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Marmara University School of Medicine 2012-2013
Y2C1
CELL AND TISSUE INJURY COURSE-1
September 03, 2012 – October 19, 2012
AIM
At the end of this course, second year students will be able to broaden their basic science
knowledge to include the understanding of how certain alterations in bodily processes may
manifest as disease and gain fundamental knowledge about the processes underlying human
diseases, as the scientific foundation for developing clinical skills.
LEARNING OBJECTIVES
At the end of this course, second year students will,
describe using proper nomenclature, the etiology, pathogenesis, structural and
functional changes at cellular and tissue level;
describe in detail what happens to cells and tissues in response to abnormal stimuli;
explain the basic principles of human immune system as it relates to defense against
disease (innate, humoral, cell mediated);
describe the principles of classifying infectious microorganisms and their pathogenic
properties;
gain knowledge about viruses and viral pathogenesis;
gain knowledge about parasites and pathogenesis of parasitic diseases;
identify major drug classes and prototype drug(s) for each class.
Textbooks and Suggested Readings
Basics and Clinical Pharmacology (Bertram G Katzung).
Clinical Pharmacology (Laurence DR, Bennet PN).
Pharmacological Basis of Therapeutics (Goddman & Gilman’s).
Radiation protection, Ch.5 (Mary Alice Statkiewicz)
Radiobiology for the radiologist (Eric J.Hall)
Physics of Life Sciences (Alan H.Cromer)
Clinical Biophysics (Anbar)
Radiologic Science for Technologist (S.C.Bushong)
Textbook of Physiology (Guyton AC).
Basic Pathology (Stanley L. Robbins, Marcia Angel, Vinay Kumar).
Histology and Cell Biology: an Introduction to Pathology (Abraham L. Kierszenbaum).
Review Medical Microbiology (Ernest Jawetz et al.).
Medical Microbiology (Cedric Mims et al.).
Review of Medical Microbiology (Patric R. Murray, Ken S. Rosenthal).
Cellular and Molecular Immunology 5th Edition (Abbas, Lichtman).
Kuby Immunology 4th Edition (Goldsby, Kindt, Osborne).
Immunobiology 6th Edition (Janeway, Travers, Walport, Schlomchik).
Immunology, Infection and Immunity (Pier, Lyczak, Wetzler).
INSTRUCTOR INFORMATION
Year 2 Coordinators
Pınar AY, Assoc. Professor of Public Health
Özgür KASIMAY, Assist. Professor of Physiology
Chairperson of Subject Course
Coordinators of Introduction to Clinical Practice
Pemra C.ÜNALAN, Assoc. Professor of Family Medicine
Sibel KALAÇA, Professor of Public Health
(See ICP-2 Program Book for the details)
Departments Contributing to the Course and Lecturers
Tunç AKKOÇ, Assoc.Professor of Immunology
Ahmet AKICI, Professor of Pharmacology
Burak AKSU, Instructor of Microbiology
İnci ALİCAN, Professor of Physiology
Erkin ARIBAL, Professor of Radiology
Mustafa BAKIR, Professor of Child Health and Disease
Işıl BARLAN, Professor of Child Health and Disease
Kemal BERKMAN, Professor of Pharmacology
Emine BOZKURTLAR, Assist. Professor of Pathology
