The Immune System Fourth Edition

Chapter 2 Innate Immunity: The Immediate

Response to Infection

Copyright © Garland Science 2015

Peter Parham

CHAPTER CONTENTS

2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens

2-2 Intracellular and extracellular pathogens require different types of immune response

2-3 Complement is a system of plasma proteins that mark pathogens for destruction

2-4 At the start of an infection, complement activation proceeds by the alternative pathway

2-5 Regulatory proteins determine the extent and site of C3b deposition

2-6 Phagocytosis by macrophages provides a first line of cellular defense against invading microorganismstes

CHAPTER CONTENTS

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-8 Small peptides released during complement activation induce local inflammation

2-9 Several classes of plasma protein limit the spread of infection

2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes

Innate Immunity: the Immediate Response to Infection

2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens

2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens

Innate Immunity: the Immediate Response to Infection

2-2 Intracellular and extracellular pathogens require different types of immune response

2-2 Intracellular and extracellular pathogens require different types of immune response

Innate Immunity: the Immediate Response to Infection

2-3 Complement is a system of plasma proteins that mark pathogens for destruction

2-3 Complement is a system of plasma proteins that mark pathogens for destruction

2-3 Complement is a system of plasma proteins that mark pathogens for destruction

2-3 Complement is a system of plasma proteins that mark pathogens for destruction

Innate Immunity: the Immediate Response to Infection

2-4 At the start of an infection, complement activation proceeds by the alternative pathway

2-4 At the start of an infection, complement activation proceeds by the alternative pathway

2-4 At the start of an infection, complement activation proceeds by the alternative pathway

2-4 At the start of an infection, complement activation proceeds by the alternative pathway

Innate Immunity: the Immediate Response to Infection

2-5 Regulatory proteins determine the extent and site of C3b deposition

2-5 Regulatory proteins determine the extent and site of C3b deposition

Innate Immunity: the Immediate Response to Infection

2-6 Phagocytosis by macrophages provides a first line of cellular defense against invading microorganisms

2-6 Phagocytosis by macrophages provides a first line of cellular defense against invading microorganisms

Innate Immunity: the Immediate Response to Infection

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

Innate Immunity: the Immediate Response to Infection

2-8 Small peptides released during complement activation induce local inflammation

2-8 Small peptides released during complement activation induce local inflammation

Innate Immunity: the Immediate Response to Infection

2-9 Several classes of plasma protein limit the spread of infection

2-9 Several classes of plasma protein limit the spread of infection

Innate Immunity: the Immediate Response to Infection

2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

Innate Immunity: the Immediate Response to Infection

2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes

2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes