B U I L D S T R O N G B O N E F A S T

NovaBone® is a 100% bioactive syntheticmaterial composed from elements thatoccur naturally in the body – silicon,sodium, calcium, phosphorus, and oxygen.

NovaBone is osteostimulative; defined as anaccelerated bone formation process charac-terized by the active stimulation of osteoblastproliferation and differentiation due to cellu-lar interaction with the ionic dissolutionreleased during absorption.

NovaBone is a bioactive synthetic materialcapable of regenerating new bone fromexisting bone.

NovaBone demonstrated equivalent rates ofbone growth when compared to autogenousbone graft.3

NovaBone causes genetic activation forosteoblast recruitment and proliferation.4,5

NovaBone is the optimum bone void filler,providing patients with reduced morbidityresulting from the harvesting of autograft.

NovaBone’s activating chemistry promotesbone formation and creates a scaffold fornew bone growth.

NovaBone is a clinically proven bonegrowth catalyst.

A BIOACTIVE SYNTHETIC BONE FOR FASTER HEALING

Putty • MIS • Particulate • Morsels

NovaBone can be easily combined withautograft, allograft or autogenous growthfactors to extend surgical options and promote accelerated healing.

NovaBone is available through MTF, theworld’s largest tissue bank.

NovaBone initiates a surface chemical reaction immediately upon introduction tothe surgical site.

Ions released from NovaBone stimulateosteoblasts and modify the material’s surfacewhich attracts and binds the critical components for bone regeneration in the surgical site.

The ion release occurs continuously over timeand is particularly critical in the initial weeksof healing. As the ion release progresses, theNovaBone material is transformed into anincreasingly porous scaffold with a resultingincrease in surface area. The ion release and sur-face modification combine to actually stimulatethe osteoblasts involved in the repair process.

A timeline of bioactive healing

WITHINMINUTESExchange ofNa+ and H+

1 HOURLoss of Na+

initiates the release of soluble silica andthe formation of

surface silanol groups (Si-OH), which

repolymerize into asilica-rich layer

10 HOURSCrystallization of alayer of hydroxyl carbonate apatite and growth from

1 to 10 days

24 HOURSAction of

macrophages

100 HOURSDifferentiation of the stem cells

6 HOURSPrecipitationof a layer ofamorphouscalcium

phosphate

20 HOURSAbsorption of biological compounds

50 HOURSFixation of thestem cells

NovaBone Putty was shown to be substantially equivalent to NovaBone Particulate in a rabbitfemoral condyle defect study. The critical sized femoral condyle model showed early bone formation at 6 weeks and mature bone at 12 weeks.

proven bone formation

B = Formation of new bone N = Residual NovaBone Particulate or Putty particles

NovaBone Particulate(control) at 6 weeks

NovaBone Puttyat 6 weeks

NovaBone Particulate(control) at 12 weeks

NovaBone Puttyat 12 weeks

Osteostimulative.4,5

Injectable into surgical site.

Stays at the surgical site, will not migrate dur-ing irrigation,

Highly malleable, easy to mold and packinto any defect,

Ready to use out of the package.

excellent handlingcharacteristics

Putty

Ordering InformationNovaBone Putty – Syringe Delivery

Cat. No. Description771600 0.5cc771601 1cc771602 2.5cc771605 5cc771610 10cc

designed to ease dispensing

Putty MIS

NovaBone Putty MIS comes with multiplepreloaded cartridges for ease of use.

Extended tube allows for graft placement indifficult to reach areas.

Discrete volume dispensing, 1/4cc per handle cycle.

Plunger marking for ease of monitoring dispensed volume.

Approved for use as stand-alone device in posterolateral spine.

Ordering InformationNovaBone Putty MIS

Cat. No. Description772610 NovaBone MIS, 10cc772605 NovaBone MIS Reload, 5cc

Surgeons prefer the properties of NovaBone Particulatenot only because it accelerates healing, but also becauseit complements a range of techniques and affordsnumerous advantages over alternative products.