Süheyla BOZKURT, Assoc. Professor of Pathology
Hülya CABADAK, Assoc. Professor of Biophysics
Çiğdem ÇELİKEL, Professor of Pathology
Nilgün ÇERİKÇİOĞLU, Professor of Microbiology
Serap ÇİFÇİLİ, Assist. Professor of Family Medicine
Elif DAĞLI, Professor of Child Health and Disease
Emel DEMİRALP, Professor of Allergy-Immunology
Haner DİRESKENELİ, Professor of Internal Medicine
Yusuf ERDİL, Professor of Nuclear Medicine
Funda EREN, Professor of Pathology
Ayşe GARİP, Assist. Professor of Biophysics
Zafer GÖREN, Professor of Pharmacology
Rezzan GÜLHAN, Assoc. Professor of Pharmacology
Goncagül HAKLAR, Professor of Biochemistry
Ufuk HASDEMİR, Professor of Microbiology
Atila KARAALP, Assoc. Professor of Pharmacology
Ayşegül KARAHASAN, Professor of Microbiology
Handan KAYA, Professor of Pathology
Hızır KURTEL, Professor of Physiology
Oya ORUN, Assist. Professor of Biophysics
Nesrin ÖZER, Professor of Biochemistry
Güner SÖYLETİR, Professor of Microbiology
Pınar MEGA TİBER, Instructor of Biophysics
Aysın TULUNAY, Assist.Professor of Immunology
Turgut TUROĞLU, Professor of Nuclear Medicine
Nurver ÜLGER, Assoc. Professor of Microbiology
Hasan Raci YANANLI, Assoc. Professor of Pharmacology
Berrak YEĞEN, Professor of Physiology
SUMMARY OF THE COURSE
DISCIPLINE LECTURE &
SMALL GROUP
DISCUSSION
LAB& PRACTICAL TOTAL
BIOCHEMISTRY 4 - 4
BIOPHYSICS 11 - 11
CHILD HEALTH &
DISEASES
4 - 4
FAMILY MEDICINE 1 - 1
ALLERGY- IMMUNOLOGY 17 - 17
MICROBIOLOGY 24 6 30
NUCLEAR MEDICINE 2 - 2
PATHOLOGY 18 6 24
PHARMACOLOGY 21 - 21
PHYSIOLOGY 5 - 5
RADIOLOGY 1 - 1
SUBTOTAL 108 12 120
INTRODUCTION TO
CLINICAL PRACTICE
16 15 31
TOTAL 124 27 151
Monday, 03 September 2012
09:40 - 10:30 Introduction to the course and opening lecture
10:40 - 11:30 Introduction to pharmacology K BERKMAN
11:40 - 12:30 Routes of drug administration A KARAALP
13:40 - 14:30 Radioactivity: the decay law; physical half-life, biological half-life
O ORUN
14:40 - 15:30 Radioactivity: the decay law; physical half-life, biological half-life
O ORUN
Tuesday, 04 September 2012
09:00 - 10:30 Introduction to ICP-2
10:40 - 11:30 Types of radiation O ORUN
11:40 - 12:30 Types of radiation O ORUN
13:40 - 14:30 Structure and Function of Complement System E DEMİRALP
14:40-15:30 B Lymphocyte Development and Biology E DEMİRALP
Wednesday,05 September 2012
08.40-09.30 Microbial pathogenicity and virulence G SÖYLETİR
09:40 - 10:30 Microbial toxins G SÖYLETİR
10:40 - 11:30 Electromagnetic spectrum A GARİP
11:40 - 12:30
13:40 - 14:30 Biochemical aspect of cell death G HAKLAR
14:40 - 15:30 Biochemical aspect of cell death G HAKLAR
Thursday, 06 September 2012
09:40 - 10:30 Microbiology of water, milk, and air N ÇERİKÇİOĞLU
10:40 - 11:30 Chemokines, Neutrophils and Monocytes in Innate Immunity T AKKOC
11:40 - 12:30 Immunoglobulins: Structure and Function, Antigen & antibody Interactions
T AKKOÇ
13:40 - 14:30 Introduction to pathology Ç ÇELİKEL
14:40 - 15:30 Adaptive cell reactions and abnormal accumulations F EREN
Friday, 07 September 2012
