colchicine the autumn crocus. structure c 22 h 25 no 6 c h no c 22 h 25 no 6 c h no
TRANSCRIPT
![Page 1: Colchicine The Autumn Crocus. Structure C 22 H 25 NO 6 C H NO C 22 H 25 NO 6 C H NO](https://reader035.vdocuments.site/reader035/viewer/2022070403/56649f2b5503460f94c45372/html5/thumbnails/1.jpg)
Colchicine
The Autumn Crocus
![Page 2: Colchicine The Autumn Crocus. Structure C 22 H 25 NO 6 C H NO C 22 H 25 NO 6 C H NO](https://reader035.vdocuments.site/reader035/viewer/2022070403/56649f2b5503460f94c45372/html5/thumbnails/2.jpg)
Structure
C22H25NO6C22H25NO6
![Page 3: Colchicine The Autumn Crocus. Structure C 22 H 25 NO 6 C H NO C 22 H 25 NO 6 C H NO](https://reader035.vdocuments.site/reader035/viewer/2022070403/56649f2b5503460f94c45372/html5/thumbnails/3.jpg)
Uses
Positive-Is an anti-inflammatory drugTreats goutPoisons cancer cells, but also poisons healthy cellsUsed “off-label” in Great Brittan and is used to
treat other things along with back painAlso treats familial Mediterranean fever and
Behçet’s disease.
Positive-Is an anti-inflammatory drugTreats goutPoisons cancer cells, but also poisons healthy cellsUsed “off-label” in Great Brittan and is used to
treat other things along with back painAlso treats familial Mediterranean fever and
Behçet’s disease.
![Page 4: Colchicine The Autumn Crocus. Structure C 22 H 25 NO 6 C H NO C 22 H 25 NO 6 C H NO](https://reader035.vdocuments.site/reader035/viewer/2022070403/56649f2b5503460f94c45372/html5/thumbnails/4.jpg)
UsesNegative-
Causes stomach upsetHigh doses can damage bone marrow, lead to hair
lose and anemiaCan cause peripheral nerve damage
Negative-Causes stomach upsetHigh doses can damage bone marrow, lead to hair
lose and anemiaCan cause peripheral nerve damage
Toxin-Poisoning is similar to arsenic poisoning. Symptoms begin 2-5 hours after toxic dose is
administered.There is no antidote but there are treatments.
Toxin-Poisoning is similar to arsenic poisoning. Symptoms begin 2-5 hours after toxic dose is
administered.There is no antidote but there are treatments.
![Page 5: Colchicine The Autumn Crocus. Structure C 22 H 25 NO 6 C H NO C 22 H 25 NO 6 C H NO](https://reader035.vdocuments.site/reader035/viewer/2022070403/56649f2b5503460f94c45372/html5/thumbnails/5.jpg)
Synthesis
Can be biosynthesized Involves the amino acids phenylalanine and
tyrosine In the end you have to add acetyl-Coenzyme A
to deacetylcolchicine to get colchicine
Can be biosynthesized Involves the amino acids phenylalanine and
tyrosine In the end you have to add acetyl-Coenzyme A
to deacetylcolchicine to get colchicine
![Page 6: Colchicine The Autumn Crocus. Structure C 22 H 25 NO 6 C H NO C 22 H 25 NO 6 C H NO](https://reader035.vdocuments.site/reader035/viewer/2022070403/56649f2b5503460f94c45372/html5/thumbnails/6.jpg)
Synthesis con’t.
![Page 7: Colchicine The Autumn Crocus. Structure C 22 H 25 NO 6 C H NO C 22 H 25 NO 6 C H NO](https://reader035.vdocuments.site/reader035/viewer/2022070403/56649f2b5503460f94c45372/html5/thumbnails/7.jpg)
Physical and Chemical Properties
Color Pale yellow but darkens with exposure to light
State Odorless powder or scales
Melting Point 153-157 C
pH In a .5% solution is 5.9
Solubility Soluble in alcohol or chloroform Slightly soluble in ether Insoluble in petroleum ether 1/25 soluble in water
Color Pale yellow but darkens with exposure to light
State Odorless powder or scales
Melting Point 153-157 C
pH In a .5% solution is 5.9
Solubility Soluble in alcohol or chloroform Slightly soluble in ether Insoluble in petroleum ether 1/25 soluble in water
![Page 8: Colchicine The Autumn Crocus. Structure C 22 H 25 NO 6 C H NO C 22 H 25 NO 6 C H NO](https://reader035.vdocuments.site/reader035/viewer/2022070403/56649f2b5503460f94c45372/html5/thumbnails/8.jpg)
Works Cited
http://upload.wikimedia.org/wikipedia/commons/2/2e/Colchicine_structure.png
http://upload.wikimedia.org/wikipedia/commons/3/3b/Colchicine_3D.png
http://en.wikipedia.org/wiki/Colchicine http://upload.wikimedia.org/wikipedia/commons/f/
f0/Colchicinebiogenesis.svg http://www.inchem.org/documents/pims/pharm/
colchic.htm http://healthmad.com/health/the-deadliest-flowers-on-
earth-two/
http://upload.wikimedia.org/wikipedia/commons/2/2e/Colchicine_structure.png
http://upload.wikimedia.org/wikipedia/commons/3/3b/Colchicine_3D.png
http://en.wikipedia.org/wiki/Colchicine http://upload.wikimedia.org/wikipedia/commons/f/
f0/Colchicinebiogenesis.svg http://www.inchem.org/documents/pims/pharm/
colchic.htm http://healthmad.com/health/the-deadliest-flowers-on-
earth-two/