cold water extraction of opioids

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Drugs Forum> Wiki Articles

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Notices

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The purpose of this wiki article is to provide easy-to-follow procedures on Cold Water Extraction of O

Drugs-Forum users; ones that you can do at home in order to minimize the risks of using OTC and p

painkillers. All steps and methods are explained both in detail and summarized throughout. Many pe

inquire and perform CWEs usually have the same questions to ask. This Wiki/FAQ will attempt to ad

these, and more.

CCoonntteennttss

1 Introduction

1.1 How Extraction Works

2 Extraction Manuals

2.1 Crushing Tablets and Pills

2.2 Quick Step-by-Step CWE-Technique (5 Minutes)

2.3 Quick Step-by-Step CWE Manual (With Pictures)

2.4 Detailed CWE Manual

2.5 Another Detailed CWE Manual

2.5.1 Do's & Don'ts by Darkglobe

2.5.2 The Results/Final Product

CCoolldd WWaatteerr EExxttrraaccttiioonn ooff OOppiiooiiddss

aarrttiiccllee

Cold Water Extraction of Opioids - Drugs Forum https://www.drugs-forum.com/forum/showwiki.php?title=Co...

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CCoonntteennttss

2.6 Quick-Links & Further Information

3 Pharmacology and Drug Interactions of Codeine

3.1 Codeine: First Use & Dosage (Beginning and Medicinal)

3.2 Codeine: Administration & Effects on the Body and Mind

3.3 Your Product

4 Chemical Properties of the Ingredients

4.1 Melting Point

4.2 Opioids

4.2.1 Codeine

4.2.2 Hydrocodone

4.2.3 Oxycodone

4.2.4 (Dextro)propoxyphene4.2.5 Heroin / Diacetylmorphine

4.2.6 Morphine

4.3 NSAIDS: Non-steroidal Anti-inflammatory Drugs & PCM/APAP

4.3.1 Paracetamol / Acetominaphen

4.3.2 Aspirin (Acetylsalicylic acid)

4.3.3 Ibuprofen

4.4 Other Ingredients Possibly Present

4.4.1 Caffeine

4.4.1.1 Removing Caffeine

4.4.2 Chlorpheniramine maleate

4.4.3 Doxylamine succinate

4.4.3.1 Removing both Chlorpheniramine Maleate and/or Doxylamine Succi

4.4.4 Promethazine Hydrochloride

4.4.5 Gluthethimide

4.4.6 Sodium Bicarbonate - NaHCO3 (Baking Soda)

4.4.7 Pseudoephedrine

4.4.8 Salicylic acid

4.4.9 Acetic acid (Vinegar)

5 Methods of Treating Ingredient Poisoning, Overdosing, and Liver Damage; How to M

Side-Effects

5.1 PCM (APAP) Poisoning: Benefits of Acetylcysteine

5.2 Aspirin Poisoning (Salicylate Poisoning)

5.3 Ibuprofen Poisoning


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IInnttrroodduuccttiioonn

Performing Cold Water Extractions is not a hard process. However, since we are dealing with potentia

ingredients, all possible precautions should be taken. For the best and safest results, each and every

should be read fully and carefully. That means allof them.

(I have recently done an entire overhaul on this Wiki to make it flow better and easier to read. Pleas

time to do so for yours and others healths sake. -Joben)

Participating in and taking drugs is a lifestyle choice, and should be taken very seriously. One can ne

much knowledge.

PPoosstt CCoonnssuummppttiioonn : If you feel sick- extremely sick- immediately contact professional help and call

ambulance! Do not induce vomiting nor try to solve the problem by consuming other drugs! Also ver

do not, under any circumstances, attempt to seek help by posting to Drugs-Forum! Medical help can

administered over the internet. Response time will never be fast enough and proper knowledge of th

can never be conveyed.All DF users will tell you the same thing: get off the forum and call the amb

HHooww EExxttrraaccttiioonn WWoorrkkss

Extraction works because APAP(Acetaminophen), ibuprofen, and aspirin are hardly soluble in water,

when cold. Opiates, however, are verysoluble in water. (This only partly applies to Ibuprofen.)

Solubility information on APAP:

According to the Merck Chemical Index, APAP is: "Soluble in methanol, ethanol, dimethyl-formamide,

dichloride, acetone, ethyl acetate; slightly soluble in ether; very slightly soluble in cold water, consid

soluble in hot water; insoluble in petroleum ether, pentane, benzene."

Solubility information on ibuprofen:

According to the Merck Chemical Index, ibuprofen is: "Relatively insoluble in water; very soluble in al

most organic solvents." The colder the water, the less aspirin dissolves.

Due to the difficulty in obtaining Rx drugs containing enough codeineto be used recreationally, I hav

procedure that allows one to extract the codeine from OTC products to obtain enough of the drugto

recreationally.

This extraction can oonnllyy be used on OTC products containing either acetaminophenor aspirin(ibupr

possible to extract) in addition to the codeine. There is one exception to this rule. Products containin

be used with the knowledge that the most of the caffeine contained in the OTC product, wwiillll be founfinished product. This should not matter to most people, but to those with problems in taking caffein

bbeeeenn wwaarrnneedd!! (See: caffeine removal section)

(I have found that it is better to use products containing aspirin, as opposed to Tylenol, because the

process goes more smoothly. And, if one is not allergic to salicilates, aspirin is safer [easier on the liv

Given its solubility, you will also end up with far less aspirin than acetaminophen per volume of the p

The idea behind the following extraction is that acetaminophen and aspirin are very insoluble in cold

Codeine phosphate (the most common form of codeine) is very soluble in water; cold water will yield

results. The following table explains:


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Type Solubility (31C water) Solubility (21C water)

Aspirin 1g / 100 ml 1g / 300ml

Acetaminophen (Paracetamol) 1g / 70 ml 1g / 150 ml

Codeine 1g / 2.3 ml 1g / 0.7 ml

So as you can see, both APAP and aspirin aren't very soluble in 21C water, so if you cool the water to

the solubility will drop even further. That way you can dissolve 20 tablets in 50ml of warm (not hot)

water down to 10C, filter the solution and end up with the same amount of codeine as the tablets co

only a fraction of the original amount of APAP and aspirin . Opiates are very soluble in water. Extracti

because the cold water dissolves opiates but not the APAP, aspirin , or ibuprofen. Also, if cold, the as

change its status and become crystals, which are caught in the filter.

It should be noted that because most of the caffeine (or other ingredients; look at your product and

chemicals on this site) will remain in the finished product, using large amounts of tablets in the follo

procedure will result in large amount of caffeine, etc., in the finished product. For example, the use o

with 15mg Caffeine may result in about 300mg of caffeine in the finished product. (15mg/tablets * 2There are strong side effectswith all of the other ingredients and one has to be aware of these.

One can use less opioids and get same effects by potentiating the effects, see the link list.

EExxttrraaccttiioonn MMaannuuaallss

Here are a few manuals- some better, some faster, some more careful, some more detailed- but the

They are all very similar, but each different in its own particular, special way. The author recommend

wants to be on the absolute safe side and also have a "near perfect" result, he/she should read the e

or at least a few manuals and the rest of the thread. The other chemicals and dosages are also ve

to study.

Listed below are many Cold Water Extraction manuals. They are all very similar, but each different in

particular way. To gain the most knowledge on the subject, one should not only read the two short

techniques, but also the detailed ones. It is recommended they also view the do's and donts list.

CCrruusshhiinngg TTaabblleettss aanndd PPiillllss

For the sake of Cold Water Extractions, one should prefer capsules, as they contain less fillers and do

crushed. They are also much easier to dissolve. However, if one has only access to tablets, he/she h

of options on how to crush them.

Listed below are a few methods on how to crush pills while minimizing powder loss. One should alwa

though, as some tablet pieces tend to fly-away when initially crushed. It is recommended that prior

break apart tablets with hands into the smallest possible segments.

