brefeldin a solution

Brefeldin A Solution (1,000X) Safety Data Sheet according to the Hazard Communication Standard (CFR29 1910.1200) HazCom 2012

Date of issue: 05/08/2015 Revision date: 05/08/2015 Version: 1.0

05/08/2015 EN (English) 1/17

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1. Product identifier

Product name : Brefeldin A Solution (1,000X)

Product code : 420601

1.2. Relevant identified uses of the substance or mixture and uses advised against

Use of the substance/mixture : Research use only

1.3. Details of the supplier of the safety data sheet

BioLegend Inc. 9727 Pacific Heights Blvd. San Diego, CA 92121 – USA T +1-858-455-9588

1.4. Emergency telephone number

Emergency number : +1-858-455-9588 (7:00AM – 5:00PM PT, M-F)

SECTION 2: Hazards identification

2.1. Classification of the substance or mixture

GHS-US classification

Flammable Liquid 4

2.2. Label elements

GHS-US labelling

Hazard pictograms (GHS-US) : Not applicable.

Signal word (GHS-US) : Warning

Hazard statements (GHS-US) : Combustible liquid.

Precautionary statements (GHS-US) : Keep away from flames and hot surfaces. – No smoking. Wear protective gloves/protective clothing/eye protection/face protection. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

2.3. Other hazards

No additional information available.

SECTION 3: Composition/information on ingredients

3.1. Substance

Not applicable.

3.2. Mixture

Name Product identifier % GHS-US classification

Dimethyl sulfoxide (CAS No) (67-68-5) 60 - 100 Flam. Liq. 4

4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-, (1R,2E,6S,10E,11aS,13S,14aR)-

(CAS No) 20350-15-6 0.1 - 1 Acute Tox. 3 (Oral)

* The exact percentage (concentration) of composition has been withheld as a trade secret in accordance with paragraph (i) of §1910.1200.

SECTION 4: First aid measures

4.1. Description of first aid measures

First-aid measures after inhalation : If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell.

First-aid measures after skin contact : In case of contact, immediately flush skin with plenty of water. Call a physician if irritation develops and persists.

First-aid measures after eye contact : In case of contact, immediately flush eyes with plenty of water. Remove contact lenses, if worn. If irritation persists, get medical attention.

First-aid measures after ingestion : If swallowed, do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical advice/attention if you feel unwell.

4.2. Most important symptoms and effects, both acute and delayed

Symptoms/injuries after inhalation : May cause respiratory tract irritation.

Symptoms/injuries after skin contact : May cause skin irritation. Symptoms may include redness, drying, defatting and cracking of the skin.


05/08/2015 EN (English) 2/17

Symptoms/injuries after eye contact : May cause eye irritation. Symptoms may include discomfort or pain, excess blinking and tear production, with possible redness and swelling.

Symptoms/injuries after ingestion : May be harmful if swallowed. May cause stomach distress, nausea or vomiting.

4.3. Indication of any immediate medical attention and special treatment needed

Symptoms may not appear immediately. In case of accident or if you feel unwell, seek medical advice immediately (show the label or SDS where possible).

SECTION 5: Firefighting measures

5.1. Extinguishing media

Suitable extinguishing media : Water spray, alcohol-resistant foam, dry chemical, carbon dioxide.

Unsuitable extinguishing media : None known.

5.2. Special hazards arising from the substance or mixture

Fire hazard : Combustible liquid. Products of combustion may include, and are not limited to: oxides of carbon, oxides of sulfur.

5.3. Advice for firefighters

Protection during firefighting : Keep upwind of fire. Wear full fire fighting turn-out gear (full Bunker gear) and respiratory protection (SCBA). Use water spray to cool exposed surfaces.

SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures

General measures : Eliminate sources of ignition. Use personal protection recommended in Section 8. Isolate the hazard area and deny entry to unnecessary and unprotected personnel. Use special care to avoid static electric charges.

6.2. Methods and material for containment and cleaning up

For containment : Contain and/or absorb spill with inert material (e.g. sand, vermiculite), then place in a suitable container. Do not flush to sewer or allow to enter waterways. Use appropriate Personal Protective Equipment (PPE).

Methods for cleaning up : Scoop up material and place in a disposal container. Vapors may be heavier than air and may travel along the ground to a distant ignition source and flash back. Provide ventilation.

