clinical cancer research · web viewset 'prc2 targets': polycomb repression complex 2 (prc)...

48
Supplementary Table 6A. Top 30 pathways Normalized Enrichment Score (NES) False Discovery Rate (FDR) q-value (%) Rank Gene Set Name 147 209 214 284 300 301 Mean NES Score 147 209 214 284 300 301 1 BENPORATH_ES_WITH_H3K27ME3 6.433 5.696 5.460 5.097 6.294 5.239 5.703 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 2 MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 6.632 4.067 6.572 4.840 4.337 4.987 5.239 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 3 BENPORATH_SUZ12_TARGETS 5.444 4.363 5.174 5.336 6.365 4.488 5.195 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 4 BENPORATH_PRC2_TARGETS 4.663 3.522 4.794 4.890 5.058 4.298 4.538 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 5 BENPORATH_EED_TARGETS 4.332 3.684 4.533 4.778 5.199 4.360 4.481 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 6 NABA_MATRISOME 4.814 4.477 4.486 4.199 3.890 3.962 4.305 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 7 MIKKELSEN_MEF_HCP_WITH_H3K27ME3 4.279 4.837 4.784 3.654 3.784 3.878 4.203 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 8 ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 4.495 4.910 4.473 2.973 4.051 3.590 4.082 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 9 MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 4.555 4.522 4.219 3.074 3.770 4.071 4.035 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 10 MARTENS_TRETINOIN_RESPONSE_UP 3.870 5.305 4.542 3.323 3.417 2.549 3.834 0.00% 0.00% 0.00% 0.00% 0.00% 0.22% 11 MEISSNER_NPC_HCP_WITH_H3K4ME2 6.256 3.910 4.114 2.109 3.341 2.862 3.766 0.00% 0.00% 0.00% 3.28% 0.00% 0.04% 12 MIKKELSEN_NPC_HCP_WITH_H3K27ME3 3.947 4.117 3.911 3.115 3.444 4.022 3.759 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 13 NABA_MATRISOME_ASSOCIATED 4.442 4.024 3.520 3.724 3.113 3.225 3.675 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 14 MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 3.974 3.281 3.843 3.225 3.046 3.574 3.490 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 15 MEISSNER_BRAIN_HCP_WITH_H3K27ME3 3.858 4.222 3.406 3.366 2.847 2.984 3.447 0.00% 0.00% 0.00% 0.00% 0.00% 0.06% 16 LIM_MAMMARY_STEM_CELL_UP 4.560 2.995 3.514 3.327 2.232 3.451 3.347 0.00% 0.00% 0.00% 0.00% 2.75% 0.00% 17 MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 3.777 3.704 3.737 3.670 2.753 2.079 3.287 0.00% 0.00% 0.00% 0.00% 0.04% 4.34% 18 NABA_SECRETED_FACTORS 3.378 3.431 2.596 3.031 2.436 2.461 2.889 0.00% 0.00% 0.21% 0.00% 0.82% 0.63% 19 DODD_NASOPHARYNGEAL_CARCINOMA_UP 3.857 1.843 2.905 2.182 3.832 2.558 2.863 0.00% 13.07% 0.00% 2.41% 0.00% 0.23% 20 MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 2.561 2.362 3.647 2.840 2.779 2.540 2.788 0.14% 1.13% 0.00% 0.00% 0.00% 0.28% 21 PEREZ_TP63_TARGETS 3.000 1.821 3.813 2.458 2.961 2.639 2.782 0.00% 13.94% 0.00% 0.65% 0.00% 0.21% 22 NABA_CORE_MATRISOME 2.342 2.583 2.913 3.179 2.835 2.720 2.762 0.63% 0.28% 0.00% 0.00% 0.00% 0.19% 23 REACTOME_GPCR_LIGAND_BINDING 3.523 2.626 3.077 2.967 2.156 2.148 2.750 0.00% 0.29% 0.00% 0.00% 3.57% 3.26% 24 GOZGIT_ESR1_TARGETS_DN 4.057 1.014 2.313 3.541 2.921 2.523 2.728 0.00% 78.56% 1.10% 0.00% 0.00% 0.29% 25 PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 3.079 2.215 2.832 2.262 2.965 2.481 2.639 0.00% 2.78% 0.02% 1.68% 0.00% 0.53% 26 WANG_MLL_TARGETS 2.948 2.639 3.224 2.241 2.447 2.007 2.584 0.00% 0.30% 0.00% 1.81% 0.88% 5.68% 27 PEREZ_TP53_TARGETS 2.532 2.973 4.017 1.903 1.403 2.421 2.542 0.18% 0.00% 0.00% 7.59% 39.39% 0.80% 28 WANG_SMARCE1_TARGETS_UP 2.771 1.859 2.404 2.844 2.309 2.394 2.430 0.01% 12.81% 0.65% 0.00% 1.85% 0.85% 29 LEE_BMP2_TARGETS_UP 2.983 2.396 2.272 2.418 2.186 2.198 2.409 0.00% 0.97% 1.22% 0.85% 3.27% 2.43% 30 PLASARI_TGFB1_TARGETS_10HR_UP 3.238 2.505 2.766 2.427 1.649 1.864 2.408 0.00% 0.41% 0.02% 0.80% 23.34% 9.41% Supplementary Table 6B. Pathway descriptions Rank Gene Set Name Brief Description URL 5 BENPORATH_EED_TARGETS Set 'Eed targets': genes identified by ChIP on chip as targets of the Polycomb protein EED [GeneID=8726] in human embryonic stem cells. http://software.broadinstitute.org/gsea/msigdb/cards/BENPORATH_EED_TARGETS.html 1 BENPORATH_ES_WITH_H3K27ME3 Set 'H3K27 bound': genes posessing the trimethylated H3K27 (H3K27me3) mark in their promoters in human embryonic stem cells, as identified by ChIP on chip. http://software.broadinstitute.org/gsea/msigdb/cards/BENPORATH_ES_WITH_H3K27ME3.html 4 BENPORATH_PRC2_TARGETS Set 'PRC2 targets': Polycomb Repression Complex 2 (PRC) targets; identified by ChIP on chip on human embryonic stem cells as genes that: posess the trimethylated H3K27 mark in their promoters and are bound by SUZ12 [GeneID=23512] and EED [GeneID=8726] Polycomb proteins. http://software.broadinstitute.org/gsea/msigdb/cards/BENPORATH_PRC2_TARGETS.html 3 BENPORATH_SUZ12_TARGETS Set 'Suz12 targets': genes identified by ChIP on chip as targets of the Polycomb protein SUZ12 [GeneID=23512] in human embryonic stem cells. http://software.broadinstitute.org/gsea/msigdb/cards/BENPORATH_SUZ12_TARGETS.html 19 DODD_NASOPHARYNGEAL_CARCINOMA_UP Genes up-regulated in nasopharyngeal carcinoma (NPC) compared to the normal tissue. http://software.broadinstitute.org/gsea/msigdb/cards/ DODD_NASOPHARYNGEAL_CARCINOMA_UP.html 24 GOZGIT_ESR1_TARGETS_DN Genes down-regulated in TMX2-28 cells (breast cancer) which do not express ESR1 [GeneID=2099]) compared to the parental MCF7 cells which do http://software.broadinstitute.org/gsea/msigdb/cards/GOZGIT_ESR1_TARGETS_DN.html 29 LEE_BMP2_TARGETS_UP Genes up-regulated in uterus upon knockout of BMP2 [GeneID=650]. http://software.broadinstitute.org/gsea/msigdb/cards/LEE_BMP2_TARGETS_UP.html 16 LIM_MAMMARY_STEM_CELL_UP Genes consistently up-regulated in mammary stem cells both in mouse and human species. http://software.broadinstitute.org/gsea/msigdb/cards/LIM_MAMMARY_STEM_CELL_UP.html 10 MARTENS_TRETINOIN_RESPONSE_UP Genes up-regulated in NB4 cells (acute promyelocytic leukemia, APL) in response to tretinoin [PubChem=444795]; based on Chip-seq data. http://software.broadinstitute.org/gsea/msigdb/cards/MARTENS_TRETINOIN_RESPONSE_UP.html 15 MEISSNER_BRAIN_HCP_WITH_H3K27ME3 Genes with high-CpG-density promoters (HCP) bearing the H3K27 tri-methylation (H3K27me3) mark in brain. http://software.broadinstitute.org/gsea/msigdb/cards/ MEISSNER_BRAIN_HCP_WITH_H3K27ME3.html 2 MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 Genes with high-CpG-density promoters (HCP) bearing histone H3 dimethylation at K4 (H3K4me2) and trimethylation at K27 (H3K27me3) in brain. http://software.broadinstitute.org/gsea/msigdb/cards/ MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3.html 17 MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED Genes with high-CpG-density promoters (HCP) that have no histone H3 methylation marks in neural precursor cells (NPC). http://software.broadinstitute.org/gsea/msigdb/cards/ MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED.html 11 MEISSNER_NPC_HCP_WITH_H3K4ME2 Genes with high-CpG-density promoters (HCP) bearing histone H3 dimethylation mark at K4 (H3K4me2) in neural precursor cells (NPC). http://software.broadinstitute.org/gsea/msigdb/cards/MEISSNER_NPC_HCP_WITH_H3K4ME2.html 14 MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 Genes with high-CpG-density promoters (HCP) bearing histone H3 dimethylation mark at K4 (H3K4me2) and trimethylation mark at K27 (H3K27me3) in neural precursor cells (NPC). http://software.broadinstitute.org/gsea/msigdb/cards/ MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3.html 9 MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 Genes with high-CpG-density promoters (HCP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MCV6 cells (embryonic fibroblasts trapped in a differentiated state). http://software.broadinstitute.org/gsea/msigdb/cards/ MIKKELSEN_MCV6_HCP_WITH_H3K27ME3.html 7 MIKKELSEN_MEF_HCP_WITH_H3K27ME3 Genes with high-CpG-density promoters (HCP) bearing histone H3 trimethylation mark at K27 (H3K27me3) in MEF cells (embryonic fibroblast) http://software.broadinstitute.org/gsea/msigdb/cards/MIKKELSEN_MEF_HCP_WITH_H3K27ME3.html 12 MIKKELSEN_NPC_HCP_WITH_H3K27ME3 Genes with high-CpG-density promoters (HCP) bearing histone H3 trimethylation mark at K27 (H3K27me3) in neural progenitor cells (NPC). http://software.broadinstitute.org/gsea/msigdb/cards/MIKKELSEN_NPC_HCP_WITH_H3K27ME3.html 20 MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 Genes with high-CpG-density promoters (HCP) bearing the bivalent histone H3 trimethylation mark at K4 and K27 (H3K4me3 and H3K27me3) in neural progenitor cells (NPC) http://software.broadinstitute.org/gsea/msigdb/cards/ MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3.html 22 NABA_CORE_MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans http://software.broadinstitute.org/gsea/msigdb/cards/NABA_CORE_MATRISOME.html 6 NABA_MATRISOME Ensemble of genes encoding extracellular matrix and extracellular matrix- associated proteins http://software.broadinstitute.org/gsea/msigdb/cards/NABA_MATRISOME.html 13 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors http://software.broadinstitute.org/gsea/msigdb/cards/NABA_MATRISOME_ASSOCIATED.html 18 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors http://software.broadinstitute.org/gsea/msigdb/cards/NABA_SECRETED_FACTORS.html 27 PEREZ_TP53_TARGETS Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of TP53 [GeneID=7157] off adenoviral vector. http://software.broadinstitute.org/gsea/msigdb/cards/PEREZ_TP53_TARGETS.html 21 PEREZ_TP63_TARGETS Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of the transcriptionally active isoform of TP63 [GeneID=8626] off adenoviral vector http://software.broadinstitute.org/gsea/msigdb/cards/PEREZ_TP63_TARGETS.html 25 PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. http://software.broadinstitute.org/gsea/msigdb/cards/ PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP.html 30 PLASARI_TGFB1_TARGETS_10HR_UP Genes up-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h. http://software.broadinstitute.org/gsea/msigdb/cards/PLASARI_TGFB1_TARGETS_10HR_UP.html 23 REACTOME_GPCR_LIGAND_BINDING GPCR ligand binding http://software.broadinstitute.org/gsea/msigdb/cards/REACTOME_GPCR_LIGAND_BINDING.html 26 WANG_MLL_TARGETS Genes requiring MLL [GeneID=4297] for H3K4me3 and expression in MEF cells (embryonic fibroblast). http://software.broadinstitute.org/gsea/msigdb/cards/WANG_MLL_TARGETS.html 28 WANG_SMARCE1_TARGETS_UP Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. http://software.broadinstitute.org/gsea/msigdb/cards/WANG_SMARCE1_TARGETS_UP.html 8 ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY Genes transiently induced only by the second pulse of EGF [GeneID=1950] in 184A1 cells (mammary epithelium). http://software.broadinstitute.org/gsea/msigdb/cards/ ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY.html Supplementary Table 6C. 25% FDR Statistics Case 147 209 214 284 300 301

Upload: others

Post on 20-Feb-2021

1 views

Category:

Documents


0 download

TRANSCRIPT

Supplementary Table 6A. Top 30 pathways

Normalized Enrichment Score (NES)

False Discovery Rate (FDR) q-value (%)

