chapter 19 the genetics of viruses & bacteria. lunchtime!! t4 bacteriophages
TRANSCRIPT
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Lunchtime!!
T4 Bacteriophages
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T4 Bacteriophage
Bacteriophage – virus that attacks bacteria
Attacks Escherichia Coli bacteria Injects its DNA into the bacterium’s DNA Virus takes over the bacterium’s genetic
mechanism
Called an obligate intracellular parasite Obligate – only exists in certain cases Intracellular – Internal or inside cell Parasite – lives off another organism
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Viral Structure
The smallest viruses are 20nm in diameter, smaller than a ribosome
What does a ribosome do?
What does that mean for its size relative to an animal cell?
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Who’s bigger?
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Let’s talk about viruses #1
1. HIV/AIDS In 2007, 33.2 million with HIV/AIDS
2.1 million fatalities from HIV 68% of infections are in Sub-Saharan Africa 2.5 million new infections in 2006 Retrovirus
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Viral Images
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Let’s talk about viruses #2
2. Influenza 7th leading cause of death worldwide, but
not in the US Causes widespread pandemics every
decade or so Fatality is more likely in the elderly &
infants
Avian influenza in the 1990’s was the last major pandemic
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Let’s talk about viruses #3
3. Ebola Hemorrhagic Virus “Occasionally, Internal and external
hemorrhage from orifices, such as the nose and mouth may also occur, as well as from incompletely healed injuries such as needle-puncture sites.”
Mortality rates are generally high, ranging from 50% - 90%
Ebola is referred to as a “slate wiper” due to its remarkably high case fatality rate
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Ebola outbreak in Congo
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Are Viruses alive?
They have DNA (or RNA) They are not able to reproduce on their
own They infect other cells in order to
perpetuate their life cycle Viruses can be crystallized, but no other
cells can be crystallized May contain a membranous envelope
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Viral Genomes
Basically – nucleic acid with a protein coat Some will have DNA (2-strands or 1-strand)
Papillomavirus, Herpesvirus, & Smallpox Parvovirus (1-strand)
Others have RNA (2 or 1 strand again) HIV, Influenza & Ebola
Amount of genes also varies widely depending on the virus
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Capsids & Envelopes
Capsid – Protein shell enclosing the viral genome Rod-shaped, polyhedral, or more complicated
(T4) Capsids are built from protein subunits called
capsomeres
Envelope – Helps viruses infect their hosts Derived from the membranes of the host cell Host phospholipids & membrane proteins
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Viral Life Cycle Animation(s)
19_04SimpViralReproCycle
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Simple Viral Reproductive Cycle
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2 Types of Viral Life cycles
Lytic Virulent cycle Results in death of host cell New phages are produced, host cell wall
destroyed, and progeny (daughter viruses) are released to infect other cells
Lysogenic Viral DNA is incorporated into host DNA This viral DNA is called prophage (provirus in
euks.) Infection silently spreads to daughter cells
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Lytic Cycle Animation
19_05PhageT4LyticCycle
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Lytic Cycle
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Lytic vs. Lysogenic Cycle
19_06LysogenicLyticCycle
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Lytic vs. Lysogenic Cycle
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HIV Life Cycle
19_08HIVReproCycle
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Viroids & Prions
Viroids Just RNA Significantly smaller than viruses Infect plants
Prions Proteins that are capable of infecting cells No DNA or RNA Causes degenerative brain diseases CJD (Creutzfeldt-Jacobs disease V1)
Bovine Spongiform Encephalopathy (BSE)
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Prions & Alzheimer's
Prions form into incorrect shape in CJD, but not so in Alzheimer
Prions interact with plaques to allows the plaques to damage brain cells
Amyloid-beta is the go between Mechanism of prion and amyloid-beta is
unknown But sci. know there is an interaction, and
this interaction = Alzheimers Possible treatment avenue