6.3. Reference to other sections

See section 8 for further information on protective clothing and equipment and section 13 for advice on waste disposal.

SECTION 7: Handling and storage

7.1. Precautions for safe handling

Precautions for safe handling : Keep away from sources of ignition - No smoking. Avoid contact with skin and eyes. Avoid breathing vapour or mist. Do not swallow. Handle and open container with care. When using do not eat, drink or smoke.

Hygiene measures : Launder contaminated clothing before reuse. Wash hands before eating, drinking, or smoking.

7.2. Conditions for safe storage, including any incompatibilities

Technical measures : Proper grounding procedures to avoid static electricity should be followed.

Storage conditions : Keep container tightly closed. Store in dry, well-ventilated area. Store under inert gas. Hygroscopic product.

7.3. Specific end use(s)

Not available.

SECTION 8: Exposure controls/personal protection

8.1. Control parameters

Dimethyl sulfoxide (67-68-5)

AIHA AIHA - Workplace Environmental Exposure Levels (WEELs) - TWAs

250 ppm

4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-, (1R,2E,6S,10E,11aS,13S,14aR)- (20350-15-6)

ACGIH Not applicable

OSHA Not applicable


05/08/2015 EN (English) 3/17

8.2. Exposure controls

Appropriate engineering controls : Use ventilation adequate to keep exposures (airborne levels of dust, fume, vapor, etc.) below recommended exposure limits.

Hand protection : Wear suitable gloves.

Eye protection : Safety glasses or goggles are recommended when using product.

Skin and body protection : Wear suitable protective clothing.

Respiratory protection : In case of insufficient ventilation, wear suitable respiratory equipment. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator.

Environmental exposure controls : Maintain levels below Community environmental protection thresholds.

Other information : Do not eat, smoke or drink where material is handled, processed or stored. Wash hands carefully before eating or smoking. Handle according to established industrial hygiene and safety practices.

SECTION 9: Physical and chemical properties

9.1. Information on basic physical and chemical properties

Physical state : Liquid

Appearance : Clear

Colour : Colourless

Odour : No data available

Odour threshold : No data available

pH : No data available

Melting point : No data available

Freezing point : No data available

Boiling point : No data available

Flash point : 87 ° C (189 °F) Closed cup

Relative evaporation rate (butylacetate=1) : No data available

Flammability (solid, gas) : Flammable

Explosive limits : No data available

Explosive properties : No data available

Oxidising properties : No data available

Vapour pressure : No data available

Relative density : No data available

Relative vapour density : No data available

Solubility : No data available

Partition coefficient: n-octanol/water : No data available

Log Kow : No data available

Auto-ignition temperature : No data available

Decomposition temperature : No data available

Viscosity : No data available

Viscosity, kinematic : No data available

Viscosity, dynamic : No data available

9.2. Other information


SECTION 10: Stability and reactivity

10.1. Reactivity

No dangerous reaction known under conditions of normal use.

10.2. Chemical stability

Stable under normal storage conditions.

10.3. Possibility of hazardous reactions


10.4. Conditions to avoid

Heat. Incompatible materials. Sources of ignition.


05/08/2015 EN (English) 4/17

10.5. Incompatible materials

Acid chlorides. Phosphorus halides. Strong acids. Strong oxidizing agents. Strong reducing agents.

10.6. Hazardous decomposition products

May include, and are not limited to: oxides of carbon, oxides of sulfur.

SECTION 11: Toxicological information

11.1. Information on toxicological effects

Acute toxicity : Not classified.

Brefeldin A Solution (1,000X)

LD50 oral rat > 2000 mg/kg

LD50 dermal rabbit > 2000 mg/kg

LC50 inhalation rat No data available.

Dimethyl sulfoxide (67-68-5)

LD50 oral rat 14500 mg/kg

LD50 dermal rabbit 40 g/kg

Skin corrosion/irritation : Based on available data, the classification criteria are not met.

Serious eye damage/irritation : Based on available data, the classification criteria are not met.

Respiratory or skin sensitisation : Based on available data, the classification criteria are not met.

Germ cell mutagenicity : Based on available data, the classification criteria are not met.

Carcinogenicity : Based on available data, the classification criteria are not met.

Reproductive toxicity : Based on available data, the classification criteria are not met.