NovaBone Particulate’s size and composition combine to create an almost magnetic effect that allows it to gently adhere to instruments. This attractive property makes working withNovaBone Particulate easy and precise.

Once NovaBone Particulate is positioned in asurgical site, it bonds to surrounding tissue andremains in situ. Additionally, NovaBone Particulateonly grows bone in a bony environment—eliminatingthe dangers associated with ectopic bone growth.

NovaBone Particulate can be used alone or mixed withautograft, allograft, or autogenous materials to extend thevolume of available grafting material to the surgical site.

In contrast to calcium phosphate ceramics,new bone formation stabilizes NovaBone particles beginning the very first week afterimplantation.1

Initially the hardness and density of NovaBoneare greater than those of bone. During thecourse of new bone formation, the NovaBoneparticles undergo resorption. Finally the densityand hardness of the graft decrease, becomingindistinguishable from those of bone.2

Optimum Graft Extender

Particulate

NovaBone vs. Hydroxyapatite NovaBone vs. Bone

Ordering Information

Cat. No. Description770704 NovaBone Particulate, 2cc770705 NovaBone Particulate, 5cc770710 NovaBone Particulate, 10cc770715 NovaBone Particulate, 15cc

Excellenthydrophilic properties

Morsels

Osteostimulative.4,5

Excellent hydrophilic properties (readilyattracts and absorbs blood, etc.).

Matrix of interconnected pores allows foraccelerated bone formation

Attractive alternative to autograft and allograft.

Porosity mimics the structure of human cancellous bone.

NovaBone Morsels – Syringe Delivery

Cat. No. Description772810 10cc (2-5mm)772815 15cc (2-5mm)771810 10cc (1-2mm)771815 15cc (1-2mm)

NovaBone MorselsCat. No. Description770805 5cc (2-5mm)770810 10cc (2-5mm)770815 15cc (2-5mm)

Ordering Information

Brochure for use outside of the USA. ©2013 Musculoskeletal Transplant Foundation 2/13 2M KAM249

125 May Street • Edison, New Jersey 08837 USATelephone: +1-732-661-0202

www.mtf.org

Putty • MIS • Particulate • Morsels

NovaBone has been the subject of more than thirty basic science,in vivo, and human studies. It has been favorably compared tomultiple alternative materials on the market today. NovaBone hasa 15-year track record of safety and efficacy in a wide range ofclinical applications. Additionally, NovaBone has demonstratedequivalent rates of bone growth when compared to autogenousbone graft.

References1. Oonishi H, Kushitani S, Yasakawa E, et al. Particulate Bioglass Compared with Hydroxyapatite as a Bone Graft

Substitute. Clin Orthop. 1997;334:316-325.2. Wheeler DL, Stokes KE, Hoellrich RG, Chamberland DL, McLoughlin SW. Effect of Bioactive Glass Particle

Size on Osseous Regeneration of Cancellous Defects. J Biomed Mater Res. 1998;41:527-533.3. Brice Ilharreborde, MD, Etienne Morel, MD, Franck Fitoussi, MD, Ana Presedo, MD, Philippe Souchet, MD,

Georges-François Penneçot, MD, and Keyvan Madza, MD. Bioactive Glass as a Bone Substitute for SpinalFusion in Adolescent Idiopathic Scoliosis. J Pediatr Orthop. 2008; 28: 347-351.

4. Larry L. Hench, Julia M. Polak. A Genetic Basis for Design of Biomaterials for In Situ Tissue Regeneration. KeyEngineering Materials 2008; 377: 151-166.

5. Larry L. Hench, David M. Gaisser, The Genetic Basis for Osteogenesis Stimulation by Controlled Release ofIonic Dissolution Products. Transactions of the Orthopedic Research Society, Annual Meeting, San Francisco,California, USA. March 2008: 1697.

The Science of NovaBone