CHM102A – General ChemistryCHM102A  General Chemistry

Part 1: Inorganic and Organic ChemistryPart 1: Inorganic and Organic ChemistryRamesh Ramapanicker

Part 2: Physical ChemistryMadhav Ranganathan

Inorganic/Organic – Section A

Lectures: MW 9:00-9:50 (L7); Tutorial: F 9:00-9:50 (L3, L4, L5 and L6)

Lectures: December 30January 1, 6, 8, 13, 15, 20, 22, 27, 29February 3, 5, 10, 12 Total 14

Tutorials: January 3, 10, 17, 24, 31February 7, 14 Total 7

Quiz will be conducted during the tutorial hour on 24th January.

Section TutorsA1 (L3)

A2 (L4)

Dr. M L N Rao and Dr. R Angamuthu

Dr M K Ghorai and Dr A K PatraA2 (L4)

A3 (L5)

A4 (L6)

Dr. M K Ghorai and Dr. A K Patra

Dr. R Gurunath and Dr. G Anantharaman

Dr. S Verma and Dr. J K Bera

Inorganic/Organic – Section B

Lectures: MW 14:00-14:50 (L7); Tutorial: T 14:00-14:50 (L3, L4, L5 and L6)

Lectures: December – 30January 1, 6, 8, 13, 15, 20, 22, 27, 29February 3, 5, 10, 12 Total 14

Tutorials: December 31January 7, 21, 28February 4, 11 Total 6

Quiz will be conducted during the tutorial hour on 28th January.

Section TutorsB1 (L3) Dr. V K Yadav and Dr. B Sundararaju

B2 (L4)

B3 (L5)

Dr. J N Moorthy and Dr. S K Kundu

Dr. D H Dethe and Mr. Subrata Kundu

B4 (L6) Dr. S P Rath and Dr. A Singh

Contents

Inorganic ChemistryCrystal Field Theory and Structure of Coordination ComplexesOxidative Addition, Reductive Elimination, Insertion ReactionsHydrogenation Hydroformylation Monsanto Acetic acid ProcessHydrogenation, Hydroformylation, Monsanto Acetic acid Processand Ziegler-Natta PolymerizationMetallaenzymes

Organic ChemistryConformational Analysis of Alkanes and CycloalkanesChiralitySubstitution and Elimination ReactionsSubstitution and Elimination ReactionsProteins, Nucleic Acids and Lipids

Booksi h i b h i d kiInorganic Chemistry by Shriver and Atkins

Inorganic Chemistry: Principles of Structure and Reactivity byJ E Huheey, E A Keiter and R L Keiter

Organic Chemistry by J Clayden, N Greeves, S WarrenFundamentals of Organic Chemistry by T W G Solomons

Periodic table

Tooth Paste

abrasives (calcium phosphates, alumina, calcium carbonate, silica) fluoride (sodium monofluorophosphate, stannous fluoride, sodium fluoride)antibacterial agents ‐ Triclosandesensitizing agents ‐ strontium chloride detergents sodium lauryl sulfatedetergents ‐ sodium lauryl sulfate sweetener ‐ xylitolhumectants ‐ sorbitol, glycerolanti‐tartar agents sodium bicarbonate (baking soda) enzymes thickener coloring agents Triclosancoloring agents  Triclosanpreservatives  

http://www.gwinnett.k12.ga.us/LilburnES/PromoteGA/beauty/toothpaste_intro.html

Tea and Coffee

Aroma Compounds in Coffee

Over 800 compounds are responsible for the aroma of coffee

http://www.coffeeresearch.org/science/aromamain.htm

Sweet Compounds

Artificial Sweeteners

Spicy Hot Compounds

Capsaicin

16,000,000

Pepper spray 2 000 000

Capsaicin

Scoville scale

Pepper spray 2,000,000

3,500Tabasco sauce

Resiniferatoxin 16,000,000,000, , ,

Bitter Compounds

Antipyretic, analgesic and antimalarial The most bitter compound known to date

Cooling Compounds

Mint Leaves

Compounds that Smell

cis-jasmone beta-Damascenone

tert-butylthiol 4-methyl-4-sulfanylpentan-2-one

Synthetic Dyes

Fluorescein(ocular, muscular angiogram)

Chicago River: fluorescein is used to dye the rivergreen on St. Patrick’s Day

Indigo the color of blue jeans

The Indigo Revolt of 1858 1861 in BengalIndigo

B 1865The Indigo Revolt of 1858 –1861 in Bengal Baeyer 1865

1897: 19,000 tons of indigo were produced from plant sources.1914: Production by natural sources dropped to 1000 tons1914: Production by natural sources dropped to 1000 tons2002: 17,000 tons of synthetic indigo were produced worldwide.

Adhesives

C lCyanoacrylateEastman 910

Eastman Kodak lab in New York by H W l C JHarry Wesley Coover, Jr.

Precious Stones - Gems

Alumina (Al O )Alumina (Al2O3)

Blue SapphireFe and Ti as Impurities

RubyRuby<1% of Cr(III)

Organic Drugs

Ranitidinepeptic ulcer

Amoxycillinantibioticpeptic ulcer antibiotic

HN

O

Metformintype 2 diabetes

Diazepamsedative

HOO

Paracetamolanalgesictype d abetes sedativeanalgesic

Chiral Drugs

(S)-NaproxenAnti-inflammatory (S)-Fluoxetine

A ti d ty

Anti-depressent

CaptoprilAnti-hypertensive

TIMOLOLAnti-hypertensive

ChloramphenicolAntibiotic

Importance of Chirality

(S)-CarvoneC S d

(R)-CarvoneS i tCaraway Seeds Spearmint

Inorganic Drugs

OH3N

O

O

Pt

H3N

O

Carboplatin (Ovarian Cancer)

A ranofin Pepto-BismolAuranofin Antirheumatic agent

Pepto Bismol

Imaging

Fluorodeoxyglucose P it E i i T hPositron Emission Tomography

Gadodiamide MRI Contrast Agent

Technetium (99mTc) sestamibiSingle photon emission computed tomography

Polymers and Conjugated Compounds

β‐carotene

Polyvinyl Chloride (PVC)

PolystyrenePolystyrene

1,2,3,4,5,6- Hexachlorocyclohexane (HCH)

Substituted cyclohexanes

Insecticide, lice removal

Voluntary recall of Lindane owing to y genvironmental pollution

DDT

ClClCl

Paul Hermann Müller: Nobel Prize in

ClCl

Physiology or Medicine in 1948 “for hisdiscovery of the high efficiency of DDT as acontact poison against several arthropods.”

ClCl

dichlorodiphenyltrichloroethane

DDT is banned in the US from 1972.DDT is banned in the US from 1972.

India is the only country stillmanufacturing DDT, with Chinahaving ceased production in 2007.

The Bad Ones

CocaineCocaineAn addictive alkaloid 2,3,7,8-tetrachlorodibenzo-p-dioxin

Viktor YushchenkoBefore and after having ChloranceStrychnine

Toxic Alkaloid