Specific target organ toxicity (single exposure) : Based on available data, the classification criteria are not met.

Specific target organ toxicity (repeated exposure) : Based on available data, the classification criteria are not met.

Aspiration hazard : Based on available data, the classification criteria are not met.





SECTION 12: Ecological information

12.1. Toxicity

Ecology - general : This product is not expected to produce significant ecotoxicity upon exposure to aquatic organisms and aquatic systems.

12.2. Persistence and degradability


Persistence and degradability Not established.

12.3. Bioaccumulative potential


Bioaccumulative potential Not established.

12.4. Mobility in soil


12.5. Other adverse effects

Effect on the global warming : No known ecological damage caused by this product.

SECTION 13: Disposal considerations

13.1. Waste treatment methods

Waste disposal recommendations : This material must be disposed of in accordance with all local, state, provincial, and federal regulations. The generation of waste should be avoided or minimized wherever possible.

Additional information : Handle empty containers with care because residual vapours are flammable.


05/08/2015 EN (English) 5/17

SECTION 14: Transport information

Department of Transportation (DOT)

In accordance with DOT

UN-No.(DOT) : NA1993

Proper Shipping Name (DOT) : Combustible liquid, n.o.s. (Dimethyl sulfoxide)

Department of Transportation (DOT) Hazard Classes

: Combustible liquid

Packing group (DOT) : III

Additional information

Other information : No supplementary information available.

Special transport precautions : Do not handle until all safety precautions have been read and understood.

SECTION 15: Regulatory information

15.1. US Federal regulations

All components of this product are listed, or excluded from listing, on the United States Environmental Protection Agency Toxic Substances Control Act (TSCA) inventory except for:

Tetradecanoyl phorbol acetate (TPA) CAS No 16561-29-8

10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, calcium salt (1:1), (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-

CAS No 56092-82-1


CAS No 20350-15-6

15.2. US State regulations


State or local regulations This product does not contain a chemical known to the State of California to cause cancer, birth defects or other reproductive harm.

SECTION 16: Other information

Date of issue : 05/08/2015

Other information : None.

Disclaimer: We believe the statements, technical information and recommendations contained herein are reliable, but they are given without warranty or guarantee of any kind. The information contained in this document applies to this specific material as supplied. It may not be valid for this material if it is used in combination with any other materials. It is the user’s responsibility to satisfy oneself as to the suitability and completeness of this information for the user’s own particular use.

Brefeldin A Solution (1,000X) Safety Data Sheet according to Regulation (EC) No. 453/2010

Date of issue: 08/05/2015 Revision date: 08/05/2015 : Version: 1.0

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1. Product identifier

Product name : Brefeldin A Solution (1,000X)

Product code : 420601

1.2. Relevant identified uses of the substance or mixture and uses advised against

1.2.1. Relevant identified uses

Main use category : Industrial use

Use of the substance/mixture : Research use only

1.2.2. Uses advised against


1.3. Details of the supplier of the safety data sheet

BioLegend Inc. 4B Highgate Business Centre 33 Greenwood Place London, NW5 1LB - UK T +44 (0) 20 3475 3880 [email protected] http://www.biolegend.com/uk 1.4. Emergency telephone number

Emergency number : +44 (0) 20 3475 3880 (9:00AM - 5:00PM GMT, M-F)

SECTION 2: Hazards identification

2.1. Classification of the substance or mixture

Classification according to Regulation (EC) No. 1272/2008 [CLP]Mixture: SDS < 2015 : Show CLP information + DPD classification insection 2.1

Not classified.

Classification according to Directive 67/548/EEC [DSD] or 1999/45/EC [DPD]

Not classified.

Adverse physicochemical, human health and environmental effects


2.2. Label elements

Labelling according to Regulation (EC) No. 1272/2008 [CLP]

No labelling applicable.

2.3. Other hazards


SECTION 3: Composition/information on ingredients

3.1. Substance

Not applicable.

3.2. Mixture

Name Product identifier % Classification according to Regulation (EC) No. 1272/2008 [CLP]


(CAS No) 20350-15-6 (EC no) 606-528-3

0.1 - 1 Acute Tox. 3 (Oral), H301

Name Product identifier % Classification according to Directive 67/548/EEC


(CAS No) 20350-15-6 (EC no) 606-528-3

0.1 - 1 T; R25

Full text of R- and H-phrases: see section 16


08/05/2015 EN (English) 7/17

SECTION 4: First aid measures

4.1. Description of first aid measures

First-aid measures after inhalation : If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell.

