calcium significance & regulation

8/12/2019 Calcium Significance & Regulation

1/25

UBKKBD BNGBD


2/25

O`trmduetom`

Gmst blu`db`t go`jrbc o` tnj lmdy

Tmtbc em`tj`t o` bduct gb` os 2.6-2.: hi

Blmut ??% ma Eb+< lm`j.

2% o` lcmmd b`d JEA

Eb+< o` lcmmd os dostrolutjd bgm`i tnrjj amrgs.b. Blmut 4:% arjj Eb+< om`s (arjj/om`ozjd Eb+


3/25


4/25

\jcjbsj ma nmrgm`js suen bs o`suco`, VTN b`d

EbceotmòÙjerjtmry prmejss suen bs j`dmeytmsos, jxmeytmsosb`d ejcc gmtocoty Betom` m` njbrt; Vrmcmì systmcjEbceoug bcsm prjvj`ts gusecj mr cji erbgps


5/25

Umurejs ma Ebceoug

Ljst smurej; Goch b`d goch prmduets

Immd smurej; Ljb`s, Ebllbij, Cjbay

vjijtblcjs, Aosn, Jii ymch


6/25

Dojtbry rjquorjgj`ts

Bducts >66gi/dbyO` prji`b`ey b`d Cbetbtom` 2.: i/dbyEnocdrj` 6.>-2.< i/dbyO`ab`ts 566-:66 gi/dby


7/25

\jiucbtom`

Tnrjj nmrgm`js brj o`vmcvjd o` rjiucbto`i tnj cjvjc ma

Ebceoug o` pcbsgb

b. Vbrbtnmrgm`j (VTN)l. Ebceotm`o` b`de. Qotbgo` D


8/25

Vbrbtnmrgm`j (VTN)

VTN sjerjtom` o` lcmmd os stogucbtjd ly b djerjbsj o`

omòzjd Eb+< b`d, em`vjrsjcy, VTN sjerjtom` os

stmppjd ly b` oèrjbsj o` omòzjd Eb+


9/25

VTN jxjrts tnrjj gbkmr jaajets m` lmtn hod`jy b`d lm`j .

2. O` tnj lm`j, VTN betovbtjs lm`j rjsmrptom` ,( betovbtjd mstjmecbsts lrjbhdmw` lm`j & rjcjbsjEb+< o` JEA)


10/25


11/25

Qotbgo` D sy`tnjsos

Uho`

Qotbgo` D5 2,


12/25

Ebceotmò`

Ebceotmò` os b`tbimòst tm VTN & vot D

Ebceotmò`s Eb+< cmwjroì jaajet, o`nolots tnj betom`ma lmtn VTN b`d votbgo` D

Ebceotmò` os sjerjtjd o` rjspm`sj tm b nypjrebcejgoestogucus.


13/25

Ebceoug \jiucbtom`


14/25

Nmw guen EBCEOZG ogpmrtb`tos!

N_VMEBCEJGOB

N_VJ\EBCEJGOB


15/25

Ebusjs ma Nypmebcejgob

Vrogbry nypmpbrbtnyrmodosog (icb`ducbr bpcbsob,djstruetom` mr rjgmvbc)

Nypmbclugo`jgob (Enrmòe covjr dosjbsj, `jpnrmtoesy`drmgj, gbcùtrotom`)

Beutj pbèrjbtotos

Qotbgo` D djaoeojèy

\j`bc dosjbsj

Vsjudmnypmpbrbtnyrmodosog


16/25

Uygptmgs ma Nypmebcejgob

@jurmguseucbr orrotblocotypbrbsjtnjsob, gusecj erbgps & tjtb`y

Ebrdobe orrjiucbrotojsbrrnytngobs mr njbrt lcmeh

O` sjvjrj nypmebcejgob, tmtbc Eb+< cjvjcs brj ljcmw2.>> ggmc/C (9.:gd/dC)


17/25

Gjtblmcoe lm`j dosjbsjs

B vbrojty ma dosjbsj stbtjs eb` baajet shjcjtbc brenotjeturj,strj`itn b`d o`tjiroty suen bs

\oehjts

\j`bc roehjts

Mstjmgbcbeob

Mstjmpmrmsos


18/25

\oehjts Mstjmpmrmsos


19/25

Ebusjs ma Nypjrebcejgob

Vrogbry nypjrpbrbtnyrmodosg (bdj`mgb mricb`ducbr nypjrpcbsob)

NypjrtnyrmodosgLjòi` abgocobc nypmebceourobGbcoi`bèyGuctopcj gyjcmgbOèrjbsjd votbgo` DTnobzodj dourjtoesVrmcmìjd oggmlocozbtom`


20/25

Uygptmgs ma nypjrebcejgob

@jurmcmioe sygptmgs (drmwso`jss, wjbh`jss,djprjssom`, cjtnbriy , emggb)IO sygptmgs (em`stopbtom`, `busjb, vmgoto`i,b`mrjxob, pjptoe ucejr dosjbsj)

\j`bc sygptmgs (`jpnrmcotnobsos ,`jpnrmebceo`msos)Nypjrebcejgob doiotbcos tmxoeoty


21/25

Cbl Dobi`msos

UVJEOGJ@ EMCCJETOM@

Amr tmtbc Eb, jotnjr sjrug mr cotnoug njpbro` pcbsgbemccjetjd wotnmut vj`mus stbsos.

B`toembiucb`ts suen bs JDTB mr mxbcbtj brju`beejptblcj amr usj ljebusj..


22/25

Ebceoug -M-erjsmcpntnbcjo` emgpcjx

(purpcj emcmrjd emgpcjx)

Ebceoug M-erjsmcpntnbcjo` emgpcjxm`j

bchbco`j smcutom`

+

Gjtnmdmcmiy EVE, Emcmrogjtroe bssby wotn j`d pmo`t djtjrgo`btom` bt:9: `g.

Vro`eopcj8


23/25

\jajrjèj rbìjs

Tmtbc Ebceoug Ujrug, VcbsgbEnocd, 32< yjbrs >.>-26.> gi/dC

Bduct >.1-26.6 gi/dCOmòzjd ebceoug UjrugEnocd 4.>-:.: gi/dC Bducts 4.1-:.5 gi/dCOmòzjd ebceoug Vcbsgb Bducts 4.2-4.? gi/dC


24/25

Vbòe vbcujs

Ot os tnj pmcoey ma BHZN tnbt bcc erotoebc rjsucts snmucd ljemgguòebtjd bs smm` bs pmssolcj lut `m cbtjr tnb` 56goùtjs batjr rjsuct vjroaoebtom`.

Vbòe vbcuj amr Tmtbc Ebceoug os 1.6 2


25/25

calcium significance & regulation

Documents