Rank

Gene Set Name

147

209

214

284

300

301

Mean NES Score

147

209

214

284

300

301

1

BENPORATH_ES_WITH_H3K27ME3

6.433

5.696

5.460

5.097

6.294

5.239

5.703

0.00%

0.00%

0.00%

0.00%

0.00%

0.00%

2

MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3

6.632

4.067

6.572

4.840

4.337

4.987

5.239

0.00%

0.00%

0.00%

0.00%

0.00%

0.00%

3

BENPORATH_SUZ12_TARGETS

5.444

4.363

5.174

5.336

6.365

4.488

5.195

0.00%

0.00%

0.00%

0.00%

0.00%

0.00%

4

BENPORATH_PRC2_TARGETS

4.663

3.522

4.794

4.890

5.058

4.298

4.538

0.00%

0.00%

0.00%

0.00%

0.00%

0.00%

5

BENPORATH_EED_TARGETS

4.332

3.684

4.533

4.778

5.199

4.360

4.481

0.00%

0.00%

0.00%

0.00%

0.00%

0.00%

6

NABA_MATRISOME

4.814

4.477

4.486

4.199

3.890

3.962

4.305

0.00%

0.00%

0.00%

0.00%

0.00%

0.00%

7

MIKKELSEN_MEF_HCP_WITH_H3K27ME3

4.279

4.837

4.784

3.654

3.784

3.878

4.203

0.00%

0.00%

0.00%

0.00%

0.00%

0.00%

8

ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY

4.495

4.910

4.473

2.973

4.051

3.590

4.082

0.00%

0.00%

0.00%

0.00%

0.00%

0.00%

9

MIKKELSEN_MCV6_HCP_WITH_H3K27ME3

4.555

4.522

4.219

3.074

3.770

4.071

4.035

0.00%

0.00%

0.00%

0.00%

0.00%

0.00%

10

MARTENS_TRETINOIN_RESPONSE_UP

3.870

5.305

4.542

3.323

3.417

2.549

3.834

0.00%

0.00%

0.00%

0.00%

0.00%

0.22%

11

MEISSNER_NPC_HCP_WITH_H3K4ME2

6.256

3.910

4.114

2.109

3.341

2.862

3.766

0.00%

0.00%

0.00%

3.28%

0.00%

0.04%

12

MIKKELSEN_NPC_HCP_WITH_H3K27ME3

3.947

4.117

3.911

3.115

3.444

4.022

3.759

0.00%

0.00%

0.00%

0.00%

0.00%

0.00%

13

NABA_MATRISOME_ASSOCIATED

4.442

4.024

3.520

3.724

3.113

3.225

3.675

0.00%

0.00%

0.00%

0.00%

0.00%

0.00%

14

MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3

3.974

3.281

3.843

3.225

3.046

3.574

3.490

0.00%

0.00%

0.00%

0.00%

0.00%

0.00%

15

MEISSNER_BRAIN_HCP_WITH_H3K27ME3

3.858

4.222

3.406

3.366

2.847

2.984

3.447

0.00%

0.00%

0.00%

0.00%

0.00%

0.06%

16

LIM_MAMMARY_STEM_CELL_UP

4.560

2.995

3.514

3.327

2.232

3.451

3.347

0.00%

0.00%

0.00%

0.00%

2.75%

0.00%

17

MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED

3.777

3.704

3.737

3.670

2.753

2.079

3.287

0.00%

0.00%

0.00%

0.00%

0.04%

4.34%

18

NABA_SECRETED_FACTORS

3.378

3.431

2.596

3.031

2.436

2.461

2.889

0.00%

0.00%

0.21%

0.00%

0.82%

0.63%

19

DODD_NASOPHARYNGEAL_CARCINOMA_UP

3.857

1.843

2.905

2.182

3.832

2.558

2.863

0.00%

13.07%

0.00%

2.41%

0.00%

0.23%

20

MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3

2.561

2.362

3.647

2.840

2.779

2.540

2.788

0.14%

1.13%

0.00%

0.00%

0.00%

0.28%

21

PEREZ_TP63_TARGETS

3.000

1.821

3.813

2.458

2.961

2.639

2.782

0.00%

13.94%

0.00%

0.65%

0.00%

0.21%

22

NABA_CORE_MATRISOME

2.342

2.583

2.913

3.179

2.835

2.720

2.762

0.63%

0.28%

0.00%

0.00%

0.00%

0.19%

23

REACTOME_GPCR_LIGAND_BINDING

3.523

2.626

3.077

2.967

2.156

2.148

2.750

0.00%

0.29%

0.00%

0.00%

3.57%

3.26%

24

GOZGIT_ESR1_TARGETS_DN

4.057

1.014

2.313

3.541

2.921

2.523

2.728

0.00%

78.56%

1.10%

0.00%

0.00%

0.29%

25

PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP

3.079

2.215

2.832

2.262

2.965

2.481

2.639

0.00%

2.78%

0.02%

1.68%

0.00%

0.53%

26

WANG_MLL_TARGETS

2.948

2.639

3.224

2.241

2.447

2.007

2.584

0.00%

0.30%

0.00%

1.81%

0.88%

5.68%

27

PEREZ_TP53_TARGETS

2.532

2.973

4.017

1.903

1.403

2.421

2.542

0.18%

0.00%

0.00%

7.59%

39.39%

0.80%

28

WANG_SMARCE1_TARGETS_UP

2.771

1.859

2.404

2.844

2.309

2.394

2.430

0.01%

12.81%

0.65%

0.00%

1.85%

0.85%

29

LEE_BMP2_TARGETS_UP

2.983

2.396

2.272

2.418

2.186

2.198

2.409

0.00%

0.97%

1.22%

0.85%

3.27%

2.43%

30

PLASARI_TGFB1_TARGETS_10HR_UP

3.238

2.505

2.766

2.427

1.649

1.864

2.408

0.00%

0.41%

0.02%

0.80%

23.34%

9.41%

Supplementary Table 6B. Pathway descriptions

Rank

Gene Set Name

Brief Description

URL

5

BENPORATH_EED_TARGETS

Set 'Eed targets': genes identified by ChIP on chip as targets of the Polycomb protein EED [GeneID=8726] in human embryonic stem cells.

http://software.broadinstitute.org/gsea/msigdb/cards/BENPORATH_EED_TARGETS.html

1

BENPORATH_ES_WITH_H3K27ME3

Set 'H3K27 bound': genes posessing the trimethylated H3K27 (H3K27me3) mark in their promoters in human embryonic stem cells, as identified by ChIP on chip.

http://software.broadinstitute.org/gsea/msigdb/cards/BENPORATH_ES_WITH_H3K27ME3.html

4

BENPORATH_PRC2_TARGETS

Set 'PRC2 targets': Polycomb Repression Complex 2 (PRC) targets; identified by ChIP on chip on human embryonic stem cells as genes that: posess the trimethylated H3K27 mark in their promoters and are bound by SUZ12 [GeneID=23512] and EED [GeneID=8726] Polycomb proteins.

http://software.broadinstitute.org/gsea/msigdb/cards/BENPORATH_PRC2_TARGETS.html

3

BENPORATH_SUZ12_TARGETS

Set 'Suz12 targets': genes identified by ChIP on chip as targets of the Polycomb protein SUZ12 [GeneID=23512] in human embryonic stem cells.

http://software.broadinstitute.org/gsea/msigdb/cards/BENPORATH_SUZ12_TARGETS.html

19

DODD_NASOPHARYNGEAL_CARCINOMA_UP

Genes up-regulated in nasopharyngeal carcinoma (NPC) compared to the normal tissue.

http://software.broadinstitute.org/gsea/msigdb/cards/DODD_NASOPHARYNGEAL_CARCINOMA_UP.html

24

GOZGIT_ESR1_TARGETS_DN

Genes down-regulated in TMX2-28 cells (breast cancer) which do not express ESR1 [GeneID=2099]) compared to the parental MCF7 cells which do

http://software.broadinstitute.org/gsea/msigdb/cards/GOZGIT_ESR1_TARGETS_DN.html

29

LEE_BMP2_TARGETS_UP

Genes up-regulated in uterus upon knockout of BMP2 [GeneID=650].

http://software.broadinstitute.org/gsea/msigdb/cards/LEE_BMP2_TARGETS_UP.html

16

LIM_MAMMARY_STEM_CELL_UP

Genes consistently up-regulated in mammary stem cells both in mouse and human species.

http://software.broadinstitute.org/gsea/msigdb/cards/LIM_MAMMARY_STEM_CELL_UP.html

10

MARTENS_TRETINOIN_RESPONSE_UP

Genes up-regulated in NB4 cells (acute promyelocytic leukemia, APL) in response to tretinoin [PubChem=444795]; based on Chip-seq data.

http://software.broadinstitute.org/gsea/msigdb/cards/MARTENS_TRETINOIN_RESPONSE_UP.html

15

MEISSNER_BRAIN_HCP_WITH_H3K27ME3

Genes with high-CpG-density promoters (HCP) bearing the H3K27 tri-methylation (H3K27me3) mark in brain.

http://software.broadinstitute.org/gsea/msigdb/cards/MEISSNER_BRAIN_HCP_WITH_H3K27ME3.html

2

MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3

Genes with high-CpG-density promoters (HCP) bearing histone H3 dimethylation at K4 (H3K4me2) and trimethylation at K27 (H3K27me3) in brain.

http://software.broadinstitute.org/gsea/msigdb/cards/MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3.html

17

MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED

Genes with high-CpG-density promoters (HCP) that have no histone H3 methylation marks in neural precursor cells (NPC).

http://software.broadinstitute.org/gsea/msigdb/cards/MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED.html

11

MEISSNER_NPC_HCP_WITH_H3K4ME2

Genes with high-CpG-density promoters (HCP) bearing histone H3 dimethylation mark at K4 (H3K4me2) in neural precursor cells (NPC).

http://software.broadinstitute.org/gsea/msigdb/cards/MEISSNER_NPC_HCP_WITH_H3K4ME2.html

14

MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3

Genes with high-CpG-density promoters (HCP) bearing histone H3 dimethylation mark at K4 (H3K4me2) and trimethylation mark at K27 (H3K27me3) in neural precursor cells (NPC).

http://software.broadinstitute.org/gsea/msigdb/cards/MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3.html

9

MIKKELSEN_MCV6_HCP_WITH_H3K27ME3

Genes with high-CpG-density promoters (HCP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MCV6 cells (embryonic fibroblasts trapped in a differentiated state).

http://software.broadinstitute.org/gsea/msigdb/cards/MIKKELSEN_MCV6_HCP_WITH_H3K27ME3.html

7

MIKKELSEN_MEF_HCP_WITH_H3K27ME3

Genes with high-CpG-density promoters (HCP) bearing histone H3 trimethylation mark at K27 (H3K27me3) in MEF cells (embryonic fibroblast)

http://software.broadinstitute.org/gsea/msigdb/cards/MIKKELSEN_MEF_HCP_WITH_H3K27ME3.html

12

MIKKELSEN_NPC_HCP_WITH_H3K27ME3

Genes with high-CpG-density promoters (HCP) bearing histone H3 trimethylation mark at K27 (H3K27me3) in neural progenitor cells (NPC).

http://software.broadinstitute.org/gsea/msigdb/cards/MIKKELSEN_NPC_HCP_WITH_H3K27ME3.html

20

MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3

Genes with high-CpG-density promoters (HCP) bearing the bivalent histone H3 trimethylation mark at K4 and K27 (H3K4me3 and H3K27me3) in neural progenitor cells (NPC)

http://software.broadinstitute.org/gsea/msigdb/cards/MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3.html

22

NABA_CORE_MATRISOME

Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans

http://software.broadinstitute.org/gsea/msigdb/cards/NABA_CORE_MATRISOME.html

6

NABA_MATRISOME

Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins

http://software.broadinstitute.org/gsea/msigdb/cards/NABA_MATRISOME.html

13

NABA_MATRISOME_ASSOCIATED

Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

http://software.broadinstitute.org/gsea/msigdb/cards/NABA_MATRISOME_ASSOCIATED.html

18

NABA_SECRETED_FACTORS

Genes encoding secreted soluble factors

http://software.broadinstitute.org/gsea/msigdb/cards/NABA_SECRETED_FACTORS.html

27

PEREZ_TP53_TARGETS

Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of TP53 [GeneID=7157] off adenoviral vector.

http://software.broadinstitute.org/gsea/msigdb/cards/PEREZ_TP53_TARGETS.html

21

PEREZ_TP63_TARGETS

Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of the transcriptionally active isoform of TP63 [GeneID=8626] off adenoviral vector

http://software.broadinstitute.org/gsea/msigdb/cards/PEREZ_TP63_TARGETS.html

25

PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP

Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes.

http://software.broadinstitute.org/gsea/msigdb/cards/PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP.html

30

PLASARI_TGFB1_TARGETS_10HR_UP

Genes up-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h.

http://software.broadinstitute.org/gsea/msigdb/cards/PLASARI_TGFB1_TARGETS_10HR_UP.html

23

REACTOME_GPCR_LIGAND_BINDING

GPCR ligand binding

http://software.broadinstitute.org/gsea/msigdb/cards/REACTOME_GPCR_LIGAND_BINDING.html

26

WANG_MLL_TARGETS

Genes requiring MLL [GeneID=4297] for H3K4me3 and expression in MEF cells (embryonic fibroblast).

http://software.broadinstitute.org/gsea/msigdb/cards/WANG_MLL_TARGETS.html

28

WANG_SMARCE1_TARGETS_UP

Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector.

http://software.broadinstitute.org/gsea/msigdb/cards/WANG_SMARCE1_TARGETS_UP.html

8

ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY

Genes transiently induced only by the second pulse of EGF [GeneID=1950] in 184A1 cells (mammary epithelium).

http://software.broadinstitute.org/gsea/msigdb/cards/ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY.html

Supplementary Table 6C. 25% FDR Statistics

Case

147

209

214

284

300

301

Number of gene sets significant at FDR < 25%

760

157

586

530

261

364

Total number of gene sets used in GSEA analysis

3991

3677

3911

3912

3741

3682

%

19.0%

4.3%

15.0%

13.5%

7.0%

9.9%

Supplementary Table 6D. Gene sets overlaps.

Supplementary Table 6E. Gene rank lists.