First-aid measures after skin contact : In case of contact, immediately flush skin with plenty of water. Call a physician if irritation develops and persists.

First-aid measures after eye contact : In case of contact, immediately flush eyes with plenty of water. Remove contact lenses, if worn. If irritation persists, get medical attention.

First-aid measures after ingestion : If swallowed, do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical advice/attention if you feel unwell.

4.2. Most important symptoms and effects, both acute and delayed





4.3. Indication of any immediate medical attention and special treatment needed

Symptoms may not appear immediately. In case of accident or if you feel unwell, seek medical advice immediately (show the label or SDS where possible).

SECTION 5: Firefighting measures

5.1. Extinguishing media

Suitable extinguishing media : Water spray, alcohol-resistant foam, dry chemical, carbon dioxide.

Unsuitable extinguishing media : None known.

5.2. Special hazards arising from the substance or mixture

Fire hazard : Combustible liquid. Products of combustion may include, and are not limited to: oxides of carbon, oxides of sulfur.

5.3. Advice for firefighters

Protection during firefighting : Keep upwind of fire. Wear full fire fighting turn-out gear (full Bunker gear) and respiratory protection (SCBA). Use water spray to cool exposed surfaces.

SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures

General measures : Eliminate sources of ignition. Use personal protection recommended in Section 8. Isolate the hazard area and deny entry to unnecessary and unprotected personnel. Use special care to avoid static electric charges.

6.2. Environmental precautions

Keep out of drains, sewers, ditches, and waterways. Minimize use of water to prevent environmental contamination.

6.3. Methods and material for containment and cleaning up

For containment : Contain and/or absorb spill with inert material (e.g. sand, vermiculite), then place in a suitable container. Do not flush to sewer or allow to enter waterways. Use appropriate Personal Protective Equipment (PPE).

Methods for cleaning up : Scoop up material and place in a disposal container. Vapors may be heavier than air and may travel along the ground to a distant ignition source and flash back. Provide ventilation.

6.4. Reference to other sections

See section 8 for further information on protective clothing and equipment and section 13 for advice on waste disposal.

SECTION 7: Handling and storage

7.1. Precautions for safe handling

Precautions for safe handling : Avoid contact with skin and eyes. Avoid breathing vapour or mist. Do not swallow. Handle and open container with care. When using do not eat, drink or smoke.

Hygiene measures : Launder contaminated clothing before reuse. Wash hands before eating, drinking, or smoking.

7.2. Conditions for safe storage, including any incompatibilities

Technical measures : Proper grounding procedures to avoid static electricity should be followed.

Storage conditions : Keep container tightly closed. Store in dry, well-ventilated area. Store under inert gas. Hygroscopic product.

7.3. Specific end use(s)

Not available.


08/05/2015 EN (English) 8/17

SECTION 8: Exposure controls/personal protection

8.1. Control parameters


8.2. Exposure controls

Appropriate engineering controls : Use ventilation adequate to keep exposures (airborne levels of dust, fume, vapor, etc.) below recommended exposure limits.

Hand protection : Wear suitable gloves.

Eye protection : Safety glasses or goggles are recommended when using product.

Skin and body protection : Wear suitable protective clothing.

Respiratory protection : In case of insufficient ventilation, wear suitable respiratory equipment. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator.

Environmental exposure controls : Maintain levels below Community environmental protection thresholds.

Other information : Do not eat, smoke or drink where material is handled, processed or stored. Wash hands carefully before eating or smoking. Handle according to established industrial hygiene and safety practices.

SECTION 9: Physical and chemical properties

9.1. Information on basic physical and chemical properties

Physical state : Liquid

Appearance : Clear

Colour : Colourless

Odour : No data available

Odour threshold : No data available

pH : No data available

Relative evaporation rate (butylacetate=1) : No data available

Melting point : No data available

Freezing point : No data available

Boiling point : No data available

Flash point : 87 ° C (189 °F) Closed cup

Auto-ignition temperature : No data available

Decomposition temperature : No data available

Flammability (solid, gas) : Not flammable by EU criteria

Vapour pressure : No data available

Relative vapour density at 20 °C : No data available

Relative density : No data available

Solubility : No data available

Partition coefficient: n-octanol/water : No data available

Viscosity, kinematic : No data available

Viscosity, dynamic : No data available

Explosive properties : No data available

Oxidising properties : No data available

Explosive limits : No data available

9.2. Other information


SECTION 10: Stability and reactivity

10.1. Reactivity


10.2. Chemical stability

Stable under normal storage conditions.

