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    Chapter 3

    Heredity and Variation

    (Keturunan dan Variasi)

    Prepared by: En. Shafie Bin Buyamin

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    3.1: Cell Division

    (Pembahagian Sel)

    Cell has a nucleus

    Nucleus contains chromosomes

    Chromosomes is thread-like structure(struktur seperti bebenang) made up of longDNA molecule

    Chromosomes come in pairs (berpasangan)

    Genes are small portion of DNA molecule

    Gene also come in pairs

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    Mitosis

    Process of cell division that occurs in allcells (somatic cell) except in sex cells

    One parent cell produces 2 daughter cells

    Number of chromosomes same

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    Stages of mitosis

    Stages of mitosis Simple explanation

    - Chromosomes shorten,

    thicken, more visible

    (Memendek, menebal, lebihjelas)

    -Replication(Replikasi) ofchromosomes

    Each strand called

    chromatid

    centromere

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    Stages of mitosis Simple explanation

    -Chromosomes align (tersusun)

    in the centre of cell

    - Nucleus membrane

    disappears

    - Chromatid separate andmove to opposite ends of cell

    - Cell starts to divide

    -Nucleus membrane formsagain

    - Two daughter cell formed

    - Each progeny cell has the

    same number of chromosomes

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    Meiosis

    Process of cell division that occurs in sexorgan

    For production of gametes or sex cells

    Parent cell produces 4 daughter cells (selanak)

    Number of chromosomes in daughtercell(sel anak) is half(separuh) in parentcell (sel induk)

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    Stages of meiosis

    Chromosomes shorten, thicken(memendek, menebal)

    Replication (replikasi) and crossingover(pindah silang) on chromatid

    1. Chromosomes align (tersusun) in the

    centre of cell (tengah sel)

    2. Nucleus membrane disappears

    First Division

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    1. Chromosomes move to

    opposite ends of the cell

    2. The cell begins to divideinto two (membahagi 2)

    1. Two daughter cells

    produced (2 sel anak

    terhasil)

    2. Nucleus membranereforms

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    1. Chromosomes align in

    the centre of cell

    2. Nucleus membrane

    disappears

    1. Chromatids separate

    2. Cell begins to divide

    Second Division

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    1. Nucleus membrane is formed again

    2. 4 daughter cells produced (4 sel

    anak terhasil)3. Each cell has half(separuh) of the

    chromosomes in the parent cell

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    Comparing Meiosis and Mitosis

    Meiosis Characteristics Mitosis

    2 Number of division

    (Bilanganpembahagian

    1

    Occurs during

    the first cell

    division

    Replication

    (Replikasi)

    Occurs

    4 Number of daughtercells (sel anak)

    produced

    2

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    Meiosis Characteristics Mitosis

    Half Number of

    chromosomes in

    daughter cell

    compared to parent

    cell

    Same

    Different Combination of

    chromosomes in

    daughter cell

    compared to parentcell

    Identical

    Occurs Crossing over

    (Pindah silang)

    Not occur

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    The Importance of Mitosis and Meiosis

    Mitosis:

    1. Produces new cells for growth

    (pertumbuhan) and replace dead /damaged cells (ganti sel mati/ rosak)

    2. Maintain genetic information

    (Mengekalkan maklumat genetik)

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    Meiosis

    1. Produces gametes

    2. Ensure number of chromosomes is kept

    constant from one generation to another

    generation

    3. Ensure each gamete produced carry

    different genetic constituents

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    3.2 : Inheritance

    (Pewarisan)

    Traits: Characteristics inherited fromparents (ciri diwarisi dari induk)

    Inheritance (Pewarisan): process ofpassing genetic information / traits from

    parents to offspring (Proses menurunkanmaklumat genetik / ciri induk ke anak)

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    Dominant and Recessive Genes1. Human have 46 chromosomes

    2. Arranged in pairs (homologous)3. 23 pairs of homologous chromosomes

    4. Each chromosomes carries a gene or a gene group

    5. Gene / gene group carries traits

    6. Each gene pairs with other gene on homologouschromosomes

    7. Paired genes / gene groups carry instructions to create/ control one of characteristics

    8. Example: one instruct curly hair, other instruct straighthair

    9. One is dominant, other is recessive gene

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    Dominant gene

    Member of a pair of genes which carriesan instruction that overrules the other(recessive) gene

    Curly hair gene is dominant, straight hairgene is recessive

    Dominant Trait

    When display the characteristics

    of dominant gene

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    Recessive gene

    Member of a pair of genes which carries aninstruction that being overrules by the other(dominant) gene

    If inherited only a pair of straight hair gene: we

    would have straight hair

    Recessive Trait

    When display the characteristics

    of recessive gene

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    Mechanism of Inheritance of Traits

    In meiosis, gamete only carry one genefrom each pair of gene

    In fertilisation, gamete fuse to form zygote(combination both parent)

    Traits inherited determined by both sets ofgenes from parent

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    Parent

    Meiosis

    Gamete

    Fertilisation

    Offspring

    H: Curly hair (Dominant gene)

    h: Straight hair (Recessive gene)

    All offspring have curly hair

    HH hh

    H H h h

    Hh Hh Hh Hh

    Schematic Diagram

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    Genotype

    Genetic composition of an organism(combination of genes)

    Example: Genotype for individual withcurly hair can be HH or Hh Genotype for straight hair is hh

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    Phenotype

    Characteristic that can be observed ordetermined (Ciri yang boleh diperhatikan)

    Example: Trait for hair type has 2phenotype that is curly hair and straight

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    Parent Phenotype

    Gamete

    PhenotypeAll offspring have Yellow Seed

    YY yy

    Y Y y y

    Yy Yy Yy Yy

    Monohybrid Cross Gregor Mendel

    Yellow seed Green seed

    F1

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    F1 : First filial generation

    F2 : Second filial generation

    - Experiment of a monohybrid cross by

    Gregor Mendel to predict the genotype

    and phenotype ratios of F1 & F2

    -Used pea plant (yellow & green seed)

    - Showed that yellow seed were

    dominant trait

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    Offspring of F1 (Dihybrid Cross)

    F1 Generation

    Gamete

    Phenotype

    Genotype ratio = 1 YY : 2 Yy : 1 yy

    Yy Yy

    Y y Y y

    Y

    Y

    Yy Yy yy

    Yellow seed Yellow seed

    F2 generation

    Phenotype ratio = 3 yellow : 1 green

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    Punnett-square method

    YY Yy

    Yy yy

    Y y

    Y

    y

    Gamete Genotype of

    offspring

    * To predict genotype and phenotype ratio