bioMérieux systems March 2015

Overview

Microbiology P. 2

Immunoassays P. 10

Molecular Biology P. 12

Industrial Applications P. 15

Services P. 19

2

Microbiology: VITEK®

Fully automated identification (ID) and antibiotic

susceptibility testing (AST)

Featuring Advanced Expert SystemTM result

interpretation software

The standard for routine identification

Coverage: 90% of the routine work in a normal

clinical laboratory

64-well cards with proprietary and innovative

substrates

The highest level of automation

Full automation and safety (inoculation, sealing,

and incubation of the card)

Accuracy

Rapid reporting (same day ID / AST results)

Resistance detection

Separate ID / AST testing

Reduced waste

After-sale service and high level of technical

support

21 CFR Part 11 compliant

Launched:

1977 - VITEK

1997 - VITEK®2

2004 - VITEK®2 Compact

3

Mass spectrometry for identification of bacteria, yeast,

fungi, and mycobacteria

Fast ID

Broad range of organisms

Cost-effective solution for large laboratories

Workflow integration via MylaTM

Integrated with VITEK® 2 for AST*

The only clinical mass spectrometry MALDI-TOF-based

system available in the U.S. for use by microbiology labs

in the routine detection of a comprehensive menu of

disease-causing microorganisms

MALDI-TOF mass spectrometry (MS)

Extract the ions from the sample: Matrix-Assisted

Laser Desorption / Ionization (MALDI)

Separate the ions by m/z: Time-of-Flight Analysis

(TOF)

Detect the ions

European commercial launch in Q1 2011

FDA clearance in Q3 2013

Microbiology: VITEK® MS

Sample Prep Station VITEK® 2

* AST: antibiotic susceptibility testing

4

Microbiology: BacT/ALERT®

Early detection of septicemia and industrial sterility

control

“Yes – No” test for bacteria

Automated colorimetric detection system -

with visual positive signal

Immediate notification of results

Plastic bottles to ensure safety

New media: synthetic resin beads to replace

activated charcoal suspension launched in Q4 2011

Neutralization of antibiotics in clinical samples

and industrial products

A clear Gram stain Launched:

BacT/ALERT® in 1991

BacT/ALERT® 3D in 1997

Bloodculture

Direct culture of blood samples and other fluids

VIRTUOTM: a new dimension in blood culture testing

5

“Set and forget” loading

Final negative bottles

removed automatically

Smart scanning technology

Sample level sensing

Intuitive touchscreen New growth detection

algorithms

On-time alert

The first CE-marked fully automated blood culture system

maximizes laboratory efficiency and provides actionable and faster results

July 2014

6

Microbiology: Lab Efficiency A strategic partnership with *

Fast growing customer needs:

automate tasks

enhance operational efficiency

make up for the growing shortage of specialized staff

obtain the accreditation they need to operate

The “bioMérieux - COPAN” offering is unique and the most complete

Streamline workflows

Deliver faster and more standardized results

Improve traceability of analyses

Transport media Decap / Recap Broth inoculation ID / AST prep.

Plates Gram smearing Incubation ID / AST run

Blood culture Gram / TB

staining Reading Middleware

Urinary screening Plate streaking Discs deposit Services

* Since January 2015, bioMérieux has been COPAN’s exclusive distributor in France, and a co-exclusive distributor in Germany

and the United Kingdom to distribute COPAN’s WASP® and WASPLabTM systems. Then bioMérieux’s commercialization rights

will gradually be expanded, on the basis of co-exclusive distribution, to a number of key countries.

WASP® and WASPLabTM systems

7

Microbiology: Urinary screening - UF-1000i/500i

Distribution agreement in France,

Germany, the Netherlands, UK, South

Korea, and Australia

High quality by accurate detection and

enumeration of urine particles

Standardized results with capabilities

to screen out negative samples

In line with customer needs

Standardization

Time-saving

Traceability

Launched in September 2007

Advanced flow cytometry technology

with hydrodynamic focusing for urinary

screening

8

Microbiology : PREVITM Color Gram

A fast, reliable & user friendly system

Result in less than 5 minutes

Accurate standardized results

No cross contamination

Clean and Safe

System entirely enclosed with

a waste container

Environmentally friendly system

Spray nozzles

Less consumption and waste

Pre-launch in about 10 European countries in 2008

Global launch in 2009

Full automated Gram staining system :

from fixation to the slide ready for

reading

Standard 12-slide capacity, upgradable

to 30-slide capacity

Direct analysis

9

Microbiology: PREVITM Isola

Standardized plate inoculation

Time saving with high throughput

180 plates / hour

No cross contamination

Optimized colony isolation

High quality for plate streaking

Enhanced productivity

Breakthrough technology for

innovation in plate streaking

Pre-launched in 2008 in the Netherlands, Germany

and the U.S.