10.3. Possibility of hazardous reactions


10.4. Conditions to avoid

Heat. Incompatible materials. Sources of ignition.

10.5. Incompatible materials

Acid chlorides. Phosphorus halides. Strong acids. Strong oxidizing agents. Strong reducing agents.


08/05/2015 EN (English) 9/17

10.6. Hazardous decomposition products

May include, and are not limited to: oxides of carbon, oxides of sulfur.

SECTION 11: Toxicological information

11.1. Information on toxicological effects

Acute toxicity : Not classified.


LD50 oral rat > 2000 mg/kg

LD50 dermal rabbit > 2000 mg/kg

LC50 inhalation rat No data available.

Skin corrosion/irritation : Based on available data, the classification criteria are not met.

Serious eye damage/irritation : Based on available data, the classification criteria are not met.

Respiratory or skin sensitisation : Based on available data, the classification criteria are not met.

Germ cell mutagenicity : Based on available data, the classification criteria are not met.

Carcinogenicity : Based on available data, the classification criteria are not met.

Reproductive toxicity : Based on available data, the classification criteria are not met.

Specific target organ toxicity (single exposure) : Based on available data, the classification criteria are not met.

Specific target organ toxicity (repeated exposure) : Based on available data, the classification criteria are not met.

Aspiration hazard : Based on available data, the classification criteria are not met.

SECTION 12: Ecological information

12.1. Toxicity

Ecology - general : This product is not expected to produce significant ecotoxicity upon exposure to aquatic organisms and aquatic systems.

12.2. Persistence and degradability


Persistence and degradability Not established.

12.3. Bioaccumulative potential


Bioaccumulative potential Not established.

12.4. Mobility in soil


12.5. Results of PBT and vPvB assessment


12.6. Other adverse effects


SECTION 13: Disposal considerations

13.1. Waste treatment methods

Waste disposal recommendations : This material must be disposed of in accordance with all local, state, provincial, and federal regulations. The generation of waste should be avoided or minimized wherever possible.

Additional information : Handle empty containers with care because residual vapours are flammable.

SECTION 14: Transport information

In accordance with ADR

14.1. UN number

Not regulated for transport.

14.2. UN proper shipping name

Not applicable.

14.3. Transport hazard class(es)

Not applicable.

14.4. Packing group

Not applicable.

14.5. Environmental hazards

Dangerous for the environment : No.


08/05/2015 EN (English) 10/17

Marine pollutant : No.

Other information : No supplementary information available.

14.6. Special precautions for user

Special transport precautions : Do not handle until all safety precautions have been read and understood.

14.7. Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

Not applicable.

SECTION 15: Regulatory information

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture

15.1.1. EU-Regulations

Contains no substances with Annex XVII restrictions.

Contains no REACH candidate substance.

Contains no REACH Annex XIV substances.

15.1.2. National regulations


15.2. Chemical safety assessment

No chemical safety assessment has been carried out.

SECTION 16: Other information

Indication of changes:

None.

Data sources : REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006.

Other information : None.

Full text of R-, H- and EUH-phrases:

Acute Tox. 3 (Oral) Acute toxicity (oral), Category 3

H301 Toxic if swallowed

R25 Toxic if swallowed

T Toxic

Disclaimer: We believe the statements, technical information and recommendations contained herein are reliable, but they are given without warranty or guarantee of any kind. The information contained in this document applies to this specific material as supplied. It may not be valid for this material if it is used in combination with any other materials. It is the user’s responsibility to satisfy oneself as to the suitability and completeness of this information for the user’s own particular use.

1．化学品及企业标识产品名称：Brefeldin A Solution [布雷菲德菌素一个解决方案]

产品英文名： Brefeldin A Solution

产品编码：420601

产品推荐用途及限制用途：工业用途（仅用于试验）。不得用于有可能污染食品或伤及人体的用途。

厂家/供应商：BioLegend Inc

地址：4B Highgate Business Centre ,33 Greenwood Place , London, NW5 1LB – UK.

