§ TargetAssessment,Engagement,andDataReplicabilitytoImproveTreatmentOutcomes§ BrettHagman,NIAAA;WillAklin,NIDA;GlenMorgan,NCI

§ TranslationalStudiesonPoly-SubstanceAbuseandAddiction§ IvanaGrakalic,NIAAA;ShellySu,NIDA;GlenMorgan,NCI

ResearchTraining◦ InstitutionswithNIAAA,NIDA,NCItrainingprograms,butlimited“cross-institute”training

◦Disincentives(e.g.,inreview)forprogramsthatproposetotrainstudentsinotherICpriorityareas

◦ Expertpanelconvenedtodiscusshowtoovercomethesebarriers

PanelRecommendationsØInstituteLeadership conveytoinvestigatorsandreviewersthatcross-substanceresearch/trainingisapriority

ØWorkshops,SymposiatoconveyInstitutes’prioritiestothefieldandtosolicitinputonopportunitiesforresearchandtraining

Response-- SupplementstoT32programsforadditionaltrainingslotsthat:

• Exposetraineestocross-cuttingresearchareasoftobacco,alcohol,andothersubstanceuse,abuse,andaddictionandrelatedhealth-consequences;

• Preparetraineestoconductindependentresearchincross-cuttingareas.

NIAAAandNIDAtohaveInstitutionalNRSAApplicationsReviewedbyaCommonPanelofExpertsbeginningin2016Issued:Dec17,2015:ForapplicationssubmittedforMay25,2016(nonAIDS)andSeptember7,2016(AIDS)duedatesforJanuary2017Council.

AsingleSpecialEmphasisPanelwillbesetupeachyeartoreviewapplicationsreceivedbyNIDAandNIAAAinresponsetotheparentFundingOpportunityAnnouncements:PAR-14-015 (T32)andPA-14-016 (T35). ThepanelswillbejointlymanagedbystafffromNIAAAandNIDAwhowillensurethatappropriateexpertiseisincludedtoreviewthefullbreadthofresearchtrainingproposedinalloftheapplications,includingthoseapplicabletoeachinstituteaswellasthoseresponsivetomulti-substancepriorityareas.

NoticeofInformation:NOT-DA-16-007

Why?• Increaseefficiency• Increasepoolofreviewersandbroadentheexpertise•Messagetotheresearchcommunity• Opportunitytoenhancetraininggoalstoincludemultiplesubstancesandaddmentoringexpertise• Addressreviewerbias—e.g.,programspenalizedfortraineesstudyingotherIC’spriorityareas(drugsforNIAAA;alcoholforNIDA)

NotalltrainingwillbeCRAN:Institutespecifictrainingprogramswillstillbesupported.

Howwillthisbeimplemented?§NIAAA/NIDAWorkingGroup:MarkSwieter,AbeBautista,SusanMcGuire,RichardRippe,MimiGhim,LindseyGrandison,KathyYoung,MinnaLiang,R.V.Srivinas

§AlternatingleadIC-- bothICSROsandESAsinvolved

§DevelopProceduresandGuidelinesforReviewers

§FAQsforProgramStaffandApplicants

§AllinformationpostedonCRAN,NIAAA,andNIDAwebsite

Staytuned……

CRANSTRATEGICPLAN:2016-2021

CRANMission

“…toprovideastrongcollaborative frameworktoenabletheNational InstituteonAlcoholAbuseandAlcoholism(NIAAA),theNational InstituteonDrugAbuse(NIDA),andtheNationalCancerInstitute(NCI)tointegrateresourcesandexpertisetoadvancesubstanceuse,abuse,andaddictionresearchandpublichealthoutcomes.”

CRANseekstofillgapsinresearchby:

Ø Expandingresearchtrainingtoincreasescientificexpertiseinmulti-substanceresearchØ CreatingcoretechnicalfacilitiesandcommondatabasesforsuchresearchØ FacilitatingaparadigmshiftinaddictionresearchculturebothwithinNIHandacrosstheresearchcommunities.

GoalsandObjectives

§ TheultimategoalisforCRANtoinvestigateanddifferentiatethecommonanddistinctivefeaturesofthedifferentmanifestationsofaddictionalongthediseasecontinuum.

§ CRANencouragesfundingtotargetemergingand/orunder-recognizedopportunitiesaddressingmultiplesubstanceuseandcomorbidityacrossthelifespan,involvingdifferentlevelsofanalysis,fromthecellular/moleculartohealthservicesandpolicyresearch.

StrategicApproachesAdvancingBasicScience:◦ Developanimalmodelsofpolysubstanceuse.◦ Identifynewtargets(e.g.,genes,epigeneticmarks,biochemicalpathways,neuralcircuits)asbiomarkersorleadsformedicationsdevelopment totreatmultipleaddictions.

PromotingClinicalResearch:◦ Determinetheefficacy/utilityofcoordinatedefforts toscreenformultiple substances.

◦ Implementmulti-armedclinicaltrialstoassessoutcomesforvarioussubstancesaloneandincombination tooptimize resourcesandspeedmedicationsandothertreatmentdevelopment.

◦ Developimprovedapproachesfortreatingmulti-substanceaddictionsandothercomorbidconditions (e.g.,mentalillness,chronicpain,HIV).

StrategicApproachesImprovingPublicHealthandReducingHealthDisparities◦ Focusonpolysubstanceuseinvulnerablepopulations(e.g.,pregnantwomen,theelderly;peoplewithmedicalcomorbidities,suchasHIVorHCV).

◦ Identifyandteststrategiestoovercomebarriersanddisincentivestoadoptionofresearch-basedtreatmentsformultipleaddictionsinthecommunity,criminaljusticesystem,andhealthcaresystems.

◦ Conductimplementationresearchtoimprovetreatmentaccessibilityinvariouspopulations,andundertheAffordableCareAct(ACA).

◦ Promoteresearchontheadversehealthconsequencesofpoly-substanceuse.◦ Supportresearchtodevelopmoreeffectiveprogram,policy,andcommunicationinterventionstargetingsubstanceabuse,andtobetterdisseminateandimplementexistingevidence-basedinterventions.

LeverageDataSystemsandShareResourcesamongtheCRANICs(andothersasappropriate)

InSummaryWeencouragetheresearchcommunitytoleveragetheopportunitiesprovidedbyCRANtoconsidertheirresearchprioritiesinordertodevelopabetterunderstandingoftheinfluenceofmultiplesubstancesonbraindevelopment,drugusepatternsandtrajectories,healthandpublichealthconsequences,treatment,prevention,andimplementationscience