!Place the tablets in an envelope, fold it shut, and then using a large rolling pin to smash them. This

near impossible to lose powder.

!Place two pills in a spoon and then use another spoon over top and apply pressure.

!A simple mortar and pestle can do the trick.

!If one has the resources, use a ball mill with steel crushing media.


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!A coffeegrinder used for only five to six seconds will sufficiently blend up to 72 tablets into fine tal

them easily dissolvable.

!Personally, my best results came using a large knife sharpening stone to pummel the tablets. After

crushing is performed, use a thick, round mug to roll on the pills turning the tiny segments into a fin

A thread that may provide further information can be found here: How to Crush Pills (Codeine)

QQuuiicckk SStteepp--bbyy--SStteepp CCWWEE--TTeecchhnniiqquuee ((55 MMiinnuutteess))

The following technique is proof of a perfect working method that can also be done in a relatively sh

time. Apart from cooling the water (which takes around 20-30 minutes), this process will take aabboouutt

mmaaxx..

This is a quick and easy way to do the CWE. Lots of other guides take the long way around and mak

harder than it actually is. This is intended to be a brief explanation, as it will not go into very detaile

SSiimmpplliiffiieedd OOvveerrvviieeww-

GGOOAALL:: To remove acetaminophen (APAP), ibuprofen, aspirin, etc., from tablets containing opiates, li

HHOOWW:: Crush tablets; dissolve powder in water; strain through a filter

SStteepp OOnnee-- CCrruusshh TTaabblleettss iinnttoo aa FFiinnee PPoowwddeerr wwhhiillee MMiinniimmiizziinngg PPoowwddeerr LLoossss

Put tablets into a thick Ziploc bag. (You can choose to put this inside another Ziploc bag for extra lea

protection.) Use an object to crush the tablets to a fine powder without puncturing the Ziploc bags.

include but are not limited to: a sharpening stone (for knives), a brick, a round glass cup, or a ham

SStteepp TTwwoo-- DDiissssoollvvee tthhee CCrruusshheedd PPoowwddeerr iinnttoo WWaarrmm//HHoott WWaatteerr

Get hot water from the tap- but not too hot! In between warm and hot is perfect. Don't use boiling w

you want to destroy the codeine.

Put it in a container or bowl with a wide surface area (cools faster) and add the powder you crushed.

using a Ziploc, some powder may stick to the plastic, but I think it's negligible.)

The amount of water used should usually be 3/4 of a cup. Start with that and experiment. It's better

much water than too little, or it won't filter properly later.

SStteepp TThhrreeee-- LLeett MMiixxttuurree SSiitt aanndd CCooooll ttoo RRoooomm TTeemmppeerraattuurree ((1100--2200 mmiinnuutteess))

Be careful about cooling the mixture too quickly, as it may destroy some codeine within. Leave it sit

counter for a period of time, until it is at or near room temperature. (It doesnt have to be perfect.)

SStteepp FFoouurr-- MMoovvee tthhee CCoonnttaaiinneerr iinnttoo tthhee FFrreeeezzeerr uunnttiill CCOOLLDD

This is where the magic happens. Leave the mixture sit in the freezer (without a lid) until it is extre

the touch. Be very careful!The key is to get the solution as cold as possible yet ccrruucciiaall to keep it fro

icing up. Pay close attention!


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SStteepp FFiivvee-- FFiilltteerriinngg ((AAllmmoosstt tthheerree!!))

First, place a pre-wet coffee filter over the top of a Solo cup and secure it with a rubber band or som

(One glass and filter will normally do the job, however, if you wish to do this as quickly as possible a

best results, you may choose to use two to three cups equipped with a filter. Thats filtering at three

speed!)

Slowly pour the solution from the freezer into the cup(s) and wait!

SStteepp SSiixx -- TThhee FFiinnaall PPrroodduucctt

When it looks like the filters arent dripping anymore, and there is nothing left to filter through, you

with a dense, marshmallow-like substance.

Some people choose to squeeze the contents of the old filters through a new filter to save any remai

moisture. Be careful not to spill any residue into the liquid solution, though.

At this point some people add a little water to the leftover mush and re-filter it, but I dont think its

worth the time. Were now ready to consume.

SStteepp SSeevveenn -- DDrriinnkk iitt!!

The final product should be very clear (like water), or just slightly cloudy. Most (if not all) of the APA

and/or aspirin have been successfully removed.

The remaining water is eexxttrreemmeellyy bbiitttteerr..Personally, I suffer through it and drink it straight, just to

with. Most people drink it with something sweet very sweet. Mixing Kool-Aid packages will cover so

bitter taste. Bottoms up!

For added effects, see: OpioidPotentiators

QQuuiicckk SStteepp--bbyy--SStteepp CCWWEE MMaannuuaall ((WWiitthh PPiiccttuurreess))


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Step One -

The product that I will be using for this manual is shown above. Its a generic painkiller/cough relief/

well-being product, available (in different brands of course) OTC in most countries. Capsules work gr

the codeine is easy to extract. If you begin with tablets, crush them to a ffiinnee powder.


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Step Two-

You can see this product contains paracetamol (acetaminophen), aspirin, and Klorfeniramin, which is

antihistamine. These should NOT be in your final product. For best results, the less of these ingredie

the product (pre-extraction), the better. Obviously, the less material needing filtered will make the p

quicker and lower the chances of any remaining in the final solution. (I will refer to the paracetamol,

Klorfeniramin blend as PPAAKK in future references [for this manual exclusively].)

Side note: Klorfeniramin in low doses doesnt pose too much of a problem, but never think about co

before getting proper information on it! That goes for any drug for that matter! (Lots of information

Drugs Forum)


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Step Three -

The following procedure will work best by using coffee filters. If they are unavailable or unobtainable,

Middle-Eastern countries), do nnoott use a t-shirt. The spaces between the threads are too wide and wil

dangerous ingredients to flow through. Use good judgment.For this example, we will be using coffee

Fill a cup with warm ((nnoott hhoott!!)) water, and dump the crushed tablets from Step One in. Stir until com

dissolved. You may have some residue rise to the top, even though youve stirred vigorously. Thats

filtered out later. At this point, the water should look snowy. To what degree will depend on the amo

you use.

For this example, we are using 30 capsules containing 10mg codeine and 300mg PAK.


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Step Four -

Once youve stirred the mixture very well, place the cup in the freezer. Wait 20-25 minutes (will diffe

and settings) until water is cold. Very cold. Be very careful!The key is to get the solution as cold as

ccrruucciiaall to keep it from freezing or icing up. Pay close attention!

At these temperatures, the PAK becomes thick and sinks to the bottom of the cup, thus becoming ea


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Step Five -

Filter the solution.

It is recommended you slightly wet the filter before using it. (Not doing it can cause this stage to go

and heighten the risk for filter tearing!) You can either secure the filter to a separate cup using a rub

like the diagram shows above, hang the filter above a wide bowl. Now thats ingenuity!

Now, pour the mixture into the filter. Do this slowly! Filter paper isnt exactly the sturdiest material

risk of tearing is always prevalent. If a tear does occur, re-filter the solution! Dont take any chances.


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(This photo was taken after the first filtration of the mixture. For this manual, there will be multiple fi

[personal choice] and as you can see, there is already a significant amount of material left behind.)


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-------

Its finally done! Wasnt that fast? The final product should look like the image above.

Great job!


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Once completed, the solution should look similar to the liquid shown in the photo above. The codeine

sometimes make the mixture cloudy, not to mention any PAK or colorants that may have made their

the filter. If you are unsure about this, you can always repeat the filtration. (For some, a tiny bit of P

the bottom of the glass is nothing to worry about.)

If you are paranoid about the PAK, but dont want to repeat the filter stage, place the glass in the fri

rest of the PAK will sink. When you finally drink it, stop before sipping the contents of the very botto

Enjoy!