Case

Rank (epigenetically most activated to least activated)

147

209

214

284

300

301

Combined gene rank list of all 6 cases

1

NCAM1

NKD2

RABGEF1

PBX2

PRAME

POLR3GL

PRAME

2

ZBTB16

CBFA2T3

ELANE

ETV5

SH3PXD2B

C11orf71

PBX2

3

ADCY5

COL5A1

C1QC

RAMP1

HOXC4

SLC8A3

NCAM1

4

NGFR

CACNA1H

EGR1

CABLES1

FAM72B

COL13A1

NKD2

5

ILDR2

LGR6

ALPL

RASD1

GPR153

ANTXR2

RABGEF1

6

FAM167A

LAMA5

SEMA3F

SALL4

TRPM4

NOG

ZBTB16

7

S1PR5

TRIM6-TRIM34

SLC46A1

ZC3H12C

BRINP2

NRP1

ADCY5

8

TBX21

FLRT1

CPAMD8

SV2A

NOTCH3

KIAA1217

CBFA2T3

9

SHE

MFI2

ARHGEF10

LAMA3

MT2A

HMCN1

COL5A1

10

ADAMTS1

FAM58A

OTUD7B

SMOC1

FAM53B

CCDC113

NGFR

11

GPRIN3

KIF26B

KCNN1

LRRC3B

EHD3

TRIM6-TRIM34

ILDR2

12

MAL

PNPLA7

HIC1

CXorf21

EPSTI1

NPR3

CACNA1H

13

TBXA2R

KIF26A

TNF

MPO

FAM20C

PTPRU

LGR6

14

EEF1A2

FBN3

GADD45G

KCNJ2

C1orf53

BTBD8

LAMA5

15

ARHGEF3

ATP5L2

DACT3

CHSY1

RASD2

OSR2

FAM167A

16

SALL1

DLGAP3

F2RL3

MCAM

DGKG

PLCL1

FLRT1

17

MET

ADAMTS10

SPEF2

GAD1

ASGR2

IL11

MFI2

18

APBB1

ADARB2

ADRB1

TMEM136

CSPG4

GUCY1B3

S1PR5

19

BMF

SHANK1

RAMP1

ZBTB7C

IL13RA1

MEST

TBX21

20

AFAP1L1

MYO7A

PRR24

PLVAP

CACNB2

FAM72D

SHE

21

TTC9

GFRA1

MGAT5B

COL1A1

GALNT10

ITGB5

ADAMTS1

22

TOX

SV2A

TINAGL1

BARX2

TNFRSF21

SRGAP1

ETV5

23

SLC26A11

FAM57B

TRIB3

SLC5A3

DDN

PKDCC

TRIM6-TRIM34

24

SEMA4C

RASAL1

PANX2

COL11A2

EMID1

HMGA2

RAMP1

25

OTUD7B

SH3RF3

PRAME

NSUN7

PLEKHH2

NHSL2

GPRIN3

26

UBASH3B

KIF1A

FXYD7

MGAT5B

IRAK3

TLL2

POLR3GL

27

CSF1

ADAMTSL2

BRD2

POU4F1

PI16

ZNF471

MAL

28

P2RX5

DPEP1

GALNT9

GPR176

PRKCA

SLIT2

TBXA2R

29

PRKCQ

DLGAP2

GJC1

SSTR2

CXCR3

GDF6

CABLES1

30

CAMK4

BLNK

TNFRSF6B

FLT1

SYNJ2

KCNK12

EEF1A2

31

GPR68

HTRA3

MAK

ARHGAP29

AGPAT9

STAC2

AFAP1L1

32

CYTH4

SYT15

CXCL12

APBA1

GPR176

MKX

RASD1

33

B4GALNT4

TNFRSF18

ANO1

CDS1

RGMB

TCTE1

SH3PXD2B

34

UBXN10

RAI1

CRABP2

ACSL1

SARM1

BMPR1B

ARHGEF3

35

SNX9

C1orf159

LNP1

C19orf59

SRGAP3

ZIC2

KIF26B

36

SLFN5

ARHGEF4

DMWD

PRRT2

PPFIBP2

GDF10

HOXC4

37

PRDM15

RADIL

KCNA5

RAB40B

VCAN

PRDM8

SALL1

38

PRDM1

ABLIM2

OLFM2

QSOX2

ASB16

MRPL30

SV2A

39

MARCH9

PDE9A

KCNJ2

ID3

SLFN5

VAV3

MET

40

PRSS23

MGAT5B

GLCE

ITGA11

VDR

HECW2

FAM58A

41

PLEKHF1

ASB16

TRIM6-TRIM34

HVCN1

CD109

ARHGAP29

APBB1

42

COL24A1

SYT5

PLEC

MYB

ZNF584

RORB

BMF

43

HPSE

MFAP2

SERPINE1

THSD7A

NBEA

DNAH3

TTC9

44

KCNA3

PITPNM2

PHF16

SOX11

PTPRF

C16orf52

SEMA4C

45

TFEB

FOXO6

ABHD8

APOLD1

ZNF788

PRKG1

FAM72B

46

MCAM

CASKIN1

JUND

GTF2H4

UPK3B

ZNHIT3

KIF26A

47

SYTL3

CHTF18

SNX33

SMAD3

AR

HTR7

UBXN10

48

PKDCC

LRRC4B

KIF26A

FAM3C

IRAK1BP1

WNT9A

PNPLA7

49

AMIGO2

PFKL

SMAD6

BMP3

RAMP1

PDGFB

ATP5L2

50

DUSP8

FBLN7

INHBB

FAM159A

TMEM67

NTRK2

FBN3

51

GIMAP6

IQCE

PTPRG

ST8SIA5

ANKH

NRCAM

TOX

52

SPON2

TRABD

CDHR1

SECTM1

PLVAP

EGR3

ADARB2

53

ITGB3

DPYSL4

FGF18

PDE9A

PRAM1

GAD2

SALL4

54

ADAMTS10

FAM69B

CCDC74A

SLC44A3

S1PR5

KCNJ5

ZC3H12C

55

PVRL3

GPSM1

HEY1

LRRC32

SYCE2

DGKG

ADAMTS10

56

ARL4C

WNK2

ASPHD1

KIT

SECTM1

NDRG4

SHANK1

57

NPY

PTPRN2

KCNK4

RAPGEF4

C17orf51

RAB36

SLC26A11

58

FAM109A

TCERG1L

MAFA

IL3RA

DDX60

LRRC37A3

MYO7A

59

AK7

TIMP3

C21orf128

IVNS1ABP

ZNF175

IGFBP5

HPSE

60

RASSF8

VGF

HSPA1L

TRIM24

RSPH4A

RBPMS

DLGAP3

61

SETBP1

FXYD7

FSTL4

CREM

TMCC3

HDAC9

C11orf71

62

PLA2G16

WDR90

RASD2

BMP2

DOCK4

EPB41L4B

PKDCC

63

BMP2

NEIL1

SOAT2

CHST11

ZHX3

TINAGL1

SMOC1

64

FAM83G

AHNAK2

GJB2

NPTX1

KIAA1614

GPC3

LRRC3B

65

CALHM2

FSTL4

IER2

PRSS57

IFITM5

SEMA6A

GFRA1

66

ISM1

LPPR3

ADORA2A

SPINK2

LHX4

VWA5B2

UBASH3B

67

ABCD2

CACNA1C

UBTD1

SLC2A5

ZNF23

SPRY4

CSF1

68

MFNG

KCNJ12

KCNH3

RAB3B

FRMD5

MYO7A

P2RX5

69

THBS1

TNK2

TMEM231

TMEM150B

ZNF429

GPR176

PRKCQ

70

EXOSC4

PLEKHG5

FAM43A

HGF

ZNF280B

HABP4

PLEKHF1

71

COL19A1

KCNJ5

CSF1

PCDH18

SYNC

GFOD1

COL24A1

72

TBC1D2

FLNC

NUMBL

C6orf25

CEBPA

BAALC

CAMK4

73

EOMES

CELSR1

JUNB

CTBP2

SCN1B

CCL3L1

GPR68

74

EPHA4

PCBP3

SYT2

TMEM200A

GOLM1

SARM1

GAD1

75

THBD

C21orf2

MN1

BCL6

PLCB1

TGFB2

CYTH4

76

SMAD6

PALM2

PADI2

INSC

ATP2A1

SDC3

BRINP2

77

IL27RA

MCF2L

ZC3H12C

CSRP2

ZNF778

CHRNA7

TRPM4

78

NMUR1

ECEL1

CEBPE

GZMA

NME9

ATP8B1

RASAL1

79

LDLRAP1

SCN5A

LRRC32

BMP6

SLC6A4

TMEM229B

C1QC

80

DPF3

KNDC1

GADD45B

ATRNL1

PLIN4

AAK1

ZBTB7C

81

NBL1

PQLC2

GAD1

RNF182

RNF144A

MEIS2

NOTCH3

82

SEMA3F

OBSL1

ANKRD11

ARL11

OPN3

FANCM

SNX9

83

CTSL

COL22A1

RARA

NOG

SMPD3

SEZ6

LAMA3

84

FYN

TBC1D16

PIM3

CD9

LTB4R

NRP2

OTUD7B

85

PTPN13

DNAH11

BACE2

ST3GAL1

EEF1A2

C10orf25

SLFN5

86

SLC2A6

FIBCD1

LRRC16B

GADL1

PARD6B

LRP4

SH3RF3

87

BIRC3

MYPOP

SLC35A2

ETNK2

SYTL2

ZNF234

PRDM15

88

SPOCK2

SELO

VASN

NPC1

TNFSF9

FAM98B

CXorf21

89

AMIGO1

TMCC2

CDKN2B

ZNF311

LOXL4

FHOD3

COL11A2

90

MAF

BCL9

TMEM201

RCBTB2

RBPMS

TET1

PRDM1

91

KLF15

CCDC125

MZF1

DACT3

WIPI1

TMEM132B

FAM57B

92

TCF7

LCN6

BGLAP

BTBD11

SLC1A4

POU4F1

MARCH9

93

SIT1

EXD3

FHDC1

BTN2A2

FGFBP2

TMEM136

ELANE

94

SYTL2

JAG2

GAS6

LUC7L2

VSTM5

RCBTB2

GPR153

95

CD40

DGAT1

NR4A1

FAM110C

PDE1B

FRMD3

B4GALNT4

96

LEPROTL1

COL18A1

THBD

FAM150B

SEL1L3

SLC4A7

PLA2G16

97

LRRC16B

KRBA1

PITX1

KIAA1257

ZNF287

USP54

ITGB3

98

FAM110C

DDR1

SLC32A1

EFNA1

TBC1D8

F2RL2

HTRA3

99

GATA3

IRX1

HES6

PCDHB7

CAP2

KCNK3

MT2A

100

INPP4B

ANK1

IL17D

HSPA1L

ZNF577

GRIN3B

MPO

101

FLNC

KIAA1199

C9orf172

CNOT6L

LRP1

ZNF790

ISM1

102

S1PR1

ZSWIM4

SLC5A3

TBC1D8

ELMOD2

RHBDF1

RAI1

103

SLC16A6

RHBDL1

WDR53

IFITM5

PROX2

AOC2

C1orf159

104

IRAK2

COL9A3

KCNK17

TNFRSF11A

EGR1

C2CD2

ARHGEF4

105

C3orf52

KCNK9

DEFA4

FZD6

CDH11

FAM3C

GPR176

106

HPCAL4

IGF2BP1

SERPINE2

ZHX2

ABCA3

COPG2

MCAM

107

GFPT2

DNAJC22

GATA2

PRKAB1

TMEM59L

FGF2

SSTR2

108

ACPL2

NINL

IL21R

CECR6

KIAA1045

CYB5D1

RADIL

109

RORA

HEYL

EFNA5

PDGFRB

EPHB2

PANK1

SLC8A3

110

DGAT2

SVEP1

APLP1

BCAM

FRMD3

FAM69B

COL19A1

111

PDLIM1

VWA1

COL6A1

ZFP14

CYP2U1

ARHGAP42

EGR1

112

C11orf24

DPY19L4

COL11A2

PPP1R16B

PSD3

DOCK10

KIF1A

113

C1QL3

TTYH3

GRB7

TUBB3

CDK5R1

RFXAP

KCNA3

114

IL10RA

GPR153

PTX3

MFGE8

XYLT1

MMP15

MGAT5B

115

PLEKHO1

SHISA9

LTF

NTRK1

VMO1

PPFIA4

SETBP1

116

HS3ST3A1

ZCCHC18

C1orf200

CORO6

TUBB6

NRXN3

KCNJ2

117

BNC2

ZMYND10

CCDC28B

VEZT

BTBD9

BTRC

PDE9A

118

NRP2

ADAM11

FMOD

EPAS1

PPP1R1A

ZFHX3

TFEB

119

SYNGR3

SCARF2

CBX6

FERMT2

TSSK3

NUAK1

ALPL

120

PDGFD

COL4A1

A2M

ZNF704

PGBD2

MOB1B

CHSY1

121

ULK2

PTPRS

CBX4

TNFRSF9

USP2

GIMAP8

ABLIM2

122

KLHL14

KLHL30

TOB2

ADARB2

AHNAK2

MYB

TNFRSF18

123

CMTM3

NEU4

CACNA1G

GSTM2

CDH23

EMID1

DPEP1

124

DUSP5

SLCO2A1

SYDE1

ADORA2A

TMEM231

ZNRF3

COL1A1

125

SEMA4B

PEX11B

PDE4C

LMO2

WFS1

WNT2B

SYTL3

126

RAP1GAP

WBSCR17

LHX2

HLX

COA5

HEY1

SYT5

127

PCNXL2

RABEP2

SOBP

GATS

BSN

ELOVL6

BLNK

128

FST

TONSL

IGFBP2

VASH2

OPLAH

CNNM2

MFAP2

129

EMP3

SCARF1

KIRREL2

SACM1L

LRP11

STC2

PRSS23

130