电话:+44 (0) 2034753880

电子邮箱：[email protected]

更多信息请联系：BioLegend Inc

紧急事故联络信息：

紧急联络电话：+44 (0) 20 3475 3880

2．危险性概述

GHS危险性类别：根据《化学品分类和危险性公示通则》（GB13690-

2009）及化学品分类、警示标签和警示性说明规范系列标准，该产品危害分类信息如下：

物理性危害：无相关分类

健康危害：急性毒性，口服-5；急性毒性，皮肤-5

水生环境危害：生水环境危险（慢性）4

标签要素：

象形图：无

警示词：警告

危险信息：

H303：吞咽可能有害（口服）。

H313：接触皮肤可能有害（皮肤）。

H413：可能对水生生物产生长期持续有害影响。

预防措施：

P273：禁止排入环境。

事故响应：

P312：如感觉不适，呼叫中毒控制中心或就医。

P391：收集泄漏物。

储存注意事项：

废弃处置：

P501：参照地方，区域，国家，国际法规（规定）处置。

3.成分/组成信息产品描述：物质（）；混合物（√）

成分名称 CAS No. 重量百分比(%)

二甲基亚砜

Dimethyl sulfoxide

67-68-5 60 - 100

布雷菲德菌素A

4H-Cyclopent[f]oxacyclotridecin-4-one,

1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-

dihydroxy-6-methyl-,

(1R,2E,6S,10E,11aS,13S,14aR)-

20350-15-6 0.1 - 1

Brefeldin A Solution 安全数据表

29/05/2015 Chinese(Simplified) 12/17

成分名称 CAS No. 重量百分比(%)

其他无害成分

Non-hazardous ingredients

商业机密 <0.1

4．急救措施如果在使用该产品时造成对人体的危害，请咨询医师或专业人士。具体措施如下:

吸入：将患者转移至空气新鲜处，休息，保持利于呼吸的体位。如感觉不适，呼

叫中毒控控制中心。

皮肤接触：立即脱掉所有被污染的衣服。用水及肥皂清洗。污染的衣服洗净后方可重

新使用。如果发生皮肤刺激，就医。

眼睛接触：用水细心冲洗数分钟，如戴隐形眼镜并可方便地取出，取出隐形眼镜，继

续冲洗。如果发生眼睛刺激，就医。

误食：请勿给予食物给无意识的吞咽者。请勿催吐。如感觉不适，就医。

接触该化学品的主要症状和对

健康的影响：

急性效应：吞咽可能有害。接触皮肤可能有害。

迟发效应：无

对施救者的忠告：请勿给予意识不清者任何食物，及时送往医院医治。

医生的特别提示：根据具体症状及接触量处理。

5．消防措施

灭火方法及灭火剂：可使用二氧化碳、泡沫、干粉灭火。请勿使用柱状水灭火，以免引起熔融物飞溅

。

特别危险性：无。

特殊灭火方法：切断空气源。在上风向灭火。喷水容器冷却，在没有危险的前提下，尽可能将容

器从火场转移至空旷处。禁止非相关人员出入。

保护消防人员的防护设备：消防人员应在上风向灭火，佩戴合适的防护设备。在有可能接触到皮肤的情况下

，佩戴防渗透手套。灭火时应佩戴防毒面罩，以免吸入一氧化碳和其他有毒气体

。

6．泄漏应急处理

作业人员防护措施、防护装备和应急处置程序：

作业人员防护措施、防护装备

:

佩戴防护手套（如：橡胶手套）/穿防护服（如：合成纤维材质防静电防护服）/

佩戴防护眼镜/面罩。在需要的情况下（比如：空气中污染物浓度较高或有蒸气

的情况下），佩戴防毒口罩，眼罩。作业人员必须经过专业培训之后方可操作。

环境保护措施: 请勿将清洗残余物倾入城市下水道及开放性水域。遵循当地及国家相关法律法规

。

应急处置程序: 隔离泄漏污染区，周围设警告标志进行隔离，限制非相关人员出入。不要直接接

触泄漏物。在没有危险的情况下，尽可能切断泄漏源。

泄漏化学品的收容、清除方法及所使用的处置材料：

少量泄漏: 用砂土、干燥石灰等惰性材料吸附泄漏液体。收集至专门的容器，贴上标签以便

合理处置。



大量泄漏:

隔离泄漏污染区，周围设警告标志，建议应急处理人员穿化学防护服，佩戴防护

手套等。不要直接接触泄漏物。

构筑围堤或挖坑收容。喷雾状水冷却和稀释蒸汽、保护现场人员、把泄漏物稀释

成不燃物，请勿直接接触泄漏物。用防爆泵转移至槽车或专用收集器内，回收或

运至废物处理场所处置。

防止发生次生危害的预防措施：

清除过程中产生的废水需无害处理后再排放。

7．操作处置与储存操作处置：

得到专门指导后操作。

在阅读并了解所有安全预防措施之前，切勿操作。

远离热源/火花/明火/热表面-禁止吸烟。

避免吸入烟气、气体、烟雾、蒸气、喷雾。

操作后彻底清洗双手。

作业场所不得进食、饮水或吸烟。

仅在户外或通风良好处使用。

污染的工作服不得带出工作场所。

戴防护手套。

搬运时要轻装轻卸，防止包装及容器损坏。

储存：

安全储存的条件：储存于阴凉，通风良好，干燥处。避免长时间日照，上锁保管，置于儿童接触不到

的地方。远离引火源（如：热表面，火花等）。

禁配物：卤化物、强酸、强氧化剂、强还原剂。

包装材料：一般采用密封的塑料容器。

其它信息：仓库应配备合适的意外泄露收集设备及消防设备。

8．接触控制和个人防护职业接触限值：

无相关数据。

监测方法：工作场所有害物质的测定按GBZ159《工作场所空气中有害物质监测的采样规范》进

行检测，也可采用国内外公认的测定方法执行。

生物限值：无相关数据。

工程控制：严格按照程序操作，保持良好的通风。如果操作过程中产生蒸气或烟雾，请使用通

风装置确保空气接触值不超过所规定的限值。

个人防护设备（针对操作工人）：

手部防护:佩戴不渗透防护性手套（如：橡胶手套）。

眼睛防护:在可能产生蒸气或烟雾的情况下或长时间作业场所，佩戴安全防护镜。



呼吸系统防护:若接触空气中的浓度超出所规定极限值或出现不适症状，使用经许可的防毒口罩。

身体防护:穿着防护服（如：合成纤维材质防静电防护服），防渗透手套，靴子等。

一般防护及卫生措施：

在休息期间及结束工作前清洗双手。

避免吸入加工过程中可能引起的蒸气。

避免接触眼睛及皮肤。

9．理化特性基本信息

形态液体

颜色无色

气味无数据

pH值无数据

沸点/沸点范围无数据

熔点/熔点范围无数据

闪点 87℃(189℉)

燃烧/爆炸极限值-下限值体积百分比% 无数据

燃烧/爆炸极限值-上限值体积百分比% 无数据

相对密度无数据

蒸气压无数据

蒸气密度无数据

溶解性无数据

n-辛醇/水分配系数无数据

自燃温度无数据

分解温度无数据

气味阈值无数据

蒸发速率无数据

粘度无数据

易燃性（固体、气体）不属于易燃液体

10．稳定性和反应性稳定性：正常条件下，稳定。



危险反应：能与酰氯、三氯硅烷等卤化物发生剧烈的化学反应。

应避免的条件：过高温度，长时间阳光直射。

应避免的物质：卤化物、强酸、强氧化剂、强还原剂。

危险的分解产物：遇明火、高热可燃。受热分解产生有毒烟气。(如：碳氧化物，氮氧化物)。

11.毒理学信息

产品毒性数据：

产品名称 CAS LD50/LC50(半数致死剂量)

布雷菲德菌素一

个解决方案

-- 急性毒性(经皮)LD50＞2000mg/kg(大鼠) (数据来源于厂家仅供参考。)

产品分类：区分5

急性毒性(经口)LD50＞2000mg/kg(家兔) (数据来源于厂家仅供参考。)