DDeettaaiilleedd CCWWEE MMaannuuaallAA.. MMeetthhooddss ooff FFiillttrraattiioonn

-Your chosen method of filtration will greatly affect how much PCM/APAP, ibuprofen, aspirin,

other ingredient) is present in your end product. The best working methods are shown below:

11.. LLaabb GGrraaddee FFiilltteerrss

a. These may not be readily available to most, but can be obtained from someone you

may know at a local school or university.

b. Aside from those places, there are plenty of companies who will sell these products t

individuals. Check your yellow pages or search the internet for distributors.


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22.. CCooffffeeee FFiilltteerrss

a. These will work almost as well as the lab grade variety, and will filter considerably

faster. The only downside is accuracy.

b. Some people recommend filtering numerous times (two to three), but it isnt always

necessary. Use your own personal judgment.

BB.. TThhee TTeecchhnniiccaall SSttuuffff

- How you perform the CWE in conjunction with your level of caution and cleanliness will affec

clean your final product will be. Below are some tips on the general method and uses of equi

11.. CCrruusshhiinngg YYoouurr PPiillllss

a. For best results, use a pill crusher.

b. If one is not available, use something enclosed/sealed.

i. Keep from getting white powder all over your hand and work area.

ii. Keep everything clean!

c. Crush to a fine powder. The finer, the better it will dissolve.

d. (There is a section earlier in the Wiki with various ideas on how to accomplish this.)

22.. DDiissssoollvviinngg YYoouurr CCrruusshheedd PPiillllss

o This is where many opinions will differ. Unless youre looking for the highest possible yield fr

your pills, follow these steps:

a. Fill a glass or solo cup about half full with warm (not hot) water. Keep the

temperature around 30 degrees Centigrade. (86 degrees Fahrenheit)

i. If a great amount of pills are being used, use more water. Use your best

judgment. Dont be afraid to use toomuch. This is much safer. You can

always change it up next time you perform a CWE.

b. Carefully pour the crushed pills into the cup of water.

c. Stir vigorously until completely dissolved.

i. Some material may rise to the surface no matter how much you stir. Not

much you can do about it. It wont cause any harm.

d. Place mixture into freezer until it is extremely cold.

i. DO NOT let the mixture freeze. Get it as cold as possible.

33.. FFiilltteerriinngg ((FFiinnaallllyy!!))

o There are many methods of filtering. For this procedure, we will be using a funnel draining d

into a cup. However, there are many ways possible. Use your imagination, but always keep it

and proper!

a. Fold your chosen filter into the correct shape.

b. Make sure your filter fits like a glove into the funnel.


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c. Pour your mixture in slowly, ensuring none escapes the filter.

i. Pour all material in, including what has already clumped together. It will

take longer, but ensure more codeine content.

1. If very paranoid, ignore the above instruction.

d. Once complete, remove the filter carefully, paying close attention that no unfiltered

content makes its way into the codeine water.

e. If you wish to, repeat filtration.

f. Throw away all sour material.

44.. DDrriinnkk!!

AAnnootthheerr DDeettaaiilleedd CCWWEE MMaannuuaall

1. Obtain a quantity of tablets containing codeine. Check to see if they contain anything other than c

caffeine, acetaminophen, or aspirin. If they do, and you arent sure about whether it will be a proble

best bet is not to use them. If you still wish to, use the list of ingredients in the latter section of this

the forums of DF to be sure they are filterable.

Measure out your desired amount of codeine. For example:

64 mg = 8 tablets @ 8 mg per tablet

You may want to add two extra tablets as it is likely you will lose some codeine in the process. As yo

more experienced with this procedure, you will be able to obtain approximately 95% of the codeine a

be extracted.

Crush the tablets into a fine powder while minimizing powder loss.

2. Now we need water in which to dissolve the crushed tablets. Choose how much water you use acc

many tablets are being dissolved. Approximately 40ml will work for 20 tablets. I would suggest you

50ml for the same amount.

Make sure you are using warm/hot water for dissolving. Boiling water will destroy codeine. Pour crus

into the cup of water and stir until the vast majority of it is dissolved.

Not all of the powder will dissolve. Some fillers are water-insoluble and not all of the PCM/APAP, aspi

ibuprofen will dissolve either, (which is exactly what we want!).

3. Place the cup containing the solution in a cold bath. I use some ice cubes and water in a large bo

mixture occasionally until the temperature drops to about 15 degrees Celsius (59 degrees Fahrenhei

You wont need a thermometer to measure the temperature, just make sure its cold. Very cold.

If you wish you speed this up, you can use less water to dissolve the crushed tablets, and add ice chi

mixture. (Dont add so much ice you drastically increase the volume of the mixture.)

Instead of a cooling in a bath, you may also choose to cool the solution in the freezer. Pay close atte

sure the mixture does not begin to freeze. This will ruin the final product.

4. Filter the solution by whatever means you wish. Coffee filters work well, but lab filters will work th


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sure you dont end up with obvious solids in the filtered solution. This process will take about one ho

aspirin, this will only take about 20-30 minutes.)

You may also want to rinse the solids left over in the filter with some ice-water to extract any remain

5. Drink and enjoy! The solution will be very bitter, so I mix a little Kool-Aid powder into it. The taste

it is similar to sucking on a lemon.

6. Sit back, wait, and enjoy! Because the codeine is already dissolved in the water, it only needs to b

Whereas normally, in tablet form, the codeine must take time to dissolve to later be absorbed.

Because of this, effects should be noticeable within 15 minutes.

NNoottee:: There are some who wish to evaporate the mixture to obtain pure codeine in powder form. I d

you do this unless you are willing to wait a while. The Merck index warns that codeine is sensitive to

light. For that reason, if you wish to evaporate the mixture, do it without heat, and shield the solutio

forms of UV light.

DDoo''ss && DDoonn''ttss bbyy DDaarrkkgglloobbee

DDooss

- Make sure youre meticulous with hygiene. Many chemical processes go tits up due to carelessness.

- Use a sensible amount of water

o Too little, and it will taste even more unpleasant and you may have too little water for the c

to properly dissolve.

o Too much, and you may end up with PCM/APAP finding its way into the codeine solution.

- Use a suitable filter, and use it properly!

o Improper filtration = to put it bluntly, imminent death. Or at least imminent pain. Probably

DDoonnttss

- Guess. Dont even guesstimate. Do not, under any circumstances do this for any measurement o

cannot stress how important a bit of caution can be for your health and well-being.

- Get impatient. My friend was guilty of this one. He couldnt wait for the solution to cool in order for

PCM/APAP to precipitate out of the solution. It ended up in him having his stomach pumped. I was t

hospital with him, and I can safely say it did notlook pleasant.

CCoonncclluussiioonn

Be careful, be methodical, and be happy. Let SWIMenjoy his/her drug use as safely as possible. Thi

the substances have risks, you dont want to add more.

Paracetamol and Acetaminophen are not friendly substances!

TThhee RReessuullttss//FFiinnaall PPrroodduucctt


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Above is an example of how the final product should appear. Sometimes slightlycloudy, but very sim

As mentioned before, if the liquid is too cloudy, (or you feel it isnt filtered enough), you may need t

another filtration. Some cloudiness may be present from ingredients other than medicines. These ma

dyes, or possibly residue on the glass preceding the CWE.

One must know that the majority of times your final product will still contain trace amounts of parac

(acetaminophen), aspirin, ibuprofen, etc. In most cases, the amount is miniscule and poses no harm

1. There are two choices as far as how you can exploit the codeine in the final product. The ea

and most exercised method is simply drinking the elixir. It will taste extremely bitter when dr

alone. Experiment with ways to improve the taste (then share the ideas!) or muster up the co

to down it with a few great, big gulps.

2. One may also choose to evaporate the water to reap only the codeine powder. This works b

when poured into a wide and shallow dish. Large glass cookware would be the nominal choice.