ENPP5

SCN1B

PRKCG

C5orf20

CHD5

GPC4

PVRL3

131

EHD3

NR2F2

KCNMA1

TNFSF4

RCAN1

SMAD3

PITPNM2

132

RNF165

NKAIN3

SCGB3A1

ZBTB26

GLI3

RET

CHTF18

133

PRKACB

ZBTB46

SYNDIG1L

ROR2

C8orf37

C12orf68

RASSF8

134

VMO1

SLC9A5

CLDN6

GP9

NCOA5

CLDN6

F2RL3

135

MYOM2

AGRN

ADSSL1

UBE2F

ARL6

PPP1R14C

SMAD6

136

KIF5C

KIAA1614

ARC

TNXB

MANSC1

COL15A1

PFKL

137

MPP6

PKMYT1

TRNP1

CRIM1

FAM58A

TRNP1

FAM20C

138

TRIM8

TP53I13

NR4A2

PCGF2

ZSWIM5

PRSS27

AMIGO2

139

RAB7L1

RET

KLHDC7A

TRH

HPGD

PGF

BARX2

140

FAM150B

CNTN1

IFITM10

LILRB1

AQP11

EXPH5

LRRC4B

141

ELOVL6

ASS1

N4BP3

FSTL4

RNF175

GPRC5A

DUSP8

142

EPAS1

RPRML

SEMA7A

ATAD3B

C10orf88

FGD6

TRABD

143

GNA15

ZNRF1

VAV2

F13A1

RDH10

SLC5A3

GIMAP6

144

MAGEF1

ADAMTS7

RGMA

NPR3

KLHL29

SERPINE1

TMEM136

145

ACE

DPCD

FFAR3

FGD4

FKTN

ANKRD16

WNK2

146

UST

HSPG2

FAM83D

MAPK8

FXYD7

NME2

APBA1

147

C17orf100

GTF2IRD1

PDF

SPARC

CTSO

PRRC2A

CDS1

148

RCAN1

RAMP3

E4F1

ALAS1

ZNF699

IER5L

SPON2

149

CCDC88C

ZNF391

CKAP4

ERO1LB

GRK5

RFX7

WDR90

150

SFXN1

TNFRSF6B

MMP17

SLC43A2

PPM1L

POU3F3

PLVAP

151

EGR2

PLCXD1

LRRC20

MTSS1L

TBC1D9

PEAR1

NEIL1

152

RING1

ZNF785

RAB20

ZNF322

GPR157

PTGS1

SEMA3F

153

EBF4

AZI1

KNDC1

KIRREL

KIAA0513

KIAA1549

KCNJ12

154

CD93

GCGR

PFKFB3

PLD6

EPPK1

TMEM204

KLF15

155

PRDM8

ASCL5

DDN

BSPRY

DGKI

METTL12

ARL4C

156

C12orf75

RHPN1

C19orf60

DEF8

DCAF4

ZNF641

ADAMTSL2

157

NFATC2

ZNF423

NUDT8

JARID2

SLC9A5

FAM124A

SYT15

158

HAPLN3

MEGF8

SDC3

CNOT2

RET

IRAK1BP1

ABCD2

159

SECTM1

SLC26A10

CABYR

NDRG4

LRRC16A

ZNF584

FBLN7

160

LRP1

ANKRD33B

COL4A2

NOS1AP

GNAL

DCHS2

CALHM2

161

CYP1A1

ATP2B3

NECAB3

TGIF2

ZNF879

LPIN2

C21orf2

162

ZNF563

ARPP21

GLRX5

C5orf15

RAB40B

ZNF37A

SLC46A1

163

MYBL1

TTC28

NTNG1

SESTD1

PPP1R3E

ALCAM

DLGAP2

164

PLEKHA1

TLL2

CYTH3

STRN3

ZMAT1

MLC1

FAM83G

165

ZNF792

NRXN2

PCSK1N

PROKR2

CILP2

CCND1

CASKIN1

166

RAB27B

KCNC4

EPHA7

GPD2

CD99L2

PPP1R9A

C1orf53

167

PERP

BOK

FOS

TBX15

PDZD7

VGF

LPPR3

168

CPNE5

ASPSCR1

NR4A3

IL1B

CD302

GPR68

KNDC1

169

PPP1R9A

DPF1

PGLYRP1

PTPN7

CLGN

PRR7

FAM109A

170

TP53INP1

INSC

BRF1

TIMP2

XXYLT1

PTGDR

CPAMD8

171

SKIV2L

DPYSL5

KIFC3

CDH4

LAYN

SCNN1A

NMUR1

172

YIPF1

PIDD

CD177

FAM72A

KCNAB3

RPP21

TIMP3

173

TNFSF14

NDRG4

TBC1D9

ACVR2B

C12orf61

MAPK14

VGF

174

SMAD3

AS3MT

GPR157

SLCO4A1

PAIP2B

KIAA1161

FXYD7

175

KCNJ11

PITPNM3

IRF8

TRAPPC6B

BACE1

SPRED3

NPY

176

FAM69A

WSCD1

ELL

SRSF12

TCF7L1

KLHL29

PQLC2

177

FAM53B

RAB11FIP3

TLR9

TMPRSS3

ZMAT3

AK4

EXOSC4

178

FXYD7

IL4I1

ISM1

FBXW11

ZNF780A

EBF3

AK7

179

RELL2

C21orf128

HECW2

YWHAG

PAPD7

CDK7

PALM2

180

PRKCH

ERG

FAM196A

TFAP2C

ABLIM2

MXRA5

TBC1D16

181

RSPH4A

FAM132A

SH2B3

SHISA2

CPVL

CACNB2

ASB16

182

IFITM1

PTPN21

TGFB1

EPHB3

MCTP1

MAML1

CACNA1C

183

TBC1D30

GRIN2D

SPRED1

TINAGL1

RAPGEF4

CACNA1C

FAM53B

184

ITGB8

PIEZO2

CDC42EP4

NDRG1

C1QL3

CADPS

ARHGEF10

185

PDE9A

FBLIM1

GJB6

DNAJC7

PLAG1

ELOVL2

SLC5A3

186

MT2A

KANK2

STARD10

LIF

C19orf26

PDE9A

PRRT2

187

C1orf21

AGT

DYNLL1

IRX1

BIVM

ITGA11

MCF2L

188

IRAK3

FAM129C

BTBD11

RCOR2

BBS5

ABTB2

GPSM1

189

LAYN

SDK2

METRNL

ARHGEF25

PCDHGA11

PLAG1

BMP3

190

COL6A1

CRTC1

LIF

ARPP21

LANCL2

SHISA7

LDLRAP1

191

STAG3

PIGQ

SYNJ2

H1F0

BRCC3

FAM135A

NSUN7

192

ADAM19

SLC34A3

SNAI1

DSCAM

FCHO2

P2RY11

BMP2

193

SH3TC1

PACS2

EPHB4

B4GALT1

MEIS3

ZNF621

TBC1D2

194

CXCL16

TNXB

MED26

SERPINE1

HSPA12B

TBC1D8

IQCE

195

SHISA9

VWA5B2

LIMS2

LGR5

COL2A1

PRAME

DPYSL4

196

RGL1

LRRC15

CCND1

DGKD

ILDR2

LRRC8D

FOXO6

197

TEAD4

ZNF432

JOSD2

GATSL3

PGBD5

KIF16B

MYPOP

198

ZBTB4

CALN1

FGF9

PADI2

HDAC4

PCSK5

SELO

199

PWWP2B

DBH

BEAN1

PRKX

SREK1IP1

KCND1

CCDC125

200

PRF1

WDR86

MPST

FADS1

ZNF18

DHX33

TMCC2

201

DOCK9

DTX1

HDHD1

PRAME

SLC25A42

CTHRC1

JAG2

202

TRERF1

FAM19A5

MAMSTR

TBL1XR1

SNTB1

GALNT14

MFNG

203

MOB3B

REXO1

KAL1

ZNF345

SKIV2L

CYB561

FIBCD1

204

CDC42EP3

TBCD

TADA2B

GPR132

ST7

HIP1

CELSR1

205

KIAA1147

PLEKHD1

IFFO2

PALM2

ZNF354C

SHC4

SLC2A6

206

PRMT6

F2RL3

NFATC1

RGL1

GAN

PBX2

DPF3

207

DRAM1

SLC6A7

LTB4R2

RAPGEF1

PTCHD2

CST6

KRBA1

208

KCTD17

MICAL3

LRIG1

LGR6

TBXAS1

ZNF69

LRRC32

209

TMEM200A

DOK3

CD248

LMCD1

TTLL6

EARS2

FSTL4

210

C16orf54

ARHGAP8

BHLHE40

PTX4

UTP20

ADAM19

EHD3

211

ARHGEF40

LINGO3

STARD13

MMP14

SLC2A13

KCNQ3

THSD7A

212

ARID3B

NOXA1

HIVEP3

TMEM100

NPDC1

CREB3L2

NBL1

213

MAST4

SNTG2

RHOV

PCDHB8

PRMT3

CDKL2

ZSWIM4

214

AKAP5

ZNF512B

TLCD2

GATA2

NEGR1

PANX2

POU4F1

215

AGAP3

ATP2B2

EGR3

KDM5B

RALGAPA2

ZNF528

DGKG

216

COPG2

CACNG6

FBXL16

GBP4

FBXO4

IVNS1ABP

ASGR2

217

GPRC5C

MYBPC2

SPIRE2

WNT11

ZBTB46

TBL1X

TCERG1L

218

ATP2B1

EMX1

TPRA1

KLHL5

ACVR2A

ANKH

RHBDL1

219

CCM2

PPP1R37

CSRNP1

DIXDC1

COL11A2

ZNF594

AMIGO1

220

ZNF268

CENPM

KLF10

TTLL9

IMPACT

ABCA1

KIT

221

RNF125

LRRC56

TRAF4

FAM69B

SYT2

DDX10

COL13A1

222

GPRIN1

CLSTN2

GPRC5C

CCL3

SMAD9

TUBA8

EPSTI1

223

TIGD6

GNG7

SLC6A12

IRS1

ANTXR2

THSD7A

FAM69B

224

GIMAP1

CCDC154

CALCB

ZNF620

NXN

HOXA11

COL9A3

225

ARNTL

TRIM2

VENTX

ANTXR1

TTC8

IPO11

COL22A1

226

RNF219

CES3

EEPD1

RBM24

LRRC6

FGF9

PTPRN2

227

CALCB

INTS1

PLEKHN1

FLNC

RGMA

SFXN1

AHNAK2

228

SYDE2

KDM4B

PRKAR1B

PAPD7

ZNF470

SPG20OS

THBS1

229

ZFYVE9

JMJD7-PLA2G4B

RGS14

SLC35E3

KLHL3

LRFN2

TNK2

230

S1PR2

PPP2R3B

FAM110C

ZNF629

CACNA2D4

C16orf45

DPY19L4

231

SNPH

SH3TC1

TMEM238

BUB1B

THSD7A

SLC26A2

NINL

232

FAS

PLXNB2

ARHGDIA

ACP1

FAM83D

ZNF879

KCNJ5

233

ATP1B1

LZTS2

GMEB2

IRF2

FUT3

TIGD4

PCBP3

234

DCBLD1

CSPG4

SCRIB

HLA-F

NMB

CASC1

PTPN13

235

PPP1R14A

OR52N5

FOSB

PYHIN1

ANKLE1

GAB1

RASD2

236

PCDH17

HDAC4

TNRC18

PPAN-P2RY11

ZSWIM3

ATP9A

CD40

237

EDNRB

ANKLE1

NIPAL1

C3orf52

ZNF853

SLC22A11

HMCN1

238

TMEM176B

TMEM189-UBE2V1

NPY

HUNK

SDK1

ADORA2A

TTYH3

239

FLVCR2

GRIN2C

RASSF5

DHRS3

KCNK9

PBOV1

FAM3C

240

TNFRSF1B

MEGF6

MESDC1

TGFB2

WDR35

DGKH

GTF2H4

241

MEIS2

ADAM33

TGFA

SH3RF1

CYP1A1

SETBP1

PLEKHG5

242

C20orf112

GJD3

LSM7

COL24A1

RGPD5

PLCG1

SHISA9

243

FUT5

APOE

MARCH2

TMEM38A

TMEM117

SH3PXD2B

MAF

244

SIDT1

ARL5C

SNX21

RET

KLF12

HHIP

IGF2BP1

245

ATP2B2

MEX3D

GET4

SLIT1

CMC1

ANKS1A

DNAJC22

246

KLHDC7B

AKR7A3

TRABD

WIPF1

ZFP2

ABCA5

ZMYND10

247

F3

SCUBE1

BLCAP

HTR3A

VASH1

PLEKHG2

FLNC

248

ZNF165

MAN1C1

DEXI

AMPD3

ABL2

SNX33

PTPRS

249

HECW2

HAAO

ATP6AP1

INHBB

TMEM163

ZNF221

GATA3

250

GDF7

CC2D1A

RTN4R

DAXX

SLC46A3

YIPF6

IL13RA1

251

KREMEN1

SHANK3

FSCN1

RCAN1

AGPAT5

SLC9A5

OBSL1

252

HMOX2

PPAPDC3

PIP5K1C

ZNF3

GPAM

TTC21B

SPINK2

253

SBK1

KIF18B

JUN

SPAG8

ERCC6

CDH19

EPHA4

254

ZNF558

KIF7

SDK2

PTH2

PGAP1

EFNB3

C19orf59

255

GBP2

UMODL1

SETD1B

FAM124A

TMEM170B

ADAMTS10

DGAT1

256

MMP11

GGN

APBA1

ASTN1

CDC42BPB

ZC3H12C

FYN

257

CTHRC1

LMOD1

HSD3B7

HSPB8

ERCC4

C18orf54

FLT1

258

SGSH

FGF17

MKNK2

CCDC64B

NEO1

