cell communications
DESCRIPTION
Cell Communications. Chapter 5.5-5.6. Types of communication. Differentiate between the following: Paracrine Endocrine Autocrine. Steps to communicate. Step 1: Multiple Receptor types. Cytoplasmic receptor proteins Membrane bound receptor proteins G-protein linked receptors - PowerPoint PPT PresentationTRANSCRIPT
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CELL COMMUNICATIO
NSChapter 5.5-5.6
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TYPES OF COMMUNICATION Differentiate between the following:
ParacrineEndocrineAutocrine
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STEPS TO COMMUNICATE
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STEP 1: MULTIPLE RECEPTOR TYPES Cytoplasmic receptor proteins Membrane bound receptor proteins
G-protein linked receptorsReceptor tyrosine kinasesLigand gated ion channels
Be able to compare and contrast each of the above.
Know what type of signals activate each Provide examples of each
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CYTOPLASMIC RECEPTORS
How do they work?
What is different about the chemistry of the signals?
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G-PROTEIN LINKED RECEPTORHow does it work?
What is different about the GDP to GTP transition as compared to the GTP to GDP transition?
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RECEPTOR TYROSINE KINASES
How does it work?
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LIGAND GATED ION CHANNELS
How does it work?
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STEP 2: TRANSDUCTION
Second messengers
Phosphorylation cascades
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SECOND MESSENGERS
What are they?
Examples?
Advantages to using them?
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SECOND MESSENGERS
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PHOSPHORYLATION CASCADE
What are they? Advantages?
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REGULATING SIGNAL TRANSDUCTION How does a cell regulate this process?
While the number of “steps” creates increased regulation, it also creates increased risk of malfunction. Explain.
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STEP 3: RESPONSE
Likely responses to a signal???
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SPECIFICITY OF THE SIGNAL
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PUTTING IT ALL TOGETHER
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EXAMPLES TO BE FAMILIAR WITH
How does caffeine interfere with a signaling pathway to keep us “perky”?
- adenosine receptor antagonist - inhibitor of cAMP phosphodiesterase
Be able to explain the epinephrine pathway from signal to response!
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