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1998 multi-membered N-heterocycles multi-membered N-heterocycles R 0690 46 - 185 A Route to Chiral, Nonracemic Macroheterocycles. — Key step in the synthesis of the title compounds is the asymmetric alkylation of chiral tetrahydroisoquinoline formamidine (I). The structures of compounds (Vb) and (VIb), obtained by LiAlH 4 reduction of the corresponding amides, are investigated by X-ray crystal structure analysis. — (HUGHES, R.; MEYERS, A. I.; Tetrahedron 54 (1998) 33, 9895-9902; Dep. Chem., Colo. State Univ., Fort Collins, CO 80523, USA; EN) 1

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Page 1: ChemInform Abstract: A Route to Chiral, Nonracemic Macroheterocycles

1998 multi-membered N-heterocycles

multi-membered N-heterocyclesR 0690

46 - 185A Route to Chiral, Nonracemic Macroheterocycles. — Key stepin the synthesis of the title compounds is the asymmetric alkylation of chiraltetrahydroisoquinoline formamidine (I). The structures of compounds (Vb)and (VIb), obtained by LiAlH4 reduction of the corresponding amides, areinvestigated by X-ray crystal structure analysis. — (HUGHES, R.; MEYERS,A. I.; Tetrahedron 54 (1998) 33, 9895-9902; Dep. Chem., Colo. State Univ.,Fort Collins, CO 80523, USA; EN)

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