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1999 antibiotics antibiotics U 1200 26 - 268 Studies Toward the Synthesis of Menogaril: Synthesis of A-Ring Precursors and Their Conversion to the Tetracyclic Core via the Benzannulation Reation. — Model compound (IX) represents the tetracyclic core of menogril, an orally active drug chosen for development of out-patient chemotherapy of lymphoma and myeloma. The strategy involves the benzannulation of a Fischer carbene complex (V) with the alkyne (IV) and construction of the tetracyclic core (VIII) by Friedel–Crafts cyclization. — (WULFF, WILLIAM D.; SU, JING; TANG, PENG-CHO; XU, YAO-CHANG; Synthesis (1999) 3, 415-422; Searle Chem. Lab., Dep. Chem., Univ. Chicago, Chicago, IL 60637, USA; EN) 1

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Page 1: ChemInform Abstract: Studies Toward the Synthesis of Menogaril: Synthesis of A-Ring Precursors and Their Conversion to the Tetracyclic Core via the Benzannulation Reation

1999 antibiotics

antibioticsU 1200

26 - 268Studies Toward the Synthesis of Menogaril: Synthesis of A-RingPrecursors and Their Conversion to the Tetracyclic Core via theBenzannulation Reation. — Model compound (IX) represents thetetracyclic core of menogril, an orally active drug chosen for development ofout-patient chemotherapy of lymphoma and myeloma. The strategy involvesthe benzannulation of a Fischer carbene complex (V) with the alkyne (IV) andconstruction of the tetracyclic core (VIII) by Friedel–Crafts cyclization. —(WULFF, WILLIAM D.; SU, JING; TANG, PENG-CHO; XU, YAO-CHANG;Synthesis (1999) 3, 415-422; Searle Chem. Lab., Dep. Chem., Univ. Chicago,Chicago, IL 60637, USA; EN)

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