产品分类：区分5

急性毒性(吸入)：无相关数据

严重眼损伤/眼刺激：无相关分类。

皮肤腐蚀/刺激：无相关分类。

致癌性：无相关分类。

致敏性: 无相关分类。

生殖细胞致变性：无相关分类。

生殖毒性：无相关分类。

吸入危险：无相关分类。

特定靶器官系统毒性：无相关分类。

毒代动力学、代谢和分布信息: 无相关信息。

12．生态学信息生态毒性：二甲基亚砜（CAS：67-68-5）：

鱼类LC50：32300 mg/l 96 hr蓝色太阳鱼（OECD Screening Information Data

Set）

甲壳类EC50：24600 mg/l 48 hr大型蚤OECD（ Screening Information Data

Set）

藻类EC50：12350-25500 mg/l 96 hr中肋骨条藻 (IUCLID)

持久性和降解性：二甲基亚砜（CAS：67-68-5）：

持久性：log Kow -1.35 ICSC

降解性：无相关资料

潜在的生物积累性：二甲基亚砜（CAS：67-68-5）：

累积性：BCF＜0.4 IUCLID

可分解性：3.1(%) 28 day（Chemical Risk Information Platform ）

(CHRIP)

土壤中的迁移性：液体状态下，可在土壤中迁移。



13．废弃处置 13.1. 废弃处置方法：

残余废弃物：废弃前尽可能使用中和，反应等方式进行无害化处理，使其危害性降到最低。

送至专门的废弃物处置中心处理。

在送至废弃物处置中心时，有必要告知该废弃物可能存在的危害性。

建议在装备有加力燃烧室和洗刷设备的化学焚烧炉内燃烧处理。

受污染的容器和包装：容器或包装可能残留有害物，作为有害废弃物处理。

废弃注意事项：请勿丢弃至下水道。

请勿丢弃至水域中。

废弃物的处置应该根据当地相关废弃物处理当局的要求进行处理。

14.运输信息

DOT.交通运输部/IATA/ICAO空运（国际航空运输协会/国际民航组织）/IMO/IMDG.海洋运输（国际海运组织/国际

海上危险货物规则）

正确装运名称：不适用

UN编号：不适用

危害分类：不适用

包装类别：不适用

包装标志：不适用

是否海洋污染物（是/否）:否

注意事项:

装运前检查包装是否完好或密封，运输过程中要确保容器不泄漏、不倒塌、不坠落、不损坏。运输时运输车辆应

配备相应品种和数量的消防器材及泄漏应急处理设备。请勿与会与其发生危险反应的化学品一起运输，中途停留

时应远离火种、热源。

15．法规信息

国内相关法规:

化学品分类和危险性公示通则（GB13690—2009）：

物理性危害：无相关分类。

健康危害：急性毒性，口服-5；急性毒性，皮肤-5。

水生环境危害：生水环境危险（慢性）-4。

危险货物运输包装类别划分方法（GB/T15098—2008）：

不适用

危险货物品名表（GB12268-2012）：

不适用

中华人民共和国安全生产法：安全生产经营，事故应急处理，法律责任等相关内容须符合该法规的相关规定。

中华人民共和国职业病防治法：该产品对人体有害，有关前期预防，劳动过程中的防护与管理，职业病诊断相关

内容可参考该法规的相关规定。

中华人民共和国环境保护法：在防治环境污染等方面要遵守该法规的相关规定。该产品虽然水生环境危害无相关

分类，但对水生环境可能会产生影响，切勿任意排放至水域中。

国际相关法规：

TSCA有毒物质控制法案：该产品成分中二甲基亚砜（CAS：67-68-5）在该法案规定的现存物质清单中。

危险警语及安全术语（67/548/EEC附录Ⅰ）：

该产品中各成分无相关资料

致癌性相关法规：无相关分类。

空气污染法案：

该产品不含有该法案下的一类臭氧层破坏物质。

该产品不含有该法案下的二类臭氧层破坏物质。



16．其他信息免责声明：

以上所有信息仅供参考且真实可靠，我司不会控制他人的使用方式且不对因此造成的后果承担任何责任。应由使

用者来决定如何正确使用该产品或者采用出于某种特殊目的的生产方式。采纳上述所提到的注意事项有助于避免

在操作及使用产品时可能引起的对财产和人生安全造成的危害。

参考资料：GB/T 16483-2008、GB 13690—2009、GB/T 15098—2008、GB12268-2012、GB/T 17519-

2013、GHS技术

文件等法规资料。

SDS最新修订日期：2015年05月29日

SDS版本：1.0

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