Your goal is to evaporate the water out of the mixture, allowing the codeine to dry and adhere

glass. This codeine can then be scraped from the sides and compiled into mass amount. Some

will use a small flame or heat source to speed up the evaporation process. Be very careful! Gr

amounts of heat can cause the break-down of opioids; this will occur at about 150 degrees Cel

and higher. Any type of UV exposure will also break down codeine, so be weary of evaporating

open light.

QQuuiicckk--LLiinnkkss && FFuurrtthheerr IInnffoorrmmaattiioonn

Dosage List of Opioids(starting dosage in this post in the chemicals list)


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A Big CWE Thread

Extracting Caffeine from CWE/Codeine combination

How to Crush Pills (Codeine)

Codeine-Basics Thread

Saving Money by Potentiating the Effects of OpioidsCareful! If taken with APAP this will also be pote

thus harder on the liver. See: APAP Poisoning section.

Extracting DXM from Syrup

Injecting Basics and Dangers of IVing Pills

PPhhaarrmmaaccoollooggyy aanndd DDrruugg IInntteerraaccttiioonnss ooff CCooddeeiinnee

In order to take full advantage of codeine, it is helpful to be familiar with some relevant pharmacolog

The body converts codeine into morphine(~10%) by using the P450 cytochrome pathway. The mos

these is cytochrome 2d6 (cyp2d6). Unfortunately, cyp2d6 is missing in about 7% of the white popula

manifestation is quite variable in the rest. Individuals who inherited a cyp2d6 deficiency will get man

adverse effects associated with codeine but little euphoria. If codeine doesn't seem to work for you,

why.

Some drugs also interfere with cyp2d6. Prime among these are the SSRIs, with the exception of Zolo

potent inhibitor is paroxetine(Paxil), followed by fluoxetine(Prozac). If you are taking an SSRI, you

experience a markedly decreased euphoria when using codeine. (Paxil has a half life of only 24 hourtaking it for a few days will do miracles; the half life of Prozac is seven days.)

Finally, codeine itself is a cyp2d6 inhibitor. This means that taking the whole dose at the exact same

probably give you the biggest sense of euphoria. It is a waste of codeine to re-dose every 20 to 30

will not experience a greater high by doing so.

CCooddeeiinnee:: FFiirrsstt UUssee && DDoossaaggee ((BBeeggiinnnniinngg aanndd MMeeddiicciinnaall))

One should also check the codeine threadand dosagethread; this being just a basic introduction.

Codeine is an excellentopiateto start experimenting with. A proper dose at which to begin using is i

mg range. This dosage will produce quite pleasurable feelings of euphoria, while low enough to keep

effects at a minimum. Some individuals may be allergic to codeine. If you have never used it before,

surpass the previously stated dosage. Wait and see how it affects you; it is dangerous to begin cons

doses.

For best results, take the drug on an empty stomach. If nausea or stomach aching is experienced, or

become hungry, eat something small. On an empty stomach the effects will become noticeable withi

(yet depends on the dose). It also must be noted that like most other drugs, some experience is req

the full effects can be noticed and enjoyed.

The effects will usually begin with a slight sedation, and a feeling of warmth coming over your body.


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relaxation is also quite noticeable. The subjective effects are quite hard to describe beyond the word

sedation associated with codeine is quite a lot less than that experienced with morphine or other str

A strong feeling of contentment is usually also experienced. Most people enter a phase where you be

content and tend to lose interest in their surroundings. A heavy feeling in the limbs also becomes qui

This will peak at about one hour with the strongest effects slowly tapering off after two hours.

Codeine is mainly used as a pain reliever, but is also used for the relief of a non-productive cough, a

anti-diarrheal agent. 120mg of codeine administered subcutaneously (injected under the skin) provi

equal to 10mg of morphine administered by the same route. Doses used to relieve cough or diarrhea

5mg to 30mg.

CCooddeeiinnee:: AAddmmiinniissttrraattiioonn && EEffffeeccttss oonn tthhee BBooddyy aanndd MMiinndd

One should also check the codeine threadand dosagethread; this being just a basic introduction

Codeine is absorbed quickly from the GI tract and its first pass through the liver results in very little l

drug. This contrasts with morphine in which over 90% of the drug is metabolized in the first pass thr

resulting in a considerable loss of potency when administered orally. This is why codeine is a commo

relief of pain; the ease of oral administration.

Codeine can be administered by many routes, this includes, SC, IM (intramuscularly), as an enema,

Note: codeine can't be administered safely by IV (intravenously) injection as it can result in pulmona

(fluid in lungs), facial swelling and other life threatening complications.

Codeine is converted to morphine in the brain. This of course will result in a positive result in a drug

opiates. It is not known whether or not the drugs heroin, morphine or codeine can be separately det

drug test. In other words, it isn't likely that the drug tester can determine which of the three above

have taken; he just knows you've taken one or more of them.

Some common side effects from codeine include drowsiness, light-headedness, dry mouth, urinary r

(difficulty in urination), constipation and of course, euphoria. Adverse effects can include itchiness (c

confusion, nausea and vomiting. The nausea experienced with codeine is less common and less inten

experienced with the stronger opiates such as morphine. A tip to all those using opiates, lying down

to the nausea. If you ever experience nausea on opiates it is different than the commonly experience

it is more of a light-headed feeling. Lying down will almost always relieve the nausea in a couple min

after you can attempt to stand up again.

Note: Addictionto codeine is possible. Tolerance is also seen with chronic use. Although the withdra

with codeine, it is not a fun time. Please be cautious in your use of the drug.

The LD50(lethal dose for %50) is 800mg in the average person. Death from codeine, unlike most op

includes restlessness, seizures, and eventually death from respiratory arrest. [Some sources indicate

lower-end LD50 may be around 500mg, so doses above 450mg are in the red zone.]

YYoouurr PPrroodduucctt

If one has a product containing Opioids (i.e. Codeine) plus PCM/APAP/Ibuprofen/Aspirin, he/she sho

overview exactly what and how much is present in the medication. The best choice is an opioid in co

PCM/APAP or aspirin, as these are the quickest and easiest to filter. Also present are colorants, which

as well as fillers (for tablets) and other things; one should check on all.


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In general, capsules will yield the best results being that they contain less filler and only contain the

chemicals and the filterable chemicals. (See: Chemicals list)

IIff ppoossssiibbllee,, eevveerryytthhiinngg eellssee sshhoouulldd bbee aavvooiiddeedd aanndd//oorr oonnee sshhoouulldd ccaarreeffuullllyy ccoonnssiiddeerr wwhhaatt hhee//ss

tthheeiirr bbooddyy.. AAllwwaayyss cchheecckk tthhee ffaaccttss aanndd iinnffoorrmmaattiioonn..

PPoossssiibbllee ootthheerr AAccttiivvee IInnggrreeddiieennttss::

Caffeine (Removing Caffeine)

Chlorpheniramine(extraction)

Sodium Bicarbonate

Pseudoephedrine

Salicylic acid

Acetic Acid

Promethazine Hydrochloride

Doxylamine (extraction)

OOtthheerr IInnaaccttiivvee IInnggrreeddiieennttss

Colorants

Fillers

See also: Chemicals List

CChheemmiiccaall PPrrooppeerrttiieess ooff tthhee IInnggrreeddiieennttssAlthough some of the chemicals can be taken safely up to a certain amount one should almost alway

Cold Water Extraction. Since one doesnt know their individual limits and other factors involved, filter

everything out nearly removes all risks involved and promotes good health! These chemicals also int

each other, yet the results of this cannot always be foretold.

Dosages-

The listed dosages for opioids are starting points for therapeutic usage. One should consider his/her

generally start as low as possible and work their way up.

The listed dosages for the other ingredients are maximum one-time amounts. Do not take that amou

regular basis; even one-time dosages can be considered high-risk.

MMeellttiinngg PPooiinntt

The melting point of a crystalline solid is defined as the temperature range at which it changes state

liquid; or the other way around. Although the phrase would suggest a specific temperature and is co

incorrectly used as such in most textbooks and literature, most crystalline compounds actually melt

of a few degrees or less. At the precise melting point the solid and liquid phases exist in equilibrium.