Gradual rollout to other regions in 2009

Pre-analytical processing

Specimen inoculation automation

10

Immunoassays : VIDAS®,mini VIDAS® and VIDAS® 3

VIDAS® : launched in 1991

mini VIDAS®: launched in 1992

VIDAS® 3:

CE-marked: Q2 2013 - SFDA-approved: Q2 2014

Antigen-antibody reaction

Detects and measures infectious agents:

bacteria, viruses, parasites, hormones,

proteins

ELFA - Enzyme Linked Fluorescent Assay

technology

* College of American Pathologists: Automated Immunoassay Analyzers – June 2009 **Mean Time Between Failures

The world’s largest installed base* in IA

laboratories, with about 29,000 VIDAS® ,

mini VIDAS® and VIDAS® 3 clinical systems

Multi-parameter instrument

Large menu with 100 parameters

One of the most reliable instrument: MTBF**

VIDAS® = 660 days / mini VIDAS® = 1,150 days

Flexible and easy-to-use

Single test concept tailored to the small volume

market

Mini VIDAS®

VIDAS®

VIDAS ® 3

VIDAS® B.R.A.H.M.S PCTTM - bioMérieux’s

best-selling test : a test to measure procalcitonin (PCT),

a biomarker recognized as the gold standard

for the early detection of sepsis in critically ill patients

VIDAS® B.R.A.H.M.S PCTTM

11

Immuoassays: DA VINCI®

Microplate immunoassay tests*

Up to 192 sample tubes loaded

at one time

Used by medium-sized blood banks

and large laboratories

Extensive set of in-process controls

Loading tower: 15 microplates

Traceability

Easy to operate

« Open » system: possibility of

adding other assays

Launched in 2003

DA VINCI® QUATTROTM

* Non strategic product line - Under divestiture process

12

Molecular Biology: NucliSENS® easyMAG®

A single generic protocol for all samples

Up to 240 extractions in an 8-hour shift

Less than 15 minutes of hands-on-time

per 24 extractions

Simultaneous processing different samples

and volumes

User comfort

Simplicity

Flexibility

Quality

Time saving

Simplification and automation of sample

preparation in molecular biology laboratories

BOOM® technology: the reference

technology in extraction

Automated nucleic acid extraction - magnetic

extraction

Launched in 2005

13

Molecular Biology: DiversiLab®

Launched in 2007

Microbial genotyping of bacteria and

fungi

Based on patented rep-PCR

technology

For tracking the spread and source

of microbial infection, contamination,

or epidemics

Microbial isolates to be quickly and

accurately distinguished at the

subspecies and strain level

Precise and economical solution

Results in 4 hours

just-in-time and syndromic molecular testing

14

FilmArray®

FilmArray® 2.0

Molecular syndromic approach to infectious diseases

A unique value proposition

Rapidity: results in about 1 hour

Automation and ease-of-use: 2 minutes of hands-on time

Comprehensiveness: more than 20 micro-organisms in

one single panel whatever their nature

FilmArray® instrument: 2 commercially-available versions

3 CE-marked and FDA-approved FilmArray® panels

The FilmArray® Respiratory Panel: 20 respiratory

viruses and bacteria

The FilmArray® Gastrointestinal Panel: 22 common

gastrointestinal pathogens including viruses, bacteria

and parasites

The FilmArray ® Blood Culture Identification (BCID)

Panel: 24 pathogens and 3 antibiotic resistance genes

associated with bloodstream infections

Launched:

FilmArray® in 2011

FilmArray® 2.0 in 2015

Emergency Use Authorization

(EUA) from the FDA received by

FilmArray® clinical Ebola virus

detection test (BioThreat-E test™)

in October 2014

bioMérieux and AES A winning combination

15

Food sample preparation: AES Blue LineTM

16

DilumatTM range

SmasherTM

Blender easyMIXTM

17

VIDAS® and

mini VIDAS®

Pathogen detection

TEMPO®

Quality indicator enumeration

BacT/ALERT® 3D Chemunex®

Rapid microbial detection & sterility

testing

VITEK® 2 compact

Automated identification

Environment monitoring

Labguard®

Industrial Applications

VITEK® MS

18

Industrial applications : TEMPO®

Ease of use

Fast turnaround time for accurate and

standardized results

Standardization of numerous

preparation steps, interpretation, and

test results

TEMPO® system’s menu: a broad

range of 10 cards to answer different

needs

Incubation of 24 to 48 hours

Launched in 2005

Automated solution for the enumeration

of quality indicator microorganisms

bioMérieux Performance SolutionsTM

19

Building an Efficient, Empowered, Learner lab