What are Probiotics and why do I need them?The human body carries nearly 100 trillion bacteria in the gut, which is more than 10 times the total number of cells in the entire body.Probiotics are those “good” bacteria that help keep the intestines healthy and assist in nutrient absorption. The benefits of Probiotics are multifaceted, however the more research that is conducted, the more the benefits are being understood.Researchers are starting to discover the real importance of gut bacteria, including the influence on the immune system. The gut accounts for 25% of the immune cells in the body while providing 50% of the body’s actual immune response.

So how do Probiotics work?Probiotics work to help maintain balance in the intestinal microbiota. By enhancing the intestinal flora, these microorganisms have a larger effect in terms of keeping people in good health.Recent research on the microbiome has shown that its influence extends far beyond the gut, playing a crucial role in both our digestive and immune systems. More recently, studies are showing the microbiomes role in areas including brain health, memory and even mental health.

So, what is special about Bulk Nutrients Probiotic?The majority of Probiotics currently available are bacteria which are “non spore” formers such as lactobacilli and Bifidobacetria.These Probiotic strains have been widely studied for their health benefits and are a popular choice for use in dietary supplements of cold pressed foods such as yoghurts. Spore forming bacteria are a diverse group of very hardy bacteria, characterised by their ability to form endospores to protect themselves in varying conditions such as high temperature and high acidic environments. Bacillius Subtilis species of microorganism has been known for almost 100 years, and is considered to be a normal inhabitant of the gut in humans. It has the ability to form spores that protect the microbes from harsh conditions until they enter an environment suitable for germination, like the GI tract. They remain viable under a wider range of conditions and don’t require refrigeration, and can survive the passage through the acidic environment of the GI tract. After surviving the GI tract they can resporulate, increasing in number.

Is there any clinical data which show these actually work?There is significant research that has been conducted on the genome sequenced and tested Bacillius Subtilis spore that we use. A randomized, double blind study has shown the ability of it to support healthy gut microflora by controlling microbial populations as well as supporting digestion and maintaining general health.

BULK NUTRIENTSPURE SUPPLEMENTS

Figure 5. Subjects taking the placebo experienced an increase in glucose levels, while the levels of subjects taking DE111 were maintained.

Figure 4. Subjects taking the placebo experienced a larger increase in cholesterol levels than those taking DE111.

Figure 6. Subjects taking the placebo experienced an increase in triglyceride levels, while the levels of subjects taking DE111 were maintained.

Cholesterol

170

168

166

164

162

160

158

156

154

mg/dL

DE111Placebo

Glucose

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Placebo DE111

Triglycerides

105

100

95

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85

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Placebo DE111

SUPPORTS DIGESTION AND MAINTAINS GENERAL HEALTH

DE111 supports the normal breakdown of complex carbohydrates and fats, promoting proper digestion and nutrient absorption.

n Cholesterol Pre (<200 mg/dL)n Cholesterol Post (<200 mg/dL)

n Glucose Pre (70-98 mg/dL)n Glucose Post (70-98 mg/dL)

n Triglyceride Pre (33-137 mg/dL)n Triglyceride Post (33-137 mg/dL)

Figure 2. Subjects who were administered the placebo demonstrated a decrease in intestinal levels of the probiotic Bifidobacterium , while those who were administered DE111 experienced a significant increase.

Figure 1. Subjects who were administered the placebo demonstrated a slight decrease in intestinal levels of the probiotic Bacillus subtilis , while those who were administered DE111 experienced a significant increase.

Figure 3. Subjects who were administered the placebo demonstrated an increase in levels of the pathogenic bacteria E. coli , while those who were administered DE111 experienced a slight decrease.

Placebo DE1110

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Clinical ResultsA randomized, double-blind, placebo controlled human clinical study has shown the ability of DE111 to support a healthy gut microflora by controlling microbial populations as well as support digestion and maintain general health.

CONTROLS MICROBIAL POPULATIONS

DE111 is a classic Bacillus subtilis strain that supports the normal proliferation of beneficial bacteria and crowds out other bacteria.

n Pre n Post n Pre n Post n Pre n Post

BACILLUS SUBTILIS

CHOLESTEROL

BIFIDOBACTERIUM

GLUCOSE

E. COLI

TRIGLYCERIDE

BULK NUTRIENTSPURE SUPPLEMENTS

BULK NUTRIENTSPURE SUPPLEMENTS