09:40 - 10:30 Pathophysiology of oedema formation H KURTEL
10:40 - 11:30 Pathophysiology of oedema formation H KURTEL
11:40 - 12:30 Molecular and radiobiological behavior H CABADAK
13:40 - 14:30 Major histocompatibility complex (MHC) olecules, antigen processing and presentation
E DEMİRALP
Monday, 10 September 2012
09:40 - 10:30 Basic principles of drug toxicity H. R. YANANLI
10:40 - 11:30 Heavy metals and antagonists H. R. YANANLI
11:40-12:20 Introduction to innate immune system H.DİRESKENELİ
13:40 - 14:30
14:40 - 15:30 Dosimetry, basic concepts O ORUN
Tuesday, 11 September 2012
09:00 - 17:30 ICP-2: Basic Clinical Skills, Human in Medicine, Student Research Activity-2
Wednesday, 12 September 2012
09:40 - 10:30 DNA viruses: Herpes viruses U HASDEMİR
10:40 - 11:30 Mechanism of viral pathogenesis G SÖYLETİR
11:40 - 12:30 Pathogenesis of parasitic disease N ÜLGER
13:40 - 14:30 Introduction to Radiology and Prevention in Radiology E ARIBAL
14:40 - 15:30 Effects of ionizing radiation on the cell and organism H CABADAK
Thursday, 13 September 2012
09:40-10:30 Development of T Cells, T lymphocyte signaling mechanisms and activation
T AKKOÇ
10:40 - 11:30 Brıdgıng Innate and Adaptive Immunty Dendritic Cells , NK Cells NKT Cells and Other Innate like T and B Lineages
H. DİRESKENELİ
11:40 - 12:30 Blood and tissue protozoa N ÜLGER
13:40 - 14.30 General principles of macroscopic evaluation (slide lecture) S BOZKURT
14:40 - 15:30 General Pathology of viral infections S BOZKURT
Friday, 14 September 2012
09:40-10:30
10:40 - 11:30 Normal body flora N ÇERİKCİOĞLU
11:40 - 12:30 RNA viruses: Orthomyxoviruses and Paramyxoviruses A KARAHASAN
13:40 - 14:30 Health effects of tobacco E DAĞLI
14:40 - 15:30 Health effects of tobacco E DAĞLI
15:40-16:30
Monday, 17 September 2012
08.40-09.30
09:40 - 10:30 General pharmacokinetic principles-1 R GÜLHAN
10:40 - 11:30 General pharmacokinetic principles-1 R GÜLHAN
11:40 - 12:30 Cultivation and identification of bacteria A KARAHASAN
13:40 - 14:30 General pharmacokinetic principles-2 R GÜLHAN
14:40 - 15:30 General pharmacokinetic principles-2 R GÜLHAN
Tuesday, 18 September 2012
09:00 - 17:30 ICP-2: Basic Clinical Skills, Human in Medicine, Student Research Activity-2
Wednesday, 19 September 2012
09:40 - 10:30 Mechanism of drug action Z GÖREN
10:40 - 11:30 Mechanism of drug action Z GÖREN
11:40 - 12:30 Mechanisms of clinically important drug interactions A KARAALP
13:40 - 14:30 Interaction of radiation with matter P MEGA TİBER
14:40 - 15:30 Interaction of radiation with matter P MEGA TİBER
15:40-16:30 Physiology of pain B YEĞEN
Thursday, 20 September 2012
09:40 - 10:30 Autocoids Z GÖREN
10:40 - 11:30 Autocoids Z GÖREN
11:40 - 12:30 Autocoids Z GÖREN
13:40 - 14:30 Host parasite interactions G SÖYLETİR
14:40 - 15:30 Host parasite interactions G SÖYLETİR
15:40-16:30 Introduction to chemotherapeutics R GÜLHAN
Friday, 21 September 2012
08:40 - 09:30 Cell injury and cell death H KAYA
09:40 - 10:30 Cell injury and cell death H KAYA