OOppiiooiiddss


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CCooddeeiinnee

Melting Point : 154-156 C (309-312 F)

Boiling Point: 250 C (482 F)

Soluble in : Water - (1g/ 2.3mL at 31C) and (1g/ 150mL at 21C)

Insoluble in:

Therapeutic dosage: Starts at: 0.5 - 2mg per kg of bodyweight

- Because codeineneeds to be metabolized to an active form, there is a ceiling effect aroun

400-450 mg per intake. This low ceiling further contributes to codeinebeing less addictive tha

opiates. Roughly 5-10% of codeinewill be converted to morphine, with the remainder either f

conjugated to form codeine-6-glucuronide(~70%), or converted to norcodeine(~10%) and

hydromorphone(~1%)

Cold Water Extraction-Codeinewill remain in the water after filtration if performed correctly.

OOtthheerr EExxttrraaccttiioonn MMeetthhooddss ((ffoorr DDiiffffeerreenntt FFoorrmmss aanndd CChheemmiiccaallss))::

Codeine monohydrate

o One gram dissolves in the following: 120mL water at room temperature, 60mL water

at 80; 2mL alcohol, 1.2mL hot alcohol; 13mL benzene; 18 ml ether; and 0.5 ml

chloroform.

o Freely soluble in: amyl alcohol, methanol, and diluted acids.

o Almost insoluble in: petroleum etheror in solutions of alkali hydroxides.

Codeine Hydrochloride dehydrate

o One gram dissolves in the following: 20mL water, 1mL boiling water, and 180mL

alcohol.

Codeine Sulfate trihydrate

o One gram dissolves in the following: 30ml water, 6.5mL water at 80, 1300mL

alcohol.

o Insoluble in: chloroform and ether.

Codeine phosphate

o One gram dissolves in 4mL of water at 20C.

Codeine-Basics

HHyyddrrooccooddoonnee

Melting Point : 198 C (388 F)

Boiling Point :

Soluble in : Water, alcohol

Insoluble in :

Therapeutic dosage : Starts at 0.1 mg per kg bodyweight.

Cold Water Extraction:Hydrocodoneremain in the water after filtration if performed correctly



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Hydrocodone Bitartrate hemipentahydrate

o One gram dissolves in: 16mL water, 150g 95% ethanol.

o Almost insoluble in: ether andchloroform.

Hydrocodone Basics & Experiences

OOxxyyccooddoonnee

Melting Point : 270-272 C (518-522 F)

Boiling Point :

Soluble in : Water

Slightly soluble in : alcohol

Insoluble in :

Therapeutic dosage : Starts at 0.075-0.1 mg per kg bodyweight

Cold Water Extraction : Oxycodonewill remain in the water after filtration if performed correctly

Oxycodone Hydrochloride

- One gram dissolves in 10ml water.

Oxycodone Basics & Experiences

((DDeexxttrroo))pprrooppooxxyypphheennee

Melting Point :

Boiling Point :

Soluble in : Water, alcohol, chloroform, acetone.

Insoluble in :benzene, ether.

Therapeutic dosage :

Cold Water Extraction:

- Dextropropoxyphene hydrochloride will remain in the water after filtration if performed corre

- Propoxyphene napsylateis nnoott water soluble and will not pass through the filter


Propoxyphene napsylate

o Some believe it is soluble in water, while others believe it is not

o 100mg propoxyphene napsylateis equivalent to 65mg propoxyphene hydrochloride.

(Dextro)propoxyphene Basics & Experiences

HHeerrooiinn // DDiiaacceettyyllmmoorrpphhiinnee

Melting Point :

Boiling Point :

Soluble in : water, chloroform, alcohol, ether, and alkalies

Insoluble in : ether


Cold Water Extraction : Heroinwill remain in the water after filtration if performed correctly



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DiacethylmorphineBase

o One gram dissolves in: 1.5mL chloroform, 31mL alcohol, 100mL ether, 1700mL water

o Slightly soluble in: ammoniaor sodium carbonatesolution.

o Soluble in alkalies.

o Decomposes by boiling with water.

Diacethylmorphine Hydrochloride monohydrate

o One gram dissolves in: 2mL water, 11mL alcohol.

o Insoluble in: ether.

Heroin Basics

MMoorrpphhiinnee

Melting Point :

Boiling Point :

Soluble in : water, alcohol, benzene, ether, chloroform, amyl alcohol, methanol, and dilute acids

Insoluble in :


Cold Water Extraction : Morphinewill remain in the water after filtration if performed correctly


Morphine monohydrate-

o One gram dissolves in: 120mL water, 60mL water at 80, 2mL alcohol, 1.2mL hot

alcohol, 13mL benzene, 18mL ether, 0.5mL chloroform

o Freely soluble in: amyl alcohol, methanol,and dilute acids.

o Almost insoluble in: petroleum etheror in solutions of alkali hydroxides.

Morphine Hydrochloride dehydrate

o One gram dissolves in: 20mL water, 1mL boiling water, 180mL alcohol.

Morphine Sulphate trihydrate

o One gram dissolves in: 30mL water, 6.5mL water at 80, 1300mL alcohol.

o Insoluble in: chloroformor ether.

Morphine Basics

NNSSAAIIDDSS:: NNoonn--sstteerrooiiddaall AAnnttii--iinnffllaammmmaattoorryy DDrruuggss && PPCCMM//AAPPAAPP

(The "Other" Painkillers in Many OTC Products)

PPaarraacceettaammooll // AAcceettoommiinnaapphheenn

Melting Point : 169 C (336 F)

Boiling point: Not applicable; PCM/APAPwill decompose

Soluble in: water (0.1-0.5 g/100mL at 22C mg/mL [20 C]), methanol, ethylene dichloride, acetone


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acetate

Slightly insoluble in : ether

Insoluble in :petroleum ether, pentane, and benzene

Therapeutic Dosage: The highest level that a person can take at once will differ with each individual;

true with every drug. If one does decide to use products containing these ingredients, they are advis

with caution. It is recommended they begin with a low dose, perhaps around 500mg to 750mg. Once

to taking it, try not to exceed 1000mg to 1500mg per dosage, and never 4000mg within a 24 hour p

Cold Water Extraction : Filtration is possible by the method of extraction using cold water. When pro

the PCM/APAPwill be separated from the codeine; considerably more in warm water than cold when i

mixed.

((TThhee iinnffoorrmmaattiioonn bbeellooww iiss vveerryy iimmppoorrttaanntt!!))

- Side-effects : Paracetamol (Acetaminophen)taken in high doses can be potentially lethal. D

the wide availability of it, there is a large potential for toxicity and overdose. Without timely

treatment, overdose can lead to liver failure and death within a matter of days. It is a slow,

extremely painful death.

- Paracetamoltoxicity is, by far, the most common cause of acute liver failure in both the UnitStates and United Kingdom. It is sometimes used in suicide attempts by those unaware of the

prolonged time course and high morbidity (likelihood of significant illness) associated with

paracetamol-induced toxicity in survivors.

DDaannggeerrss ooff PPootteennttiiaattiinngg wwiitthh WWhhiittee GGrraappeeffrruuiitt JJuuiiccee

- White Grapefruit Juice is an inhibitor of CYP3A4, which is a minor metabolizer of hydrocodon

major metabolizer of acetaminophen. This means that the degree to which plasma concentrati

acetaminophen increase would be much greater than the degree to which plasma levels of

hydrocodone would increase; thus the risk of liver toxicity is made higher.

AAssppiirriinn ((AAcceettyyllssaalliiccyylliicc aacciidd))

Melting point : 138-140 C (280-284 F)

Boiling point: 140 C (284 F)

Soluble in: Water 10 mg/mL

Insoluble in: ?

