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    Chapter 15

    Blood Vessels & Circulation

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    Blood Vessels

    Arteries blood vessels carrying blood away

    from heart

    Arterioles small extensions of arteries

    Capillaries thin walled vessels that allow forexchange of substances to and from blood

    Venules receive blood from capillaries (small

    extensions of veins) Veins blood vessels carrying blood to heart

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    Blood Circuits

    Pulmonary Circuit

    Carries blood from the heart to the lungs,

    where carbon dioxide is eliminated and

    oxygen is replinished, and carries oxygenatedblood back to the heart

    Systemic Circuit

    Carries oxygenated blood from the heart tothe rest of the body, and delivers oxygen-

    depleted blood back to the heart

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    Blood Circuits

    Pulmonary Circuit

    Pulmonary Trunk

    Pulmonary arteries

    Pulmonary capillaries

    Pulmonary Veins

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    Blood Circuits

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    Right atrium

    Right ventricle

    Left atrium

    Left ventricle

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    Right atrium

    Right ventricle

    Left atrium

    Left ventricle

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    Pulmonary trunk

    Right ventricle

    Left atrium

    Left ventricle

    Right atrium

    Pulmonary arteries

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    Pulmonary trunk

    Right ventricle

    Left atrium

    Left ventricle

    Right atrium

    Pulmonary arteries

    Lung

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    Pulmonary trunk

    Right ventricle

    Left atrium

    Left ventricle

    Right atrium

    Pulmonary arteries

    Lung

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    Pulmonary trunk

    Right ventricle

    Left atrium

    Left ventricle

    Right atrium

    Pulmonary arteries

    Lung

    Pulmonary veins

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    Blood Circuits

    Systemic Circuit

    Aorta

    Systemic arteries

    Systemic capillaries

    Systemic veins

    Inferior & Superior vena cava

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    Blood Circuits

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    Right atrium

    Right ventricle

    Left atrium

    Left ventricle

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    Right atrium

    Right ventricle

    Left atrium

    Left ventricle

    Aorta

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    Right atrium

    Right ventricle

    Left atrium

    Left ventricle

    Aorta

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    Right atrium

    Right ventricle

    Left atrium

    Left ventricle

    Aorta

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    Superior or Inferior Vena Cava

    Right ventricle

    Left atrium

    Left ventricle

    Aorta

    Right atrium

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    Vessel Structure

    Blood vessels have 3 layers called tunics

    Tunica intima innermost layer

    Lines the lumen

    Made of simple squamous epithelial cells

    Tunica media middle layer

    Made up of smooth muscle & elastic tissue

    Tunica externa outer layer Made of connective tissue

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    Vessel Structure

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    Vessel Structure

    Smooth muscle in middle tunic controlled

    by autonomic nervous system

    Muscles contract, vessels constrict

    Muscles relax, vessels dilate

    Elastic fibers allow stretching of vessels

    and return to normal

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    Vessel Structure

    Capillaries

    Only composed of tunica intima (the

    innermost layer)

    Single layer of epithelial cells allows for

    exchange of substances such as nutrients

    and gases

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    Vessel Structure

    Arteries vs. Veins

    Arteries have thicker tunica media (smooth muscle

    layer); Veins have thin tunica media

    Veins have one-way valves extending into thelumen; Arteries do not

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    Arteries vs. Veins

    Arteries depend on pumping of the heart for

    circulation

    Veins depend on:

    Contraction of skeletal muscles

    Valves

    Thoracic expansion during breathing (p. 336)

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    Systemic Arteries

    Aorta

    Ascending aorta

    Aortic arch

    Descending aorta

    Thoracic aorta

    Abdominal aorta

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    Systemic Arteries

    Aortic arch

    Brachiocephalic Trunk

    Right common carotid a.

    Right subclavian a.

    Left Common Carotid artery

    Left Subclavian artery

    Brachiocephalic: Brachio = arm ; Cephalic = head

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    Systemic Arteries

    Celiac trunk

    Common hepatic artery

    Left gastric artery

    Splenic artery

    Renal arteries

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    Systemic Arteries

    Common iliac artery

    External iliac a.

    Internal iliac a.

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    Systemic Arteries

    External Iliac a.

    Femoral a.

    Popliteal a.

    Anterior tibial a.

    Posterior tibial a.

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    Systemic Arteries

    Subclavian artery

    Axillary artery

    Brachial artery Radial a.

    Ulnar a.

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    Systemic Veins

    Superior Vena Cava

    Brachiocephalic v. (R & L)

    Internal jugular v.