10:40 - 11:30 Prostaglandins N ÖZER
11:40 - 12:30 Prostaglandins N ÖZER
13:40 - 14:30 Introduction to elective studies
14:40 - 15:30 Elective Course
15:40-16:30 Elective Course
Monday, 24 September 2012
08:40 – 09:30 DNA viruses: Adenoviruses, Parvoviruses, Papavoviruses, and Poxviruses
A KARAHASAN
09:40 - 10:30 RNA viruses: Togaviruses, Bunyaviruses, Flaviviruses and other RNA viruses
A KARAHASAN
10:40 - 11:30 Body temperature and its regulation İ ALİCAN
11:40 - 12:30 Body temperature and its regulation İ ALİCAN
13:40 - 14:30 Hepatitis viruses G SÖYLETİR
14:40 - 15:30 Tissue renewal and repair: regeneration, healing, and fibrosis E BOZKURTLAR
15:40-16:30 Tissue renewal and repair: regeneration, healing, and fibrosis E BOZKURTLAR
Tuesday, 25 September 2012
09:00 - 16:30 ICP-2: Basic Clinical Skills, Human in Medicine, Student Research Activity-2
Wednesday, 26 September 2012
09:40 - 10:30 Intestinal and urogenital protozoa N ÜLGER
10:40 - 11:30 LAB: Normal body flora (GROUP A) Microbiology
11:40 - 12:30 LAB: Normal body flora (GROUP A) Microbiology
13:40 - 14:30 Cytokins I BARLAN
14:40 - 15:30 Cytokins I BARLAN
15:40- 16:30 LAB: Normal body flora (GROUP B) Microbiology
16.40-17.30 LAB: Normal body flora (GROUP B) Microbiology
Thursday, 27 September 2012
09:40 - 10:30 Cestodes and Trematodes N ÜLGER
10:40 - 11:30 Miscellaneous viruses; Coronavirus, Flavivirus, Calicivirus N ÇERİKÇİOĞLU
11:40 - 12:30 Pharmacotherapy in viral infections H. R. YANANLI
13:40 - 14:30 Basic principles of immunopathology S BOZKURT
14:40 - 15:30 Autoimmune disorders S BOZKURT
15.40-16.30 Application of Nuclear medicine and radiotherapy T TUROĞLU
Friday, 28 September 2012
09:40 - 10:30 Haemodynamic disorders Ç ÇELİKEL
10:40 - 11:30 Thromboembolic disease Ç ÇELİKEL
11:40 - 12:30 Thromboembolic disease Ç ÇELİKEL
13:40 - 14:30 Intestinal and tissue nematodes N ÜLGER
14:40 - 15:30 Elective Course
15.40-16.30 Elective Course
Monday, 01 October 2012
08:40 - 09:30 Immun response to extracellular and intracellular infections A TULUNAY
09:40 - 10:30 Immune Responses to Extracellular and Intracellular Infections; A. TULUNAY
11:40 - 12:30 RNA viruses: Picornaviruses, Rhabdoviruses and Reoviruses U HASDEMİR
13:40 - 14:30 Pharmacotherapy in parasitic infections A AKICI
14:40 - 15:30 General principles of medical toxicology A KARAALP
15:40 - 16:30 Patient with fever and rash S ÇİFÇİLİ
Tuesday, 02 October 2012
09:00 - 17:30 ICP-2: Basic Clinical Skills, Human in Medicine, Student
Research Activity-2
Wednesday, 03 October 2012
08:40 - 09:30
09:40 - 10:30
10:40 - 11:30 LAB: Examination of protozoa (GROUPA) Microbiology
11:40 - 12:30 LAB: Examination of protozoa (GROUP A) Microbiology
13:40 - 14:30 LAB: Examination of protozoa (GROUP B) Microbiology
14:40 - 15:30 LAB: Examination of protozoa (GROUP B) Microbiology
Thursday, 04 October 2012
09:40 - 10:30 RNA viruses: Retroviruses and HIV U.HASDEMİR
10:40 - 11:30 Laboratory diagnosis of viral infections A.KARASAHAN
11:40 - 12:30 Laboratory diagnosis of viral infections A.KARASAHAN
