chapter 18, part 1
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Chapter 18, part 1. The Endocrine System. Learning Objectives. Compare the major chemical classes and general mechanisms of hormones. Describe the location and structure of the pituitary gland, and explain its structural and functional relationships with the hypothalamus. - PowerPoint PPT PresentationTRANSCRIPT
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Fundamentals of
Anatomy & PhysiologySIXTH EDITION
Frederic H
. Martini
PowerPoint® Lecture Slide Presentation prepared by Dr. Kathleen A. Ireland, Biology Instructor, Seabury Hall, Maui, Hawaii
Chapter 18, part 1
The Endocrine System
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Learning Objectives
• Compare the major chemical classes and general mechanisms of hormones.
• Describe the location and structure of the pituitary gland, and explain its structural and functional relationships with the hypothalamus.
• Describe the location and structure of each of the endocrine glands.
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Learning Objectives
• Identify the hormones produced by each of the endocrine glands and specify the functions of those hormones.
• Describe the functions of the hormones produced by the kidneys, heart, thymus, testes, ovaries and adipose tissue.
• Explain how hormones interact to produce coordinated physiological responses.
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SECTION 18-1 Intercellular Communication
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• Nervous system performs short term crisis management
• Endocrine system regulates long term ongoing metabolic
• Endocrine communication is carried out by endocrine cells releasing hormones
• Alter metabolic activities of tissues and organs
• Target cells
• Paracrine communication involves chemical messengers between cells within one tissue
Endocrine versus Nervous system
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
SECTION 18-2 An Overview of the Endocrine System
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• Includes all cells and endocrine tissues that produce hormones or paracrine factors
Endocrine system
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 18.1
Figure 18.1 The Endocrine System
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
• Amino acid derivatives
• Structurally similar to amino acids
• Peptide hormones
• Chains of amino acids
• Lipid derivatives
• Steroid hormones and eicosanoids
Hormone structure
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 18.2
Figure 18.2 A Structural Classification of Hormones
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Hormones can be
• Freely circulating
• Rapidly removed from bloodstream
• Bound to transport proteins
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• Receptors for catecholamines, peptide hormones, eicosanoids are in the cell membranes of target cells
• Thyroid and steroid hormones cross the membrane and bind to receptors in the cytoplasm or nucleus
Mechanisms of hormone action
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Figure 18.3 G Proteins and Hormone Activity
Figure 18.3
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Figure 18.4 Hormone Effects on Gene Activity
Figure 18.4
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• Endocrine reflexes are the counterparts of neural reflexes
• Hypothalamus regulates the activity of the nervous and endocrine systems
• Secreting regulatory hormones that control the anterior pituitary gland
• Releasing hormones at the posterior pituitary gland
• Exerts direct neural control over the endocrine cells of the adrenal medullae
Control of endocrine activity
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 18.5
Figure 18.5 Three Methods of Hypothalamic Control over the Endocrine System
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SECTION 18-3 The Pituitary Gland
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• Releases nine important peptide hormones
• All nine bind to membrane receptors and use cyclic AMP as a second messenger
Hypophysis
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Figure 18.6 The Anatomy and Orientation of the Pituitary Gland
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• Subdivided into the pars distalis, pars intermedia and pars tuberalis
• At the median eminence, neurons release regulatory factors through fenestrated capillaries
• Releasing hormones
• Inhibiting hormones
The anterior lobe (adenohypophysis)
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• All blood entering the portal system will reach the intended target cells before returning to the general circulation
Hypophyseal portal system
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Figure 18.7 The Hypophyseal Portal System
Figure 18.7
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 18.8a
Figure 18.8 Feedback control of Endocrine Secretion
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Figure 18.8 Feedback control of Endocrine Secretion
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
• Thyroid stimulating hormone (TSH)
• Triggers the release of thyroid hormones
• Thyrotropin releasing hormone promotes the release of TSH
• Adrenocorticotropic hormone (ACTH)
• Stimulates the release of glucocorticoids by the adrenal gland
• Corticotrophin releasing hormone causes the secretion of ACTH
Hormones of the adenohypophysis
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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings
• Follicle stimulating hormone (FSH)
• Stimulates follicle development and estrogen secretion in females and sperm production in males
• Leutinizing hormone (LH)
• Causes ovulation and progestin production in females and androgen production in males
• Gonadotropin releasing hormone (GNRH) promotes the secretion of FSH and LH
Hormones of the adenohypophysis
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• Prolactin (PH)
• Stimulates the development of mammary glands and milk production
• Growth hormone (GH or somatotropin)
• Stimulates cell growth and replication through release of somatomedins or IGF
• Growth-hormone releasing hormone (GH-RH)
• Growth-hormone inhibiting hormone (GH-IH)
Hormones of the adenohypophysis
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• May be secreted by the pars intermedia during fetal development, early childhood, pregnancy or certain diseases
• Stimulates melanocytes to produce melanin
Melanocyte stimulating hormone (MSH)
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• Contains axons of hypothalamic nerves
• neurons of the supraoptic nucleus manufacture antidiuretic hormone (ADH)
• Decreases the amount of water lost at the kidneys
• Elevates blood pressure
The posterior lobe of the pituitary gland (neurohypophysis)
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• Neurons of the paraventricular nucleus manufacture oxytocin
• Stimulates contractile cells in mammary glands
• Stimulates smooth muscle cells in uterus
The posterior lobe of the pituitary gland (neurohypophysis)
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Figure 18.9 Pituitary Hormones and Their Targets