changing the incidence of glomerular diseases in adults
DESCRIPTION
Changing the Incidence of Glomerular Diseases in Adults. G. Braden, J. Mulhern, M. O’Shea, S. Nash, A. Ucci & J. Germain AJKD, Vol 35 No.5:2000; pp 878-83. Background. For the last 50 years, MN was the leading cause of Idiopathic NS in up to .5 of W and AA adults, whereas FSGS was .1-.15 - PowerPoint PPT PresentationTRANSCRIPT
November 2000, Journal Club
Changing the Incidence of Glomerular Diseases in Adults
G. Braden, J. Mulhern, M. O’Shea,
S. Nash, A. Ucci & J. Germain
AJKD, Vol 35 No.5:2000; pp 878-83
Background
• For the last 50 years, MN was the leading cause of Idiopathic NS in up to .5 of W and AA adults, whereas FSGS was .1-.15
• 3 academic Ctrs. reported FSGS in AA• No info on sm. urban (< 150 K population)
& rural areas • No info on Hispanics
Methods
• Renal Bx & chart review from 1974-94 at Baystate Med. Ctr. in Springfield, Mass.
• >18 y.o, 2 gm proteinuria/day, 5 yr intervals• Excluded: IVDA, HIV, SS, VUR, meds,
tumors, Hep B, MPGN (2o to cryoglob or hepatitis), collagen, SLE, Crescentic GN, Acute Prolif. GN, Focal necrotizing GN, vasculitis, amyloidosis & fibrilary GN
Results
• Sample: 965, eligible n = 616 adults
• AA catchment pop. in 20 years .056 .065
• 2o FSGS went from 0 in the 1st and 2nd quartiles, to .12 (3rd q) to .06 (4th q)
• 2o MN: .3 in the 1st .12 .15 .06
• No sig. in other 1o Glomerulopathies
• 1990-94 new FSGS 15 vs. MN 7 (p<.05)
Discussion (1): Idiopathic FSGS Increase
Unlikely due to detection (tissue levels on light microscopy/Bx = in 20 years)
Unlikely due to frequency of 2o causes of FSG or MN because these patients along with the idiopathic FSGS cases.
• No in 2o MN that could Idiopathic MN
Discussion (2): Idiopathic FSGS Increase
• FSGS in AA & H (significantly) & in W
• No in age and sex distribution in 20 y.
• Inclusion of all 2 g/d proteinuria, not all patients had NS overestimation
• Most Hispanics from Puerto Rico