13:40 - 14:30 Acute inflammatory response S BOZKURT
14:40 - 15:30 Acute inflammatory response S BOZKURT
15:40-16:30 Pathology of hypersensitivity reactions S BOZKURT
Friday, 05 October 2012
08:40 – 09:30 Amiloidosis E BOZKURTLAR
09:40 - 10:30 Chronic inflammatory response H KAYA
10:40 - 11:30 Transplant pathology H KAYA
11:40 - 12:30 Tissue and organ response to radiation and genetic effects of radiation
Y ERDİL
13:40 - 14:30 Antiseptics and disenfectants H R YANANLI
14:40 - 15:30 Bioterrorism: a global threat A.KARASAHAN
15:40-16:30
Monday, 08 October 2012
08:40 - 09:30 Immunomodulators H.R. YANANLI
09:40 - 10:30 Drug induced immune response and antiallergic treatment H R YANANLI
10:40 - 11:30 LAB: Examination of helminths and medically important arthropods (GROUP A)
Microbiology
11:40 - 12:30 LAB: Examination of helminths and medically important arthropods (GROUP A)
Microbiology
13:40- 14:30 LAB: Examination of helminths and medically important arthropods (GROUP B)
Microbiology
14:40- 15:30 LAB: Examination of helminths and medically important arthropods (GROUP B)
Microbiology
Tuesday, 09 October 2012
08:40-09:30 LAB: Cell response to injury and adaptive cell reactions-Group A
Pathology (S. BOZKURT)
09:40 - 10:30 LAB: Cell response to injury and adaptive cell reactions-Group A
Pathology (S. BOZKURT)
10:40 - 11:30 LAB: Hemodynamic disorders and abnormal accumulations-Group A
Pathology (S.BOZKURT)
11:40 - 12:30 LAB: Hemodynamic disorders and abnormal accumulations-Group A
Pathology (S. BOZKURT)
13:40 - 14:30 LAB: Cell response to injury and adaptive cell reactions-Group B
Pathology (S. BOZKURT)
14:40 - 15:30 LAB: Cell response to injury and adaptive cell reactions-Group B
Pathology (S. BOZKURT)
15:40 - 16:30 LAB: Hemodynamic disorders and abnormal accumulations-Group B
Pathology (S. BOZKURT)
16:40- 17:30 LAB: Hemodynamic disorders and abnormal accumulations-Group B
Pathology (S.BOZKURT)
Wednesday, 10 October 2012
08:40-09:30 LAB: Changes in the size, consistency, colour, and composition of organs-Group B
Pathology (S. BOZKURT)
09:40 - 10:30 LAB: Changes in the size, consistency, colour, and composition of organs-Group B
Pathology (S. BOZKURT)
10:40 - 11:30 LAB: Changes in the size, consistency, colour, and composition of organs-Group A
Pathology (S. BOZKURT)
11:40 - 12:30 LAB: Changes in the size, consistency, colour, and composition of organs-Group A
Pathology (S. BOZKURT)
13:40 - 14:30 FREE STUDY TIME
14:40 - 15:30
15:40 - 16:30
16:40- 17:30
Thursday, 11 October 2012
08:40-09:30 FREE STUDY TIME
09:40 - 10:30
10:40-11:30
11:40-12.30
13:40 - 14:30 FREE STUDY TIME
14:40 - 15:30
Friday, 12 October 2012
08:40-09:30 FREE STUDY TIME
09:40 - 10:30
10:40-11:30
11:40-12.30
13:40 - 14:30 FREE STUDY TIME
14:40 - 15:30
Monday, 15 October 2012 PRACTICAL EXAMINATION
Tuesday, 16 October 2012 PRACTICAL EXAMINATION
Wednesday, 17 October 2012 FREE STUDY TIME
Thursday, 18 October 2012 FREE STUDY TIME
Friday, 19 October 2012 THEORETICAL EXAMINATION