Therapeutic Dosage :

Cold Water Extraction: Filtration is possible by the method of extraction using cold water. When prop

the Aspirinwill be separated from the codeine; considerably more in warm water than cold when initi

AAcceettyyllssaalliiccyylliicc aacciidd

- One gram dissolves in: 300mL water at 25, in 100mL water at 37, in 5mL alcohol, 17mL

chloroform, and 10-15mL ether.

- Less soluble in: anhydrous ether.

- Decomposes by: boiling it in water or when dissolved in solutions of alkali hydroxides and

carbonates.

(Inorganic salts of acetylsalicylic acidare soluble in water (especially the Ca salt, q.v.), but ar

decomposed quickly.)



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- High Dosage : The toxic dose of aspirinis generally considered greater than 150mg per kg o

mass. Moderate toxicity occurs at doses up to 300mg/kg, severe toxicity occurs between 300

500mg/kg, and a potentially lethal dose is greater than 500mg/kg. This is the equivalent of m

dozens of the common 325mg tablets, depending on body weight. However, children cannot t

as much aspirinper unit body weight as adults can.

- Side-effects : Aspirinoverdose has potentially serious consequences, sometimes leading to

significant morbidity and mortality. Patients with mild intoxication frequently have nausea and

vomiting, abdominal pain, lethargy, tinnitus, and dizziness. More significant symptoms occur i

severe poisonings and include hyperthermia, tachypnea, respiratory alkalosis, metabolic acido

hyperkalemia, hypoglycemia, hallucinations, confusion, seizure, cerebral edema, and coma. T

common cause of death following an aspirin overdose is cardiopulmonary arrest usually due to

pulmonary edema.

For more info, see: poisoning section

IIbbuupprrooffeenn

Melting Point : 76C (169 F)

Boiling Point:

Soluble in : organic solvents

Insoluble in : water

Therapeutic Dosage : 1200mg of ibuprofen is the maximum standard dose for a day. In medical prac

3200mg can be used reportedly.

Cold Water Extraction: Possible to filter out, but not as easy & efficient as Paracetamol (Acetaminoph


- High Dosage : High doses involve a whole plethora of nasty side effects ranging from

gastrointestinal ulceration to diarrhea.

- Side-effects: Human response in cases of overdose ranges from absence of symptoms to fat

outcome in spite of intensive care treatment. Most symptoms are an excess of the pharmacol

action of ibuprofen and include abdominal pain, nausea, vomiting, drowsiness, dizziness, head

tinnitus, and nystagmus. Rarely more severe symptoms such as gastrointestinal bleeding, seiz

metabolic acidosis, hyperkalaemia, hypotension, bradycardia, tachycardia, atrial fibrillation, co

hepatic dysfunction, acute renal failure, cyanosis, respiratory depression, and cardiac arrest h

been reported.

For more info, see: poisoning section

OOtthheerr IInnggrreeddiieennttss PPoossssiibbllyy PPrreesseenntt

If using the CWE method with tablets/capsules containing the following ingredients, one should be a

these may alter the effects of opioids. Because of this, severe side effects are perfectly possible; in

scenarios, an OD can occur.

CCaaffffeeiinnee

Melting point : 237 C (Non-equilibrium, Superheated; Caffeine'sublimes'- goes from solid to gas, n

phase)

Boiling point: 178 C

Soluble in: Water (22 mg/ 1mL [25 C]), (180 mg/ 1mL [80 C]), (670 mg/ 1mL [100 C])


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- Solubility in water is increased by alkali benzoates, cinnamates, citratesor salicylates.

Insoluble in : ?

Therapeutic Dosage :

Cold Water Extraction: When using this method to remove caffeine, one must be prepared to wait a

of time and do not rush the process. Studying the chemicals and subject beforehand is recommende

ample amount of time and be careful.


- One gram dissolves in: 46mL water, 5.5mL water at 80, 1.5 L boiling water, 66mL alcohol,

alcohol at 60, 50mL acetone, 5.5mL chloroform, 530mL ether,100mL benzene, and 22mL boi

benzene.

- Freely soluble in: pyrrole, in tetrahydrofurancontaining about 4% water, and ethyl acetate.

- Slightly soluble: in petr ether.


- High Dosage : Though achieving the lethal dose with caffeinewould be exceptionally difficult

regular coffee, there have been reported deaths from overdosing on caffeinepills; with seriou

symptoms of overdose requiring hospitalization occurring from as little as 2 grams of caffeine.

should judge for him/herself whether or not they have a tolerance to caffeine. In theory every

above 300mg constitutes an OD, but can be higher in reality. One should not go a lot further!

check tolerance levels, one can look up caffeine contents in the following database:

http://www.energyfiend.com/the-caffeine-database/

- Side effects : Altered effects of other drugs consumed (i.e. opioids), nervousness, irritability,

anxiety, tremulousness, muscle twitching (hyperreflexia), insomnia, headaches, respiratory al

and heart palpitations.

o An acute overdose of caffeine, usually in excess of 250 milligrams, can result in an

over stimulation of the central nervous system called caffeine intoxication. It may

include restlessness, nervousness, excitement, insomnia, flushing of the face, increased

urination, gastrointestinal disturbance, muscle twitching, a rambling flow of thought an

speech, irritability, irregular or rapid heartbeat, and psychomotor agitation.

o In cases of much larger overdoses, mania, depression, lapses in judgment,

disorientation, loss of social inhibition, delusions, hallucinations, psychosis,

rhabdomyolysis, and death may occur.

o In cases of extreme overdose, death can result.

The Combined Snorting Caffeine Thread On the subject of insufflation, but also includes other usef

about the effects of caffeine.

RReemmoovviinngg CCaaffffeeiinnee

Upon searching, there seems to be several methods. Each should be performed with the utmost pati

attention. One should still be careful though, especially if using any solvents such as acetone. For m

information, a thread is available: https://www.drugs-forum.com/forum/showthread.php?t=44769

DDiiffffeerreenntt MMeetthhooddss ffoorr tthhee RReemmoovvaall ooff CCaaffffeeiinnee::

Activated Carbon Method:


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Prior to this step, a Cold Water Extraction should have already been performed. Following this, simpl

solution through Activated Carbon. This should be available at any local pet shop for a low price. Be

the carbon prior to filtering as to avoid turning the water black! One may use a permanent coffee filt

small screen strainer will work. Dump the solution cup to cup, (or however you so choose), for sever

making multiple passes through the carbon. By doing so, you will succeed in creating a caffeine-free

Not only will the carbon filter out caffeine, but can remove any remaining traces of APAPthat might

is recommended that the AC filtering only be performed when caffeineis present, and not as a way t

APAP/PCM.

Filtering Using Solvents:

Your product may have different amounts of the following substances, but it shouldnt be of great im

Stay on the safe side and calculate it up or follow the manual below. For the examples shown, the pr

will be AC&C.

8mg codeine phosphate(1.6g codeine phosphate/ 200ct)

15mg caffeine(3g caffeine/ 200ct)

325mg aspirin (75g aspirin/ 200ct)

127mg junk (25.4g / 200ct)

Read carefully.

- 200ct uncrushed AC&C added to 600ml beaker (net 95g). Hot water was added to 550ml ma

Stirred every 30 minutes (3). Cooled in fridge for 4h.

o 360ml decanted to 2nd beaker.

- 190ml left in sludge layer. (65% of 1.6g codeineextracted.)

- 200ml hot water added to 600ml beaker. Stirred 5min. Cooled in fridge for 4h.

o Decanted 200ml to 2nd beaker. (18% of 1.6g codeineextracted.)

- 190ml hot water added to 600ml beaker. Stirred 5min. Cooled in fridge for 4h.

o Decanted 190ml to 2nd beaker. (9% of 1.6g codeineextracted.)

This means that 92% of the total codeine/caffeinewas extracted into a net volume of 750ml. (1.47g

2.74g caffeine.) What remains in the beaker is mostly junk & aspirin.

