biosynthesis of
DESCRIPTION
Biosynthesis of. Group 3. 生科系博士班 884234 李曉青 資工系博士班 914338 張君天 資工系博士班 928307 林沿妊. Powerful antioxidant, reduces the risk of Coronary heart disease by preventing oxidation of low density lipoprotein (LDL) cholesterol Atherosclerosis by protecting plasma lipids from oxidation - PowerPoint PPT PresentationTRANSCRIPT
Biosynthesis ofBiosynthesis of
生科系博士班 884234 李曉青資工系博士班 914338 張君天資工系博士班 928307 林沿妊
Group 3
Powerful antioxidant, reduces the risk of
– Coronary heart disease by preventing oxidation of low density lipoprotein (LDL) cholesterol
– Atherosclerosis by protecting plasma lipids from oxidation
– Oxidative damage of lymphocyte DNA
– Cancer
Protein ID
Protein name Gene
2.2.1.7 1-deoxy-D-xylulose-5-phosphate synthase dxs E.coli1.1.126
72-C-methyl-D-erythritol 4-phosphate (MEP) synthase dxr E.coli
2.7.7.602-C-methyl-D-erythritol 4-phosphate cytidylyltransf
erase ygbP E.coli
2.7.1.148
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase ychB E.coli
4.6.1.122-C-methyl-D-erythritol 2,4-cyclodiphosphate synth
ase ygbB E.coli
1.17.4.3
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase gcpE E.coli
1.17.1.2 4-hydroxy-3-methylbut-2-enyl diphosphate reducta
se lytB E.coli
5.3.3.2 isopentenyl-diphosphate delta-isomerase b2889
E.coli
2.5.1.10 farnesyl-diphosphate synthase ispA E.coli
2.5.1.29 geranylgeranyl pyrophosphate synthetase crtE E.uredovora
2.5.1.32 phytoene synthetase crtB E.uredovora
1.3.99- oxidoreductase crtI E.uredovora
1.14.99.30
zeta-carotene desaturase crtQ E.uredovora
dxs:DXP synthaseidi: IPP isomeraseispA: Farnesyl-PP synthase
crt E: GGPP synthasecrt B: phytoene synthasecrt I: lycopene synthase from E.uredovora gps:ggpp synthase
from A.fulgidus
Red : E.coli
Blue : A.fulgidus
Green: E.uredovora
Wang CW, Oh MK, Liao JC. Engineered isoprenoid pathway enhances astaxanthin production in Escherichia coli.Biotechnol Bioeng. 1999 Jan 20;62(2):235-41.
Misawa N, Nakagawa M, Kobayashi K, Yamano S, Izawa Y, Nakamura K, Harashima K. Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli.J Bacteriol. 1990 Dec;172(12):6704-12.
Farmer WR, Liao JC. Improving lycopene production in Escherichia coli by engineering metabolic control.Nat Biotechnol. 2000 May;18(5):533-7.
References