Clinical Translational Research Center:Funding for New Projects

Eric Kleerup

Version 2/17/12

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Clinical Translational Research CenterOperations Committee

Eric Kleerup, Chair

John Adams

Tony Butch

Lin Chang

Michael Irwin

Ron Mitsuyasu

Isidro Salusky

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New Model for UCLA CTRC3-Bed

Inpatient CTRC (RRMC)36 bed-days per monthInpatient scatter supportHigh-risk outpatient visits

23-Hour Outpatient CTRC (CHS)

M-F 1

weekend/monthDietitian & KitchenCommunity Nurse (48

hours/month)

Future continuous inpatient units at

NPI, VA and/or SM-UCLA

Hospital Sleep Center

Continuous Inpatient Unit at Harbor-UCLA

Harbor-UCLA Special Dietary KitchenCommunity (CERP)Nursing, specimen

processing, phlebotomy, dietary, currier,

participant transportation

Clinical Translational Research Laboratory

Group 1 Resources: CTRC Nursing and Nutrition• Research Nursing support (CHS 23-Hour Unit) hourly

nursing based on intensity of subject contact

• Supplemental Research Nursing support (RRMC 6W Inpatient unit)hourly nursing based on intensity of subject contact. Routine (1:4) nursing is included in the Hospital overnight rate

• Nutrition (Research Nutritionist and meals)

• Metabolic diets of different levels of complexity including controlled feeding studies

• Anthropometry measures, bioelectrical impedance analysis, resting energy expenditure by indirect calorimetry, and CPX testing

• Collection, analysis, coding and reporting of dietary intake data

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Group 2 Resources: Inpatient Overnight Stays (RRMC)• Three dedicated beds on 6 West

• Includes basic nursing care

• Current Hospital charge $1557.62/night

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Group 3 Resources: Patient Care Supplied Outside the CTRC• Clinical Translational Research Lab

• Department of Pathology

• Adjacent to CTRC

• Currently 150 common tests for research

• Will source suppliers including the Hospital lab for other tests

• Not for inpatient (RRMC) stays

• Other Ancillary Services purchased from the Hospital

• Inpatient clinical labs, Radiology, Cardiac, PFT etc.

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Group 4 Resources: Other Costs• CTRC Other Costs

• Extensive/off site training of personnel needed for protocol

• Non-CTRC Other Costs

• Pharmacy dispensing and set-up

• Parking

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Model for Transition: Non-Profit Grants Funded 9/1/12-12/31/15

CTSI Grant Year PI Charges

6/1/11-2/29/12 0%

3/1/12-2/28/13 5%

3/1/13-2/28/14 10%

3/1/14-2/28/15 15%

3/1/15-2/29/16 20%

3/1/16-beyond 50%

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CTRC Subsidy Plan:Grants Funded after 1/1/16

CTRC Subsid

yLimits

Prior GCRC Limits

Group 1: CTRC Labor

(Nursing and dietary)

50%$50,000

10% direct cost PI grant

Group 2: Inpatient

Hospital Stays50%

$50,00020% direct cost PI

grant$30,000-60,000

Group 3: Clinical

Translational Research Lab &

Hospital Ancillary

50%$6,000

10% direct cost PI grant

Median $3,000IQR $1,050-

6,000Max $21,500

Group 4: NIH “Other Costs”

Category0% $0

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Model for Transition: New Grants Funded 9/1/12-12/31/15

Duration of GrantFunding Start Date 5 Year 4 Year 3 Year 2 Year 1 Year

9/1/12- 12/31/12 23% 16% 11% 9% 6%

1/1/13- 12/31/13 31% 27% 19% 14% 11%

1/1/14- 12/31/14 39% 36% 32% 23% 16%

1/1/15- 12/31/15 46% 45% 43% 39% 29%

1/1/16-continuing 50% 50% 50% 50% 50%

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Model for Transition:Grants Funded Before 9/1/12

Grant End Date PI Cost from 6/1/11-

End of Grant

CTRCTransition

Funding

CTRC Standard Funding

6/1/11-12/31/11 0% 50% 50%

1/1/12-12/31/12 1% 49% 50%

1/1/13-12/31/13 4% 46% 50%

1/1/14-12/31/14 7% 43% 50%

1/1/15-12/31/15 9% 41% 50%

1/1/16-12/31/16 13% 37% 50%

1/1/17-8/31/17 19% 31% 50%

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Additional SubsidiesNew Investigators–20%

NIH definition, as PI or Co-PI on parent grant

CTSI Translational Research Cluster grants–10%

Funding Limits:Per Project

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Resource Type Limit as Percent of Direct Costs

Absolute $ Limit per Calendar Year

Group 1 (CTRC Labor) 10% $50,000

Group 2 (Inpatient Stay) 20% $50,000

Group 3 (CTRL and Hospital Ancillary)

10% $6,000

Group 4 (NIH “Other Costs”)

0% $0

Direct Cost Limits• Percent of project limits doubled for Oppenheimer

seed grants and CTSI Research Education, Training and Career Development Program (CTSI-ED), R21 (exploratory/developmental) and R03 (if pilot)

• K23 grants may use both salary and research support components to calculate limits

• Program project grants and Clinical Trials consortium grants use the portion of direct costs attributed to the particular project.

• Sub-contracts use the UCLA specific portion

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Annual Review• Utilization/Activity

• Changes in plan, protocol, expectations

• Reports from OSMB/DSMB and IRB renewal

• Review from Nursing and other service providers

• Review from Investigator regarding problems/difficulties

• Recognition of support in publications

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