CNOT6

INPP4B

259

SRXN1

KANK3

WNT9A

C21orf128

MGAT5

STON2

SCN5A

260

ITPRIPL1

LRP5L

ID3

HMX3

FAM89A

PDCD1

ARHGAP29

261

TTC22

CORO2B

FAM167A

RHCE

ZFYVE21

PTBP2

THBD

262

SNTA1

PRR12

HOMER2

TAF1A

C15orf41

ZC3H6

IL27RA

263

METTL7B

ANO1

IKBKE

ADIPOR2

C1orf106

LCA5L

EOMES

264

TSPAN13

DMKN

PLCD3

AURKB

SLC22A5

PCSK6

ITGA11

265

HOXA1

POU5F1

CITED4

DOCK4

MINPP1

AHNAK2

ACSL1

266

CD97

TSPAN9

TMEM184A

ENDOD1

TMEM2

YPEL4

SLC44A3

267

WDR86

LY6H

CDR2L

MAG

SCRN3

ZNF485

CACNB2

268

CCDC136

LPHN1

BAHD1

GAS2L3

GLRA2

GADD45G

GALNT10

269

CCDC102A

HIP1

NFE2L1

RCBTB1

TGFBRAP1

CMKLR1

TONSL

270

ZBP1

POMT1

OXCT2

KIAA1549

SDC2

LCORL

ECEL1

271

RGS10

MAG

APCDD1

AMN1

GSTO2

ACE

RAB40B

272

IGFBP4

ATP2A1

LRRC45

AMOTL1

AK4

MDN1

GFPT2

273

BAALC

KAZN

BIRC7

CLEC11A

ZNF251

ZNF720

ZBTB46

274

RAMP1

CELF3

HLA-F

AUTS2

SFXN5

LPO

LRRC16B

275

GRAMD1C

C21orf58

CCDC144NL

PLK2

NIPAL3

DPF3

SLC16A6

276

IL12RB2

NKX6-3

MAFF

GKAP1

YIPF5

SNX27

C6orf25

277

NUAK1

RPH3AL

C22orf34

CLK4

LPIN3

F3

SLC9A5

278

IFI30

FLYWCH1

VWA1

CASP3

CA14

RARB

DDR1

279

TSPAN9

SARDH

ZNF620

CHST15

ZNF578

FLT1

COL18A1

280

ZNF286A

MXD3

SPRED2

GRB7

DPCD

RAB27B

BCL9

281

TCEA3

C1QTNF4

PQLC2

ANKRD29

PCYT2

ETV5

LCN6

282

PLCXD2

TRPM2

ADAM8

ACHE

DCHS2

GPR63

CTSL

283

PRTG

DSCAML1

SAMD11

ARHGEF7

SLC32A1

BCL11A

QSOX2

284

PARP8

SH2D5

FCHO1

YPEL4

KSR1

FKTN

KIAA1199

285

EXTL3

EEF2K

LAMA5

SOD2

VSX2

C3orf52

ZNRF1

286

CD226

ATN1

NEGR1

NOS2

ZNF582

ARL10

DNAH11

287

IL2RA

FBXW9

C10orf54

CCDC93

SPRY4

MEIS3

SIT1

288

NEIL2

HSPA4L

MEGF6

DDX5

MBLAC2

SCARF2

SCN1B

289

KIFC3

ZNF696

METTL2A

SLC37A4

ST7-OT4

RERE

NR2F2

290

SPATA13

CLCN7

LINGO3

CALCB

SLC30A4

KIF7

NKAIN3

291

EIF5A

GPR173

TMEM222

KCNE3

UPP1

PREPL

EXD3

292

PBXIP1

ZDHHC24

ENDOV

CHST3

CLU

RFX3

IRX1

293

STAT4

CHADL

CDH23

GNG12

TMEM177

C1orf145

TCF7

294

NCKAP1

MYO15A

KSR1

SYNC

GLIPR2

LOXL4

FAM159A

295

AXIN2

HMX2

BCL9L

JRKL

SLC25A15

ZNF491

KCNN1

296

ATXN1

ATAD3B

TRIM65

ALOX5AP

SLC16A10

SLCO3A1

SYTL2

297

SAMD14

LRP5

FZD4

ZBED1

ASB13

ZFHX2

HSPG2

298

FZD3

P2RX2

PARD3B

UBL3

APOLD1

KIAA0196

BIRC3

299

MRFAP1L1

SGK223

IGSF3

PTGIR

CXCL16

ARNTL2

LEPROTL1

300

MTSS1

ADCY4

DNAH2

STON1-GTF2A1L

RPS6KA2

CHGA

ID3

301

TRIB2

CYP4F11

PTRHD1

PLXND1

RFTN1

BEGAIN

TNFRSF21

302

FCHO1

TCTE1

SERTAD1

HMGB1

PCDH12

NAA25

ANK1

303

TAGLN2

SSTR2

ZG16B

ANAPC10

B3GNT4

TTC30A

GTF2IRD1

304

PHF1

DRGX

SELO

BTN2A1

FHOD3

ADC

DPCD

305

TRPV2

SPRED3

AHDC1

PER2

ITGAX

LCLAT1

C1QL3

306

TMEM169

PPP1R13L

CITED2

CYGB

C6orf25

TNIK

RAP1GAP

307

CYB561

TMEM8A

CA14

HRH2

NAPEPLD

PKD2

INSC

308

LDOC1L

ZIC2

EPB41L1

MRPL49

SPRED3

SUFU

ZNF785

309

HMOX1

DRD4

ABTB2

HHIP

FAM78A

SPDYA

PLCXD1

310

C1orf95

SLC17A6

SIVA1

SYTL2

PAM

POU2F1

ZNF423

311

DCHS1

SYNDIG1

PRR7

AK7

ZNF594

DGKE

ANKRD33B

312

KIR3DX1

TMEM59L

SNAP47

C17orf80

HGSNAT

PIBF1

CSPG4

313

OCA2

EPX

NOTCH1

SLC8A3

ATMIN

TSHZ1

MEGF8

314

PDE4A

RHBG

CCDC85B

DDX17

TMEM5

PPARGC1B

EMID1

315

FGL2

MMD2

RAB11FIP4

ZBED5

FN3KRP

SLC25A27

CNTN1

316

KCNN1

OSR1

SNX24

AKAP12

RBMS3

SETD5

ASS1

317

SGSM1

SLC25A48

IRF2BP1

MSH2

MYO7A

KIAA1244

RPRML

318

ARID5B

SOX17

MAN2B1

DEPDC1

WNT10B

NAPEPLD

HEYL

319

HIVEP3

LMO1

STAB1

KIF20A

MAN2B2

ADAMTS7

HPCAL4

320

CCDC107

PGBD5

F3

KCNK17

TBR1

LRRC27

ASPSCR1

321

PFKP

C9orf50

KCNH2

CSNK1D

APCDD1

PLEKHA3

HGF

322

PLXNB2

C10orf67

CNTD2

HIVEP2

PGM3

ZNF433

ZNF391

323

CUX2

RIPK4

TLE3

BUD13

GGN

ZNF75A

RHPN1

324

TRIM47

LHFPL5

FAM86C1

NPY

CHRNA7

ADCY6

SPOCK2

325

FKBP11

C15orf59

FAM132A

TCL1A

HOMER3

MED31

HVCN1

326

TIGIT

SP9

NT5M

COQ7

MAST4

ST3GAL1

PANX2

327

FAM102A

CYFIP1

ATP6V0B

HIST1H2BF

ITPR2

BRD4

PLEKHH2

328

NRP1

INPP5E

C12orf44

PTTG1

DPP8

PRDM15

DGAT2

329

TRAF1

PCDHGC3

SFT2D3

FAM122A

DHX35

LRRD1

TLL2

330

CAMK2D

GNB1L

PHOSPHO1

LRP4

CRIM1

ARHGEF16

KCNK9

331

HDAC7

CDR2L

ID1

ITPKC

XYLB

WRN

NDRG4

332

VGF

GPR83

ADRB2

MED9

CHRNA3

LGR5

C11orf24

333

CHN2

RTN1

XIRP1

RABGEF1

AGGF1

SPAM1

ARPP21

334

CD52

MSX1

ARRDC2

WDR66

FITM2

TNRC6A

HS3ST3A1

335

SFXN3

RBPMS2

CACNB1

WNT9A

DNM3

POU3F2

MYB

336

SHANK1

CREG2

GNAZ

KANK2

MAP2K1

MAPK8

PDLIM1

337

CD109

MN1

PTMS

PTPRE

KCNMB4

SNAI3

TMEM150B

338

EREG

NPAS1

GAB3

ZNF200

URB1

TANC1

UST

339

MLLT3

NES

TFEB

DGKE

DPYD

ZNF2

C17orf100

340

GPD1L

CCDC61

DAPK2

H1FX

ITGAV

ANKRD28

S1PR1

341

DFFA

SBF1

CA2

ZNF660

KCNIP4

SRCIN1

IL4I1

342

BLK

CDC42BPG

CCNA1

TMEM155

PLEKHH1

MSX1

ERG

343

RNF182

MYO18A

ARMC9

ELL2

ABCC10

VWC2L

RAB11FIP3

344

IFT43

SEMA6C

RHEBL1

EBF3

RAB42

KDELR3

NRXN2

345

PLEKHA7

PPFIA4

RAB26

SUOX

ZNF132

PSEN2

KCNC4

346

OXCT2

MRPL41

GNA11

B3GNT5

EFEMP2

SFT2D3

BOK

347

DHCR24

PTCHD2

B3GNT4

TMEM86A

SIGLEC9

AGFG2

ADAM11

348

FKBP5

CDH4

BCL3

C19orf77

CNTNAP1

PTCHD2

SVEP1

349

FAM69B

IL9R

NINJ1

MX1

MANEA

ARAP3

VWA1

350

RBPMS

INF2

NAB2

CENPA

PRKX

MON1A

KLHL30

351

RHOBTB3

CXCL12

MAP2K3

PRSS50

CEND1

C1orf101

PITPNM3

352

SGMS1

RAD9A

NDST3

COX8C

QRFP

LRP6

RNF165

353

GTF2E1

RND2

PRTN3

AGPAT9

PDE5A

WDR96

SYNGR3

354

TMEM176A

NARFL

ZFP36

ENTPD4

SCARA3

SPRED2

KANK2

355

RNF157

REXO4

BASP1

ZNF154

ZNF563

URB1

SOX11

356

IKZF1

DENND2A

R3HCC1

TRAPPC2

HS3ST3B1

ZNF275

IRAK3

357

CD3E

LTBP3

ZNF576

MTIF3

ITM2A

CREG2

ANTXR2

358

COPZ2

SORCS2

CAPN5

IQCC

TESC

AUTS2

ENPP5

359

EPB41L4B

TP53I11

AGPAT1

RFTN1

TPPP3

MMP28

NPTX1

360

PPP4R4

GLTSCR1

SEPT9

SH2B2

TREX2

RBL1

FAM129C

361

FRAS1

SIN3B

TNS3

TSG101

ICMT

PLEKHA8

ACPL2

362

ANKRD31

RPS6KA2

ZNF668

UBTD1

SSH1

MLH3

APOLD1

363

HMGA2

TSC2

PER2

ZNF566

ALDH1L2

EXOC1

PEX11B

364

PLEKHH2

TPM2

CFD

PCDHGB4

OSBPL6

RTTN

NEU4

365

CPXM1

C16orf59

ZFAND2A

C10orf10

ISM1

ZCCHC18

SCARF2

366

SPIRE1

AJAP1

TMEM151A

TMPRSS15

ICAM5

ANGPTL2

BRD2

367

MAFF

MICALL2

SAMD10

F11R

HPN

LAMB1

PI16

368

RGS9

TNFRSF13C

GNA12

FKBP10

SERPINB6

MAP3K4

RABEP2

369

PLA2G15

DZIP1

CLN8

HCFC2

BARHL1

ZNF251

KIAA1614

370

ITGA2

ARHGEF17

FBRSL1

ITIH3

VSTM2L

ARHGEF37

IL10RA

371

SCML1

BRF1

ADAMTS6

ZNF181

MYCBPAP

SPNS2

SCARF1

372

PLCH1

NRN1L

SPSB1

TMEM132A

DISP2

ZNF283

ST8SIA5

373

DUSP16

DOHH

FUT7

JAG1

NPM2

CDHR2

DDN

374

PAOX

TBC1D17

CNIH3

SLC16A3

TMEM130

DACT3

COL4A1

375

ASAP3

PLXNB1

BEND5

DPF3

OVOL1

ST5

SMAD3

376

CRTC2

FAM27E2

OPN3

BMP4

ODF3B

FBLN5

WDR86

377

FAM86C1

FFAR1

KLHL26

ZNF626

CCDC113

ZNF445

TP53I13

378

PRKAG2

FMNL3

PITPNM3

AASDHPPT

RTN4RL2

NIPBL

VWA5B2

379

STIM2

APC2

TRIM9

GYPC

ITSN1

ZNF407

PACS2

380

GIMAP5

PDGFRB

HOXA1

DNAJC18

LACE1

ACHE

PDGFD

381

IL18R1

HR

REEP6

BET1

CELSR3

C17orf67

ZCCHC18

382

AFAP1L2

ESRRA

WNT10A

LRP5L

SHISA7

SRPX

BNC2

383

ZNF652

POU5F2

SDK1

C16orf71

ZNF491

PRKCG

PCDH18

384

SH2D3C

WBP5

GPR27

GFOD1

VANGL1

LRRC17

PRSS57

385

EHD4

NHLRC4

SLCO2A1

FNBP1L

PCSK5

GPR143

WBSCR17

386

MTUS1

DIP2C

C2CD4C

BRF1

NRSN2

ZNF8

FAM110C

387

RARG

FAM131B

LHFP

CLEC4A

