carbohydrates & lipids
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Carbohydrates & Lipids. Concept 5.2: Carbohydrates serve as fuel and building material. Carbohydrates include sugars and the polymers of sugars The simplest carbohydrates are monosaccharides, or single sugars - PowerPoint PPT PresentationTRANSCRIPT
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Carbohydrates & Lipids
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Concept 5.2: Carbohydrates serve as fuel and building material
• Carbohydrates include sugars and the polymers of sugars
• The simplest carbohydrates are monosaccharides, or single sugars
• Carbohydrate macromolecules are polysaccharides, polymers composed of many sugar building blocks
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Sugars
• Monosaccharides have molecular formulas that are usually multiples of CH2O
• Glucose is the most common monosaccharide
• Monosaccharides are classified by location of the carbonyl group and by number of carbons in the carbon skeleton
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LE 5-3Triose sugars
(C3H6O3)
GlyceraldehydeAld
ose s
Ket
ose s
Pentose sugars(C5H10O5)
Ribose
Hexose sugars(C5H12O6)
Glucose Galactose
Dihydroxyacetone
Ribulose
Fructose
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• Monosaccharides serve as a major fuel for cells and as raw material for building molecules
• Though often drawn as a linear skeleton, in aqueous solutions they form rings
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LE 5-4
Linear andring forms
Abbreviated ringstructure
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• A disaccharide is formed when a dehydration reaction joins two monosaccharides
• This covalent bond is called a glycosidic linkage
Animation: Disaccharides
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LE 5-5
Glucose
Maltose
Fructose Sucrose
Glucose Glucose
Dehydrationreaction in thesynthesis of maltose
Dehydrationreaction in thesynthesis of sucrose
1–4glycosidic
linkage
1–2glycosidic
linkage
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Polysaccharides
• Polysaccharides, the polymers of sugars, have storage and structural roles
• The structure and function of a polysaccharide are determined by its sugar monomers and the positions of glycosidic linkages
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Storage Polysaccharides
• Starch, a storage polysaccharide of plants, consists entirely of glucose monomers
• Plants store surplus starch as granules within chloroplasts and other plastids
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LE 5-6aChloroplast Starch
1 µm
Amylose
Starch: a plant polysaccharide
Amylopectin
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• Glycogen is a storage polysaccharide in animals
• Humans and other vertebrates store glycogen mainly in liver and muscle cells
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LE 5-6bMitochondria Glycogen granules
0.5 µm
Glycogen
Glycogen: an animal polysaccharide
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Structural Polysaccharides
• Cellulose is a major component of the tough wall of plant cells
• Like starch, cellulose is a polymer of glucose, but the glycosidic linkages differ
• The difference is based on two ring forms for glucose: alpha () and beta ()
Animation: Polysaccharides
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LE 5-7
a Glucose
a and b glucose ring structures
b Glucose
Starch: 1–4 linkage of a glucose monomers.
Cellulose: 1–4 linkage of b glucose monomers.
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• Polymers with alpha glucose are helical• Polymers with beta glucose are straight• In straight structures, H atoms on one strand
can bond with OH groups on other strands• Parallel cellulose molecules held together this
way are grouped into microfibrils, which form strong building materials for plants
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LE 5-8
Cellulosemolecules
Cellulose microfibrilsin a plant cell wall
Cell walls Microfibril
Plant cells
0.5 µm
Glucosemonomer
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• Enzymes that digest starch by hydrolyzing alpha linkages can’t hydrolyze beta linkages in cellulose
• Cellulose in human food passes through the digestive tract as insoluble fiber
• Some microbes use enzymes to digest cellulose• Many herbivores, from cows to termites, have
symbiotic relationships with these microbes
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• Chitin, another structural polysaccharide, is found in the exoskeleton of arthropods
• Chitin also provides structural support for the cell walls of many fungi
• Chitin can be used as surgical thread
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Concept 5.3: Lipids are a diverse group of hydrophobic molecules
• Lipids are the one class of large biological molecules that do not form polymers
• The unifying feature of lipids is having little or no affinity for water
• Lipids are hydrophobic becausethey consist mostly of hydrocarbons, which form nonpolar covalent bonds
• The most biologically important lipids are fats, phospholipids, and steroids
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Fats
• Fats are constructed from two types of smaller molecules: glycerol and fatty acids
• Glycerol is a three-carbon alcohol with a hydroxyl group attached to each carbon
• A fatty acid consists of a carboxyl group attached to a long carbon skeleton
Animation: Fats
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LE 5-11a
Dehydration reaction in the synthesis of a fatGlycerol
Fatty acid(palmitic acid)
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• Fats separate from water because water molecules form hydrogen bonds with each other and exclude the fats
• In a fat, three fatty acids are joined to glycerol by an ester linkage, creating a triacylglycerol, or triglyceride
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LE 5-11b
Ester linkage
Fat molecule (triacylglycerol)
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• Fatty acids vary in length (number of carbons) and in the number and locations of double bonds
• Saturated fatty acids have the maximum number of hydrogen atoms possible and no double bonds
• Unsaturated fatty acids have one or more double bonds
• The major function of fats is energy storage
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• Fats made from saturated fatty acids are called saturated fats
• Most animal fats are saturated• Saturated fats are solid at room temperature• A diet rich in saturated fats may contribute to
cardiovascular disease through plaque deposits
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LE 5-12a
Saturated fat and fatty acid.
Stearic acid
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• Fats made from unsaturated fatty acids are called unsaturated fats
• Plant fats and fish fats are usually unsaturated
• Plant fats and fish fats are liquid at room temperature and are called oils
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LE 5-12b
Unsaturated fat and fatty acid.
Oleic acid
cis double bondcauses bending
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Phospholipids
• In a phospholipid, two fatty acids and a phosphate group are attached to glycerol
• The two fatty acid tails are hydrophobic, but the phosphate group and its attachments form a hydrophilic head
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LE 5-13
Structural formula Space-filling model Phospholipid symbol
Hydrophilichead
Hydrophobictails
Fatty acids
Choline
Phosphate
Glycerol
Hyd
rop h
obic
tails
Hy d
r op h
ilic
h ea d
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• When phospholipids are added to water, they self-assemble into a bilayer, with the hydrophobic tails pointing toward the interior
• The structure of phospholipids results in a bilayer arrangement found in cell membranes
• Phospholipids are the major component of all cell membranes
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LE 5-14
WATERHydrophilichead
Hydrophobictails WATER
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Steroids
• Steroids are lipids characterized by a carbon skeleton consisting of four fused rings
• Cholesterol, an important steroid, is a component in animal cell membranes
• Although cholesterol is essential in animals, high levels in the blood may contribute to cardiovascular disease
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