cheminform abstract: synthesis of 1-[(1r)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted...

ChemInform 2011, 42, issue 23 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Urea derivatives Q 0640 DOI: 10.1002/chin.201123072 Synthesis of 1-[(1R)-1-(6-Fluoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted Phe- nyl Ureas and Their Inhibition Activity to Acetylcholinesterase and Butyrylcho- linesterase. — Several novel unsymmetrically substituted ureas (III) are synthesized. Preliminary bioassays indicate that they display excellent activity. — (PEJCHAL*, V.; STEPANKOVA, S.; DRABINA, P.; J. Heterocycl. Chem. 48 (2011) 1, 57-62, http://dx.doi.org/10.1002/jhet.502 ; Inst. Org. Chem. Technol., Univ. Pardubice, CZ-532 10 Pardubice, Czech Republic; Eng.) — H. Haber 23- 072

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Page 1: ChemInform Abstract: Synthesis of 1-[(1R)-1-(6-Fluoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted Phenyl Ureas and Their Inhibition Activity to Acetylcholinesterase and Butyrylcholinesterase

Urea derivativesQ 0640 DOI: 10.1002/chin.201123072

Synthesis of 1-[(1R)-1-(6-Fluoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted Phe-nyl Ureas and Their Inhibition Activity to Acetylcholinesterase and Butyrylcho-linesterase. — Several novel unsymmetrically substituted ureas (III) are synthesized. Preliminary bioassays indicate that they display excellent activity. — (PEJCHAL*, V.; STEPANKOVA, S.; DRABINA, P.; J. Heterocycl. Chem. 48 (2011) 1, 57-62, http://dx.doi.org/10.1002/jhet.502 ; Inst. Org. Chem. Technol., Univ. Pardubice, CZ-532 10 Pardubice, Czech Republic; Eng.) — H. Haber

23- 072

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The Reaction Mechanism of Butyrylcholinesterase

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