PSD2

C1orf173

PKMYT1

388

WT1

SLC6A11

C4orf48

FLT3

ZNF362

ZFYVE9

PTPN21

389

RYR1

RAPGEFL1

CASZ1

NUF2

DNAJC11

NOS1AP

GRIN2D

390

EPHA1

CLIP2

RBM38

LRRC15

BCDIN3D

OR11H4

PIEZO2

391

LDLR

ARHGAP39

MVD

ZNF282

ZNF25

FBXL4

FBLIM1

392

CD244

DAB2IP

SBSN

RDH10

C8orf31

DNAJC25-GNG10

LUC7L2

393

PTGDS

PSD2

SBNO2

WDR75

EML5

KCNMA1

AGRN

394

GNGT2

CORO6

QSOX2

KIF23

RBBP6

NTN1

IL11

395

ZCCHC12

CACNA2D4

GABRD

TNFRSF1A

TULP3

NIPAL4

SLCO2A1

396

POU2F2

CDK3

ID2

ZSCAN16

MC1R

MUC1

C3orf52

397

FRMD4B

UNC5B

LAMC3

CDCA8

LINS

ZSWIM6

ITGB5

398

BTLA

GAK

SLC2A11

CES3

MFSD4

PP13439

MEST

399

ATP6AP1

WDFY4

CD70

IQUB

EPM2A

GNL1

NRP2

400

PHOX2A

GAS8

MXD4

ZEB1

RTN2

CEP290

SEMA4B

401

COL6A2

ZNF219

RCE1

NR4A3

COG2

TPPP

IRAK2

402

BIN1

SHISA7

PIEZO1

ORAOV1

LRRC4B

LRIG1

RAPGEF4

403

CDH2

FGFR2

ZNF578

PKHD1

CCDC3

IKZF4

CMTM3

404

RBM47

C19orf35

NXT1

ZNF543

MKKS

USP14

IL3RA

405

PBX4

LCN8

ZNF324

SLC35E1

PIGF

QPCT

TNFRSF6B

406

SH2D2A

AATK

PDGFA

DNAJB5

TXNIP

YLPM1

MICAL3

407

GPR137B

RASIP1

FURIN

ASGR2

BMP8A

LRRC34

TBCD

408

POMP

VIPR2

CDA

TMEM17

GNA12

NEXN

SECTM1

409

RAC3

PLEKHA7

NDRG4

MAP4K3

SFRP5

FLVCR1

AZI1

410

GAS8

TAF6L

RSG1

CCDC63

SBSPON

THAP6

RORA

411

FOXD1

EGFL7

PHLDA3

VPREB1

TNFRSF10B

PDF

RET

412

GRAP2

PRKACG

FAM49A

PEX11B

ARV1

LRRC14B

DUSP5

413

TMBIM1

PDE1B

ILDR1

UNKL

RUNX3

USP24

CENPM

414

ZAP70

ARHGAP40

RNPEPL1

SKIV2L

KREMEN1

KCNH7

HIC1

415

DSC2

LPIN3

C5orf20

FN3KRP

WDR38

CNIH2

ADAMTS7

416

ARHGAP8

PDCD1

FEM1A

AGPAT5

FSTL5

RNFT2

PPP1R37

417

GJB2

ARHGEF25

RPS6KA2

MEX3B

POLR3G

C3orf70

TRIM2

418

LAX1

ADCY9

ACY3

KIAA0907

FUT7

LETM2

FST

419

CRIP1

BRAT1

TNK2

TCF7L2

ZNF320

METTL1

SLC6A7

420

MXRA7

LRP1B

PIK3AP1

SEMA6A

NIM1

SORL1

IVNS1ABP

421

HIP1R

JAKMIP3

H2AFX

KLHDC9

ITGB5

TMEM184C

GCGR

422

COBLL1

PDGFB

NME3

TAF1D

GAS6

TRIM2

RING1

423

TTC39B

PCDHGA12

GPR176

TRIM7

FBXO32

OSBPL6

PRKCA

424

TMEM198

LCN10

AMN

PVRL1

HMX2

C9orf116

EMP3

425

KIAA0355

IGLL5

CRMP1

HENMT1

TMEM72

KCNJ2

ZNF512B

426

PON2

NOTCH3

ZBTB7B

TBC1D7

TMEM128

IGFBP2

DACT3

427

TRAF5

CCDC85A

KBTBD11

FOSL2

FAM174A

ABL2

PRKACB

428

KCNA2

ZC3H3

SLC39A13

BTBD3

EPHX3

KIAA1919

GADL1

429

WNT10B

GRAMD4

DUSP2

BCL6B

CCDC51

EFR3B

CXCR3

430

DTX3

RNF208

RPS19BP1

AP1S3

DLK2

YIPF4

MYOM2

431

ZDBF2

IL12B

RELT

MAML1

ERG

ZNF322

ANKLE1

432

VPS45

PCDHB14

CDKN2D

C6orf222

RGS9

SYT7

MYBPC2

433

AK8

CYP46A1

PVRL3

CYP24A1

ACOT13

HOXA13

EMX1

434

CCR7

TAF1C

HAAO

MECOM

NBEAL2

TSPAN8

BMP6

435

AGPAT5

ARHGEF10L

LZTS1

CACNG7

NCALD

TTC29

TRIM24

436

CNST

SUSD3

PLEKHH3

HPN

FUT2

C1QTNF2

TNF

437

MFSD6

STMN3

C19orf26

HOXA13

CAGE1

RSPO3

CLSTN2

438

SLC25A23

FUT2

NKAIN4

CDH15

LRRC1

SLC26A5

RNF182

439

ARL4A

PLEKHG2

CHRNA4

ADAMTS8

PXMP4

HOXB9

PCNXL2

440

ATP6V0E2

NFATC1

EEF1A2

FRAS1

ZBTB16

HES7

CREM

441

NPC1

KCNJ6

FA2H

INA

CHRND

C9orf171

RAB3B

442

ITPKB

FAM207A

NECAB2

OSR2

ADCY5

KLRG2

ULK2

443

ZBTB46

C10orf71

HOXA13

DYDC1

C3orf70

FAM47E

TTC28

444

FSD1

LMCD1

NKX3-2

PTCRA

ZNF560

LPAR1

SYNJ2

445

SPECC1

NRBP2

SLC4A3

ARHGEF37

SFN

C2orf72

MAGEF1

446

PHOSPHO1

HMGA2

SLC9A2

SYNDIG1L

EFR3B

LGALSL

RAMP3

447

APBA2

ZNF837

FBXO2

ZNF385C

STXBP1

GNPDA1

HDAC4

448

TMEM229B

TMEM200C

PPP4R4

SMTN

HAPLN3

SBF2

ASCL5

449

WFS1

GIGYF1

HOXB5

USP36

TMEM169

TRIO

SLC26A10

450

SLC6A20

POLG2

TBX2

NMT2

PCYOX1L

ITGA8

MPP6

451

IL7R

NKD1

TMEM54

THAP5

ZC3H12C

ZNF878

CHST11

452

VARS2

SUSD4

RAMP3

PHF12

MT1X

SYNJ2BP

DPF1

453

ITPRIPL2

MAPK4

BMP4

PCDHGB6

JAK2

CORIN

ZNF563

454

PIK3IP1

RPTOR

DOCK6

CEP68

OTUD3

NME9

TRIM8

455

KCNK17

RTKN

CACNG6

TP53INP1

PINK1

OVGP1

PIDD

456

GPR153

AIRE

FIBCD1

KPTN

NRG4

ISYNA1

GNA15

457

S100A10

BTN1A1

NPAS1

DCUN1D3

DCAF10

IPMK

FAM132A

458

CSNK1G3

NXN

CHAD

HMHB1

F3

C12orf61

AS3MT

459

SATB1

PAK4

ANGPTL2

PDCL

ST8SIA5

ARL15

APOE

460

ARAP2

PDE4C

CDKL2

IGFBP4

DUOXA1

LY6H

EBF4

461

MGAT5

SMO

CDH11

HOMER1

SP2

ROR2

ADAM33

462

LIMD2

ZNF70

PNMT

AK8

CES3

FAM132B

GADD45G

463

KLF13

SPTB

PRDM16

LZTS2

NLRP11

DOCK9

VMO1

464

MYOF

TMEM8B

MYOM3

ANKRD61

REM2

UBXN10

PIGQ

465

LIG4

PTCHD1

OSR1

TNFRSF13B

SPATA7

DBN1

C21orf128

466

KIAA1324

KLHL29

MSGN1

UBE2T

ENAH

TTC34

DPYSL5

467

LGALS1

TINAGL1

SERP2

WDR91

MAP7

RNF152

SLC2A5

468

TPST1

NRARP

SH2D6

LIPT2

HDHD1

ZMIZ1

WSCD1

469

PYHIN1

IGFALS

C9orf116

CELSR1

ASB1

TTC21A

PLEKHO1

470

NLRC3

MUM1

LRRC38

EBF4

BAALC

TRDMT1

ELOVL6

471

ST6GALNAC6

WDR62

VANGL2

SGCA

TFDP2

DBT

SPEF2

472

PLXDC1

PABPN1L

NPPC

ZNF17

A2M

ATP2B1

TMEM200A

473

SRSF12

GNA11

OSR2

ZNF740

AQP3

TMEM194B

LRRC15

474

PTGDR

ENTPD8

KCNJ4

OXSM

ZNF8

ZNF248

ZNF311

475

DAPK2

EHD3

GNG4

PAN3

CTSW

ETNK1

ACE

476

CASZ1

OSBPL5

NUDT6

NEIL3

TPCN1

COL5A2

KIF5C

477

ASPH

CCDC42B

EPHX4

GNA15

PSKH1

FAM53A

ATP2B3

478

ST8SIA6

FSTL3

SNTG2

CCNT1

CPT2

SP6

CC2D1A

479

TMEM163

NLGN3

OVOL1

INSR

CKAP4

C7orf61

ZNF432

480

PDE1B

BOC

BRSK2

PTPRM

ZNF710

C1orf61

ADRB1

481

RAB8B

COL12A1

CHST1

RASD2

GATSL3

LSM11

CALN1

482

SEMA3G

HHIPL1

C15orf56

RASSF3

RBFOX2

BEND3

FAM19A5

483

NECAB2

WIPF3

CTXN1

ZNF606

CENPQ

RFWD2

AGPAT9

484

WNT1

BAI1

FAM132B

TMX4

RNF208

FGD4

DTX1

485

VSTM2L

IQSEC1

TMEM52

CYP2E1

ANKS6

GSDMA

RGMB

486

HES4

IKZF4

ALOXE3

ABHD12B

RASSF4

HOXC9

GGN

487

USP6NL

C19orf55

TMIE

ZNF670

IQCH

ENOX1

CTBP2

488

HRK

SLC22A18

PHLDA2

INPP5D

SMOX

TWIST1

BCL6

489

SFMBT2

HOXC10

LDOC1

KLHL24

OAS2

PUM2

C12orf75

490

GPR150

WDR87

BMP8A

HIPK3

CST7

ANKRD32

CPNE5

491

PHLDA2

EME2

POU3F2

RAI1

ZNF98

ZNF324B

CCDC88C

492

GIPR

TOM1L2

ZBTB7C

ZNF100

GNAO1

DOCK7

REXO1

493

FBXO25

RTEL1

ADARB2

CCRL2

CKM

FAR2

SLC34A3

494

FOXP4

ARHGAP6

ADAMTSL5

POMP

BHLHA15

RAB43

CORO2B

495

POU6F1

BAIAP3

EFCAB6

NSMAF

APBB1

CAMSAP2

PDGFRB

496

PACSIN1

NHSL1

C17orf82

TSHZ2

ZNF660

LONRF3

CD9

497

FAM86B1

SH2D4B

C9orf171

TMEM37

CAPN14

SVIL

BTN2A2

498

TAP1

ENDOV

TMEM198

IPMK

PCDHGC4

NRG4

KCNJ11

499

HSF4

BHLHB9

TEAD4

SPRED2

AKAP5

FAN1

SFXN1

500

INSR

PGAM5

C1orf53

KIF2C

GPR135

NCOR1

KLHL14

501

LPIN2

EPN1

CCDC160

SRCIN1

WDR81

TAF1A

TSPAN9

502

GIPC3

NEURL2

HBM

KLHL3

SLCO4C1

ITPRIPL2

LINGO3

503

CD44

CD19

C3orf72

ZNF33A

PARP4

SPEN

LPHN1

504

MYL12A

GNA14

C17orf100

TMEM33

ALS2

FZD7

OSR2

505

LGR6

FADS3

RCC2

CYB5D2

TET1

HLA-F

AGT

506

ZMYM1

KLF15

SPNS3

NCKAP5

PDIA5

MFSD4

CSRP2

507

CD8A

MYO15B

ARMC5

SLIT2

LRTOMT

ICA1L

EFNA1

508

TUBA4A

IDUA

CRY1

CCNJ

TMEM17

RBPJ

PERP

509

GIMAP8

FAAH

IQCD

ASCC1

ATP2B2

NRG2

CD93

510

PHB

ASGR1

PRICKLE3

ARRDC3

DNAJC16

ZNF169

ARHGAP8

511

AES

CAPN10

ITGB5

PNRC2

ZNF438

WWP1

LRP5L

512

OLFM2

DOK7

CTDP1

BRD8

IL17C

FGF19

CCDC113

513

CORIN

SNAPC4

BTD

CNKSR3

SLC25A28

ZNF682

GZMA

514

RTN4RL1

GNMT

DIRAS1

MYO7A

ZNF81

ZNF345

POMT1

515

KLRK1

STK11

FAM110A

FGFR1

ZNF347

PIK3C2A

SRGAP3

516

DIRAS1

C9orf117

DHX33

ENDOU

RNF130

STX6

NOG

517

PPP2R5C

SLC6A20

CLDND2