    External jugular v.

    Subclavian v.

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    Systemic Veins

    Subclavian vein

    Basilic v.

    Axillary v.

    Cephalic v.

    Brachial v.

    Radial v.

    Ulnar v.

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    Systemic Veins

    Inferior vena cava

    Hepatic vein

    Hepatic portal vein

    Collects blood from intestines, stomach, pancreas,spleen

    Renal vein

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    Systemic Veins

    Inferior vena cava

    Common iliac v.

    Internal Iliac v.

    External Iliac v. Great saphenous v.

    Femoral v.

    Popliteal v.

    Anterior tibial v. Posterior tibial v.

    Fibular v.

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    Circulation Physiology

    Tissue fluid / Interstitial fluid

    Surrounds all body cells

    Fluid and contents leaked from capillaries

    Diffusion

    Blood Pressure

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    Circulation Physiology

    Vasodilation widening of blood vessels

    Vasoconstriction decrease of diameter of

    blood vessels

    Vasomotor center located in medulla;

    regulates vasomotor activities

    Precapillary sphincter loop of smooth

    muscle around arterioles leading to the

    capillary

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    Pulse

    Wave of pressure exerted on arterial walls

    by force of the heart

    Pulse can only be taken at an artery

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    Blood Pressure

    Force exerted by blood against walls of

    the vessels

    Determined by: cardiac output &

    resistance to flow

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    Blood Pressure

    Cardiac Output volume of blood pumped

    out of each ventricle in 1 minute; based

    on:

    Heart rate

    Stroke volume

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    Blood Pressure

    Resistance to blood flow:

    Vasomotor changes

    Vasoconstriction increases resistance

    Elasticity of blood vessels Atherosclerosis increases resistance

    Viscosity

    Thicker blood has more resistance Total blood volume

    Blood loss = less blood = less resistance

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    Blood Pressure

    Measurement

    Sphygmomanometer

    Systolic pressure

    Pressure in arteries during ventricular systole(contraction)

    ~120 mmHg

    Diastolic pressure

    Pressure in arteries during ventricular diastole(relaxation)

    ~80 mmHg

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    Blood Pressure

    Abnormally low blood pressure -

    Hypotension

    Abnormally high blood pressure

    Hypertension

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    Blood Pressure

    Hypertensions effects

    Weakens vessels and leads to aneurysms

    Add stress to the heart, causing enlargement

    and eventual weakening

    Stress kidneys, damage renal vessels

    Damage lining of vessels, leading to

    atherosclerosis

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    Blood Pressure

    Hypertensions treatments

    Diet, exercise, weight loss

    Drugs

    Diuretics water loss

    Drugs that limit production of renin (ACE inhibitors)

    Renin is a hormone produced in kidney, causes water &

    salt retention, & vasoconstriction

    Drugs that relax blood vessels (vasodilators)

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    Vascular disorders

    Atherosclerosis

    Hardening of the arteries by fatlike substance

    called plaque, separating smooth muscle from

    elastic tissueAccounts for 40% of all deaths in the US

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    Vascular disorders

    Aneurysm

    Weakness in walls of a blood vessel that

    leads to formation of a bulging sac

    Sac can put pressure on surrounding organs

    Can rupture, causing death

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    Vascular disorders

    Shock

    Inadequate blood flow to body tissues

    Cardiogenic shock heart muscle damage, as in

    myocardial infarction Septic shock overwhelming bacterial infection

    Hypovolemic shock burns or hemorrhage cause

    low blood volume

    Anaphylactic shock severe allergic reaction toforeign substances

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    Vascular disorders

    Thrombosis formation of a blood clot in

    a vessel

    Embolus the clot dislodges and moves

    throughout the vessel Pulmonary embolism the embolus reaches

    the lungs; fatal

    Phlebitis inflammation of a vein; cancontribute to embolus formation

    (thrombophlebitis)

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    Vascular disorders

    Varicose veins

    Most commonly in saphenous veins

    Swollen, distorted veins

    Faulty valves

    In the rectum = hemorrhoids

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    1. pulmonary circuit (include chambers, vessels,capillaries, organs)

    2. systemic circuit

    3. draw aorta, including: Brachiocephalic trunk

    Common carotid arteries

    Subclavian arteries

    Celiac trunk (3 parts)

    Renal arteries

    Common iliac branches

    External, internal iliac a. Femoral a.

    Popliteal a.

    Anterior, posterior tibial a.