Clinical ‘Recovery’ by Day 4 vs BaselineNimodipine Ischemic Stroke Neuroprotection Study 1985

Mathew Score (100 = intact)

Baseline Day 4

Time from Onset

Total

Cases

Mathew

> 95

Mathew

> 95

< 6 hrs 25 0 2

< 12 hrs 150 0 2

< 18 hrs 250 0 5

< 24 hrs 373 0 8

< 48 hrs 943 0 15

Treatment Effect by Time of Rx Start

Nimodipine Ischemic Stroke Neuroprotection Study 1985 Mathew Score (100 = intact) Covarient Adjusted Means

Hours to Rx Mean Score Std Err P vs < 18 hr

< 18 69.2 3.6

18-24 49.2 5.4 0.002

24-30 50.9 4.8 0.002

30-36 53.1 4.2 0.004

36-42 55.7 5.8 0.05

42-48 57.0 4.5 0.04

Hrs Onset to Arrival &Neuro Exam NINDS MR/CT Study 1988

Interval # % Cum %

< 1 hrs 14 3.4

< 2 hrs 6 1.5 5.6

< 3 hrs 10 2.4 8.0

< 4 hrs 8 1.9 9.9

< 6 hrs 71 2.7 12.6

< 12 hr 26 5.2 18.9

< 24 hr 74 17.0 36.8

tPA CPMC Cumulative by Month to 10-02

0

5

10

15

20

25

30

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

tPA < 3 hrs Rxd per Month CPMC Aug-2000 to Oct-2002

0

1

2

3

4

1 3 5 7 9 11 13 15 17 19 21 23 25

Acute Stroke Admissions per Month CPMC Aug-2000 to Oct-2002

0

25

50

75

1 3 5 7 9 11 13 15 17 19 21 23 25

Acute Stroke Admissions per Month CPMC Aug-2000 to Oct-2002

0

25

50

75

1 3 5 7 9 11 13 15 17 19 21 23 25

CPMC Consecutive Cases Aug-00/Oct-02Hrs onset to arrival (green) then to tPA (red)

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

S1

0:00

0:28

0:57

1:26

1:55

2:24

2:52

3:21

Series1

Series2