VPS33B

LYRM7

TRPC3

LRRC56

518

OSBPL3

NOTCH1

SH3RF3

NUCB2

CASKIN1

CPZ

TUBB3

519

CD70

MAP7D2

CHI3L1

SH2D2A

CLDN9

MPP6

SDK2

520

GYLTL1B

LMO3

EID2

TMEM87A

XPNPEP2

LHX2

DOK3

521

EP400NL

TSKU

TRIB1

EIF2AK3

SMEK2

ZNF638

ETNK2

522

WDR35

PHLDA3

LPHN1

ATP9A

CELF6

MLLT10

RSPH4A

523

ZNF827

KAZALD1

TSPAN15

MRPL33

PTPRU

SLC4A4

CYP1A1

524

MED11

PNPLA3

HS3ST3B1

NRXN3

SLC16A8

CTTNBP2NL

SARM1

525

IL15

C9orf169

CD83

COL2A1

BBS10

ICAM5

CRTC1

526

SYNJ2

C11orf45

S1PR2

VANGL2

PTPN14

ILDR2

CCDC154

527

CCNA1

THAP10

HDAC10

ZNF217

NPTXR

KLHL3

HAPLN3

528

FAM171A1

JPH3

NTNG2

CNIH3

PHOSPHO1

C15orf27

FLYWCH1

529

DPY19L1

IQGAP3

GP1BB

ZNF146

ZNF396

FAM120B

KDM4B

530

MMD

DLX1

CYTH4

FMO5

PPFIA4

TIAL1

PRDM8

531

KIAA1217

HOXD13

RPS6KA4

KLHDC4

GNAQ

SLCO4C1

COL6A1

532

ANXA2

PLEKHH3

ZNF428

ARHGEF12

ZNF471

NFE2L3

INTS1

533

ELOVL7

ENG

NAGPA

RNF25

SLC26A2

GPR173

NFATC2

534

MATK

SH2B2

MAP3K11

LAIR1

GAD1

SCARF1

EGR2

535

MDFIC

LRRC24

SEMA6B

FPGS

TMEM180

B4GALNT1

EPAS1

536

LRRC8D

IL1RAPL1

FAM188B

ZNF613

BTRC

CNKSR2

VCAN

537

TRPS1

MAPK8IP3

ALX3

PCDHGA10

BBS12

FOXD1

MXD3

538

TNFRSF25

BCL11A

PIAS4

ZFP36L1

LSM11

TTC30B

NPR3

539

PLAG1

KREMEN2

FAM47E

HLA-DRA

TRPV3

ATP2A1

RCBTB2

540

MAFB

ENDOU

GNB1L

DYNC1LI2

CSAD

AIM2

ITGB8

541

DOK2

RAB11B

IRX1

DDIT4L

F2RL3

SLC35G6

KIAA1217

542

KNDC1

KIF12

EHD1

FOXJ3

PCDHGB7

CCL3

FBXW9

543

ORAI2

ADIG

NEK8

C5orf34

DTWD2

FGF18

ZNF696

544

MOCS2

AQP5

GLTPD1

DHX40

APOBEC2

HECTD2

SH3TC1

545

SDC2

C9orf171

ATP13A2

ZFP30

RNF141

NANOS1

ZDHHC24

546

TSEN54

AQP11

RNF157

SLC35A3

ULBP1

GP1BB

NRP1

547

AGPAT4

CUX2

UGT3A2

SLC26A2

GGH

USP53

GPR173

548

LATS2

WIZ

FAM76A

ST8SIA4

ZNF302

CDH5

LZTS2

549

TNFRSF10A

SAP25

NUAK2

TNR

GPRIN1

FLNC

DBH

550

SLC2A1

ZGPAT

CASKIN2

PCDHGB7

C1orf21

GPRC5C

HMX2

551

NTPCR

D2HGDH

METRN

RIN1

RAB9B

FXYD3

PLXNB2

552

HFM1

UCP3

EFNB2

SNX5

DCUN1D2

PRDM10

CLCN7

553

LUZP2

TMEM106A

MYCBPAP

MRPL14

DOLK

AFAP1

CACNG6

554

LRFN2

SUFU

KLHDC8B

CTH

ZMYND15

CACNA2D1

PLEKHD1

555

CD63

ZIC5

RTN4RL1

ZNF22

GPT2

PREP

ZNF788

556

STAM

ABHD15

ARHGAP27

HIST1H2AE

AFAP1

GOSR2

COPG2

557

ZNF853

ICOSLG

GPN2

TRABD

RHBDL1

CNPY1

ATRNL1

558

ODF2L

AMDHD2

FXYD2

FGFBP2

TECPR2

PI16

FAM69A

559

RHOF

FAM186B

PLEKHA7

RRM2

SEC22A

PTPN14

PRR24

560

SFMBT1

TFAP4

PDRG1

PAX7

CTTNBP2NL

MAST2

BTBD8

561

NME2

SRRM4

CHRNB4

NPAS2

STXBP4

AMOTL2

ARL11

562

ZNHIT3

PHRF1

ZNF319

TTF1

CEBPD

MC4R

TNFRSF11A

563

CD247

QSOX2

ASTN1

SDK2

SIGLEC15

PLCB1

TNXB

564

E2F5

PHF21B

RELB

SH3TC1

TSHZ1

ABLIM3

GRIN2C

565

ZNF582

HPCA

IGFBP4

KIF16B

GPR179

PTPN12

TEAD4

566

CLIC3

SERTAD4

ZFP36L1

CD22

NCS1

EPS8

ATAD3B

567

ESAM

GABBR2

GPR3

MALT1

KCNH3

CASKIN1

MEX3D

568

MBP

ADAMTS14

PACSIN2

PRC1

CD3EAP

ZNF385A

ST3GAL1

569

TPRA1

PNMT

MICB

SDC2

OSTM1

CSDC2

SGK223

570

MYO1G

MEIS1

TMEM56

PPP1R10

PIP5KL1

ARL13B

PLEKHA1

571

MAP3K9

GNG4

ACTA2

POLH

SAP30L

TRAF1

ZNF792

572

C1R

KCNK3

DNAH10

ZNF260

MCF2L2

DIRC1

ATP2B2

573

IL1RAP

NPAS4

SLC22A5

AFAP1L2

STAM2

TCF7L2

FAM150B

574

FHOD1

ADAMTS2

HS3ST3A1

CSNK1A1

C11orf74

BTBD9

PCDHB7

575

SLC1A1

TNR

CAPN10

ALLC

TMTC3

SGPP2

HSPA1L

576

BMP8B

MLLT1

EBF4

GATAD2B

TRIB3

ZNF250

BCAM

577

SLC26A2

STARD13

HDDC3

TESC

HSDL1

MYOM2

TNFSF4

578

UBE2E3

PPP1R3F

USP2

POLN

KIAA0196

ARL6

MEGF6

579

OAS2

RFX1

ZC3H18

SMAD7

TICAM2

GPR142

PPAPDC3

580

YES1

MYBPHL

ADAP1

SPRY1

SOBP

CBLB

TMEM8A

581

CORO6

PAH

PLA2G4B

TNFRSF1B

CSNK1D

PLCB4

NPC1

582

ARHGEF18

GPR3

B3GALNT2

SIRT4

CBX6

GABRQ

RAB7L1

583

NT5E

HRH3

C1QTNF4

LYRM4

RFXAP

SH2D4A

CYFIP1

584

ZFYVE28

SMTN

PPP1R16B

MRPL46

HTATIP2

ELMOD2

MN1

585

GRM2

EMCN

MED16

ZNF189

C3orf33

PON2

TBC1D30

586

LPAR1

HSPA12B

AKAP17A

C1QC

SLC2A12

ABCA2

PPFIBP2

587

CRTC3

PCDHGA11

CCDC114

C10orf25

GCLC

C1orf21

PCDHGC3

588

TLE1

ULK1

SLC6A9

ZNF419

C20orf195

TLE3

KCNA5

589

ST6GALNAC4

RNF224

DHDH

CYP2R1

CPT1C

TMEM105

PPP1R9A

590

PRKD2

TCEA2

SLC45A1

IP6K1

HEATR3

NT5DC3

TINAGL1

591

ZNF462

MPPED2

PUF60

PDHX

PNMAL2

SAMD15

HAAO

592

NID1

MYO18B

C12orf55

C9orf96

SETBP1

ARFGEF1

ZIC2

593

ZNF2

WDR24

CACNA2D4

C18orf54

UBASH3B

NOTUM

DRD4

594

CLUAP1

FAM173A

ARHGEF4

TMEM217

DSP

ZNF284

SLC17A6

595

SLC46A3

TUBB4A

SHD

HIST1H2BM

AGAP3

C12orf77

SYNDIG1

596

RAPH1

TCF3

ISL2

TBC1D23

B4GALT2

PRRG1

TMEM59L

597

SLMO2

BSN

NXNL2

EEPD1

PCNXL2

LTN1

EPX

598

HLF

CC2D1B

GPR148

LRRC8C

C3orf62

RBM41

RHBG

599

WDR66

ZNF628

ENOX1

ABHD4

GLCE

ONECUT3

MMD2

600

TIPARP

PCSK1N

MAP1S

GPRC5C

HINT3

PRSS23

OSR1

601

RARA

NDFIP2

RNF165

METTL18

RPH3AL

KIFAP3

SLC25A48

602

DNAJB5

RILPL1

KCTD14

RELL1

TSHZ2

FNDC3B

SOX17

603

LIPT2

VPS41

ZNF391

DYNLRB2

ADAM11

MCEE

LMO1

604

BUB3

PLIN4

CEND1

UMODL1

PRKAB2

DTWD2

PGBD5

605

ZNF470

SPRYD7

SMOC1

SPNS3

CNNM2

SCUBE1

C9orf50

606

PCDH1

SLC26A9

SH3BP2

ALG9

PTPN3

ATAD1

C10orf67

607

SLC43A2

THSD7A

ANGPT4

SMURF1

DNAJC24

ZFP28

RIPK4

608

LHX4

GLI4

CCDC152

COL16A1

NFS1

GIGYF2

LHFPL5

609

KRAS

CX3CL1

AGRP

CDK1

LIMA1

PYHIN1

C15orf59

610

TNFRSF12A

SAMD10

NRXN2

SEPT3

ZER1

DDHD1

SP9

611

BCL6B

SH3PXD2A

KRTAP5-5

NPAS1

THY1

ESRP2

SCUBE1

612

TNIK

MMRN2

EDN1

ACER2

IP6K1

NPPA

NPAS1

613

RASSF3

MYL3

SYT1

ZBTB17

GOSR1

ZCCHC12

NES

614

DBNDD2

VASN

MEIS2

YIPF4

IMPA2

PLXDC1

AR

615

SAMD10

CUEDC1

LOXL2

SPTLC3

TUBGCP5

ZCCHC14

MAN1C1

616

PDCD10

AEBP1

TMEM206

CCNB2

FASTKD3

CD300LG

PPP1R16B

617

EMR2

PALM

PROK2

EGR1

ZNF202

C21orf128

KIF7

618

DNM3

DUS3L

ESPNL

FHIT

GPR3

TSPAN15

CD109

619

N4BP3

FZD4

CCDC64

SRGN

INHBE

TGFB3

NTRK1

620

PSD4

PKN3

ICOSLG

HAAO

DGCR2

CDH3

CCDC61

621

USP53

ST6GALNAC4

CYP26B1

APOBEC2

L3MBTL2

CYTH3

BTBD11

622

PPARG

KCNA1

GLI4

LAX1

ANKFY1

FRA10AC1

SYDE2

623

C9orf40

DOT1L

HDAC5

RRAGD

BAIAP3

BCAN

CDR2L

624

ABCA2

AVPR2

IER5

PANX2

ARHGAP31

PCDHGC4

GPR83

625

TMEM104

SP7

C22orf15

HINFP

COL27A1

LPA

RTN1

626

MYRIP

LILRB1

FBXL15

RAPGEF2

GNPDA2

KRTAP12-3

MSX1

627

BCDIN3D

ZNF154

HORMAD2

TRIM38

ZNF507

ZACN

RBPMS2

628

OPLAH

OPRK1

ANGPTL4

KDM4A

FGD6

LCN6

CREG2

629

MPZL3

TNFAIP2

ATG16L2

CBLB

UBIAD1

WARS2

SNTG2

630

RASD2

EVI5L

MKL1

DSEL

HSF5

C6orf226

OLFM2

631

IL4R

MIOX

MPPE1

IMPAD1

ZNF415

ARID2

SBF1

632

SHPK

COL20A1

RIN3

IGF2BP2

CTIF

DNAAF1

CES3

633

SLC4A4

ATP13A2

HOXC9

DPEP1

RASA4

TBL1XR1

ARL5C

634

MYBPC2

ALDH16A1

FGFR1

XBP1

PDCD2L

ZNF607

UPK3B

635

SLC9A5

ALDH1L2

CORIN

KIAA0226

QSOX1

CRABP2

UMODL1

636

CD300A

ARHGEF1

IL12B

LRP2

ADCY3

ENDOV

SEMA6C

637

BMPR1A

TSPAN18

POU2F2

ARFGEF1

PDZD2

TEX9

LRP1

638

LPXN

MAVS

TMEM107

MTMR6

SLC35B4

ABI2

CALCB

639

SH3BGRL3

IL17RD

SAFB

GLE1

CENPBD1

RIMKLA

RCAN1

640

TUBB3

MYOM2

GPR68

CPXM1

HSPA4L

NMUR1

RAD9A

641

SNN

BDNF

CACNB2

USP12

TMEM150C

ABHD2

GJD3

642

FAM69C

DNAH10OS

ICAM4

CDKN3

DOC2A

TYSND1

IL9R

643

EVL

SORBS3

KCNC4

UXS1

WDR59

NETO1

INF2

644

DUSP6

EP400NL

MFSD2A

IL23A

PLCL1

SLC19A2

LMOD1

645

SLC12A4