- Reduced volume in 2nd beaker to 150mL by boiling.

The room will fill with the mild smell of vinegar as some of the aspirindecomposes. The solution is c

fridge and then filtered (1). The volume is again reduced to 50mL. The solution is cooled in the fridg

filtered (2). After this treatment, less than 15% of the original amount of caffeinewill remain in the

What remains is a solution of codeinewithout a discernable amount of caffeine. The solution can be

a powder that looks something like brown sugar and is intensely bitter. (This step is not normally rec

high temperatures cause the break-down of codeine.) This is a relatively concentrated form of codei

Enjoy responsibly.

Some amount of caffeineis filtered off at this step. Remember to wash your filter pa

bit of ice-cold water to reduce the losses. What you're doing is actually re-crystallizin

caffeine, and for people who haven't seen it before, it almost looks like cotton candy.

1.


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More caffeineis filtered off at this step.2.

If you don't have automated stirring, just stir occasionally over a half-hour period of3.

Note how this technique refrains from using acids, bases, or organic solvents to accomplish the remo

from the caffeine/codeine; thus I feel it is a significant breakthrough.

Chromicwould like to thank a name-withheld codeine fanatic who he worked alongside with via PM

this technique.

CChhlloorrpphheenniirraammiinnee mmaalleeaattee

Melting Point :

Boiling Point :

Soluble in : water (0.55g/ 100mL, liquid mg/mL [20 C])

Insoluble in :

Therapeutic dosage : A maximum of 24-30 mg/day. An antihistamine, Chlorpheniraminerelieves red,

eyes; sneezing; and runny nose caused by allergies, hay fever, and the common cold. It may also relitching of insect bites, bee stings, poison ivy, and poison oak.

Cold Water Extraction : Chlorpheniramineis nearly impossible to extract using a CWE. See extraction

working, non CWE, method for filtering.

- Soluble in mg/mL at 25: ethanol 330 mg, chloroform240mg, water 160 mg, methanol 130

- Slightly soluble in: benzene, ether.


- Side-Effects: Symptoms of a Chlorpheniramineoverdose include extreme fatigue, confusion,

weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking,

insomnia, hallucinations, and possibly raising the risk of seizures.

- Potentiating Effects: It has analgesic-sparing (potentiating) effects on opioid analgesics, com

reducing codeine, dihydrocodeine, and hydrocodonerequirements by 10 to 35 per cent.

Chlorpheniramine maleate thread

DDooxxyyllaammiinnee ssuucccciinnaattee

Melting Point :

Boiling Point :

Soluble in : water, alcohol, chloroform.

Insoluble in :

Therapeutic dosage : Doxylamineis an anti-histamine in the same class as chlorpheniramine and

diphenhydramine. Large quantities could prove fatal. Even smaller doses can lead to an awful experi

Cold Water Extraction : Doxylamineis nearly impossible to extract using a CWE. See extractionfor a

CWE, method of filtering.

- One gram soluble in: 1mL water, 2mL alcohol, 2mL chloroform.

- Slightly soluble in: benzene, ether.


- Side-Effects: May include- dysphoria, vision problems, difficulty urinating, muscle weakness,


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excitement, and hallucinations. Given the danger of antihistamines, these sound like some of

more benign side effects (See: chlorpheniramineside effects; they are very similar!) More tim

not, achieving an opiate high with these chemicals present is not worth the risk.

- Potentiating Effects: Doxylaminehas analgesic-sparing (potentiating) effects on opioid analg

commonly reducing codeine, dihydrocodeine, and hydrocodonerequirements by 10 to 35 per

Questions about Doxylamine Succinate

RReemmoovviinngg bbootthhCChhlloorrpphheenniirraammiinnee MMaalleeaattee aanndd//oorr DDooxxyyllaammiinnee SSuucccciinnaattee

1. Crush the tablets into powder as fine as possible.

2. Wash them sseevveerraall times using anhydrous ethanolthat has been dried with calcium oxide.

3. Normally, two to three washes of 10mL dried ethanolis sufficient for several boxes of codeinewith

Chlorpheniramine maleateand/or Doxylamine succinate present.

Hardly anycodeine is dissolved while using this method!

PPrroommeetthhaazziinnee HHyyddrroocchhlloorriiddee

Melting Point :

Boiling Point :

Soluble in : water, alcohol, chloroform.

Insoluble in : acetone, ether, ethyl acetate.


Cold Water Extraction : Not known to be possible to filter using a CWE.

Promethazine Recreational Potential?

GGlluutthheetthhiimmiiddee

- A combination of codeineand gluthethimide(a sleeping agent) has been used in some place

heroinsubstitute.

- Gluthethimideis an enzyme-inducer, allowing the body to convert more than 10% of codeine

consumed into morphine.

- NNoottee:: TThhiiss ccoommbbiinnaattiioonn iinnccrreeaasseess tthhee aaddddiiccttiioonn ppootteennttiiaall ooff ccooddeeiinnee..

Further information is needed on the subject and is currently being worked on. Be safe; do not try wi

additional information!

SSooddiiuumm BBiiccaarrbboonnaattee -- NNaaHHCCOO33 ((BBaakkiinngg SSooddaa))

-- NNoott ttoo bbee ccoonnffuusseedd wwiitthh SSooddiiuumm CChhlloorriiddee NNaaCCll ((SSaalltt))!!

Melting Point :

Boiling Point :

Soluble in :

Insoluble in :

Therapeutic dosage : The maximum daily dosage of sodium bicarbonateis 200mEq (16.6 grams of N

patients younger than 60 years of age and 100mEq (8.3 grams of NNaaHHCCOO33) in patients 60 years of a

Generally not dangerous, high doses should be avoided due to risk of harming organs. Drinking lotsadvised.


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Cold Water Extraction : It is not possible to filter out NaHCO3using a CWE.

EEffffeeccttss::

- As an Alkalizer (systemic): Increases the plasma bicarbonate, buffers excess hydrogen ion

concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis.

- As an Alkalizer (urinary): Increases the excretion of free bicarbonate ions in the urine, thuseffectively raising the urinary pH. By maintaining alkaline urine, the actual dissolution of uric a

stones may be accomplished.

- As an Antacid: Reacts chemically to neutralize or buffer existing quantities of stomach acid b

no direct effect on its output. This action results in increased pH value of stomach contents, th

providing relief of hyperacidity symptoms.

For more information, see: https://www.drugs.com/mmx/sodium-bicarbonate.html

PPsseeuuddooeepphheeddrriinnee

Pseudoephedrinealters the effects of opioids. If overdosed on, serious side-effects experienced will b

those of caffeinebut much stronger. Melting Point :

Boiling Point :

Soluble in : water (slightly)

Insoluble in :


Cold Water Extraction : It is practically impossible to filter out pseudoephedrineusing a CWE.


Pseudoephedrine Base:

o Freely Soluble in: alcohol, ether.

o Slightly soluble in: water.

Pseudoephedrine Hydrochloride:

o Solubility at 25 C (g/ml): water (2.0g), chloroform(0.011g), ethanol(0.278g).

For further information, see:

https://www.drugs.com/pseudoephedrine.html

Pseudoephedrine filtration with Active Carbone?

SSaalliiccyylliicc aacciidd

Melting Point : 159 C

Boiling Point : 211 C

Soluble in :

Insoluble in :


Cold Water Extraction :


- Safety : Salicylic acidhas an ototoxic effect, and can induce transient hearing loss in zinc-deindividuals.


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o This finding is based on clinical studies with rats. An injection of salicylic acidinduced

hearing loss in zinc-deficient rats, while a simultaneous injection of zincreversed the

hearing loss. An injection of magnesiumin the zinc-deficient rats did not reverse the

salicylic acid-induced hearing loss.

- Salicylic acidis toxic in large amounts.

For further information, see: http://en.wikipedia.org/wiki/Salicylic_acid

AAcceettiicc aacciidd ((VViinneeggaarr))

Melting Point : 16.5 C

Boiling Point : 118.1 C

Soluble in : Miscible with water.

