2002 amino acids, peptides

amino acids, peptidesU 0400

28 - 247Kinetic Control of Proline Amide Rotamers: Total Synthesis oftrans,trans- and cis,cis-Ceratospongamide. — A synthetic route forthe preparation of both conformers of the title cyclic peptide is presented. Thetwo stable conformers having either two trans or two cis proline amide bonds, donot interconvert at heating to 90◦C. — (DENG, SHAOJIANG; TAUNTON,JACK; J. Am. Chem. Soc. 124 (2002) 6, 916-917; Dep. Cell. Mol. Pharm.,Univ. Calif., San Francisco, CA 94143, USA; EN)

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