ANKRD16

C11orf35

FAM171A1

EVPL

MEOX2

HECW2

646

TMIGD2

PDDC1

ZGPAT

MSGN1

HIPK2

NKD2

GDF7

647

IQGAP2

CRB1

C6orf223

SPTLC2

LIN52

TEX19

KIAA1257

648

C5orf51

STAC2

TUBG1

TNFRSF8

FAH

CCDC132

FGF17

649

SLC5A5

CCDC108

DAXX

INSIG2

ZNF777

ZNF582

SORCS2

650

B3GAT1

SLC7A2

GPR133

SIAH3

AFAP1L2

COL24A1

VDR

651

BHLHE41

GJA3

FOXJ1

WDR38

ZNF285

DEPTOR

GUCY1B3

652

ITGAL

RNFT2

BRAT1

TMEM216

PRKCQ

SBK1

NARFL

653

PGAP1

EBF4

SHC4

METTL6

SLC6A20

COL22A1

CECR6

654

ZC3H12D

FAM174B

RARG

DNAJC6

CCDC30

RAPGEFL1

PPP1R14A

655

ATP10A

RSPH6A

SSTR1

SUPT4H1

COL13A1

HIVEP2

C1orf21

656

ZFPM1

ADAMTS17

MICALL1

QPCTL

STXBP5L

BAIAP2

KIF18B

657

IP6K1

MYO1B

DVL1

TRIM36

LRP2BP

CD93

NOXA1

658

PPARD

DEXI

RFX1

CLPX

SLC39A5

PPM1E

KANK3

659

LRRC8B

ATCAY

FOXL2

MTF2

RYR3

SHANK3

OR52N5

660

ZNF860

CBX2

TNFRSF10B

UCN2

PHTF2

CRB2

LY6H

661

RAB12

CEL

MOCOS

IL8

ZSCAN22

ZFP64

NHSL2

662

CARD10

MPV17L

FLNC

MYO18B

SYNGR3

ENDOD1

ATN1

663

CERKL

PKD1

HES2

PPT2

ZSCAN20

TMEM161B

MEIS2

664

RINL

NEURL

LTBP3

CALN1

SLC30A9

DLEU1

YIPF1

665

CGRRF1

PCDH11X

BCAM

ACSL3

PAPSS2

FARP2

PWWP2B

666

IRF8

CAMK2N2

GPAA1

PARL

POLR1B

RAD52

LILRB1

667

NTSR1

POLRMT

SLC25A6

ZNF680

PPP1R3B

GSTA4

TNFRSF13C

668

LHFPL2

PRAM1

P2RX7

PHTF2

MEST

ZNF302

ANO1

669

CBLB

RALGPS1

CNPPD1

TSPAN9

PRKAG2

FAT4

C16orf59

670

MTMR1

LMF1

ZNF385B

ZNF250

UFL1

DOCK4

AJAP1

671

SLAMF6

CPZ

GATA4

NUP98

FAM115A

BTN1A1

MYO15A

672

DLGAP4

ZSCAN10

IGDCC3

ZNF491

SPRYD7

RING1

RPH3AL

673

CD79A

C6orf123

XYLB

CCNA1

PC

PLIN4

MYBL1

674

CCL3L1

CTF1

RNPS1

RAC3

PDE3B

MKL2

TBC1D17

675

ITGA4

SEMA3D

KIF3C

ZNF70

CCDC151

TUBB3

PRKCH

676

CAMKK1

IGDCC3

MEF2D

EEA1

GLS2

LILRA2

SKIV2L

677

ZNF284

GRIN2A

SLC6A20

MAP3K3

ASAH1

PNMAL2

KAZN

678

CXXC5

ITGA9

GRIA4

ZNF572

C9orf9

FBXO22

DMKN

679

CA11

SLC9A3R2

ZNF177

CCNB1

VPS53

BPTF

POU5F1

680

PHF15

TROAP

GOLGA2

KCNIP1

SLC29A3

NXN

ZNF584

681

FCHSD1

C6orf132

MLYCD

POLG2

MAPK8IP1

CHRNB4

HMGA2

682

C21orf119

RYR3

PIEZO2

HEY1

GDPD5

PPP4R4

MAG

683

LYNX1

ZNF579

OPRL1

THBD

HRH3

CABP1

ESRRA

684

STX2

ZNF346

PTGIR

DNTTIP1

ZNF510

TMEM51

PRR12

685

ZBTB2

NR2F6

CCDC97

SFMBT1

ALX4

SCUBE2

GNG7

686

PROK2

UNC5CL

REXO1

EGLN3

OPA3

RTN4RL2

NKX6-3

687

HRAS

NTRK2

B4GALNT4

RRM1

ETNK1

FOXO6

RELL2

688

CCDC96

TAS1R3

CCDC88B

LOH12CR1

SMARCA1

HEG1

SYCE2

689

GNAI1

CNIH2

SIX2

HIST1H3I

TRERF1

TM4SF1

TRIB3

690

RCAN3

HAND1

SPNS2

DENND3

LZTS1

ZNF177

INPP5E

691

KLF7

ESPNL

MRPS2

MEGF11

ZNF174

MTERFD3

ATP1B1

692

PHF23

SZT2

SEPT8

WAPAL

C16orf45

VPS37C

CELF3

693

NRL

DAPK3

ISYNA1

CAP2

VPS52

CSGALNACT1

FAM72D

694

CDK6

RTN2

MBOAT7

NR4A1

CMTM4

MYO1E

TNFRSF9

695

WIPF1

SYVN1

PSMA8

BCOR

NIF3L1

CDH10

IFITM5

696

FMNL1

OGFOD2

C19orf44

JAG2

TLR9

ANKFY1

PRAM1

697

TRH

ZNF648

NOL12

C6orf48

CDH15

LIMCH1

TNFSF14

698

ZNF599

ZBTB42

NOV

RFX8

CARD10

PACRGL

LRP5

699

FBLN7

VSX2

EMP1

RSBN1L

ATXN1

EXT1

JMJD7-PLA2G4B

700

SH2B3

MYBPH

KLF16

C16orf96

ZNF221

UNC5B

S1PR2

701

ZNF343

KCNT2

ZNF524

PLSCR1

KLF3

GLDC

PPP2R3B

702

LRP5

KIAA1244

PIR

STAT5A

ITGA9

TRIML1

CDC42BPG

703

PHF19

ZNF865

B3GNT5

DBI

ZCCHC14

KIF26B

GP9

704

DCLRE1A

GPR156

RNH1

DHX16

ERMP1

PARP11

PPFIA4

705

CYFIP1

FAM131C

LRPAP1

C1orf74

FFAR3

GSTO2

ZNF219

706

TRIM16L

C1orf220

HOXA7

MAML3

C14orf28

C16orf46

AATK

707

HS3ST3B1

KCNA5

FKRP

NETO1

N6AMT1

XYLT2

FGFR2

708

GGA2

FAT4

TSSC4

MCF2L2

ZNF596

ZNF780B

GAK

709

GDAP1

MGMT

LGR6

NKX2-3

C6orf132

SNX13

TMCC3

710

C8orf56

GPR146

NETO1

C12orf23

PHACTR2

BEAN1

TAF6L

711

DUOX2

TBL3

TOMM40

GGPS1

TBC1D20

TSKU

EGFL7

712

CD6

MEIS2

THPO

DRG1

ZBED3

KIAA1958

FZD6

713

LRRFIP1

USP43

UNC93B1

APPL2

SFMBT2

NOTCH2

SNPH

714

PPIF

GRIK4

BZRAP1

KIAA1033

MAP1A

ENAH

DOCK4

715

GABARAPL1

HES6

ATP2B2

PTPRK

TTLL3

TRIT1

C1QTNF4

716

RAPGEF6

ARSI

SCN8A

KIF7

MARVELD1

ABL1

SPRED3

717

CCL2

PSD

BIN3

ANAPC13

C12orf66

FAM86C1

FLVCR2

718

IKZF3

TAL1

C12orf65

SOX4

ZNF462

UACA

VIPR2

719

IDI1

GALR2

ALKBH4

SETX

DSTYK

NEIL1

NOS1AP

720

HLCS

PXDN

ZSCAN22

CDON

GDPD1

HLA-E

PRMT6

721

KIF2A

MBD3

XYLT2

ZNF79

ALG10

METRNL

CDH4

722

PDZD4

CRABP2

PPOX

STK19

JAM2

IL17REL

SHISA7

723

LY6E

ZNF587

ADAM33

DRAM1

IGFBP2

EHD3

C5orf20

724

ANKRD12

CNTN2

ZFYVE28

PPP1R3G

DLAT

RARS

ZNF471

725

TCP11L1

GALNS

C15orf27

UBR5

TYROBP

ZC3HAV1L

PLEKHA7

726

ZNF132

NCLN

WDR86

BMF

LRRC3B

FGFRL1

AGAP3

727

PCGF5

TEKT2

ADRA2B

CHMP4B

PSAT1

NPHP3

PLCL1

728

POU3F3

SLC12A7

NPTX1

NUDT7

MAML3

HSPB6

TP53INP1

729

FAM65B

LARGE

JAG2

PLEKHO1

ZNF32

PRSS33

BRAT1

730

SARM1

PHF16

CST7

ZNF225

RNLS

FST

SH2D5

731

NTAN1

FOXP2

SYP

KCNMB4

ABCA1

NLN

DRAM1

732

SELPLG

CCDC57

GNB2

NUP54

CCDC147

RAB26

MAST4

733

ARHGAP17

KIAA0195

CARD11

ANKRD11

ZNF324B

ERG

LTBP3

734

CXCR2

METTL21A

WIZ

ZNF672

SHANK3

STC1

TCTE1

735

ERBB4

NTN5

NACAD

CDCA3

VPS33A

IRS1

RAB27B

736

GIMAP7

SETD1B

CISD1

SESN3

NUMBL

HOMER3

TBC1D8

737

ZNF485

SLC13A5

PPL

FRMPD1

RHOBTB3

LTC4S

CNOT6L

738

LAMB1

HDGFRP2

CCDC106

LHB

GRM2

CCKBR

CCDC102A

739

CHD7

LTB4R2

ANKLE1

PPP1CB

ANKS1B

PKN2

RPS6KA2

740

FAM20A

SYT3

HIST1H2AL

RGMA

CATSPERG

MAGEB6

STAG3

741

PDCD1LG2

PLIN5

UMODL1

SERPING1

C11orf71

RASA1

TMEM176B

742

EIF5A2

TELO2

RASD1

SLC29A3

CDKL5

TSPO2

ADORA2A

743

EVC

DUOXA2

CNNM4

COL9A2

PERP

GPATCH2

ADAM19

744

GEMIN6

NDOR1

LGMN

DDX47

TMEM99

APLP1

TMEM189-UBE2V1

745

BHLHA15

PRKCZ

MANSC1

UBE2J1

FAM160A2

NFAT5

ZC3H3

746

GATA2

AP2A2

ULK1

TAB3

RRBP1

FGFR1

ARHGEF40

747

CLIC1

KLC3

NFATC2

ZFP36L2

TTC3

CABLES1

TPM2

748

PBX1

TNRC18

CHN1

TACC3

CD160

GPR89A

ZHX2

749

PCDHGC3

LMX1A

ZNF582

NRP2

JHDM1D

FAM58A

RGL1

750

GZMM

CCDC122

TNKS1BP1

TRPM6

ALG11

UCN2

IRAK1BP1

751

JARID2

RRP1

NOC4L

TGFB3

PTPDC1

C9orf3

TRERF1

752

TCP11L2

ANGPT2

PGP

KAT6A

PEX3

NCOA6

DRGX

753

FAM89A

SYT14

ANKRD33B

TNFAIP1

JAKMIP2

GPR4

ZBTB4

754

SLC1A4

MKX

PDE9A

UGP2

TP73

RPE

PRKAB1

755

P4HA1

RAD52

ARHGAP29

CBR4

KIAA1161

CAMK2N1

GRAMD4

756

AP4E1

CILP2

LDB3

PCTP

APBA1

TMEM182

MMP11

757

UCKL1

WNT2B

KLF11

ARID5B

SNX10

SNTG2

AKR7A3

758

ERCC6

OPCML

RAVER1

F3

PHF8

MITF

ZFYVE9

759

LRP12

DNAH1

CRTC1

CERK

DAK

LSAMP

METTL7B

760

INTS9

RAMP2

NIM1

ZNF257

P2RX5

G2E3

FERMT2

761

RCBTB2

PKNOX2

MAP2K2

PELP1

RAB6B

UBN2

TIGD6

762

ZIC2

RHOV

TFE3

ABHD10

P4HTM

C8orf44

NFATC1

763

CHGB

TMPRSS3

LRRC8A

FBXO48

TSEN2

ADNP

STMN3

764

NRCAM

TXNDC15

ATP6V0D1

MFN2

OSBPL10

FAR1

MYO18A

765

EFNA2

GABRG1

BARX2

NT5C2

RASAL2

ZNF414

GPRC5C

766

SEZ6L

TYR

DPF1

TMEM9

SLC38A6

PAQR8

TAF1C

767

ADAM23

ANO2

CHGA

GAB2

TMEM194B

ZNF707

ZNF837

768

GJA3

SLC35E3

FAM198A

DNMBP

OBSL1

CLDN7

NUAK1

769

CDC42EP1

ACOX1

ALOX15

SFMBT2

GHR

FGFR3

PLEKHG2

770

SDSL

GRIN1

GDNF

ZNF695

BAI2

TBC1D30

CYP46A1

771

SLC45A1

RENBP

PPIC

NEIL1

TMED8

WIF1

ZFP14

772

RBPMS2

STK11IP

SOCS3

SMAD6

GALT

ADAM23

DOCK9

773

VPS37D

CSF3

PAFAH2

RASAL2

WDR7

TNNC2

GNB1L

774