Insoluble in :


Cold Water Extraction :


- Safety: Concentrated acetic acidis corrosive and must therefore be handled with appropriat

since it can cause skin burns, permanent eye damage, and irritation to the mucous membrane

These burns or blisters may not appear until hours after exposure. Latexgloves offer no prote

so special resistant gloves, such as those made of nitrile rubber, should be worn when handlin

compound.

- Concentrated acetic acidcan be ignited with difficulty in the laboratory. It becomes a flamma

if the ambient temperature exceeds 39 C (102 F), and can form explosive mixtures with air

this temperature (explosive limits: 5.4%16%).

For further information, see: http://en.wikipedia.org/wiki/Acetic_acid

MMeetthhooddss ooff TTrreeaattiinngg IInnggrreeddiieenntt PPooiissoonniinngg,, OOvveerrddoossiinngg,, aannLLiivveerr DDaammaaggee;; HHooww ttoo MMiinniimmiizzee SSiiddee--EEffffeeccttss

AAss ssttaatteedd eexxaaccttllyy iinn tthhee iinnttrroodduuccttiioonn:: IIff yyoouu ffeeeell ssiicckk-- eexxttrreemmeellyy ssiicckk-- iimmmmeeddiiaatteellyy ccoonnttaacctt pprro

hheellpp aanndd ccaallll tthhee aammbbuullaannccee!! DDoo nnoott iinndduuccee vvoommiittiinngg nnoorr ttrryy ttoo ssoollvvee tthhee pprroobblleemm bbyy ccoonnssuummii

ddrruuggss!!

The steps listed are best used for preventative measures rather than treatment. Aside from the follo

to uphold a healthy nutrition and to take breaks between uses. Drinking plenty of water is also advis

PPCCMM ((AAPPAAPP)) PPooiissoonniinngg:: BBeenneeffiittss ooff AAcceettyyllccyysstteeiinnee

PCM (APAP) Poisoning Experiences, Infos & Discussion Thread

Using Acetylcysteineas antidote: Overdosed toxic itself; drinking lots of water is always recommend

possible harm to kidneys.

Administration of activated charcoal should be considered if paracetamol in excess of 150mg/kg or 1

is smaller) is thought to have been ingested within the previous hour.

Acetylcysteineprotects the liver if infused within 24 hours of ingesting paracetamol. It is most effectiwithin 8 hours of ingestion, after which effectiveness declines sharply. If more than 24 hours has ela


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advice should be sought from a Poisons Information Center or from a liver unit on the management

damage. In remote areas, methionine(2.5g) by mouth is an alternative if acetylcysteinecannot be g

promptly. Once the patient reaches hospital the need to continue treatment with the antidote will be

from the plasma-paracetamolconcentration.

Patients at risk of liver damage and therefore requiring treatment can be identified from a single me

the plasma-paracetamolconcentration, related to the time from ingestion, provided this time interval

than 4 hours; earlier samples may be misleading. The concentration is plotted on a paracetamoltrea

of a reference line (normal treatment line') joining plots of 200mg/L (1.32mmol/L) at 4 hours and 6.

(0.04mmol/L) at 24 hours. Those whose plasma-paracetamolconcentration is above the normal trea

treated with acetylcysteineby intravenous infusion. If acetylcysteineis not available, the patient will

with methionineby mouth, provided the overdose occurred within 1012 hours and the patient is no

Patients on enzyme-inducing drugs (e.g. carbamazepine, phenobarbital, phenytoin, primidone, rifam

and St Johns Wort) or who are malnourished (e.g. in anorexia, in alcoholism, or those who are HIV-

develop toxicity at lower plasma-paracetamolconcentration and should be treated if the concentratio

the high-risk treatment line (which joins plots that are at 50% of the plasma-paracetamol concentra

normal treatment line.)

The prognostic accuracy of a plasma-paracetamolconcentration measurement taken after 15 hours i

but a concentration above the relevant treatment line should still be regarded as carrying a serious ri

damage.

Plasma-paracetamolconcentration may be difficult to interpret when paracetamolhas been ingested

hours. If there is doubt about timing or the need for treatment then the patient should be treated wi

in any case. -Thanks to Jatelka.

AAssppiirriinn PPooiissoonniinngg ((SSaalliiccyyllaattee PPooiissoonniinngg))

Aspirin Poisoning: Infos, Basics & Discussion Thread

There is no antidote to salicylate poisoning (the active ingredient in aspirin). Frequent blood work is

check metabolic, salicylate, and blood sugar levels while arterial blood gas assessments are perform

respiratory alkalosis and metabolic acidosis. Patients are monitored and often treated according to th

symptoms.

Patients may be given intravenous potassium chlorideto counteract hypokalemia, glucoseto restore

levels, benzodiazepinesfor any seizure activity, fluids for dehydration, and most importantly sodium

to restore the blood's sensitive pH balance. Sodium bicarbonatealso has the effect of increasing the

which in turn increases the elimination of salicylate.

Additionally, hemodialysis can be implemented to enhance the removal of salicylatefrom the blood.

is usually used in severely poisoned patients; for example, patients with significantly high salicylate

significant neurotoxicity (agitation, coma, and convulsions), renal failure, pulmonary edema, or cardi

instability. Hemodialysis also has the advantage of restoring electrolyte and acid-base abnormalities,

plays life-saving roles in severely ill patients.

All overdose patients should be conveyed to a hospital for assessment immediately. Initial treatment

overdose includes gastric decontamination. This is achieved by administering activated charcoal whic

aspirinin the gastrointestinal tract. Repeated doses of charcoal have been proposed to be beneficial i

overdose. A study performed found that repeating doses of charcoal might not be of significant value

most toxicologists will administer additional charcoal if serum salicylatelevels are increasing.


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Stomach pumps are no longer routinely used in the treatment of poisonings but are sometimes consi

patient has ingested a potentially lethal amount within one hour beforehand.

IIbbuupprrooffeenn PPooiissoonniinngg

Basics, Infos & Experiences on Ibuprofen Poisoning Thread

Therapy is largely symptomatic. In cases presenting early, gastric decontamination is recommended.

achieved using activated charcoal to absorb the drug before it can enter the systemic circulation. Ga

now rarely used, but can be considered if the amount ingested is potentially life threatening and it ca

performed within 60 minutes of ingestion.

Emesis is not recommended. The majority of ibuprofeningestions produce only mild effects and the

of overdose is straightforward. Standard measures to maintain normal urine output should be institu

function monitored. Since ibuprofenhas acidic properties and is also excreted in the urine, forced alk

is theoretically beneficial. However, due to the fact ibuprofenis highly protein-bound in the blood, th

renal excretion of unchanged drug. Forced alkaline diuresis is therefore of limited benefit.

Symptomatic therapy for hypotension, GI bleeding, acidosis, and renal toxicity may be indicated. Oc

close monitoring in an intensive care unit for several days is necessary. If a patient survives the acut

he/she will usually experience no late sequelae.

AAnnyy ffeeeeddbbaacckk oonn aannyytthhiinngg ppoosstteedd aabboovvee,, oorr iinnffoorrmmaattiioonn,, cchhaannggeess,, lliinnkkss,, mmaannuuaallss,, aanndd ccrriittiicciiss

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uusseeffuull aanndd tthhee iinnffoorrmmaattiioonn llaaiidd oouutt iinn aa cclleeaarr aanndd ccoonncciissee mmaannnneerr..

WWhheenn ppeerrffoorrmmiinngg CCoolldd WWaatteerr EExxttrraaccttiioonnss,, pplleeaassee bbee ccaarreeffuull!! BBeesstt ooff lluucckk ttoo yyoouu aallll!!

Contributors: Joben, AAllffaa, salviablue , csharpprogrammer, 0utrider Created by AAllffaa, 27-

Last edited by salviablue , 21-

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